CY1376A - Benzisothiazole and benzisoxazole derivatives - Google Patents

Benzisothiazole and benzisoxazole derivatives

Info

Publication number
CY1376A
CY1376A CY137682A CY137682A CY1376A CY 1376 A CY1376 A CY 1376A CY 137682 A CY137682 A CY 137682A CY 137682 A CY137682 A CY 137682A CY 1376 A CY1376 A CY 1376A
Authority
CY
Cyprus
Prior art keywords
benzisothiazole
benzisoxazole derivatives
benzisoxazole
derivatives
Prior art date
Application number
CY137682A
Other languages
English (en)
Inventor
L Temple Davis
P Yevich Joseph
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CY1376A publication Critical patent/CY1376A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CY137682A 1981-12-23 1982-11-24 Benzisothiazole and benzisoxazole derivatives CY1376A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/333,830 US4411901A (en) 1981-12-23 1981-12-23 Benzisothiazole and benzisoxazole piperazine derivatives

Publications (1)

Publication Number Publication Date
CY1376A true CY1376A (en) 1987-08-07

Family

ID=23304433

Family Applications (1)

Application Number Title Priority Date Filing Date
CY137682A CY1376A (en) 1981-12-23 1982-11-24 Benzisothiazole and benzisoxazole derivatives

Country Status (26)

Country Link
US (1) US4411901A (xx)
JP (2) JPS58110576A (xx)
KR (1) KR870001022B1 (xx)
AU (1) AU550780B2 (xx)
BE (1) BE895469A (xx)
CA (1) CA1205806A (xx)
CH (2) CH656617A5 (xx)
CY (1) CY1376A (xx)
DE (1) DE3247530A1 (xx)
DK (2) DK160939C (xx)
ES (4) ES518168A0 (xx)
FI (1) FI78697C (xx)
FR (2) FR2521561B1 (xx)
GB (1) GB2114119B (xx)
GR (1) GR77108B (xx)
HK (1) HK5088A (xx)
HU (2) HU190997B (xx)
IE (1) IE54789B1 (xx)
IT (1) IT1158037B (xx)
KE (1) KE3718A (xx)
LU (1) LU84550A1 (xx)
NL (1) NL8204910A (xx)
PT (1) PT76017B (xx)
SE (2) SE453502B (xx)
SG (1) SG30087G (xx)
ZA (1) ZA828544B (xx)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4656280A (en) * 1984-03-07 1987-04-07 E. I. Du Pont De Nemours And Company Radioiodinated dopamine receptor ligand
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
AU593194B2 (en) * 1986-09-26 1990-02-01 Sumitomo Pharmaceuticals Company, Limited Imide derivatives ,and their production and use
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
EP0348460A4 (en) * 1987-11-12 1991-11-27 American Home Products Corporation Polycyclicamines with psychotropic activity
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
WO1990002552A1 (en) * 1988-09-16 1990-03-22 Pfizer Inc. Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
US4847252A (en) * 1988-10-25 1989-07-11 Bristol-Myers Company Method for alleviation of vascular headache
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
GB9226857D0 (en) * 1992-12-23 1993-02-17 Boyd Edward A Pharmaceutical compositions
EP0635506A4 (en) * 1993-02-04 1995-04-12 Meiji Seika Co CONNECTION WITH ANTIPSYCHOTIC EFFECT.
HUT69376A (en) * 1993-05-04 1995-09-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing heterocyclic compounds
IL117295A (en) 1995-02-28 1999-11-30 Lundbeck & Co As H 4-Aminotetrahydro-benzisoxazole or-isothiazole compounds and pharmaceutical compositions comprising them
PT833820E (pt) * 1995-06-06 2001-07-31 Aventis Pharmaceuticals Inc Av Derivados de benzisoxazol e indazol uteis como agentes antipsicoticos
EP1757292A1 (en) 1997-09-05 2007-02-28 Pfizer Products Inc. Method of treating ocd and tic disorders
WO2000059489A2 (en) * 1999-04-06 2000-10-12 Sepracor Inc. Methods and compositions for the treatment of psychotic and related disorders using ziprasidone metabolites
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
EP1558608A1 (en) * 2002-10-28 2005-08-03 Warner-Lambert Company LLC Oxindole substituted piperazine derivatives
CA2505397A1 (en) * 2002-11-08 2004-05-21 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
HUE032743T2 (en) 2006-11-22 2017-10-30 Clinical Res Ass Llc A method for treating Down syndrome, fragilis X syndrome and autism
US8981095B2 (en) 2011-07-28 2015-03-17 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof
CN105669665A (zh) * 2016-03-15 2016-06-15 烟台贝森医药科技有限公司 哌罗匹隆的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1595920B2 (de) * 1964-11-04 1978-08-10 Merck Patent Gmbh, 6100 Darmstadt 4-(co-Piperazinoalkyl)-pyrazole, ihre Salze und Verfahren zu ihrer Herstellung
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
DE1695410A1 (de) * 1967-04-20 1971-04-08 Merck Patent Gmbh Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
DE1670907B2 (de) * 1967-08-16 1976-07-22 Bayer Ag, 5090 Leverkusen N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US3528989A (en) * 1967-11-14 1970-09-15 Colgate Palmolive Co 3-aminoalkyl derivatives of 2,1-benzisothiazoline
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
AR207986A1 (es) * 1974-07-01 1976-11-22 Sumitomo Chemical Co Un procedimiento para producir compuestos del 3-(aminoalquil n-sustituido)-benz-2,1-isoxazol
US3940398A (en) * 1975-01-23 1976-02-24 E. R. Squibb & Sons, Inc. 2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
DE2734866A1 (de) * 1977-08-03 1979-02-22 Basf Ag Neue 1,2-benzisothiazole und verfahren zu ihrer herstellung
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
DK251079A (da) * 1978-06-20 1979-12-21 Synthelabo Fremgangsmaade til fremstilling af phenylpiperazinderivater

Also Published As

Publication number Publication date
JPH0517457A (ja) 1993-01-26
BE895469A (fr) 1983-06-23
IE823053L (en) 1983-06-23
SE8702389D0 (sv) 1987-06-09
DE3247530A1 (de) 1983-06-30
CH659070A5 (de) 1986-12-31
DK307590D0 (da) 1990-12-28
DK162601C (da) 1992-05-11
DK160939B (da) 1991-05-06
KE3718A (en) 1987-04-16
JPS58110576A (ja) 1983-07-01
ES8502991A1 (es) 1985-02-01
SE462162B (sv) 1990-05-14
HU195806B (en) 1988-07-28
FR2521561A1 (fr) 1983-08-19
ES524946A0 (es) 1985-04-01
SE8207350D0 (sv) 1982-12-22
SE8207350L (sv) 1983-08-10
LU84550A1 (fr) 1983-09-08
DK162601B (da) 1991-11-18
KR840002832A (ko) 1984-07-21
ES8401970A1 (es) 1984-01-16
CH656617A5 (de) 1986-07-15
SE8702389L (sv) 1987-06-09
GR77108B (xx) 1984-09-06
IT1158037B (it) 1987-02-18
US4411901A (en) 1983-10-25
ES525470A0 (es) 1985-02-01
AU550780B2 (en) 1986-04-10
FI824379A0 (fi) 1982-12-20
ES518168A0 (es) 1984-01-16
IT8249709A0 (it) 1982-12-21
DK307590A (da) 1990-12-28
SE453502B (sv) 1988-02-08
JPH0577669B2 (xx) 1993-10-27
DK566282A (da) 1983-06-24
FR2531431A1 (xx) 1984-02-10
FI824379L (fi) 1983-06-24
ES525471A0 (es) 1985-02-01
AU9087282A (en) 1983-06-23
HU190997B (en) 1986-12-28
HK5088A (en) 1988-01-29
KR870001022B1 (ko) 1987-05-23
FR2521561B1 (fr) 1986-10-10
FI78697B (fi) 1989-05-31
SG30087G (en) 1987-07-17
PT76017B (en) 1985-12-20
ZA828544B (en) 1983-09-28
DK160939C (da) 1991-10-21
CA1205806A (en) 1986-06-10
GB2114119A (en) 1983-08-17
ES8503349A1 (es) 1985-02-01
ES8503683A1 (es) 1985-04-01
PT76017A (en) 1983-01-01
FI78697C (fi) 1989-09-11
IE54789B1 (en) 1990-02-14
FR2531431B1 (xx) 1986-10-10
GB2114119B (en) 1985-11-27
NL8204910A (nl) 1983-07-18

Similar Documents

Publication Publication Date Title
GB2114119B (en) Benzisothiazole and benzisoxazole derivatives
DE3276317D1 (en) 7-oxabicyclopheptane and 7-oxabicycloheptene compounds
IL76090A (en) 26,26,26,27,27,27,-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1alpha,2alpha-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof
DE3273329D1 (en) Analgesic process and composition
EP0092786A3 (en) 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives
NZ201520A (en) Substituted aminopyridazines and pharmaceutical compositions
JPS57179117A (en) Analgesic composition and use
EP0080442A3 (en) Di-galactose derivatives and their preparation
IL64933A0 (en) 1 alpha,25-dihydroxy-2 beta-fluorovitamin d3 and derivatives thereof
DE3275377D1 (en) Fungicidal alkinyl-azole derivatives and their use
IL65650A0 (en) Lysozyme-sensitive microorganisms and processes for the preparation thereof
IL64774A (en) Hexahydro-trans and tetrahydropyridoindole derivatives
ZW7782A1 (en) 2,4-disubstituted-5-thiazolecarboxylic acids and derivatives
DE3266355D1 (en) Octahydrotetracyanoquinodimethane and derivatives thereof
AU555220B2 (en) Isoindole and thiazole(1,2) derivatives
PH18239A (en) 1-substituted-4-phenyl-polyhydropyridines and pyrrolidines
IL67581A0 (en) Aminopropylaminobleomycin derivatives and process for preparation thereof
IL65539A0 (en) New 13-thia-prostacycline derivatives and process for the preparation thereof
AR243249A1 (es) Procedimiento para obtener derivados de acidos ¡oxo-4-4h-(1)-benzopiran-8-il¿alcanoicos, intermediarios de aplicacion exclusiva a dicho procedimiento y proceso para prepararlos.
GB2095247B (en) N-(b-amenoethyl)-4-hydroxy-2,2,6,6-tetramethyl-piperidene and derivatives thereof
JPS57179198A (en) 3-oxo-17 alpha-ethynyl-17 beta-trifluoroacetoxy- gonane derivatives and manufacture
IL65491A0 (en) 4-oxo-pgi2 derivatives and process for the preparation thereof
JPS57134458A (en) N-haloalkylthiobenzanilides and use as mildewcide
IL65492A0 (en) New 13-oxa-prostacycline derivatives and process for the preparation thereof
AU7993382A (en) I-spiro isobenzofuranic and i-spiro isobenzothiophenic derivatives