ES2540457A1 - Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica - Google Patents

Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica Download PDF

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Publication number
ES2540457A1
ES2540457A1 ES201300600A ES201300600A ES2540457A1 ES 2540457 A1 ES2540457 A1 ES 2540457A1 ES 201300600 A ES201300600 A ES 201300600A ES 201300600 A ES201300600 A ES 201300600A ES 2540457 A1 ES2540457 A1 ES 2540457A1
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ES
Spain
Prior art keywords
corema
album
translation
machine
legally binding
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201300600A
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English (en)
Other versions
ES2540457B2 (es
Inventor
Antonio José LEÓN GONZÁLEZ
Carmen MARTÍN CORDERO
María Cruz DÍAZ BARRADAS
Inmaculada NAVARRO ZAFRA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
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Universidad de Sevilla
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Publication date
Application filed by Universidad de Sevilla filed Critical Universidad de Sevilla
Priority to ES201300600A priority Critical patent/ES2540457B2/es
Priority to PCT/ES2014/000099 priority patent/WO2014202803A1/es
Publication of ES2540457A1 publication Critical patent/ES2540457A1/es
Application granted granted Critical
Publication of ES2540457B2 publication Critical patent/ES2540457B2/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención tiene por objeto a un extracto citotóxico procedente de las hojas de Corema album (Ericaceae), así como a sus fracciones y principios activos aislados, que generan especies reactivas de oxígeno (ERO) e inducen apoptosis. También incluye las composiciones farmacológicas que contienen tanto al extracto como a fracciones o principios activos aislados de éste y al uso de estas composiciones en la preparación de medicamentos para la prevención y el tratamiento del cáncer. La presente invención tiene su aplicación en el sector farmacéutico.

Description

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Claims (1)

  1. imagen1
ES201300600A 2013-06-19 2013-06-19 Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica Active ES2540457B2 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES201300600A ES2540457B2 (es) 2013-06-19 2013-06-19 Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica
PCT/ES2014/000099 WO2014202803A1 (es) 2013-06-19 2014-06-17 Procedimiento de obtención de extractos de hojas de corema album y su aplicación terapéutica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201300600A ES2540457B2 (es) 2013-06-19 2013-06-19 Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica

Publications (2)

Publication Number Publication Date
ES2540457A1 true ES2540457A1 (es) 2015-07-09
ES2540457B2 ES2540457B2 (es) 2015-12-28

Family

ID=52103989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201300600A Active ES2540457B2 (es) 2013-06-19 2013-06-19 Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica

Country Status (2)

Country Link
ES (1) ES2540457B2 (es)
WO (1) WO2014202803A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105796548B (zh) * 2016-04-19 2020-04-24 中国科学院西北高原生物研究所 一种黄酮类药物组合物及制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2181806T3 (es) * 1994-12-20 2003-03-01 Indena Spa Chalconas y sus eteres con actividad antiproliferativa en los tumores de utero, ovario y mama.
ES2244075T3 (es) * 1997-06-19 2005-12-01 Indena S.P.A. Chalconas que tienen actividad antiproliferativa.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2181806T3 (es) * 1994-12-20 2003-03-01 Indena Spa Chalconas y sus eteres con actividad antiproliferativa en los tumores de utero, ovario y mama.
ES2244075T3 (es) * 1997-06-19 2005-12-01 Indena S.P.A. Chalconas que tienen actividad antiproliferativa.

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FOREJTNIKOVA, H. et al. Chemoprotective and toxic potentials of synthetic and natural chalcones and dihydrochalcones in vitro. Toxicology, 2005. Vol. 208, nº 1, páginas 81-93. ISSN 0300-483X. Doi: 10.1016/j.tox.2004.11.011 *
LEÓN-GONZÁLEZ, A. J. et al. Chemo-protective activity and characterization of phenolic extracts from Corema album. Food Research International, 2012, vol. 49, nº 2, páginas 728-738. ISSN 0963-9969 Doi:10.1016/j.foodres.2012.09.016 *
LEÓN-GONZÁLEZ, A. J. et al. Phenolic acids, flavonol and anthocyanins in Corema album (L.) D. Don berries. Journal of Food Composition and Analysis. Febrero 2013, vol. 29, nº 1, páginas 58-63. ISSN 0889-1575 Doi:10.1016/j.jfca.2012.10.003 *

Also Published As

Publication number Publication date
ES2540457B2 (es) 2015-12-28
WO2014202803A1 (es) 2014-12-24

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