ES2244075T3 - Chalconas que tienen actividad antiproliferativa. - Google Patents

Chalconas que tienen actividad antiproliferativa.

Info

Publication number
ES2244075T3
ES2244075T3 ES98936334T ES98936334T ES2244075T3 ES 2244075 T3 ES2244075 T3 ES 2244075T3 ES 98936334 T ES98936334 T ES 98936334T ES 98936334 T ES98936334 T ES 98936334T ES 2244075 T3 ES2244075 T3 ES 2244075T3
Authority
ES
Spain
Prior art keywords
phenyl
hydroxy
propen
pyridyl
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98936334T
Other languages
English (en)
Spanish (es)
Inventor
Ezio Bombardelli
Piero Valenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2244075T3 publication Critical patent/ES2244075T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ES98936334T 1997-06-19 1998-06-12 Chalconas que tienen actividad antiproliferativa. Expired - Lifetime ES2244075T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9712966 1997-06-19
GBGB9712966.2A GB9712966D0 (en) 1997-06-19 1997-06-19 Novel chalcones

Publications (1)

Publication Number Publication Date
ES2244075T3 true ES2244075T3 (es) 2005-12-01

Family

ID=10814591

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98936334T Expired - Lifetime ES2244075T3 (es) 1997-06-19 1998-06-12 Chalconas que tienen actividad antiproliferativa.

Country Status (21)

Country Link
US (1) US6147082A (enExample)
EP (1) EP0989973B1 (enExample)
JP (1) JP4064471B2 (enExample)
KR (1) KR20010013603A (enExample)
CN (1) CN1198802C (enExample)
AT (1) ATE303362T1 (enExample)
AU (1) AU742784C (enExample)
CA (1) CA2294278C (enExample)
CZ (1) CZ294976B6 (enExample)
DE (1) DE69831409T2 (enExample)
DK (1) DK0989973T3 (enExample)
ES (1) ES2244075T3 (enExample)
GB (1) GB9712966D0 (enExample)
HU (1) HU227628B1 (enExample)
NO (1) NO314802B1 (enExample)
PL (1) PL190495B1 (enExample)
PT (1) PT989973E (enExample)
RU (1) RU2203883C2 (enExample)
SI (1) SI0989973T1 (enExample)
SK (1) SK283077B6 (enExample)
WO (1) WO1998058913A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014202803A1 (es) * 2013-06-19 2014-12-24 Universidad De Sevilla Procedimiento de obtención de extractos de hojas de corema album y su aplicación terapéutica

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060095786A (ko) * 2000-01-27 2006-09-01 다카라 바이오 가부시키가이샤 치료제
KR100377514B1 (ko) * 2000-05-23 2003-03-26 신국현 찰콘 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물
DE10060677A1 (de) 2000-12-05 2002-06-20 Aventis Pharma Gmbh Klainetine und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben
AU2003243594A1 (en) * 2002-06-13 2003-12-31 Johns Hopkins University Novel boronic chalcone derivatives and uses thereof
KR20050070032A (ko) * 2002-10-01 2005-07-05 다카라 바이오 가부시키가이샤 치료제
NZ552298A (en) * 2004-05-23 2011-04-29 Gerard M Housey Method for identifying inhibitors or activators of a theramutein by comparing the phenoresponse of cells exposed to a test compound
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
CN102060792B (zh) * 2010-12-24 2016-08-03 西南大学 2′-胺基查尔酮唑类化合物及其吡唑啉和环丙基唑类衍生物、制备方法与用途
CN103360338B (zh) * 2013-07-30 2015-04-01 中国科学院新疆理化技术研究所 一种查尔酮苯并噻唑酰胺类衍生物的制备方法和用途
CN103910691A (zh) * 2014-04-18 2014-07-09 山东药品食品职业学院 卤代苯基查尔酮衍生物及其制备方法和应用
CN103896932A (zh) * 2014-04-18 2014-07-02 山东药品食品职业学院 异恶唑基芳基查尔酮衍生物及其制备方法和应用
CZ307046B6 (cs) * 2015-09-02 2017-12-13 Univerzita PalackĂ©ho v Olomouci Komplexy mědi s deriváty (E)-1-(2´-hydroxyfenyl)-3-fenylprop-2-en-1-onu a jejich použití jako léčiv v protinádorové terapii
WO2017103637A1 (en) 2015-12-18 2017-06-22 Blirt S.A. Diphenylpropane compounds and their cytotoxic activity
CN106279082B (zh) * 2016-08-02 2019-02-01 浙江大学 取代的呋喃查耳酮类衍生物及其制备方法
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
KR102496887B1 (ko) * 2020-10-15 2023-02-06 경상국립대학교산학협력단 부테인 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 유방암의 예방, 개선 또는 치료용 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE376077B (enExample) * 1973-09-13 1975-05-05 Asea Ab
JPH05509078A (ja) * 1990-05-17 1993-12-16 ベイラー カレッジ オブ メディシン 成長抑制因とガンおよび細胞増殖性疾患措置法
AU2393992A (en) * 1991-07-24 1993-02-23 Baylor College Of Medicine Combination therapy using bioflavonoid compounds with anti-cancer drugs
IT1271301B (it) * 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014202803A1 (es) * 2013-06-19 2014-12-24 Universidad De Sevilla Procedimiento de obtención de extractos de hojas de corema album y su aplicación terapéutica
ES2540457A1 (es) * 2013-06-19 2015-07-09 Universidad De Sevilla Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica

Also Published As

Publication number Publication date
EP0989973A1 (en) 2000-04-05
US6147082A (en) 2000-11-14
NO996287L (no) 2000-02-21
HU227628B1 (en) 2011-10-28
AU742784B2 (en) 2002-01-10
NO314802B1 (no) 2003-05-26
WO1998058913A1 (en) 1998-12-30
PL337361A1 (en) 2000-08-14
HUP0003068A2 (hu) 2001-01-29
CA2294278C (en) 2007-09-25
PL190495B1 (pl) 2005-12-30
JP2002506439A (ja) 2002-02-26
DE69831409D1 (de) 2005-10-06
DE69831409T2 (de) 2006-06-08
EP0989973B1 (en) 2005-08-31
CN1198802C (zh) 2005-04-27
CA2294278A1 (en) 1998-12-30
CZ294976B6 (cs) 2005-04-13
CZ459999A3 (cs) 2000-05-17
GB9712966D0 (en) 1997-08-27
KR20010013603A (ko) 2001-02-26
HUP0003068A3 (en) 2002-02-28
PT989973E (pt) 2005-11-30
SK179599A3 (en) 2000-06-12
SK283077B6 (sk) 2003-02-04
AU8537598A (en) 1999-01-04
JP4064471B2 (ja) 2008-03-19
HK1023770A1 (en) 2000-09-22
NO996287D0 (no) 1999-12-17
AU742784C (en) 2005-08-18
DK0989973T3 (da) 2005-10-17
SI0989973T1 (sl) 2006-02-28
CN1261349A (zh) 2000-07-26
ATE303362T1 (de) 2005-09-15
RU2203883C2 (ru) 2003-05-10

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