AR017500A1 - Derivados de naftilpiperacin-ftalacinonas - Google Patents

Derivados de naftilpiperacin-ftalacinonas

Info

Publication number
AR017500A1
AR017500A1 ARP980101765A ARP980101765A AR017500A1 AR 017500 A1 AR017500 A1 AR 017500A1 AR P980101765 A ARP980101765 A AR P980101765A AR P980101765 A ARP980101765 A AR P980101765A AR 017500 A1 AR017500 A1 AR 017500A1
Authority
AR
Argentina
Prior art keywords
group
derivatives
well
short chain
naftilpiperacin
Prior art date
Application number
ARP980101765A
Other languages
English (en)
Original Assignee
Icos Se Faes Fabrica Espanola De Productos Quimicos Y Farmaceut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Se Faes Fabrica Espanola De Productos Quimicos Y Farmaceut filed Critical Icos Se Faes Fabrica Espanola De Productos Quimicos Y Farmaceut
Publication of AR017500A1 publication Critical patent/AR017500A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen derivados de naftilpiperacin-ftalacinonas, de formula general (I), donde R1 y R2 iguales o diferentes entre sí, pueden se hidrogeno, ungrupo alquilo de cadena corta, halogeno, un grupo nitro, un grupo amino, un grupo acilamino, y un grupo alcoxi de cadena corta; n puede tomar valoresentre 2 y 5; y R3 puede ser un radical metoxilo, un átomo de fluor e hidrogeno, así como sus sales de adicion con ácidos farmacéuticamenteaceptables. Los compuestos presentan afinidad por los receptores5HT(1A) y 5HT(2) de la serotonina, así como por los receptores D2 de la dopaminay pueden ser utiles como antipsicoticos. También se describe su preparacion.
ARP980101765A 1997-04-16 1998-04-16 Derivados de naftilpiperacin-ftalacinonas AR017500A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700812 1997-04-16

Publications (1)

Publication Number Publication Date
AR017500A1 true AR017500A1 (es) 2001-09-12

Family

ID=8298980

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101765A AR017500A1 (es) 1997-04-16 1998-04-16 Derivados de naftilpiperacin-ftalacinonas

Country Status (15)

Country Link
EP (1) EP0875512A3 (es)
JP (1) JPH10287658A (es)
KR (1) KR19980081366A (es)
CN (1) CN1197067A (es)
AR (1) AR017500A1 (es)
AU (1) AU6192298A (es)
BR (1) BR9801075A (es)
CA (1) CA2234789A1 (es)
CO (1) CO4940468A1 (es)
CZ (1) CZ111898A3 (es)
HR (1) HRP980204A2 (es)
HU (1) HUP9800889A1 (es)
NO (1) NO981689L (es)
PL (1) PL325816A1 (es)
ZA (1) ZA983168B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.
US20030073692A1 (en) 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
JP2008500383A (ja) * 2004-05-21 2008-01-10 ファイザー・プロダクツ・インク ５−ｈｔ１ｂアンタゴニスト、インバースアゴニストおよび部分アゴニストとしてのテトラヒドロナフチルピペラジン類

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1222867B (it) * 1987-10-12 1990-09-12 Zambon Spa Ftalazino derivati ad attivita' farmaceutica
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
FR2655988B1 (fr) * 1989-12-20 1994-05-20 Adir Cie Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680172B1 (fr) * 1991-08-05 1993-11-19 Fabre Medicament Pierre Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
FR2727682A1 (fr) * 1994-12-02 1996-06-07 Pf Medicament Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament

Also Published As

Publication number Publication date
JPH10287658A (ja) 1998-10-27
CA2234789A1 (en) 1998-10-16
ZA983168B (en) 1998-10-20
PL325816A1 (en) 1998-10-26
BR9801075A (pt) 2000-02-08
CN1197067A (zh) 1998-10-28
AU6192298A (en) 1998-10-22
CO4940468A1 (es) 2000-07-24
EP0875512A2 (en) 1998-11-04
KR19980081366A (ko) 1998-11-25
HU9800889D0 (en) 1998-06-29
HRP980204A2 (en) 1999-02-28
NO981689D0 (no) 1998-04-15
HUP9800889A1 (hu) 2000-11-28
CZ111898A3 (cs) 1998-11-11
NO981689L (no) 1998-10-19
EP0875512A3 (en) 1999-04-07

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