SI0989973T1 - Halkoni z antiproliferativno aktivnostjo - Google Patents
Halkoni z antiproliferativno aktivnostjoInfo
- Publication number
- SI0989973T1 SI0989973T1 SI9830801T SI9830801T SI0989973T1 SI 0989973 T1 SI0989973 T1 SI 0989973T1 SI 9830801 T SI9830801 T SI 9830801T SI 9830801 T SI9830801 T SI 9830801T SI 0989973 T1 SI0989973 T1 SI 0989973T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pct
- compounds
- chalcones
- date dec
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9712966.2A GB9712966D0 (en) | 1997-06-19 | 1997-06-19 | Novel chalcones |
| PCT/EP1998/003558 WO1998058913A1 (en) | 1997-06-19 | 1998-06-12 | Chalcones having antiproliferative activity |
| EP98936334A EP0989973B1 (en) | 1997-06-19 | 1998-06-12 | Chalcones having antiproliferative activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI0989973T1 true SI0989973T1 (sl) | 2006-02-28 |
Family
ID=10814591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9830801T SI0989973T1 (sl) | 1997-06-19 | 1998-06-12 | Halkoni z antiproliferativno aktivnostjo |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6147082A (enExample) |
| EP (1) | EP0989973B1 (enExample) |
| JP (1) | JP4064471B2 (enExample) |
| KR (1) | KR20010013603A (enExample) |
| CN (1) | CN1198802C (enExample) |
| AT (1) | ATE303362T1 (enExample) |
| AU (1) | AU742784C (enExample) |
| CA (1) | CA2294278C (enExample) |
| CZ (1) | CZ294976B6 (enExample) |
| DE (1) | DE69831409T2 (enExample) |
| DK (1) | DK0989973T3 (enExample) |
| ES (1) | ES2244075T3 (enExample) |
| GB (1) | GB9712966D0 (enExample) |
| HU (1) | HU227628B1 (enExample) |
| NO (1) | NO314802B1 (enExample) |
| PL (1) | PL190495B1 (enExample) |
| PT (1) | PT989973E (enExample) |
| RU (1) | RU2203883C2 (enExample) |
| SI (1) | SI0989973T1 (enExample) |
| SK (1) | SK283077B6 (enExample) |
| WO (1) | WO1998058913A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060095786A (ko) * | 2000-01-27 | 2006-09-01 | 다카라 바이오 가부시키가이샤 | 치료제 |
| KR100377514B1 (ko) * | 2000-05-23 | 2003-03-26 | 신국현 | 찰콘 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물 |
| DE10060677A1 (de) | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Klainetine und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben |
| AU2003243594A1 (en) * | 2002-06-13 | 2003-12-31 | Johns Hopkins University | Novel boronic chalcone derivatives and uses thereof |
| KR20050070032A (ko) * | 2002-10-01 | 2005-07-05 | 다카라 바이오 가부시키가이샤 | 치료제 |
| NZ552298A (en) * | 2004-05-23 | 2011-04-29 | Gerard M Housey | Method for identifying inhibitors or activators of a theramutein by comparing the phenoresponse of cells exposed to a test compound |
| CN100336797C (zh) * | 2005-08-19 | 2007-09-12 | 浙江大学 | 四取代查耳酮衍生物及制备方法和用途 |
| CN102060792B (zh) * | 2010-12-24 | 2016-08-03 | 西南大学 | 2′-胺基查尔酮唑类化合物及其吡唑啉和环丙基唑类衍生物、制备方法与用途 |
| ES2540457B2 (es) * | 2013-06-19 | 2015-12-28 | Universidad De Sevilla | Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica |
| CN103360338B (zh) * | 2013-07-30 | 2015-04-01 | 中国科学院新疆理化技术研究所 | 一种查尔酮苯并噻唑酰胺类衍生物的制备方法和用途 |
| CN103910691A (zh) * | 2014-04-18 | 2014-07-09 | 山东药品食品职业学院 | 卤代苯基查尔酮衍生物及其制备方法和应用 |
| CN103896932A (zh) * | 2014-04-18 | 2014-07-02 | 山东药品食品职业学院 | 异恶唑基芳基查尔酮衍生物及其制备方法和应用 |
| CZ307046B6 (cs) * | 2015-09-02 | 2017-12-13 | Univerzita PalackĂ©ho v Olomouci | Komplexy mědi s deriváty (E)-1-(2´-hydroxyfenyl)-3-fenylprop-2-en-1-onu a jejich použití jako léčiv v protinádorové terapii |
| WO2017103637A1 (en) | 2015-12-18 | 2017-06-22 | Blirt S.A. | Diphenylpropane compounds and their cytotoxic activity |
| CN106279082B (zh) * | 2016-08-02 | 2019-02-01 | 浙江大学 | 取代的呋喃查耳酮类衍生物及其制备方法 |
| CN111138264B (zh) * | 2019-11-29 | 2023-08-04 | 温州医科大学 | 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用 |
| KR102496887B1 (ko) * | 2020-10-15 | 2023-02-06 | 경상국립대학교산학협력단 | 부테인 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 유방암의 예방, 개선 또는 치료용 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE376077B (enExample) * | 1973-09-13 | 1975-05-05 | Asea Ab | |
| JPH05509078A (ja) * | 1990-05-17 | 1993-12-16 | ベイラー カレッジ オブ メディシン | 成長抑制因とガンおよび細胞増殖性疾患措置法 |
| AU2393992A (en) * | 1991-07-24 | 1993-02-23 | Baylor College Of Medicine | Combination therapy using bioflavonoid compounds with anti-cancer drugs |
| IT1271301B (it) * | 1994-12-20 | 1997-05-27 | Indena Spa | Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono |
-
1997
- 1997-06-19 GB GBGB9712966.2A patent/GB9712966D0/en active Pending
-
1998
- 1998-06-12 HU HU0003068A patent/HU227628B1/hu not_active IP Right Cessation
- 1998-06-12 US US09/445,179 patent/US6147082A/en not_active Expired - Fee Related
- 1998-06-12 SI SI9830801T patent/SI0989973T1/sl unknown
- 1998-06-12 SK SK1795-99A patent/SK283077B6/sk not_active IP Right Cessation
- 1998-06-12 AT AT98936334T patent/ATE303362T1/de active
- 1998-06-12 DE DE69831409T patent/DE69831409T2/de not_active Expired - Lifetime
- 1998-06-12 CN CNB988062127A patent/CN1198802C/zh not_active Expired - Fee Related
- 1998-06-12 CZ CZ19994599A patent/CZ294976B6/cs not_active IP Right Cessation
- 1998-06-12 AU AU85375/98A patent/AU742784C/en not_active Ceased
- 1998-06-12 EP EP98936334A patent/EP0989973B1/en not_active Expired - Lifetime
- 1998-06-12 JP JP50370599A patent/JP4064471B2/ja not_active Expired - Fee Related
- 1998-06-12 RU RU2000101307/04A patent/RU2203883C2/ru not_active IP Right Cessation
- 1998-06-12 PL PL98337361A patent/PL190495B1/pl not_active IP Right Cessation
- 1998-06-12 KR KR19997011613A patent/KR20010013603A/ko not_active Ceased
- 1998-06-12 ES ES98936334T patent/ES2244075T3/es not_active Expired - Lifetime
- 1998-06-12 CA CA002294278A patent/CA2294278C/en not_active Expired - Fee Related
- 1998-06-12 DK DK98936334T patent/DK0989973T3/da active
- 1998-06-12 WO PCT/EP1998/003558 patent/WO1998058913A1/en not_active Ceased
- 1998-06-12 PT PT98936334T patent/PT989973E/pt unknown
-
1999
- 1999-12-17 NO NO19996287A patent/NO314802B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL337361A1 (en) | Chalkones of antiproliferative activity | |
| FR2727117B1 (enExample) | ||
| NZ294933A (en) | Thienopyridine or thienopyrimidine derivatives, pharmaceutical compositions and use as anti-inflammatory agents | |
| ZA200109995B (en) | Nematicidal Trifluorobutenes. | |
| MX9805253A (es) | Antagonistas del receptor de vitronectina. | |
| BG102259A (en) | Compostions with controlled paroxetine release | |
| YU18400A (sh) | Prostaglanidin agonisti i njihova primena za tretiranje koštanih poremećaja | |
| CA2337991A1 (en) | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents | |
| IL110943A (en) | Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders | |
| AP9801269A0 (en) | Prostaglandin agonists. | |
| ATE171873T1 (de) | Antiglucocorticoidsteroide zur behandlung von angststörungen | |
| CY2198B1 (en) | 1-Aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists | |
| MX9709398A (es) | N-aril-1,2,4-triazolin-5-onas. | |
| BG104038A (en) | Use of specific antagonist of 5ht2 receptors for preparing medicines useful for treating sleep-disordered breathing | |
| BG105275A (en) | Tan-1057 derivatives | |
| YU12000A (sh) | Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova | |
| BG104179A (en) | Phanquinon administration for the treatment of the alzheimer's disease | |
| CA2311423A1 (en) | Method for treating hyperlipidemia | |
| BG105710A (en) | 5ht1 antagonists for antidepressant therapy | |
| DE69808475D1 (de) | Aminosäurederivate zur behandlung von schlaganfall | |
| MXPA02001204A (es) | Compuestos calciliticos. | |
| BG103649A (en) | Method for the preparation of eprosartan | |
| NO975413D0 (no) | Koboltmetallagglomerater, samt fremgangsmåte for fremstilling og anvendelse derav | |
| BG103650A (en) | Method for the preparation of eprosartan | |
| NZ320522A (en) | Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the compounds |