ES2159549T3 - Derivados de 3-pirazolcarboxamida con una afinidad para el receptor de los cannabinoides. - Google Patents

Derivados de 3-pirazolcarboxamida con una afinidad para el receptor de los cannabinoides.

Info

Publication number
ES2159549T3
ES2159549T3 ES94402890T ES94402890T ES2159549T3 ES 2159549 T3 ES2159549 T3 ES 2159549T3 ES 94402890 T ES94402890 T ES 94402890T ES 94402890 T ES94402890 T ES 94402890T ES 2159549 T3 ES2159549 T3 ES 2159549T3
Authority
ES
Spain
Prior art keywords
alkilo
hydrogen
radical
nr5r6
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94402890T
Other languages
English (en)
Inventor
Francis Barth
Pierre Casellas
Christian Congy
Serge Martinez
Murielle Rinaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2159549T3 publication Critical patent/ES2159549T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DEL 3PIRAZOLOCARBOXAMIDA DE FORMULA (I): EN LA QUE - G2,G3,G4,G5,G6 Y W2,W3,W4,W5,W6 SON IDENTICOS O DIFERENTES Y REPRESENTAN INDEPENDIENTEMENTE HIDROGENO, UN ATOMO DE CLORO, BROM O YODO, UN (C1-C3)ALKILO, UN (C1-C3)ALCOXI, UN TRIFLUORMETILO, UN GRUPO NITRO Y G4 REPRESENTA EVENTUALMENTE UN GRUPO FENILO; - R4 REPESENTA HIDROGENO O UN (C1-C6)ALKILO, - R1 REPRESENTA UN (C1C6)ALKILO O UN HIDROGENO; - R2 REPRESENTA -+NR3R5R6 O -NR5R6; R5 REPRESENTA HIDROGENO O UN (C1-C6)ALKILO Y R6 REPRESENTA HIDROGENO, UN (C1-C6)ALKILO, UN FENILO, UN (C3-C8)CICLOAKILO O R5 Y R6 JUNTOS CON EL ATOMO DE NITROGENO AL QUE ESTA UNIDOS CONSITUYEN UN RADICAL HETEROCICLICO, SATURADO O INSATURADO, DE 5 A 10 ESLABONES, NO SUSTITUIDO O SUSTITUIDO UNA O VARIAS VECES POR UN ALKILO EN C1-C6, UN BENCILO, UN FENILO, UN HIDROXILO, UN ALCOXI EN C1-C6, UN HALOGENO; - R3 REPRESENTA UN (C1-C6)ALKILO O R3 FORMA UN PUENTE CON UNO DE LOS ATOMOS DEL RADICAL HETEROCICLICO FORMADO POR NR5R6; SIEMPRE QUE CUANDO R2 REPESENTA NR5R6 Y R6 JUNTOS CON EL ATOMO DE NITROGENO AL QUE ESAN UNIDO CONSTITUYEN UN RADICAL HETEROCICLICO DISTINTO DE UN RADICAL SATIRADO DE 5 A 8 ESLABONES NO SUSTITUIDO O SUS SALES Y SUS SOLVATOS. LA PRESENTE INVENCION SE REFIERE A UN PROCESO DE OBTENCION DE ESTOS NUEVOS DERIVADOS, Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES94402890T 1993-12-17 1994-12-15 Derivados de 3-pirazolcarboxamida con una afinidad para el receptor de los cannabinoides. Expired - Lifetime ES2159549T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9315221A FR2714057B1 (fr) 1993-12-17 1993-12-17 Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.

Publications (1)

Publication Number Publication Date
ES2159549T3 true ES2159549T3 (es) 2001-10-16

Family

ID=9454059

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94402890T Expired - Lifetime ES2159549T3 (es) 1993-12-17 1994-12-15 Derivados de 3-pirazolcarboxamida con una afinidad para el receptor de los cannabinoides.

Country Status (11)

Country Link
US (1) US5462960A (es)
EP (1) EP0658546B1 (es)
JP (1) JP3825062B2 (es)
AT (1) ATE201399T1 (es)
DE (1) DE69427269T2 (es)
DK (1) DK0658546T3 (es)
ES (1) ES2159549T3 (es)
FR (1) FR2714057B1 (es)
GR (1) GR3036378T3 (es)
PT (1) PT658546E (es)
SI (1) SI0658546T1 (es)

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EP0658546A1 (fr) 1995-06-21
JPH07324076A (ja) 1995-12-12
PT658546E (pt) 2001-11-30
DK0658546T3 (da) 2001-09-10
SI0658546T1 (en) 2001-10-31
FR2714057B1 (fr) 1996-03-08
EP0658546B1 (fr) 2001-05-23
FR2714057A1 (fr) 1995-06-23
US5462960A (en) 1995-10-31
GR3036378T3 (en) 2001-11-30
ATE201399T1 (de) 2001-06-15
JP3825062B2 (ja) 2006-09-20
DE69427269D1 (de) 2001-06-28
DE69427269T2 (de) 2002-03-14

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