TNSN88128A1 - Nouveaux derives de pyridazinamine, et procede de destruction de virus ou de prevention contre leur developpement chez les animaux a sang chaud, composition antivirale en comportant application ainsi que leur procede de preaparation - Google Patents

Nouveaux derives de pyridazinamine, et procede de destruction de virus ou de prevention contre leur developpement chez les animaux a sang chaud, composition antivirale en comportant application ainsi que leur procede de preaparation

Info

Publication number
TNSN88128A1
TNSN88128A1 TNTNSN88128A TNSN88128A TNSN88128A1 TN SN88128 A1 TNSN88128 A1 TN SN88128A1 TN TNSN88128 A TNTNSN88128 A TN TNSN88128A TN SN88128 A TNSN88128 A TN SN88128A TN SN88128 A1 TNSN88128 A1 TN SN88128A1
Authority
TN
Tunisia
Prior art keywords
development
well
novel
application
preparation process
Prior art date
Application number
TNTNSN88128A
Other languages
English (en)
Inventor
Antoine Stockbroeks Raymond
Jozef Maria Van Der Aa Marcel
Gerebernus Maria Luyckx Marcel
Arthur Jules Grauwels Gilbert
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TNSN88128A1 publication Critical patent/TNSN88128A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA PRESENTE INVENTION EST RELATIVE A DE NOUVEAUX DERIVES DE PYRIDAZINAMINE AYANT UNE ACTIVITE ANTIVIRALE, A DES COMPOSITIONS CONTENANT CES COMPOSES EN TANT QU'INGREDIENT ACTIF, A UN PROCEDE DE DESTRUCTION DE VIRUS OU DE PREVENTION CONTRE LEUR DEVELOPPEMENT CHEZ LES ANIMAUX A SANG CHAUD SOUFFRANT DE MALADIES PROVOQUEES PAR CES VIRUS, AINSI QU'A DES PROCEDES DE PREPARATION DE CES COMPOSES.
TNTNSN88128A 1987-11-23 1988-11-21 Nouveaux derives de pyridazinamine, et procede de destruction de virus ou de prevention contre leur developpement chez les animaux a sang chaud, composition antivirale en comportant application ainsi que leur procede de preaparation TNSN88128A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12453087A 1987-11-23 1987-11-23

Publications (1)

Publication Number Publication Date
TNSN88128A1 true TNSN88128A1 (fr) 1990-07-10

Family

ID=22415413

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN88128A TNSN88128A1 (fr) 1987-11-23 1988-11-21 Nouveaux derives de pyridazinamine, et procede de destruction de virus ou de prevention contre leur developpement chez les animaux a sang chaud, composition antivirale en comportant application ainsi que leur procede de preaparation

Country Status (26)

Country Link
EP (1) EP0320032B1 (fr)
JP (1) JPH0629255B2 (fr)
KR (1) KR0125280B1 (fr)
CN (1) CN1021328C (fr)
AT (1) ATE117296T1 (fr)
AU (1) AU611504B2 (fr)
BG (1) BG60676B1 (fr)
CA (1) CA1327573C (fr)
DE (1) DE3852816T2 (fr)
DK (1) DK651288A (fr)
ES (1) ES2070126T3 (fr)
FI (1) FI92584C (fr)
GR (1) GR3015816T3 (fr)
HU (1) HU200762B (fr)
IE (1) IE65768B1 (fr)
IL (1) IL88429A (fr)
JO (1) JO1552B1 (fr)
MA (1) MA21446A1 (fr)
MY (1) MY104343A (fr)
NO (1) NO171980C (fr)
NZ (1) NZ226920A (fr)
PH (1) PH26670A (fr)
PT (1) PT89047B (fr)
SU (1) SU1724013A3 (fr)
TN (1) TNSN88128A1 (fr)
ZA (1) ZA888744B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
JO1645B1 (en) * 1989-12-26 1991-11-27 شركة جانسين فارماسوتيكا ان. في Pyridazine compounds are antibacterial viruses
US5169855A (en) * 1990-03-28 1992-12-08 Du Pont Merck Pharmaceutical Company Piperidine ether derivatives as psychotropic drugs or plant fungicides
MX9100513A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
FR2668151A1 (fr) * 1990-10-23 1992-04-24 Rhone Poulenc Agrochimie Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant.
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5242924A (en) * 1992-07-02 1993-09-07 Sterling Winthrop Inc. Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents
CA2099630A1 (fr) * 1992-07-02 1994-01-03 Guy Dominic Diana Utilisation de phenoxyalkyl-piperidinylpyridazines heterocycliques comme agents antiviraux
US5364865A (en) * 1992-12-30 1994-11-15 Sterling Winthrop Inc. Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
SK120895A3 (en) * 1993-03-29 1996-06-05 Zeneca Ltd Pyridine derivatives, process for preparing the same and intermediate products in this process and pharmaceutical compositions containing them
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
SK285198B6 (sk) * 1997-10-27 2006-08-03 Neurosearch A/S Homopiperazínový derivát, farmaceutická kompozícia obsahujúca tento derivát a jeho použitie
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
RU2229476C2 (ru) 1998-02-19 2004-05-27 Эйсай Ко., Лтд. Производные фталазина и терапевтические средства для эректильной дисфункции
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US6316500B1 (en) * 1999-01-05 2001-11-13 Isp Investments Inc. Aliphatically unsaturated hydroxy benzoates and preservative compositions thereof
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
EP1423120A4 (fr) 2001-08-15 2005-12-28 Icos Corp 2h-phtalazine-1-ones et procedes d'utilisation de celles-ci
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
ATE522502T1 (de) * 2002-11-25 2011-09-15 Mochida Pharm Co Ltd Therapeutisches mittel gegen atemwegserkrankungen,das ein 4-hydroxypiperidinderivat als wirkstoff enthält
EP3042895A1 (fr) 2003-07-30 2016-07-13 Xenon Pharmaceuticals Inc. Dérivés de la pipérazine et leur utilisation en tant qu'agents thérapeutiques
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
SG145699A1 (en) 2003-07-30 2008-09-29 Xenon Pharmaceuticals Inc Pyridazine derivatives and their use as therapeutic agents
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
MXPA06014542A (es) * 2004-06-30 2007-03-23 Janssen Pharmaceutica Nv Derivados de ftalazina como inhibidores de poli(adp-ribosa) polimerasa-i.
EP1804799B1 (fr) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Dérivés hétérocycliques et leur utilisation en tant qu'agents thérapeutiques
TW200626154A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
JP5149009B2 (ja) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
JP5043668B2 (ja) 2004-09-20 2012-10-10 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
BRPI0515483A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
MX2007015216A (es) 2005-06-03 2008-02-22 Xenon Pharmaceuticals Inc Derivados de aminotiazol y sus usos como agentes terapeuticos.
BRPI0613505A2 (pt) * 2005-06-30 2011-01-11 Prosidion Ltd agonistas de gpcr
CN1887875B (zh) * 2005-06-30 2011-04-06 深圳市东阳光实业发展有限公司 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途
MX2007015675A (es) 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
CN101460487A (zh) 2006-05-29 2009-06-17 高点制药有限责任公司 3-(1，3-苯并间二氧杂环戊烯- 5-基)-6-(4-环丙基哌嗪-1-基)-哒嗪、其盐和溶剂合物及其作为组胺h3受体拮抗剂的用途
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Also Published As

Publication number Publication date
SU1724013A3 (ru) 1992-03-30
HUT48617A (en) 1989-06-28
KR890008126A (ko) 1989-07-08
IL88429A (en) 1993-05-13
DE3852816T2 (de) 1995-06-08
FI885409A0 (fi) 1988-11-22
NO171980C (no) 1993-05-26
BG86132A (bg) 1993-12-24
CN1033274A (zh) 1989-06-07
PT89047B (pt) 1993-03-31
CA1327573C (fr) 1994-03-08
PH26670A (en) 1992-09-15
JO1552B1 (en) 1989-12-16
FI885409A (fi) 1989-05-24
HU200762B (en) 1990-08-28
KR0125280B1 (ko) 1997-12-05
NZ226920A (en) 1990-06-26
NO885190D0 (no) 1988-11-22
DK651288A (da) 1989-05-24
GR3015816T3 (en) 1995-07-31
NO885190L (no) 1989-05-24
EP0320032B1 (fr) 1995-01-18
IE65768B1 (en) 1995-11-15
JPH01207278A (ja) 1989-08-21
IE883486L (en) 1989-05-23
AU611504B2 (en) 1991-06-13
BG60676B1 (bg) 1995-12-29
CN1021328C (zh) 1993-06-23
IL88429A0 (en) 1989-06-30
JPH0629255B2 (ja) 1994-04-20
DK651288D0 (da) 1988-11-22
AU2575188A (en) 1989-05-25
EP0320032A1 (fr) 1989-06-14
ATE117296T1 (de) 1995-02-15
FI92584B (fi) 1994-08-31
MY104343A (en) 1994-03-31
MA21446A1 (fr) 1989-07-01
NO171980B (no) 1993-02-15
PT89047A (pt) 1988-12-01
DE3852816D1 (de) 1995-03-02
ZA888744B (en) 1990-07-25
FI92584C (fi) 1994-12-12
ES2070126T3 (es) 1995-06-01

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