FR2592043A1 - 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12h-dibenzo-(d, g) (1, 3, 6)-dioxazocines optiquement actives, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

2-chloro-12-(3-dimethylamino-2-methylpropyl)-12h-dibenzo-(d, g) (1, 3, 6)-dioxazocines optiquement actives, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2592043A1
FR2592043A1 FR8617825A FR8617825A FR2592043A1 FR 2592043 A1 FR2592043 A1 FR 2592043A1 FR 8617825 A FR8617825 A FR 8617825A FR 8617825 A FR8617825 A FR 8617825A FR 2592043 A1 FR2592043 A1 FR 2592043A1
Authority
FR
France
Prior art keywords
optically active
dibenzo
methylpropyl
dimethylamino
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8617825A
Other languages
English (en)
Other versions
FR2592043B1 (fr
Inventor
Laszlo Rozsa
Lujza Petocz
Eniko Szirt
Nee Kiszelly
Peter Tompe
Gabor Gigler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of FR2592043A1 publication Critical patent/FR2592043A1/fr
Application granted granted Critical
Publication of FR2592043B1 publication Critical patent/FR2592043B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02T—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
    • Y02T50/00—Aeronautics or air transport
    • Y02T50/10—Drag reduction

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)

Abstract

La présente invention est relative à des 2-chloro-12- (3-diméthylamino-2-méthylpropyl)-12H-dibenzo [d, g] [1, 3, 6]-dioxazocines optiquement actives. Ces composés racémiques sont résolus avec un acide organique optiquement actif et les énantiomètres sont séparés. Application en tant que médicaments pour traiter la maladie de Parkinson notamment.
FR868617825A 1985-12-20 1986-12-19 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12h-dibenzo-(d, g) (1, 3, 6)-dioxazocines optiquement actives, procede pour leur preparation et compositions pharmaceutiques les contenant Expired - Lifetime FR2592043B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU854881A HU195491B (en) 1985-12-20 1985-12-20 Process for production of optically active 2-chlor-12-/3-/dimethil-amin/-2-methil-prophil/-12h-dibenzol /d,g/ /1,3,6/-diaxazocine and medical compositions containing such compounds

Publications (2)

Publication Number Publication Date
FR2592043A1 true FR2592043A1 (fr) 1987-06-26
FR2592043B1 FR2592043B1 (fr) 1991-10-11

Family

ID=10969129

Family Applications (1)

Application Number Title Priority Date Filing Date
FR868617825A Expired - Lifetime FR2592043B1 (fr) 1985-12-20 1986-12-19 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12h-dibenzo-(d, g) (1, 3, 6)-dioxazocines optiquement actives, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (27)

Country Link
US (1) US4906622A (fr)
JP (1) JPS62158265A (fr)
CN (1) CN86108260A (fr)
AT (1) AT394366B (fr)
AU (1) AU589725B2 (fr)
BE (1) BE905907A (fr)
BG (1) BG46004A3 (fr)
CA (1) CA1291133C (fr)
CH (1) CH670638A5 (fr)
CS (1) CS262681B2 (fr)
DD (1) DD256695A5 (fr)
DE (1) DE3643991A1 (fr)
DK (1) DK616886A (fr)
ES (1) ES2003994A6 (fr)
FI (1) FI83644C (fr)
FR (1) FR2592043B1 (fr)
GB (1) GB2184445B (fr)
HU (1) HU195491B (fr)
IT (1) IT1199821B (fr)
NL (1) NL8603236A (fr)
NO (1) NO865179L (fr)
PH (1) PH24385A (fr)
PL (1) PL263134A1 (fr)
PT (1) PT83979B (fr)
SE (1) SE466399B (fr)
SU (1) SU1470187A3 (fr)
YU (1) YU45814B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198194B (en) * 1986-12-30 1989-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of new derivatives of dioxazocin and medical compositions containing them
HU201318B (en) * 1987-12-31 1990-10-28 Egyt Gyogyszervegyeszeti Gyar Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same
ATE91487T1 (de) * 1989-10-20 1993-07-15 Akzo Nv Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate.
WO1997011071A1 (fr) * 1995-09-19 1997-03-27 Novo Nordisk A/S Nouveaux composes heterocycliques

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2705M (fr) * 1963-04-18 1964-08-03 Rhone Poulenc Sa Nouvelles compositions anti-émétiques.
GB2001980A (en) * 1977-08-02 1979-02-14 Egyt Gyogyszervegyeszeti Gyar Dioxazocine derivatives their preparation and compositions containing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7202963A (fr) * 1972-03-07 1973-09-11
NL176458C (nl) * 1972-09-23 1985-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat en werkwijze voor de bereiding van daartoe geschikte actieve stoffen.
DE3426720A1 (de) * 1984-07-20 1986-01-23 Hoechst Ag, 6230 Frankfurt Benzthiazepinon- und benzthiazocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2705M (fr) * 1963-04-18 1964-08-03 Rhone Poulenc Sa Nouvelles compositions anti-émétiques.
GB2001980A (en) * 1977-08-02 1979-02-14 Egyt Gyogyszervegyeszeti Gyar Dioxazocine derivatives their preparation and compositions containing them

Also Published As

Publication number Publication date
GB8630431D0 (en) 1987-01-28
SE8605457L (sv) 1987-06-21
BE905907A (fr) 1987-06-12
NO865179L (no) 1987-06-22
AU589725B2 (en) 1989-10-19
NO865179D0 (no) 1986-12-19
IT1199821B (it) 1989-01-05
DK616886A (da) 1987-06-21
DE3643991A1 (de) 1987-06-25
IT8622780A0 (it) 1986-12-19
YU45814B (sh) 1992-07-20
NL8603236A (nl) 1987-07-16
DK616886D0 (da) 1986-12-19
FI83644B (fi) 1991-04-30
FI83644C (fi) 1991-08-12
PT83979A (en) 1987-01-01
DD256695A5 (de) 1988-05-18
FI865244A0 (fi) 1986-12-19
HU195491B (en) 1988-05-30
AU6676586A (en) 1987-06-25
CH670638A5 (fr) 1989-06-30
YU218886A (en) 1988-04-30
CA1291133C (fr) 1991-10-22
US4906622A (en) 1990-03-06
GB2184445B (en) 1989-10-18
ATA326986A (de) 1991-09-15
CN86108260A (zh) 1987-09-09
PL263134A1 (en) 1988-06-23
SU1470187A3 (ru) 1989-03-30
GB2184445A (en) 1987-06-24
DE3643991C2 (fr) 1990-08-09
CS262681B2 (en) 1989-03-14
FR2592043B1 (fr) 1991-10-11
JPS62158265A (ja) 1987-07-14
BG46004A3 (en) 1989-09-15
SE8605457D0 (sv) 1986-12-18
HUT44247A (en) 1988-02-29
AT394366B (de) 1992-03-25
CS960686A2 (en) 1988-08-16
SE466399B (sv) 1992-02-10
FI865244A (fi) 1987-06-21
PT83979B (pt) 1989-01-17
PH24385A (en) 1990-06-13
ES2003994A6 (es) 1988-12-01

Similar Documents

Publication Publication Date Title
FR2635265B1 (fr) Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation
FR2430403A1 (fr) Nouvelles 15-deoxy-16-hydroxy-prostaglandines, leur procede de production et medicament les contenant
ATE83659T1 (de) Verwendung von indolon-derivaten zur herstellung von arzneimitteln zur behandlung des parkinsonismus.
MA26723A1 (fr) Acides oxamiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
DE69713526D1 (de) Lösliche prodrugs von paclitaxel
MC2094A1 (fr) Medicament contenant de l'acide dihydrolipoique en tant que substance active,procede de preparation
UA19171A (uk) Спосіб одержаhhя фіhілалкіламіhів або їх фармакологічhо прийhятhих солей
BE1002415A4 (fr) 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine, ses sels d'addition acides et procede pour les preparer.
FR2424908A1 (fr) Nouveaux analogues de prostacycline, leur procede de production et medicament les contenant
TNSN90021A1 (fr) Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales
FR2585572B3 (fr) Nouvelles compositions pharmaceutiques a base d'un sel de l'acide p. chlorophenoxyacetique destinees au traitement des neuropathies et assurant la regeneration nerveuse
FR2434162A1 (fr) Nouveaux derives de 4-amino-2-piperidino-quinazoline, leur procede de production et medicament les contenant
FR2398067A1 (fr) Nouvelles 4-pyrones substituees en positions 2, 3 et 6 et medicament les contenant
FR2592043A1 (fr) 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12h-dibenzo-(d, g) (1, 3, 6)-dioxazocines optiquement actives, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2441617A1 (fr) Nouveaux derives de s-triazine, leur procede de preparation et compositions pharmaceutiques les contenant
OA08165A (fr) Nouveaux dérivés thiosulfonates, leur procédé de préparation ainsi que les compositions pharmaceutiques les contenant.
FR2434804A1 (fr) Derives de la n-phenyl-indoline, leur preparation et leur application comme medicaments
FR2440353A1 (fr) Nouveaux arylethanols, leurs procedes d'obtention et leur emploi comme medicament
TNSN97143A1 (fr) Derives de trans-piperazine-1-yl-spiro(cyclohexane-1, 1'- isobenzofuranne), procede pour leur preparation et compositions pharmaceutiques les contenant
BE1002121A4 (fr) Derives de la 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine (ou -1,4-benzoxazonine), procede pour leur preparation et medicaments les contenant.
FR2430947A1 (fr) Nouveaux composes de 2-amino-octahydro-indolo-(2,3-a)-quinazoline, leur procede de production et medicament les contenant
IT8125243A0 (it) Composti ad attivita'analgesica e antiinfiammatoria, processo per la loro preparazione e relative composizioni farmaceutiche.
ES2062329T3 (es) Composiciones anestesicas por via oral.
FR2375225A1 (fr) Nouvelles o-propyloximes substituees basiquement, leur procede de preparation et leur emploi comme medicaments
FR2567402B1 (fr) Nouvelles compositions pharmaceutiques et cosmetiques contenant comme ingredient actif la dihydroxy-1,8 phenyl-10 anthrone-9, et procede de preparation de l'ingredient actif

Legal Events

Date Code Title Description
ST Notification of lapse