ES2070126T3 - Derivados de piridazinamina. - Google Patents
Derivados de piridazinamina.Info
- Publication number
- ES2070126T3 ES2070126T3 ES88202572T ES88202572T ES2070126T3 ES 2070126 T3 ES2070126 T3 ES 2070126T3 ES 88202572 T ES88202572 T ES 88202572T ES 88202572 T ES88202572 T ES 88202572T ES 2070126 T3 ES2070126 T3 ES 2070126T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- formula
- compounds
- piridazinamine
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 AMINO Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical class O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
NUEVOS DERIVADOS DE PIRIDAZINAMINA DE FORMULA(I), EN LA QUE R1 ES H, ALQUILO DE 1 A 6 C, HALO, OH, SH, TRIFLUORMETIL, AMINO, MONO O DI (ALQUIL DE 1 A 6 C) - AMINO, CIANO ALQUILOXI DE 1 A 6 C, ARILOXI, ARILALQUILOXI DE 1 A 6 C, ALQUILTIO DE 1 A 6 C, ARILTIO, ALQUIL (DE 1 A 6 C) - SULFINIL O - SULFONILO, ARIL SULFINILO, ARIL - SULFONILO, ALQUIL (DE 12 A 6 C) - CARBONILO O OXICARBONILO, O ARILO; R2 Y R3 SON INDEPENDIENTEMENTE H, ALQUILO DE 1 A 6 C, O JUNTOS PUEDEN FORMAR UN RADICAL BIVALENTE DE FORMULA - CH = CH - XCH = CH -; G ES UN RADICAL BIVALENTE SELECCIONADO DE ENTRE LOS DE LAS FORMULA(II); Y X ES O, S, NR8 O UN ENLACE DIRECTO (SIENDO R8 H O ALQUILO DE 1 A 6 C). TAMBIEN SE INCLUYEN LAS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES Y SUS POSIBLES ISOMEROS ESTEROQUIMICOS. LOS COMPUESTOS CITADOS SON ANTIVIRICOS. EN LA INVENCION SE INCLUYEN TAMBIEN COMPOSICIONES FARMACEUTICAS QUE CONTINEN DICHOS COMPUESTOS COMO INGREDIENTE ACTIVO Y METODOS PARA LA PREPARACION DE LOS COMPUESTOS YDE LAS COMPOSICIONES FARMACEUTICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12453087A | 1987-11-23 | 1987-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2070126T3 true ES2070126T3 (es) | 1995-06-01 |
Family
ID=22415413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88202572T Expired - Lifetime ES2070126T3 (es) | 1987-11-23 | 1988-11-17 | Derivados de piridazinamina. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0320032B1 (es) |
| JP (1) | JPH0629255B2 (es) |
| KR (1) | KR0125280B1 (es) |
| CN (1) | CN1021328C (es) |
| AT (1) | ATE117296T1 (es) |
| AU (1) | AU611504B2 (es) |
| BG (1) | BG60676B1 (es) |
| CA (1) | CA1327573C (es) |
| DE (1) | DE3852816T2 (es) |
| DK (1) | DK651288A (es) |
| ES (1) | ES2070126T3 (es) |
| FI (1) | FI92584C (es) |
| GR (1) | GR3015816T3 (es) |
| HU (1) | HU200762B (es) |
| IE (1) | IE65768B1 (es) |
| IL (1) | IL88429A (es) |
| JO (1) | JO1552B1 (es) |
| MA (1) | MA21446A1 (es) |
| MY (1) | MY104343A (es) |
| NO (1) | NO171980C (es) |
| NZ (1) | NZ226920A (es) |
| PH (1) | PH26670A (es) |
| PT (1) | PT89047B (es) |
| SU (1) | SU1724013A3 (es) |
| TN (1) | TNSN88128A1 (es) |
| ZA (1) | ZA888744B (es) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106973A (en) * | 1987-11-23 | 1992-04-21 | Janssen Pharmaceutica N.V. | Pyridzainamine derivatives |
| GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
| US5070090A (en) * | 1989-05-15 | 1991-12-03 | Janssen Pharmaceutica N.V. | Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers |
| JO1645B1 (en) * | 1989-12-26 | 1991-11-27 | شركة جانسين فارماسوتيكا ان. في | Pyridazine compounds are antibacterial viruses |
| US5169855A (en) * | 1990-03-28 | 1992-12-08 | Du Pont Merck Pharmaceutical Company | Piperidine ether derivatives as psychotropic drugs or plant fungicides |
| MX9100513A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
| FR2668151A1 (fr) * | 1990-10-23 | 1992-04-24 | Rhone Poulenc Agrochimie | Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant. |
| HU214320B (hu) * | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| CA2099630A1 (en) * | 1992-07-02 | 1994-01-03 | Guy Dominic Diana | Heterocyclyl-phenoxyalkyl-piperidinylpyridazines as antiviral agents |
| US5242924A (en) * | 1992-07-02 | 1993-09-07 | Sterling Winthrop Inc. | Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents |
| US5364865A (en) * | 1992-12-30 | 1994-11-15 | Sterling Winthrop Inc. | Phenoxy- and phenoxyalkyl-piperidines as antiviral agents |
| US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
| AU692439B2 (en) * | 1993-03-29 | 1998-06-11 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
| US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
| ATE202345T1 (de) * | 1993-03-29 | 2001-07-15 | Astrazeneca Ab | Heterozyklische derivate als plätchenaggregationsinhibitoren |
| US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
| HU226859B1 (en) * | 1997-10-27 | 2009-12-28 | Neurosearch As | Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them |
| US6683100B2 (en) | 1999-01-19 | 2004-01-27 | Novartis Ag | Organic compounds |
| PL339836A1 (en) | 1998-02-19 | 2001-01-02 | Eisai Co Ltd | Phtalazine compounds and therapeutic agents suitable to treat erection disorders |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US6316500B1 (en) * | 1999-01-05 | 2001-11-13 | Isp Investments Inc. | Aliphatically unsaturated hydroxy benzoates and preservative compositions thereof |
| AUPR213700A0 (en) | 2000-12-18 | 2001-01-25 | Biota Scientific Management Pty Ltd | Antiviral agents |
| AU2002331621B2 (en) | 2001-08-15 | 2008-06-05 | Icos Corporation | 2H-phthalazin-1-ones and methods for use thereof |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US7494987B2 (en) * | 2002-11-25 | 2009-02-24 | Mochida Pharmaceutical Co., Ltd. | Agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient |
| US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| BRPI0412343A (pt) | 2003-07-30 | 2006-09-05 | Xenon Pharmaceuticals Inc | derivados de piridazina e seu uso como agentes terapêuticos |
| US7754711B2 (en) | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| ES2568769T3 (es) | 2003-07-30 | 2016-05-04 | Xenon Pharmaceuticals Inc. | Derivados de piperazina y su uso como agentes terapéuticos |
| WO2006003147A1 (en) * | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Phthalazine derivatives as parp inhibitors |
| AU2005286793A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
| US7777036B2 (en) | 2004-09-20 | 2010-08-17 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| MX2007003325A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa. |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| AU2005286731A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| EP1804799B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| CA2580856A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP2029138A1 (en) | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| CN1887875B (zh) * | 2005-06-30 | 2011-04-06 | 深圳市东阳光实业发展有限公司 | 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途 |
| CA2613235A1 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
| RU2499795C2 (ru) | 2005-07-04 | 2013-11-27 | Хай Пойнт Фармасьютикалс, ЛЛС | Антагонисты гистаминовых н3-рецепторов |
| WO2007137968A1 (en) | 2006-05-29 | 2007-12-06 | High Point Pharmaceuticals, Llc | 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
| EP2014656A3 (en) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
| CN101864003B (zh) * | 2010-06-11 | 2012-05-02 | 漆又毛 | 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法 |
| CN102344416B (zh) * | 2010-08-02 | 2015-09-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 哒嗪衍生物及其作为抗小rna病毒感染药物的用途 |
| CN102485717B (zh) * | 2010-12-06 | 2015-12-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑胺衍生物及其作为抗小rna病毒感染药物的用途 |
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| WO2019152977A2 (en) | 2018-02-05 | 2019-08-08 | Bio-Rad Laboratories, Inc. | Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand |
| CN118047485B (zh) * | 2024-04-08 | 2024-06-25 | 西安文理学院 | 一种污水治理的复合微生物菌剂及其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8802151A1 (es) * | 1985-07-31 | 1988-04-01 | Janssen Pharmaceutica Nv | Un procedimiento para la preparacion de nuevos piridazinaminas. |
-
1988
- 1988-10-26 MY MYPI88001214A patent/MY104343A/en unknown
- 1988-11-02 CA CA000581965A patent/CA1327573C/en not_active Expired - Fee Related
- 1988-11-09 NZ NZ226920A patent/NZ226920A/xx unknown
- 1988-11-17 ES ES88202572T patent/ES2070126T3/es not_active Expired - Lifetime
- 1988-11-17 EP EP88202572A patent/EP0320032B1/en not_active Expired - Lifetime
- 1988-11-17 DE DE3852816T patent/DE3852816T2/de not_active Expired - Fee Related
- 1988-11-17 AT AT88202572T patent/ATE117296T1/de not_active IP Right Cessation
- 1988-11-18 AU AU25751/88A patent/AU611504B2/en not_active Ceased
- 1988-11-21 BG BG86132A patent/BG60676B1/bg unknown
- 1988-11-21 IL IL88429A patent/IL88429A/xx not_active IP Right Cessation
- 1988-11-21 TN TNTNSN88128A patent/TNSN88128A1/fr unknown
- 1988-11-22 SU SU884356881A patent/SU1724013A3/ru active
- 1988-11-22 IE IE348688A patent/IE65768B1/en not_active IP Right Cessation
- 1988-11-22 MA MA21689A patent/MA21446A1/fr unknown
- 1988-11-22 HU HU885991A patent/HU200762B/hu not_active IP Right Cessation
- 1988-11-22 ZA ZA888744A patent/ZA888744B/xx unknown
- 1988-11-22 DK DK651288A patent/DK651288A/da not_active Application Discontinuation
- 1988-11-22 JO JO19881552A patent/JO1552B1/en active
- 1988-11-22 FI FI885409A patent/FI92584C/fi not_active IP Right Cessation
- 1988-11-22 PT PT89047A patent/PT89047B/pt not_active IP Right Cessation
- 1988-11-22 JP JP63293739A patent/JPH0629255B2/ja not_active Expired - Fee Related
- 1988-11-22 NO NO885190A patent/NO171980C/no unknown
- 1988-11-23 CN CN88108173A patent/CN1021328C/zh not_active Expired - Fee Related
- 1988-11-23 KR KR1019880015415A patent/KR0125280B1/ko not_active IP Right Cessation
- 1988-11-23 PH PH37851A patent/PH26670A/en unknown
-
1995
- 1995-04-17 GR GR950400946T patent/GR3015816T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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