ES2263206T3 - Adn regulador transcripcional de ef-1-alfa de hamster. - Google Patents
Adn regulador transcripcional de ef-1-alfa de hamster.Info
- Publication number
- ES2263206T3 ES2263206T3 ES98920128T ES98920128T ES2263206T3 ES 2263206 T3 ES2263206 T3 ES 2263206T3 ES 98920128 T ES98920128 T ES 98920128T ES 98920128 T ES98920128 T ES 98920128T ES 2263206 T3 ES2263206 T3 ES 2263206T3
- Authority
- ES
- Spain
- Prior art keywords
- dna
- baselineskip
- seq
- plasmid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
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- Proteomics, Peptides & Aminoacids (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
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Applications Claiming Priority (2)
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| US847218 | 1997-05-01 | ||
| US08/847,218 US5888809A (en) | 1997-05-01 | 1997-05-01 | Hamster EF-1α transcriptional regulatory DNA |
Publications (1)
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| ES2263206T3 true ES2263206T3 (es) | 2006-12-01 |
Family
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Family Applications (1)
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| ES98920128T Expired - Lifetime ES2263206T3 (es) | 1997-05-01 | 1998-05-01 | Adn regulador transcripcional de ef-1-alfa de hamster. |
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| US (1) | US5888809A (zh) |
| EP (2) | EP1676916A1 (zh) |
| JP (1) | JP2000513948A (zh) |
| CN (2) | CN100430477C (zh) |
| AT (1) | ATE318900T1 (zh) |
| AU (1) | AU742561B2 (zh) |
| BR (1) | BR9804896B1 (zh) |
| CZ (1) | CZ296544B6 (zh) |
| DE (1) | DE69833649T2 (zh) |
| DK (1) | DK0920498T3 (zh) |
| ES (1) | ES2263206T3 (zh) |
| HK (1) | HK1022719A1 (zh) |
| HU (1) | HU225764B1 (zh) |
| IL (1) | IL127897A (zh) |
| NO (1) | NO323853B1 (zh) |
| PL (1) | PL195604B1 (zh) |
| PT (1) | PT920498E (zh) |
| RU (2) | RU2249617C2 (zh) |
| SK (1) | SK285664B6 (zh) |
| WO (1) | WO1998049289A1 (zh) |
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| US8183344B2 (en) * | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
| US6479256B1 (en) | 1998-03-04 | 2002-11-12 | Icos Corporation | Lectomedin materials and methods |
| KR20000046969A (ko) * | 1998-12-31 | 2000-07-25 | 이선경 | 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더 |
| CN1479872A (zh) * | 2000-10-12 | 2004-03-03 | 艾科斯有限公司 | 调节含有变构调节位点的α/β蛋白的配体结合/酶活性的物质和方法 |
| AU2002230773A1 (en) * | 2000-12-18 | 2002-07-01 | Wyeth | Promoters and recombinant expression constructs |
| BRPI0210771B8 (pt) * | 2001-07-04 | 2021-05-25 | Chromagenics Bv | construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna |
| WO2003106674A2 (en) * | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
| DK1513937T3 (da) * | 2002-06-14 | 2011-05-16 | Chromagenics Bv | Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved |
| DK1573058T3 (da) * | 2002-12-18 | 2012-01-16 | Chromagenics Bv | Fremgangsmåde til forbedring af proteinproduktion |
| AU2003290453A1 (en) * | 2002-12-20 | 2004-07-14 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
| WO2006101474A1 (en) | 2005-03-15 | 2006-09-28 | University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin k-dependent proteins |
| EP2336360A1 (en) | 2003-09-23 | 2011-06-22 | University Of North Carolina At Chapel Hill | Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| BRPI0517380A (pt) * | 2004-11-08 | 2008-10-07 | Chromagenics Bv | molécula de dna, cassete de expressão, célula hospedeira, e, métodos para gerar uma célula hospedeira que expressa um polipeptìdeo de interesse e para produzir um polipeptìdeo de interesse |
| ES2384391T3 (es) | 2004-11-08 | 2012-07-04 | Chromagenics B.V. | Selección de células hospedantes que expresan proteína a altos niveles |
| US8039230B2 (en) * | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| WO2006063292A1 (en) * | 2004-12-08 | 2006-06-15 | Icos Corporation | Recombinant method for making multimeric proteins |
| WO2007008848A2 (en) * | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| US8343928B2 (en) | 2005-07-07 | 2013-01-01 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus |
| EP1941043B1 (en) * | 2005-10-21 | 2011-04-13 | F. Hoffmann-La Roche AG | Method for the recombinant expression of a polypeptide |
| CN101341252B (zh) | 2005-10-28 | 2011-08-17 | 弗·哈夫曼-拉罗切有限公司 | 啮齿动物细胞中的蛋白质表达 |
| DK1969127T4 (en) * | 2005-12-21 | 2017-10-16 | Cnj Holdings Inc | Process for the preparation of biologically active vitamin K-dependent proteins by recombinant methods |
| WO2007081336A1 (en) * | 2006-01-13 | 2007-07-19 | Five Prime Therapeutics, Inc. | Mammalian vectors for high-level expression of recombinant proteins |
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| US20090203077A1 (en) * | 2006-06-30 | 2009-08-13 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
| AU2007269233B2 (en) * | 2006-06-30 | 2011-06-09 | Cnj Holdings, Inc. | Method of producing Factor VIII proteins by recombinant methods |
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| JP6050927B2 (ja) | 2007-04-26 | 2016-12-21 | シーエヌジェイ ホールディングス，インコーポレイテッド | 高シアル酸含量を有する組換えビタミンｋ依存性タンパク質およびその調製方法 |
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| US9631002B2 (en) | 2010-12-21 | 2017-04-25 | The University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin K-dependent proteins |
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| BR112014013035A2 (pt) | 2011-12-22 | 2018-10-09 | Hoffmann La Roche | métodos de seleção de células, conjuntos de expressão bicistrônica, células eucarióticas, vetores lentivirais, uso de vetor lentiviral, bibliotecas de ventores lentivirais e de células eucarióticas, métodos de seleção de células, fluxos de trabalho e uso de célula |
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| US5266491A (en) * | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
| JP3051411B2 (ja) * | 1989-03-14 | 2000-06-12 | 持田製薬株式会社 | 新規ｄｎａならびにそれを含有する発現プラスミド |
| EP0779362B2 (en) * | 1989-12-22 | 2012-06-13 | Laboratoires Serono SA | DNA constructs for endogenous gene activation and expression modification |
| US5650294A (en) * | 1990-06-25 | 1997-07-22 | Basf Aktiengesellschaft | Isolated promoter and terminator of elongation factor 1-α |
| AU664847B2 (en) * | 1991-05-15 | 1995-12-07 | Cell Genesys, Inc. | Genomic modifications with homologous DNA targeting |
| CA2051085C (en) * | 1991-09-10 | 2001-08-21 | Shigekazu Nagata | Expression plasmids |
| TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
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1997
- 1997-05-01 US US08/847,218 patent/US5888809A/en not_active Expired - Lifetime
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1998
- 1998-05-01 AU AU72770/98A patent/AU742561B2/en not_active Expired
- 1998-05-01 PL PL98331005A patent/PL195604B1/pl unknown
- 1998-05-01 BR BRPI9804896-1B1A patent/BR9804896B1/pt active IP Right Grant
- 1998-05-01 WO PCT/US1998/008906 patent/WO1998049289A1/en active Application Filing
- 1998-05-01 CN CNB988009137A patent/CN100430477C/zh not_active Expired - Lifetime
- 1998-05-01 CZ CZ0028099A patent/CZ296544B6/cs not_active IP Right Cessation
- 1998-05-01 DE DE69833649T patent/DE69833649T2/de not_active Expired - Lifetime
- 1998-05-01 RU RU99101788/13A patent/RU2249617C2/ru active
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- 1998-05-01 EP EP06003954A patent/EP1676916A1/en not_active Withdrawn
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- 1998-05-01 JP JP10547444A patent/JP2000513948A/ja active Pending
- 1998-05-01 CN CNA2008101103936A patent/CN101570753A/zh active Pending
- 1998-05-01 SK SK118-99A patent/SK285664B6/sk not_active IP Right Cessation
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1999
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