MX2016010272A - Derivado de indolona sustituido por pirrol, metodo de preparacion del mismo, composicion que comprende el mismo y uso del mismo. - Google Patents

Derivado de indolona sustituido por pirrol, metodo de preparacion del mismo, composicion que comprende el mismo y uso del mismo.

Info

Publication number
MX2016010272A
MX2016010272A MX2016010272A MX2016010272A MX2016010272A MX 2016010272 A MX2016010272 A MX 2016010272A MX 2016010272 A MX2016010272 A MX 2016010272A MX 2016010272 A MX2016010272 A MX 2016010272A MX 2016010272 A MX2016010272 A MX 2016010272A
Authority
MX
Mexico
Prior art keywords
pyrrole
preparation
same
method therefor
indolone derivative
Prior art date
Application number
MX2016010272A
Other languages
English (en)
Other versions
MX369473B (es
Inventor
Liu Peng
Hu Lihong
Zhao Shaohua
Li Xiangjun
An Junyong
Zhou Mengxia
Zhang Lili
Yao Zijian
Original Assignee
Shijiazhuang Yiling Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Yiling Pharmaceutical Co Ltd filed Critical Shijiazhuang Yiling Pharmaceutical Co Ltd
Publication of MX2016010272A publication Critical patent/MX2016010272A/es
Publication of MX369473B publication Critical patent/MX369473B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

La presente invención se refiere a un derivado de indolona sustituido por pirrol, un método de preparación del mismo, una composición que comprende el derivado, y el uso del mismo. El derivado de indolona sustituido por pirrol tiene una estructura mostrada en la fórmula (I) a continuación. La presente invención se refiere además al uso del derivado de indolona sustituido por pirrol para el tratamiento de enfermedades mediadas por receptor de tirosina quinasa, y a una composición farmacéutica que comprende compuestos que tienen tal estructura tal para el tratamiento de enfermedades relacionadas, tales como tumores. (ver Fórmula).
MX2016010272A 2014-02-10 2015-02-04 Derivado de indolona sustituido por pirrol, método de preparación del mismo, composición que comprende el mismo y uso del mismo. MX369473B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410046278.2A CN104829596B (zh) 2014-02-10 2014-02-10 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
PCT/CN2015/072230 WO2015117551A1 (zh) 2014-02-10 2015-02-04 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途

Publications (2)

Publication Number Publication Date
MX2016010272A true MX2016010272A (es) 2017-02-06
MX369473B MX369473B (es) 2019-11-08

Family

ID=53777341

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010272A MX369473B (es) 2014-02-10 2015-02-04 Derivado de indolona sustituido por pirrol, método de preparación del mismo, composición que comprende el mismo y uso del mismo.

Country Status (17)

Country Link
US (1) US9556154B2 (es)
EP (1) EP3106459B1 (es)
JP (1) JP6211205B2 (es)
KR (1) KR101805693B1 (es)
CN (1) CN104829596B (es)
AU (1) AU2015215335B2 (es)
BR (1) BR112016018371B1 (es)
CA (1) CA2939012C (es)
ES (1) ES2687418T3 (es)
MX (1) MX369473B (es)
MY (1) MY176521A (es)
PL (1) PL3106459T3 (es)
PT (1) PT3106459T (es)
RU (1) RU2650682C2 (es)
SA (1) SA516371644B1 (es)
SG (1) SG11201606545SA (es)
WO (1) WO2015117551A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017079132A1 (en) 2015-11-02 2017-05-11 Dolby Laboratories Licensing Corporation Layered representation containing crc codes and delivery of high dynamic range video
CN108727341B (zh) * 2017-04-13 2021-02-19 勤浩医药（苏州）有限公司 一种吡咯取代吲哚酮类衍生物或其药学上可接受的盐、及它们的制备方法和用途
CN108191835A (zh) * 2018-01-09 2018-06-22 中国药科大学 一类新型的含吡咯环和吲哚啉结构rip1激酶抑制剂及其用途
RS65150B1 (sr) * 2018-09-19 2024-02-29 Suzhou Genhouse Pharmaceutical Co Ltd Pirol-supstituisan derivat indolona ili njegova farmaceutski prihvatljiva so i postupak njihove pripreme i njihova primena
CN109232580A (zh) * 2018-11-14 2019-01-18 南阳师范学院 一种1H-吡咯并[1,2-a]吲哚-2(3-H)-酮的合成方法
CN112321568B (zh) * 2020-09-22 2023-02-17 南京中医药大学 4-甲基吡咯取代的吲哚酮衍生物、其制备方法及其医药用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060814A2 (en) 2000-02-15 2001-08-23 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
AR035721A1 (es) * 2000-12-20 2004-07-07 Sugen Inc Indolinonas 4-aril sustituidas; sus composiciones farmaceuticas y metodo para modular la actividad catalitica de una proteina quinasa
WO2002081466A1 (en) * 2001-04-09 2002-10-17 Sugen, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
EP1434774A1 (en) * 2001-10-10 2004-07-07 Sugen, Inc. 3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
US7109185B2 (en) * 2001-11-21 2006-09-19 Sugen, Inc. Pharmaceutical formulations comprising indolinone derivatives
TW200418836A (en) * 2002-09-10 2004-10-01 Pharmacia Italia Spa Formulations comprising an indolinone compound
CN101007801A (zh) * 2006-01-27 2007-08-01 上海恒瑞医药有限公司 吡咯取代的2－二氢吲哚酮衍生物、其制法与医药上的用途
CN101553482B (zh) * 2006-09-15 2013-11-20 艾科睿制药公司 激酶抑制剂化合物
RU2525114C2 (ru) * 2007-12-03 2014-08-10 Бёрингер Ингельхайм Интернациональ Гмбх Способ получения производного индолинона
CN102066362B (zh) * 2008-05-23 2014-07-30 上海医药工业研究院 二氢吲哚酮衍生物
CN102276584A (zh) * 2010-06-08 2011-12-14 齐鲁制药有限公司 吡咯取代的2-二氢吲哚酮衍生物、其制备方法及用途
CN103130744B (zh) 2012-08-28 2014-10-15 沈阳药科大学 一种硒唑甲酸类化合物及其制备方法和用途

Also Published As

Publication number Publication date
SG11201606545SA (en) 2016-09-29
CN104829596B (zh) 2017-02-01
RU2650682C2 (ru) 2018-04-17
EP3106459A1 (en) 2016-12-21
US20160347740A1 (en) 2016-12-01
KR101805693B1 (ko) 2017-12-06
MY176521A (en) 2020-08-13
MX369473B (es) 2019-11-08
ES2687418T3 (es) 2018-10-25
CA2939012A1 (en) 2015-08-13
RU2016136351A3 (es) 2018-03-15
PT3106459T (pt) 2018-10-18
WO2015117551A1 (zh) 2015-08-13
AU2015215335B2 (en) 2017-07-27
US9556154B2 (en) 2017-01-31
BR112016018371A2 (pt) 2017-10-17
AU2015215335A1 (en) 2016-09-01
KR20160117605A (ko) 2016-10-10
PL3106459T3 (pl) 2018-11-30
CN104829596A (zh) 2015-08-12
SA516371644B1 (ar) 2019-08-29
EP3106459A4 (en) 2017-07-12
RU2016136351A (ru) 2018-03-15
JP6211205B2 (ja) 2017-10-11
EP3106459B1 (en) 2018-07-04
CA2939012C (en) 2018-11-06
JP2017505803A (ja) 2017-02-23
BR112016018371B1 (pt) 2022-06-14

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