CN1198802C - 具有抗增殖活性的查耳酮类化合物 - Google Patents

具有抗增殖活性的查耳酮类化合物 Download PDF

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Publication number
CN1198802C
CN1198802C CNB988062127A CN98806212A CN1198802C CN 1198802 C CN1198802 C CN 1198802C CN B988062127 A CNB988062127 A CN B988062127A CN 98806212 A CN98806212 A CN 98806212A CN 1198802 C CN1198802 C CN 1198802C
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CN
China
Prior art keywords
phenyl
oxygen base
hydroxyl
ketone
propylene
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Expired - Fee Related
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CNB988062127A
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English (en)
Chinese (zh)
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CN1261349A (zh
Inventor
E·波姆巴德利
P·瓦伦蒂
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Indena SpA
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Indena SpA
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Publication of CN1261349A publication Critical patent/CN1261349A/zh
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Publication of CN1198802C publication Critical patent/CN1198802C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB988062127A 1997-06-19 1998-06-12 具有抗增殖活性的查耳酮类化合物 Expired - Fee Related CN1198802C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9712966.2A GB9712966D0 (en) 1997-06-19 1997-06-19 Novel chalcones
GB9712966.2 1997-06-19

Publications (2)

Publication Number Publication Date
CN1261349A CN1261349A (zh) 2000-07-26
CN1198802C true CN1198802C (zh) 2005-04-27

Family

ID=10814591

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988062127A Expired - Fee Related CN1198802C (zh) 1997-06-19 1998-06-12 具有抗增殖活性的查耳酮类化合物

Country Status (21)

Country Link
US (1) US6147082A (enExample)
EP (1) EP0989973B1 (enExample)
JP (1) JP4064471B2 (enExample)
KR (1) KR20010013603A (enExample)
CN (1) CN1198802C (enExample)
AT (1) ATE303362T1 (enExample)
AU (1) AU742784C (enExample)
CA (1) CA2294278C (enExample)
CZ (1) CZ294976B6 (enExample)
DE (1) DE69831409T2 (enExample)
DK (1) DK0989973T3 (enExample)
ES (1) ES2244075T3 (enExample)
GB (1) GB9712966D0 (enExample)
HU (1) HU227628B1 (enExample)
NO (1) NO314802B1 (enExample)
PL (1) PL190495B1 (enExample)
PT (1) PT989973E (enExample)
RU (1) RU2203883C2 (enExample)
SI (1) SI0989973T1 (enExample)
SK (1) SK283077B6 (enExample)
WO (1) WO1998058913A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100711537B1 (ko) 2000-01-27 2007-04-27 다카라 바이오 가부시키가이샤 치료제
KR100377514B1 (ko) * 2000-05-23 2003-03-26 신국현 찰콘 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물
DE10060677A1 (de) 2000-12-05 2002-06-20 Aventis Pharma Gmbh Klainetine und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben
WO2003106384A2 (en) * 2002-06-01 2003-12-24 Johns Hopkins University Novel boronic chalcone derivatives and uses thereof
CA2500527A1 (en) * 2002-10-01 2004-04-15 Takara Bio Inc. Remedies
ES2777924T3 (es) * 2004-05-23 2020-08-06 Hmi Medical Innovations Llc Moduladores de teramuteína
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
CN102060792B (zh) * 2010-12-24 2016-08-03 西南大学 2′-胺基查尔酮唑类化合物及其吡唑啉和环丙基唑类衍生物、制备方法与用途
ES2540457B2 (es) * 2013-06-19 2015-12-28 Universidad De Sevilla Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica
CN103360338B (zh) * 2013-07-30 2015-04-01 中国科学院新疆理化技术研究所 一种查尔酮苯并噻唑酰胺类衍生物的制备方法和用途
CN103896932A (zh) * 2014-04-18 2014-07-02 山东药品食品职业学院 异恶唑基芳基查尔酮衍生物及其制备方法和应用
CN103910691A (zh) * 2014-04-18 2014-07-09 山东药品食品职业学院 卤代苯基查尔酮衍生物及其制备方法和应用
CZ307046B6 (cs) * 2015-09-02 2017-12-13 Univerzita PalackĂ©ho v Olomouci Komplexy mědi s deriváty (E)-1-(2´-hydroxyfenyl)-3-fenylprop-2-en-1-onu a jejich použití jako léčiv v protinádorové terapii
WO2017103637A1 (en) 2015-12-18 2017-06-22 Blirt S.A. Diphenylpropane compounds and their cytotoxic activity
CN106279082B (zh) * 2016-08-02 2019-02-01 浙江大学 取代的呋喃查耳酮类衍生物及其制备方法
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
KR102496887B1 (ko) * 2020-10-15 2023-02-06 경상국립대학교산학협력단 부테인 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 유방암의 예방, 개선 또는 치료용 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE376077B (enExample) * 1973-09-13 1975-05-05 Asea Ab
AU7963691A (en) * 1990-05-17 1991-12-10 Baylor College Of Medicine Growth inhibitors and methods of treating cancer and cell proliferative diseases
WO1993001824A1 (en) * 1991-07-24 1993-02-04 Baylor College Of Medicine Combination therapy using bioflavonoid compounds with anti-cancer drugs
IT1271301B (it) * 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono

Also Published As

Publication number Publication date
HK1023770A1 (en) 2000-09-22
AU742784B2 (en) 2002-01-10
WO1998058913A1 (en) 1998-12-30
AU742784C (en) 2005-08-18
RU2203883C2 (ru) 2003-05-10
SK283077B6 (sk) 2003-02-04
SI0989973T1 (sl) 2006-02-28
HUP0003068A2 (hu) 2001-01-29
DE69831409T2 (de) 2006-06-08
CA2294278C (en) 2007-09-25
EP0989973B1 (en) 2005-08-31
CZ459999A3 (cs) 2000-05-17
CZ294976B6 (cs) 2005-04-13
CA2294278A1 (en) 1998-12-30
PL190495B1 (pl) 2005-12-30
GB9712966D0 (en) 1997-08-27
AU8537598A (en) 1999-01-04
PL337361A1 (en) 2000-08-14
NO314802B1 (no) 2003-05-26
CN1261349A (zh) 2000-07-26
NO996287D0 (no) 1999-12-17
ATE303362T1 (de) 2005-09-15
HU227628B1 (en) 2011-10-28
DE69831409D1 (de) 2005-10-06
SK179599A3 (en) 2000-06-12
DK0989973T3 (da) 2005-10-17
PT989973E (pt) 2005-11-30
JP4064471B2 (ja) 2008-03-19
HUP0003068A3 (en) 2002-02-28
ES2244075T3 (es) 2005-12-01
EP0989973A1 (en) 2000-04-05
JP2002506439A (ja) 2002-02-26
US6147082A (en) 2000-11-14
KR20010013603A (ko) 2001-02-26
NO996287L (no) 2000-02-21

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050427

Termination date: 20120612