EA199900447A1 - Противопаразитарные пиразолы - Google Patents

Противопаразитарные пиразолы

Info

Publication number
EA199900447A1
EA199900447A1 EA199900447A EA199900447A EA199900447A1 EA 199900447 A1 EA199900447 A1 EA 199900447A1 EA 199900447 A EA199900447 A EA 199900447A EA 199900447 A EA199900447 A EA 199900447A EA 199900447 A1 EA199900447 A1 EA 199900447A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
cycloalkyl group
pharmaceuticals
bromo
Prior art date
Application number
EA199900447A
Other languages
English (en)
Other versions
EA002278B1 (ru
Inventor
Бернард Джозеф Бэнкс
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625290.3A external-priority patent/GB9625290D0/en
Priority claimed from GBGB9702235.4A external-priority patent/GB9702235D0/en
Priority claimed from GBGB9712045.5A external-priority patent/GB9712045D0/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA199900447A1 publication Critical patent/EA199900447A1/ru
Publication of EA002278B1 publication Critical patent/EA002278B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Соединения формулы (I), либо их приемлемые в фармацевтике, ветеринарии или сельском хозяйстве соли, либо приемлемые в фармацевтике, ветеринарии или сельском хозяйстве сольваты каждого из них, где Rпредставляет собой 2,4,6-трехзамещенный фенил или 3,5-двузамещенный пиридин-2-ил; Rпредставляет собой C-C-алкил, возможно замещенный гидрокси или одним или более чем одним галогеном-; циано, C-Cалканоил или фенил; Rпредставляет собой водород, C-Cалкил, амино или галоген-; Rи R, каждый независимо, представляют собой C-Cалкил, фтор-, хлор- и бром-, либо вместе с атомом углерода, к которому они присоединены, образуют C-Cциклоалкильную группу; Rи R, каждый независимо, представляют собой водород, C-Cалкил, фтор-, хлор- и бром-; либо, когда Rи Rне образуют часть циклоалкильной группы, Rи Rвместе с атомами углерода, к которым они присоединены, могут образовывать C-Cциклоалкильную группу; и Rпредставляет собой водород, C-Cалкил, возможно замещенный одним или более чем одним галогеном-, или C-Cалкокси; являются противопаразитарными агентами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900447A 1996-12-05 1997-11-25 Противопаразитарные пиразолы EA002278B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9625290.3A GB9625290D0 (en) 1996-12-05 1996-12-05 Parasiticidal agents
GBGB9702235.4A GB9702235D0 (en) 1997-02-04 1997-02-04 Parasiticidal agents
GBGB9712045.5A GB9712045D0 (en) 1997-06-10 1997-06-10 Parasiticidal agents
PCT/EP1997/006697 WO1998024767A1 (en) 1996-12-05 1997-11-25 Parasiticidal pyrazoles

Publications (2)

Publication Number Publication Date
EA199900447A1 true EA199900447A1 (ru) 2000-02-28
EA002278B1 EA002278B1 (ru) 2002-02-28

Family

ID=27268619

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900447A EA002278B1 (ru) 1996-12-05 1997-11-25 Противопаразитарные пиразолы

Country Status (40)

Country Link
US (2) US6075043A (ru)
EP (1) EP0946515B1 (ru)
JP (2) JP3950483B2 (ru)
KR (1) KR100354311B1 (ru)
CN (1) CN1106386C (ru)
AR (1) AR013879A1 (ru)
AT (1) ATE233736T1 (ru)
AU (1) AU720705B2 (ru)
BG (1) BG64127B1 (ru)
BR (1) BR9713565A (ru)
CA (1) CA2273951C (ru)
CO (1) CO5031251A1 (ru)
CZ (1) CZ295295B6 (ru)
DE (1) DE69719547T2 (ru)
DK (1) DK0946515T3 (ru)
DZ (1) DZ2360A1 (ru)
EA (1) EA002278B1 (ru)
ES (1) ES2191870T3 (ru)
HK (1) HK1029111A1 (ru)
HR (1) HRP970663B1 (ru)
HU (1) HUP0000544A3 (ru)
ID (1) ID21556A (ru)
IL (1) IL129866A (ru)
IS (1) IS1982B (ru)
MA (1) MA24414A1 (ru)
MY (1) MY117021A (ru)
NO (2) NO313518B1 (ru)
NZ (1) NZ335611A (ru)
OA (1) OA11055A (ru)
PA (1) PA8442101A1 (ru)
PE (1) PE20199A1 (ru)
PL (1) PL190926B1 (ru)
PT (1) PT946515E (ru)
RS (1) RS49720B (ru)
SK (1) SK285203B6 (ru)
TN (1) TNSN97197A1 (ru)
TW (1) TW524667B (ru)
UA (1) UA60321C2 (ru)
UY (2) UY24798A1 (ru)
WO (1) WO1998024767A1 (ru)

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JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
CN104271568B (zh) 2012-05-09 2016-05-04 硕腾服务有限责任公司 作为抗寄生虫剂的氮杂环丁烷衍生物
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Also Published As

Publication number Publication date
IL129866A (en) 2004-05-12
IS1982B (is) 2005-01-14
HK1029111A1 (en) 2001-03-23
OA11055A (en) 2002-03-07
DZ2360A1 (fr) 2002-12-28
CZ295295B6 (cs) 2005-06-15
JP2000505812A (ja) 2000-05-16
UY24798A1 (es) 2000-09-29
BG64127B1 (bg) 2004-01-30
MY117021A (en) 2004-04-30
EP0946515B1 (en) 2003-03-05
SK285203B6 (sk) 2006-08-03
NO313518B1 (no) 2002-10-14
KR20000057432A (ko) 2000-09-15
PL333922A1 (en) 2000-01-31
CA2273951A1 (en) 1998-06-11
AU720705B2 (en) 2000-06-08
AR013879A1 (es) 2001-01-31
PA8442101A1 (es) 2000-05-24
CA2273951C (en) 2003-04-01
KR100354311B1 (ko) 2002-09-28
US6268509B1 (en) 2001-07-31
JP3950483B2 (ja) 2007-08-01
PE20199A1 (es) 1999-03-05
HUP0000544A2 (hu) 2000-06-28
TW524667B (en) 2003-03-21
US6075043A (en) 2000-06-13
NO992732D0 (no) 1999-06-04
MA24414A1 (fr) 1998-07-01
SK74099A3 (en) 2001-02-12
HRP970663A2 (en) 1998-10-31
CO5031251A1 (es) 2001-04-27
NZ335611A (en) 2001-01-26
HUP0000544A3 (en) 2002-01-28
BR9713565A (pt) 2000-03-14
ID21556A (id) 1999-06-24
YU25299A (sh) 2002-10-18
HRP970663B1 (en) 2003-10-31
DE69719547D1 (de) 2003-04-10
UA60321C2 (ru) 2003-10-15
ATE233736T1 (de) 2003-03-15
TNSN97197A1 (fr) 2005-03-15
IS5050A (is) 1999-05-11
JP2007211016A (ja) 2007-08-23
EP0946515A1 (en) 1999-10-06
CN1258282A (zh) 2000-06-28
PL190926B1 (pl) 2006-02-28
EA002278B1 (ru) 2002-02-28
UY24923A1 (es) 1998-09-01
NO992736D0 (no) 1999-06-04
BG103454A (en) 2000-01-31
WO1998024767A1 (en) 1998-06-11
DE69719547T2 (de) 2003-10-02
DK0946515T3 (da) 2003-07-14
RS49720B (sr) 2007-12-31
AU5485998A (en) 1998-06-29
PT946515E (pt) 2003-06-30
CN1106386C (zh) 2003-04-23
ES2191870T3 (es) 2003-09-16
IL129866A0 (en) 2000-02-29
NO992732L (no) 1999-08-05
CZ195199A3 (cs) 2000-08-16

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