PA8442101A1 - Pirazoles parasiticidas - Google Patents

Pirazoles parasiticidas

Info

Publication number
PA8442101A1
PA8442101A1 PA19978442101A PA8442101A PA8442101A1 PA 8442101 A1 PA8442101 A1 PA 8442101A1 PA 19978442101 A PA19978442101 A PA 19978442101A PA 8442101 A PA8442101 A PA 8442101A PA 8442101 A1 PA8442101 A1 PA 8442101A1
Authority
PA
Panama
Prior art keywords
alkyl
hydrogen
group
parasiticide
halogens
Prior art date
Application number
PA19978442101A
Other languages
English (en)
Inventor
Bernard Joseph Banks
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625290.3A external-priority patent/GB9625290D0/en
Priority claimed from GBGB9702235.4A external-priority patent/GB9702235D0/en
Priority claimed from GBGB9712045.5A external-priority patent/GB9712045D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PA8442101A1 publication Critical patent/PA8442101A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

COMPUESTOS DE FÓRMULA (1): O LAS SALES ACEPTABLES DESDE EL PUNTO DE VISTA FARMACÉUTICO, VETERINARIO O AGRÍCOLA DE LOS MISMOS, O SOLVATOS ACEPTABLES DESDE EL PUNTO DE VISTA FARMACÉUTICO, VETERINARIO O AGRÍCOLA DE CUALQUIERA DE LAS ENTIDADES, EN LA QUE R1 ES FENILO 2,4,6-TRISUSTITUIDO O PIRIDIN-2-ILO 3,5- SUSTITUIDO; R3 ES ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON HIDROXI O CON UNO O MÁS HALÓGENOS; CIANO, ALCANOILO C1-C5 O FENILO; R5 ES HIDRÓGENO,ALQUILO C1-C4, AMINO O HALÓGENO; R2 Y R4 SE SELECCIONAN CADA UNO, INDEPENDIENTEMENTE, ENTRE HIDRÓGENO, ALQUILO C1-C4, FLUORO, CLORO Y BROMO O, JUNTO AL ÁTOMO DE CARBONO AL QUE SE ENCUENTRAN UNIDOS FORMAN UN GRUPO CICLOALQUILO C3-C6; R6 Y R8 SE SELECCIONAN CADA UNO, INDEPENDIENTEMENTE, ENTRE HIDRÓGENO, ALQUILO C1-C4, FLUORO, CLORO Y BROMO; O, CUANDO R2 Y R4 NO FORMAN PARTE DE UN GRUPO CICLOALQUILO, R2 Y R6, JUNTO A LOS ÁTOMOS DE CARBONO A LOS QUE SE ENCUENTRAN UNIDOS, PUEDEN FORMAR UN GRUPO CICLOALQUILO C5-C7; Y R7 ES HIDRÓGENO, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON UNO O MÁS HALÓGENOS, O ALCOXI C1-C4; SON AGENTES PARASITICIDAS .
PA19978442101A 1996-12-05 1997-11-28 Pirazoles parasiticidas PA8442101A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9625290.3A GB9625290D0 (en) 1996-12-05 1996-12-05 Parasiticidal agents
GBGB9702235.4A GB9702235D0 (en) 1997-02-04 1997-02-04 Parasiticidal agents
GBGB9712045.5A GB9712045D0 (en) 1997-06-10 1997-06-10 Parasiticidal agents

Publications (1)

Publication Number Publication Date
PA8442101A1 true PA8442101A1 (es) 2000-05-24

Family

ID=27268619

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19978442101A PA8442101A1 (es) 1996-12-05 1997-11-28 Pirazoles parasiticidas

Country Status (40)

Country Link
US (2) US6075043A (es)
EP (1) EP0946515B1 (es)
JP (2) JP3950483B2 (es)
KR (1) KR100354311B1 (es)
CN (1) CN1106386C (es)
AR (1) AR013879A1 (es)
AT (1) ATE233736T1 (es)
AU (1) AU720705B2 (es)
BG (1) BG64127B1 (es)
BR (1) BR9713565A (es)
CA (1) CA2273951C (es)
CO (1) CO5031251A1 (es)
CZ (1) CZ295295B6 (es)
DE (1) DE69719547T2 (es)
DK (1) DK0946515T3 (es)
DZ (1) DZ2360A1 (es)
EA (1) EA002278B1 (es)
ES (1) ES2191870T3 (es)
HK (1) HK1029111A1 (es)
HR (1) HRP970663B1 (es)
HU (1) HUP0000544A3 (es)
ID (1) ID21556A (es)
IL (1) IL129866A (es)
IS (1) IS1982B (es)
MA (1) MA24414A1 (es)
MY (1) MY117021A (es)
NO (2) NO313518B1 (es)
NZ (1) NZ335611A (es)
OA (1) OA11055A (es)
PA (1) PA8442101A1 (es)
PE (1) PE20199A1 (es)
PL (1) PL190926B1 (es)
PT (1) PT946515E (es)
RS (1) RS49720B (es)
SK (1) SK285203B6 (es)
TN (1) TNSN97197A1 (es)
TW (1) TW524667B (es)
UA (1) UA60321C2 (es)
UY (2) UY24798A1 (es)
WO (1) WO1998024767A1 (es)

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MX2008000250A (es) 2005-07-06 2008-03-19 Sepracor Inc Combinaciones de eszopiclona y trans-4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-n-metil-1-naftalenamina o trans 4-(3,4-diclorofenil)-1, 2,3,4-tetrahidro-1-naftalenamina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y
EP1783114A1 (en) * 2005-11-03 2007-05-09 Novartis AG N-(hetero)aryl indole derivatives as pesticides
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WO2011124998A1 (en) 2010-04-08 2011-10-13 Pfizer Inc. Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides
EP2601190B1 (en) 2010-08-05 2018-07-04 Zoetis Services LLC Isoxazoline derivatives as antiparasitic agents
EP2619189B1 (en) 2010-09-24 2020-04-15 Zoetis Services LLC Isoxazoline oximes as antiparasitic agents
ME02412B (me) 2011-03-10 2016-09-20 Zoetis Services Llc Spirociklični derivati izoksazolina kao antiparazitska sredstva
WO2012127347A1 (en) 2011-03-22 2012-09-27 Pfizer Inc. Isoxazoline derivatives as antiparasitic agents
WO2013000572A1 (de) 2011-06-30 2013-01-03 2LUTION GmbH Mittel zur bekämpfung von parasiten an tieren
ES2571444T3 (es) 2012-02-03 2016-05-25 Zoetis Services Llc Derivados de dihidrofurano-azetadina como agentes antiparasitarios
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
CN104271568B (zh) 2012-05-09 2016-05-04 硕腾服务有限责任公司 作为抗寄生虫剂的氮杂环丁烷衍生物
MX363173B (es) 2012-12-12 2019-03-12 Zoetis Services Llc Composiciones inyectables de fenilpirazol.
PL3474820T3 (pl) 2017-08-24 2024-05-13 Novo Nordisk A/S Kompozycje glp-1 i ich zastosowania
CN111116478B (zh) * 2019-12-18 2021-10-26 浙江金伯士药业有限公司 一种兽用抗生素维吉霉素中间体的制备方法
EP4106724A1 (en) 2020-02-18 2022-12-28 Novo Nordisk A/S Glp-1 compositions and uses thereof
CN115894374A (zh) * 2023-02-16 2023-04-04 广州佳途科技股份有限公司 一种氟甲腈的制备方法及其应用

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DE3706993A1 (de) * 1987-03-05 1988-09-15 Bayer Ag 5-amino-3-halogenalkyl-1-aryl-pyrazole
SE455750B (sv) 1987-06-11 1988-08-01 Ericsson Telefon Ab L M Digitalt tidsmultiplext mobiltelefonisystem med ett effektivt utnyttjande av varje tidsram
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FR2739255B1 (fr) * 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
DE69627281T2 (de) * 1995-12-19 2003-11-13 Bayer Cropscience Sa Neue 1-Aryl Pyrazol Derivate und ihre Verwendung als Schädlingsbekämpfungsmittel
GR970100096A (el) * 1996-03-29 1997-11-28 Merial Εξωτερικη διαταξη κατα των παρασιτων για βοοειδη με βαση τη ν-φαινυλπυραζολη, ειδικα σκουλαρικια.
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IE80657B1 (en) * 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
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Also Published As

Publication number Publication date
IL129866A (en) 2004-05-12
IS1982B (is) 2005-01-14
HK1029111A1 (en) 2001-03-23
OA11055A (en) 2002-03-07
DZ2360A1 (fr) 2002-12-28
CZ295295B6 (cs) 2005-06-15
JP2000505812A (ja) 2000-05-16
UY24798A1 (es) 2000-09-29
BG64127B1 (bg) 2004-01-30
MY117021A (en) 2004-04-30
EP0946515B1 (en) 2003-03-05
SK285203B6 (sk) 2006-08-03
NO313518B1 (no) 2002-10-14
KR20000057432A (ko) 2000-09-15
PL333922A1 (en) 2000-01-31
CA2273951A1 (en) 1998-06-11
AU720705B2 (en) 2000-06-08
AR013879A1 (es) 2001-01-31
CA2273951C (en) 2003-04-01
KR100354311B1 (ko) 2002-09-28
US6268509B1 (en) 2001-07-31
JP3950483B2 (ja) 2007-08-01
PE20199A1 (es) 1999-03-05
HUP0000544A2 (hu) 2000-06-28
TW524667B (en) 2003-03-21
US6075043A (en) 2000-06-13
NO992732D0 (no) 1999-06-04
MA24414A1 (fr) 1998-07-01
SK74099A3 (en) 2001-02-12
HRP970663A2 (en) 1998-10-31
CO5031251A1 (es) 2001-04-27
NZ335611A (en) 2001-01-26
HUP0000544A3 (en) 2002-01-28
BR9713565A (pt) 2000-03-14
ID21556A (id) 1999-06-24
YU25299A (sh) 2002-10-18
HRP970663B1 (en) 2003-10-31
DE69719547D1 (de) 2003-04-10
UA60321C2 (uk) 2003-10-15
ATE233736T1 (de) 2003-03-15
TNSN97197A1 (fr) 2005-03-15
IS5050A (is) 1999-05-11
JP2007211016A (ja) 2007-08-23
EP0946515A1 (en) 1999-10-06
CN1258282A (zh) 2000-06-28
PL190926B1 (pl) 2006-02-28
EA002278B1 (ru) 2002-02-28
UY24923A1 (es) 1998-09-01
NO992736D0 (no) 1999-06-04
BG103454A (en) 2000-01-31
WO1998024767A1 (en) 1998-06-11
DE69719547T2 (de) 2003-10-02
DK0946515T3 (da) 2003-07-14
RS49720B (sr) 2007-12-31
AU5485998A (en) 1998-06-29
PT946515E (pt) 2003-06-30
CN1106386C (zh) 2003-04-23
ES2191870T3 (es) 2003-09-16
EA199900447A1 (ru) 2000-02-28
IL129866A0 (en) 2000-02-29
NO992732L (no) 1999-08-05
CZ195199A3 (cs) 2000-08-16

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