ES2536449T3 - Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer - Google Patents

Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer Download PDF

Info

Publication number
ES2536449T3
ES2536449T3 ES10185669.8T ES10185669T ES2536449T3 ES 2536449 T3 ES2536449 T3 ES 2536449T3 ES 10185669 T ES10185669 T ES 10185669T ES 2536449 T3 ES2536449 T3 ES 2536449T3
Authority
ES
Spain
Prior art keywords
group
ch2x
rph
alkyl group
amyloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10185669.8T
Other languages
English (en)
Spanish (es)
Inventor
William E. Klunk
Chester A. Mathis, Jr.
Yanming Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Application granted granted Critical
Publication of ES2536449T3 publication Critical patent/ES2536449T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nuclear Medicine (AREA)
ES10185669.8T 2000-08-24 2001-08-24 Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer Expired - Lifetime ES2536449T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22760100P 2000-08-24 2000-08-24
US227601P 2000-08-24

Publications (1)

Publication Number Publication Date
ES2536449T3 true ES2536449T3 (es) 2015-05-25

Family

ID=22853739

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10185669.8T Expired - Lifetime ES2536449T3 (es) 2000-08-24 2001-08-24 Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer
ES01966165T Expired - Lifetime ES2395721T3 (es) 2000-08-24 2001-08-24 Derivados de tioflavina y su uso en diagnosis y terapia de la enfermedad de alzheimer

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01966165T Expired - Lifetime ES2395721T3 (es) 2000-08-24 2001-08-24 Derivados de tioflavina y su uso en diagnosis y terapia de la enfermedad de alzheimer

Country Status (18)

Country Link
US (5) US20020133019A1 (https=)
EP (2) EP2264018B1 (https=)
JP (2) JP5022554B2 (https=)
CN (1) CN1285582C (https=)
AU (3) AU2001286702B2 (https=)
BR (1) BRPI0113470B8 (https=)
CA (1) CA2419420C (https=)
CY (1) CY1113311T1 (https=)
DK (2) DK2264018T3 (https=)
ES (2) ES2536449T3 (https=)
HU (2) HU230375B1 (https=)
LT (1) LTC1334091I2 (https=)
NO (1) NO330176B1 (https=)
PL (1) PL215711B1 (https=)
PT (2) PT1334091E (https=)
RU (1) RU2324686C2 (https=)
SI (1) SI1334091T1 (https=)
WO (1) WO2002016333A2 (https=)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689753B1 (en) * 1999-11-05 2004-02-10 Axonyx, Inc. β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide
EP1266884A4 (en) * 2000-03-22 2003-04-23 Bf Res Inst Inc IMAGE DIAGNOSIS PROBE, BASED ON SUBSTITUTED AZOBENZOL OR ITS ANALOGA, FOR DISEASES WHICH ARE ATTRIBUTED TO AMYLOID ACCUMULATION, AND MIXTURES CONTAINING THIS IMAGE
US7297326B2 (en) * 2000-08-21 2007-11-20 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
EP1322959A1 (en) 2000-08-21 2003-07-02 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
PT1334091E (pt) * 2000-08-24 2013-01-07 Univ Pittsburgh Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer
CA2427014A1 (en) * 2000-11-02 2002-08-22 Cornell Research Foundation, Inc. In vivo multiphoton diagnostic detection and imaging of a neurodegenerative disease
EP1345914A1 (en) * 2000-12-22 2003-09-24 AstraZeneca AB Therapeutic compounds
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
WO2003045930A1 (en) * 2001-11-28 2003-06-05 Astrazeneca Ab Therapeutic compounds
US6774248B2 (en) 2001-12-18 2004-08-10 Wyeth Substituted 2-phenyl benzofurans as estrogenic agents
EP1820806A1 (en) * 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Affinity regions
AU2003239508A1 (en) 2002-05-21 2003-12-12 Bristol-Myers Squibb Company Indole compounds useful as impdh inhibitors
AU2003242233A1 (en) * 2002-06-12 2003-12-31 Bf Research Institute, Inc. Probe compound for image diagnosis of disease with amyloid accumulation, compound for staining age spots/diffuse age spots, and remedy for disease with amyloid accumulation
EP1380290A1 (en) 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-beta structure pathway and its therapeutic relevance
US20070003552A1 (en) * 2002-07-09 2007-01-04 Gebbink Martijn F B Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
EP1547996A4 (en) * 2002-08-30 2006-08-02 Bf Res Inst Inc DIAGNOSTIC PROBES AND REMEDIES FOR DISEASES IN WHICH PRION PROTEIN IS ACCUMULATED, AND ANIMAL FEVERING FOR PRION PROTEIN
ATE405840T1 (de) 2002-12-19 2008-09-15 Scripps Research Inst Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
AU2004221897B2 (en) * 2003-03-14 2010-11-18 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Benzothiazole derivative compounds, compositions and uses
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
GB0307855D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
US20040223912A1 (en) * 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
WO2004100998A2 (en) 2003-05-07 2004-11-25 General Electric Company Compositions and methods for non-invasive imaging of soluble beta-amyloid
AU2003304416A1 (en) * 2003-08-13 2005-03-07 Bf Research Institute, Inc. Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change
EP1655287A1 (en) * 2003-08-13 2006-05-10 BF Research Institute, Inc. Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
WO2005042461A1 (ja) * 2003-10-30 2005-05-12 Dojindo Laboratories アミロイド親和性化合物
EP1719529A4 (en) * 2004-02-25 2008-05-21 Astellas Pharma Inc CONTRASTING FOR THROMBUS EDUCATION
MXPA06012403A (es) 2004-04-27 2007-01-17 Wyeth Corp Purificacion de moduladores de receptor progesterona.
GB0410448D0 (en) 2004-05-11 2004-06-16 Hammersmith Imanet Ltd Purification methods
KR20070032700A (ko) 2004-05-20 2007-03-22 폴드알엑스 파마슈티칼스, 인크. 트랜스티레틴을 안정화하고 트랜스티레틴 미스폴딩을억제하기 위한, ２-((헤테로)아릴)-벤즈옥사졸 화합물 및유도체, 그리고 조성물 및 방법
CN101060865B (zh) * 2004-07-02 2011-10-05 匹兹堡大学高等教育联邦体系 诊断淀粉样蛋白沉积相关疾病的前驱形式的方法
CA2830939C (en) 2004-07-02 2017-02-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of thioflavin radiolabelled derivatives in amyloid imaging for identifying patients prodromal to a disease associated with amyloid deposition
EP1771169A1 (en) 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Methods for treating hepatitis c
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EP1814876A2 (en) * 2004-07-15 2007-08-08 The General Hospital Corporation Heterocyclic dye compounds for in vivo imaging and diagnosis of alzheimer's disease
JP2008507518A (ja) 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するためのチエノピリジン
US20070015133A1 (en) * 2005-07-13 2007-01-18 Umc Utrecht Holding B.V. Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
CA2615028A1 (en) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Cross-.beta. structure binding compounds
EP1906995A2 (en) * 2005-07-13 2008-04-09 Crossbeta Biosciences B.V. Adjuvation through cross- structure
JP2009508863A (ja) * 2005-09-16 2009-03-05 ユニバーシティー オブ ピッツバーグ 少なくとも１種のアミロイド形成タンパク質を含むアミロイド沈着物を検出するためのｉｎｖｉｖｏまたはｉｎｖｉｔｒｏ方法
KR100778888B1 (ko) * 2005-11-29 2007-11-28 재단법인서울대학교산학협력재단 베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물
EP1956013B1 (en) 2005-11-30 2016-04-13 Fujifilm RI Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
CN101351458A (zh) * 2005-12-01 2009-01-21 匹兹堡大学 作为促淀粉样变蛋白成像剂的同位素标记的苯并噻唑化合物
WO2007075595A2 (en) * 2005-12-20 2007-07-05 Vertex Pharmacueticals Incorporated Biofilm assay
US7781187B2 (en) * 2005-12-30 2010-08-24 Corning Incorporated Fluorescent dyes
TW200736252A (en) 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
MX2008010187A (es) 2006-02-10 2008-10-31 Summit Corp Plc Tratamiento de distrofia muscular de duchenne.
WO2007111179A1 (ja) * 2006-03-28 2007-10-04 Shiga University Of Medical Science 神経難病の画像診断薬
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
US7700616B2 (en) * 2006-05-08 2010-04-20 Molecular Neuroimaging, Llc. Compounds and amyloid probes thereof for therapeutic and imaging uses
RU2008150377A (ru) 2006-05-19 2010-06-27 Нихон Меди-Физикс Ко., Лтд. (Jp) Новое соединение, обладающее сродством к амилоиду
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
CN101501033B (zh) 2006-06-21 2012-08-01 通用电气医疗有限公司 对淀粉状蛋白具有亲和性的化合物
WO2008015391A1 (en) * 2006-08-03 2008-02-07 Hammersmith Imanet Limited Method for the purification of radiolabelled compounds
EP2098522B1 (en) 2006-11-30 2011-10-19 Nihon Medi-Physics Co., Ltd. Compounds having affinity for amyloid
CN101668560A (zh) * 2006-12-07 2010-03-10 宾夕法尼亚大学理事会 乙炔衍生物及它们在结合和显像淀粉样斑块中的应用
ES2414614T3 (es) * 2007-01-30 2013-07-22 Ge Healthcare Limited Herramientas para ayudar en el diagnóstico de enfermedades neurodegenerativas
TWI406674B (zh) 2007-02-13 2013-09-01 日本藥學物理公司 Method for manufacturing diagnostic radiographic diagnostic agents
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
CN101293878B (zh) * 2007-04-25 2010-12-15 中国科学院上海应用物理研究所 苯并噻唑苯胺类化合物及其制备方法和应用
JP2010535708A (ja) 2007-08-03 2010-11-25 ビオマリン アイジーエー リミテッド デュシェンヌ型筋ジストロフィーの治療のための薬物併用
MX2010002196A (es) * 2007-08-30 2010-03-18 Ge Healthcare Ltd Composicion radiofarmaceutica.
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
AU2008314871A1 (en) 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
KR20100094478A (ko) * 2007-10-30 2010-08-26 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
WO2009057578A1 (ja) 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物の使用及び製造方法
US20090123373A1 (en) * 2007-11-05 2009-05-14 Yanming Wang Amyloid-imaging agents
EP2058000A1 (en) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Immunogenic compositions capable of activating T cells
EP2058001A1 (en) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Enhancement of immunogenicity of antigens
AU2009260526A1 (en) * 2008-05-30 2009-12-23 Merck Sharp & Dohme Corp. Novel substituted indoles
CA2725940A1 (en) 2008-05-30 2009-12-23 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
CN102047061A (zh) * 2008-05-30 2011-05-04 福斯特韦勒能源股份公司 通过氧化燃料燃烧发电的方法和系统
US20110293520A1 (en) 2008-06-09 2011-12-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases
US20100099609A1 (en) * 2008-07-28 2010-04-22 Buck Institute For Age Research eAPP AND DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE
EP2910945B1 (en) 2008-09-30 2018-07-18 Case Western Reserve University Molecular probes for imaging of myelin
CN102272132A (zh) * 2008-11-06 2011-12-07 首尔大学教产学协力团 氟化苯并噻唑衍生物、其制备方法以及利用其用于诊断阿尔茨海默病的显像剂
US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
CN101598703B (zh) * 2009-07-03 2012-08-22 中国人民解放军第三军医大学第一附属医院 dGTpase蛋白在制备用于鉴别诊断唐氏胎儿药物中的应用
FR2948685A1 (fr) * 2009-07-30 2011-02-04 Biomerieux Sa Nouveaux substrats
US20110081428A1 (en) * 2009-09-16 2011-04-07 The Buck Institute For Age Research Use of thioflavin-like compounds to increase life span and/or health span
WO2012041292A2 (de) 2010-09-20 2012-04-05 Klinikum Darmstadt Gmbh Verbindungen für die diagnostik neurodegenerativer erkrankungen an der retina
DE102010045797A1 (de) 2010-09-20 2012-03-22 Klinikum Darmstadt Gmbh Verbindungen für die Diagnostik neurodegenerativer Erkrankungen am Riechepithel
CA2836872A1 (en) 2011-05-20 2012-11-29 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
JP5167436B2 (ja) 2011-06-24 2013-03-21 日本メジフィジックス株式会社 新規アミロイド親和性化合物
WO2013027694A1 (ja) * 2011-08-24 2013-02-28 国立大学法人京都大学 コンフォメーション病診断用分子イメージングプローブ
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
CN102526765B (zh) * 2011-12-31 2014-07-30 郑州泰基鸿诺药物科技有限公司 一种Aβ斑块显像剂及其制备方法
KR20130111082A (ko) * 2012-03-30 2013-10-10 한미약품 주식회사 베타-아밀로이드 피브릴 형성 저해 효능을 갖는 아미노스티릴벤조퓨란 화합물 및 이를 함유하는 약학 조성물
DK2890700T3 (en) 2012-08-28 2018-03-12 Univ Tuebingen Medizinische Fakultaet HALOGENATED BENZOXAZINES AND THEIR USE
EP2890700B1 (de) * 2012-08-28 2017-12-13 Eberhard Karls Universität Tübingen Medizinische Fakultät Halogenierte benzoxazine und ihre verwendung
EP2767532B1 (en) 2012-12-21 2016-07-13 National Institutes for Quantum and Radiological Science and Technology Novel compound for imaging tau protein accumulated in the brain
US9246108B2 (en) 2012-12-28 2016-01-26 Dow Global Technologies Llc Quinoline-benzoxazole derived compounds for electronic films and devices
EP2958596B1 (en) 2013-02-15 2019-12-04 Case Western Reserve University Psma ligands and uses thereof
JP6182668B2 (ja) 2013-09-26 2017-08-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン
WO2015051188A1 (en) * 2013-10-02 2015-04-09 Washington University Heterocyclic molecules for biomedical imaging and therapeutic applications
EP4039255B1 (en) 2014-04-24 2025-10-15 Omoidesouzou Co. Ltd. Amyloid fiber formation limiter or inhibitor
CN104059028B (zh) * 2014-06-06 2020-10-16 北京智博高科生物技术有限公司 与Aβ斑块具有亲和力的含手性侧链取代的氟代2-芳基苯并杂环化合物、其制备方法及应用
JP6498412B2 (ja) * 2014-10-17 2019-04-10 国立大学法人群馬大学 新規チオフラビンｔ誘導体及びその利用
US9842938B2 (en) 2015-03-24 2017-12-12 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and display device including semiconductor device
US10765763B2 (en) 2016-03-09 2020-09-08 Case Western Reserve University Radioligands for myelin
NZ746901A (en) * 2016-03-11 2023-06-30 Ac Immune Sa Bicyclic compounds for diagnosis and therapy
WO2018062588A1 (ko) 2016-09-29 2018-04-05 한국원자력연구원 커큐민 유도체, 이의 제조방법 및 이를 포함하는 베타-아밀로이드 플라크 검출용 광음향 영상화제
CR20200553A (es) 2018-04-18 2021-04-08 Constellation Pharmaceuticals Inc Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos
US11167283B2 (en) 2018-05-04 2021-11-09 University Of South Carolina Dot blot box and use thereof
JP7293343B2 (ja) 2018-05-09 2023-06-19 アプリノイア セラピューティクス リミテッド ヘテロアリール化合物及びその使用
CN120097995A (zh) 2018-05-21 2025-06-06 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
HUE072464T2 (hu) * 2019-01-31 2025-11-28 Spinogenix Inc Spinogenézis egy promoterének szilárd formái
WO2021016414A1 (en) 2019-07-24 2021-01-28 Constellation Pharmaceuticals, Inc. Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide
CA3161455A1 (en) 2019-11-13 2021-05-20 Aprinoia Therapeutics Limited Compounds for degrading tau protein aggregates and uses thereof
KR102426160B1 (ko) 2020-07-13 2022-07-29 (주)바이오액츠 알츠하이머 진단용 신규 형광화합물 및 이의 제조방법

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA241942A (en) 1924-08-05 Martinetto Vittorio Asynchronous machine
US2715629A (en) * 1952-07-16 1955-08-16 Du Pont Sulfonic acid derivatives of 2-(4'-dialkylaminophenyl)-benzothiazole
NL242547A (https=) * 1958-08-22
DE3148291A1 (de) * 1981-12-05 1983-06-09 Basf Ag, 6700 Ludwigshafen Harnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
DE3307364A1 (de) * 1983-03-02 1984-09-06 Hoechst Ag, 6230 Frankfurt Zweikomponenten-diazontypiematerial
US4666829A (en) 1985-05-15 1987-05-19 University Of California Polypeptide marker for Alzheimer's disease and its use for diagnosis
AU620327B2 (en) * 1987-04-08 1992-02-20 Salutar, Inc. Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor
US4933156A (en) * 1987-04-08 1990-06-12 Salutar, Inc. Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
CA1339014C (en) 1987-10-08 1997-03-25 Ronald E. Majocha Antibodies to a4 amyloid peptide
US5231000A (en) 1987-10-08 1993-07-27 The Mclean Hospital Antibodies to A4 amyloid peptide
US5297562A (en) 1991-04-01 1994-03-29 President And Fellows Of Harvard College Method for detecting and treating Alzheimer's disease
US5434050A (en) 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
GB9317949D0 (en) * 1993-08-28 1993-10-13 Stevens Malcolm F G Benzothiazole compounds
JPH09511492A (ja) * 1994-02-03 1997-11-18 ザ ピコワー インスティテュート フォア メディカル リサーチ アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法
US6168776B1 (en) * 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6417178B1 (en) * 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
GB9503946D0 (en) * 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
EP1110945A3 (en) 1995-05-01 2003-05-07 University Of Pittsburgh Azocompounds for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
WO1997026919A2 (en) * 1996-01-24 1997-07-31 Warner-Lambert Company Method of imaging amyloid deposits
WO1998017267A1 (en) * 1996-10-23 1998-04-30 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
WO1998022493A2 (en) 1996-11-22 1998-05-28 Elan Pharmaceuticals, Inc. N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
KR20010032175A (ko) * 1997-11-20 2001-04-16 야스이 쇼사꾸 비페닐아미딘 유도체
AU1089900A (en) 1998-06-30 2000-01-24 Kevin Mcclung Controlled-penetration projectile
JP3820037B2 (ja) * 1998-11-05 2006-09-13 三井化学株式会社 光記録媒体
GB9919673D0 (en) * 1999-08-20 1999-10-20 Cancer Res Campaign Tech 2-Arlybenzazole compounds
US7270800B2 (en) * 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
PT1334091E (pt) 2000-08-24 2013-01-07 Univ Pittsburgh Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer
EP1345914A1 (en) 2000-12-22 2003-09-24 AstraZeneca AB Therapeutic compounds
WO2002085903A2 (en) * 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
AU2004221897B2 (en) * 2003-03-14 2010-11-18 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Benzothiazole derivative compounds, compositions and uses
US8236282B2 (en) * 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
CA2830939C (en) * 2004-07-02 2017-02-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of thioflavin radiolabelled derivatives in amyloid imaging for identifying patients prodromal to a disease associated with amyloid deposition
WO2007047204A1 (en) * 2005-10-11 2007-04-26 University Of Pittsburgh Isotopically-labeled benzofuran compounds as imagingagents foramyloidogenic proteins

Also Published As

Publication number Publication date
HU230375B1 (hu) 2016-03-29
AU8670201A (en) 2002-03-04
AU2008202626A1 (en) 2008-07-03
AU2001286702B2 (en) 2008-03-13
US20020133019A1 (en) 2002-09-19
PT2264018E (pt) 2015-06-03
LTPA2015001I1 (lt) 2015-02-25
JP2004506723A (ja) 2004-03-04
CA2419420A1 (en) 2002-02-28
HU230581B1 (hu) 2017-01-30
NO330176B1 (no) 2011-02-28
CA2419420C (en) 2011-08-02
PT1334091E (pt) 2013-01-07
US7351401B2 (en) 2008-04-01
SI1334091T1 (sl) 2013-01-31
NO20030860L (no) 2003-04-24
JP2012102106A (ja) 2012-05-31
JP5022554B2 (ja) 2012-09-12
BR0113470A (pt) 2003-12-30
US20050043377A1 (en) 2005-02-24
HUP0302956A2 (hu) 2003-12-29
EP1334091B1 (en) 2012-09-19
US20150190400A1 (en) 2015-07-09
HK1058041A1 (en) 2004-04-30
US20120095235A1 (en) 2012-04-19
ES2395721T3 (es) 2013-02-14
HK1146725A1 (en) 2011-07-08
LTC1334091I2 (lt) 2018-05-25
CN1535268A (zh) 2004-10-06
EP1334091A2 (en) 2003-08-13
CN1285582C (zh) 2006-11-22
WO2002016333A3 (en) 2002-05-30
PL360550A1 (en) 2004-09-06
US9833458B2 (en) 2017-12-05
EP2264018A2 (en) 2010-12-22
US20080154042A1 (en) 2008-06-26
BRPI0113470B8 (pt) 2021-05-25
HUP0302956A3 (en) 2006-05-29
NO20030860D0 (no) 2003-02-24
AU2008202626B9 (en) 2010-02-11
DK1334091T3 (da) 2012-10-15
EP2264018B1 (en) 2015-02-11
EP2264018A3 (en) 2012-04-25
WO2002016333A2 (en) 2002-02-28
RU2324686C2 (ru) 2008-05-20
CY1113311T1 (el) 2016-04-13
PL215711B1 (pl) 2014-01-31
AU2008202626B2 (en) 2010-02-04
HUP1500560A2 (en) 2003-12-29
BRPI0113470B1 (pt) 2019-04-16
DK2264018T3 (en) 2015-05-11

Similar Documents

Publication Publication Date Title
ES2536449T3 (es) Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer
ES2907992T5 (en) Novel imaging agents for detecting neurological dysfunction
US20120263646A1 (en) Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
AU2001286702A1 (en) Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease
EP2436666B1 (en) Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of alzheimer 's disease
CA2587248A1 (en) Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies
AU2011200667A1 (en) Benzothiazole derivative compounds, compositions and uses
CN104478862B (zh) 适于作为用于对淀粉样沉积物成像的化合物的前体的新的苯并呋喃
TW201026336A (en) Benzothiazole amides for detection of amyloid beta
JP2021102593A (ja) タウを画像化する新規化合物
HK1146725B (en) Thioflavin derivatives for use in the diagnosis of alzheimer's disease
HK1058041B (en) Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease