ES2728459T3 - Composiciones que comprenden PEG y ascorbato - Google Patents
Composiciones que comprenden PEG y ascorbato Download PDFInfo
- Publication number
- ES2728459T3 ES2728459T3 ES13762101T ES13762101T ES2728459T3 ES 2728459 T3 ES2728459 T3 ES 2728459T3 ES 13762101 T ES13762101 T ES 13762101T ES 13762101 T ES13762101 T ES 13762101T ES 2728459 T3 ES2728459 T3 ES 2728459T3
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- ES
- Spain
- Prior art keywords
- solution
- per liter
- ascorbate
- composition
- ascorbic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 488
- 239000000203 mixture Substances 0.000 title claims abstract description 314
- 235000010323 ascorbic acid Nutrition 0.000 title claims abstract description 246
- 239000011668 ascorbic acid Substances 0.000 title claims abstract description 246
- 229940072107 ascorbate Drugs 0.000 title claims description 48
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 198
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 194
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 192
- CIWBSHSKHKDKBQ-JLAZNSOCSA-M L-ascorbate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CIWBSHSKHKDKBQ-JLAZNSOCSA-M 0.000 claims abstract description 91
- 150000003839 salts Chemical class 0.000 claims abstract description 88
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 66
- 238000002156 mixing Methods 0.000 claims abstract description 26
- 210000001072 colon Anatomy 0.000 claims description 235
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 196
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 196
- 235000002639 sodium chloride Nutrition 0.000 claims description 191
- 239000000796 flavoring agent Substances 0.000 claims description 180
- 235000003599 food sweetener Nutrition 0.000 claims description 172
- 239000003765 sweetening agent Substances 0.000 claims description 172
- 239000011780 sodium chloride Substances 0.000 claims description 99
- 239000001103 potassium chloride Substances 0.000 claims description 98
- 235000011164 potassium chloride Nutrition 0.000 claims description 98
- 229960005055 sodium ascorbate Drugs 0.000 claims description 85
- 235000013355 food flavoring agent Nutrition 0.000 claims description 84
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 84
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 84
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 84
- -1 alkaline earth metal sulfates Chemical class 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 61
- 108010011485 Aspartame Proteins 0.000 claims description 59
- 239000000605 aspartame Substances 0.000 claims description 59
- 235000010357 aspartame Nutrition 0.000 claims description 59
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 59
- 229960003438 aspartame Drugs 0.000 claims description 59
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 53
- 239000007788 liquid Substances 0.000 claims description 48
- 239000000843 powder Substances 0.000 claims description 48
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 46
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 45
- 235000011152 sodium sulphate Nutrition 0.000 claims description 45
- 239000003792 electrolyte Substances 0.000 claims description 44
- 238000002360 preparation method Methods 0.000 claims description 41
- 238000011282 treatment Methods 0.000 claims description 35
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 28
- 229910052936 alkali metal sulfate Inorganic materials 0.000 claims description 27
- 229940074358 magnesium ascorbate Drugs 0.000 claims description 26
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 claims description 26
- 241000124008 Mammalia Species 0.000 claims description 21
- 229940017794 potassium ascorbate Drugs 0.000 claims description 17
- 239000004260 Potassium ascorbate Substances 0.000 claims description 16
- 235000019275 potassium ascorbate Nutrition 0.000 claims description 16
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 claims description 16
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 14
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 14
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 14
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 14
- 235000011151 potassium sulphates Nutrition 0.000 claims description 14
- 206010010774 Constipation Diseases 0.000 claims description 5
- 230000002550 fecal effect Effects 0.000 claims description 5
- 230000014759 maintenance of location Effects 0.000 claims description 5
- 235000010376 calcium ascorbate Nutrition 0.000 claims description 3
- 229940047036 calcium ascorbate Drugs 0.000 claims description 3
- 239000011692 calcium ascorbate Substances 0.000 claims description 3
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 547
- 239000000306 component Substances 0.000 description 282
- 238000004140 cleaning Methods 0.000 description 126
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 114
- 235000019634 flavors Nutrition 0.000 description 96
- 239000003599 detergent Substances 0.000 description 48
- 235000015165 citric acid Nutrition 0.000 description 38
- 239000004376 Sucralose Substances 0.000 description 37
- 235000019408 sucralose Nutrition 0.000 description 37
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 37
- 235000013399 edible fruits Nutrition 0.000 description 33
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 32
- 239000002535 acidifier Substances 0.000 description 32
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 26
- 229910052783 alkali metal Inorganic materials 0.000 description 26
- 239000000619 acesulfame-K Substances 0.000 description 24
- 150000001340 alkali metals Chemical class 0.000 description 24
- 240000000560 Citrus x paradisi Species 0.000 description 19
- 238000001356 surgical procedure Methods 0.000 description 17
- 235000005979 Citrus limon Nutrition 0.000 description 16
- 244000131522 Citrus pyriformis Species 0.000 description 16
- 235000019640 taste Nutrition 0.000 description 16
- 239000002775 capsule Substances 0.000 description 15
- 230000008569 process Effects 0.000 description 15
- 238000002052 colonoscopy Methods 0.000 description 14
- 230000037406 food intake Effects 0.000 description 14
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 13
- 235000011941 Tilia x europaea Nutrition 0.000 description 13
- 239000004571 lime Substances 0.000 description 13
- 239000007787 solid Substances 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 12
- 235000010358 acesulfame potassium Nutrition 0.000 description 12
- 230000000968 intestinal effect Effects 0.000 description 12
- 235000004936 Bromus mango Nutrition 0.000 description 11
- 241001093152 Mangifera Species 0.000 description 11
- 235000014826 Mangifera indica Nutrition 0.000 description 11
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 11
- 235000009184 Spondias indica Nutrition 0.000 description 11
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 11
- 239000007968 orange flavor Substances 0.000 description 11
- 229910052700 potassium Inorganic materials 0.000 description 11
- 239000011591 potassium Substances 0.000 description 11
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
- 229960004998 acesulfame potassium Drugs 0.000 description 10
- 238000002405 diagnostic procedure Methods 0.000 description 10
- 239000000975 dye Substances 0.000 description 10
- 229960003975 potassium Drugs 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 241000207199 Citrus Species 0.000 description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 235000020971 citrus fruits Nutrition 0.000 description 9
- 229910052708 sodium Inorganic materials 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 238000005538 encapsulation Methods 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 150000000994 L-ascorbates Chemical class 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000008143 stimulant laxative Substances 0.000 description 7
- 244000099147 Ananas comosus Species 0.000 description 6
- 235000007119 Ananas comosus Nutrition 0.000 description 6
- 235000016623 Fragaria vesca Nutrition 0.000 description 6
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- 206010047700 Vomiting Diseases 0.000 description 6
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 210000000936 intestine Anatomy 0.000 description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 5
- 235000009499 Vanilla fragrans Nutrition 0.000 description 5
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 5
- 229910052788 barium Inorganic materials 0.000 description 5
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 4
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- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 4
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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| US201261699488P | 2012-09-11 | 2012-09-11 | |
| US201361787366P | 2013-03-15 | 2013-03-15 | |
| PCT/EP2013/068738 WO2014040994A1 (en) | 2012-09-11 | 2013-09-10 | Compositions comprising peg and ascorbate |
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| ES2728459T3 true ES2728459T3 (es) | 2019-10-24 |
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| ES13762101T Active ES2728459T3 (es) | 2012-09-11 | 2013-09-10 | Composiciones que comprenden PEG y ascorbato |
| ES15709665T Active ES2831412T3 (es) | 2012-09-11 | 2015-03-09 | Composiciones que comprenden PEG y ascorbato |
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| ES18210570T Active ES2909386T3 (es) | 2012-09-11 | 2013-09-10 | Composiciones que comprenden polietilenglicol y sulfatos de metales alcalinos o alcalinotérreos para su uso como composiciones de limpieza de colon |
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| ES15709665T Active ES2831412T3 (es) | 2012-09-11 | 2015-03-09 | Composiciones que comprenden PEG y ascorbato |
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| EA028866B1 (ru) * | 2012-09-11 | 2018-01-31 | Норджин Бв | Композиция и раствор для очищения толстой кишки, лекарственное средство (варианты), набор и способ очищения толстой кишки |
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| KR102234803B1 (ko) * | 2014-03-10 | 2021-04-02 | 노어긴 비.브이. | 대장 세척 방법 |
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| WO2017120385A1 (en) * | 2016-01-06 | 2017-07-13 | California Institute Of Technology | Polymeric compositions and related systems and methods for regulating biological hydrogels |
| FR3049464B1 (fr) * | 2016-03-29 | 2021-08-06 | Marc Girard | Preparations coliques |
| KR101981069B1 (ko) | 2018-02-01 | 2019-05-22 | 주식회사태준제약 | 장세척 조성물 |
| WO2019151829A1 (ko) * | 2018-02-01 | 2019-08-08 | 주식회사태준제약 | 장세척 조성물 |
| JP7011629B2 (ja) * | 2019-07-11 | 2022-01-26 | ノージン ビーブイ | 結腸を洗浄する方法 |
| CN110339158B (zh) * | 2019-08-21 | 2020-11-13 | 扬子江药业集团上海海尼药业有限公司 | 一种硫酸钠钾镁口服溶液及其制备方法 |
| US20210196748A1 (en) * | 2019-12-30 | 2021-07-01 | Robert Olson | Composition and therapy for treatment of gag reflexes |
| KR20220033790A (ko) * | 2020-09-10 | 2022-03-17 | 강윤식 | 장 정결용 조성물 |
| WO2022182173A1 (ko) * | 2021-02-26 | 2022-09-01 | 주식회사태준제약 | 장세척을 위한 조성물 |
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