YU45814B - Postupak za dobivanje optički aktivnog 2-hloro-12-(3-dimetilamino-2-metil-propil )-12h-dibenzo/d,g/ /1,3,6/dioksazocina - Google Patents

Postupak za dobivanje optički aktivnog 2-hloro-12-(3-dimetilamino-2-metil-propil )-12h-dibenzo/d,g/ /1,3,6/dioksazocina

Info

Publication number
YU45814B
YU45814B YU218886A YU218886A YU45814B YU 45814 B YU45814 B YU 45814B YU 218886 A YU218886 A YU 218886A YU 218886 A YU218886 A YU 218886A YU 45814 B YU45814 B YU 45814B
Authority
YU
Yugoslavia
Prior art keywords
dibenzo
dimethylamino
chloro
propyl
methyl
Prior art date
Application number
YU218886A
Other languages
English (en)
Other versions
YU218886A (en
Inventor
L. Rozsa
L. Petocz
E. Szirt
P. Tompe
G. Gigler
Original Assignee
Egis Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar filed Critical Egis Gyogyszergyar
Publication of YU218886A publication Critical patent/YU218886A/xx
Publication of YU45814B publication Critical patent/YU45814B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02T—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
    • Y02T50/00—Aeronautics or air transport
    • Y02T50/10—Drag reduction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)

Abstract

POSTUPAK ZA DOBIVANJE OPTIČKI AKTIVNOG 2-HLORO-12-(3-DIMETILAMINO-2-METIL-PROPIL )-12H-DIBENZO/D,G/ /1,3,6/DIOKSAZOCINA, formule: i njihovih farmaceutski prihvatljivih adicionih soli sa kiselinama, na značen time, što racemski 2-hloro-12-(3-dimetilamino-2-metil-propil)-12H-dibenzo/d,g/ /1,3,6/ dioksazocin reaguje sa optički aktivnom vinskom kiselinom u vodi, C1-3 alkanolu ili dihlorometanu na temperaturi od 18-33 C, i dalje se jedan od tartaratnih antipoda izdvaja i antipod se oslobadja pomoću baze.
YU218886A 1985-12-20 1986-12-19 Postupak za dobivanje optički aktivnog 2-hloro-12-(3-dimetilamino-2-metil-propil )-12h-dibenzo/d,g/ /1,3,6/dioksazocina YU45814B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU854881A HU195491B (en) 1985-12-20 1985-12-20 Process for production of optically active 2-chlor-12-/3-/dimethil-amin/-2-methil-prophil/-12h-dibenzol /d,g/ /1,3,6/-diaxazocine and medical compositions containing such compounds

Publications (2)

Publication Number Publication Date
YU218886A YU218886A (en) 1988-04-30
YU45814B true YU45814B (sh) 1992-07-20

Family

ID=10969129

Family Applications (1)

Application Number Title Priority Date Filing Date
YU218886A YU45814B (sh) 1985-12-20 1986-12-19 Postupak za dobivanje optički aktivnog 2-hloro-12-(3-dimetilamino-2-metil-propil )-12h-dibenzo/d,g/ /1,3,6/dioksazocina

Country Status (27)

Country Link
US (1) US4906622A (sh)
JP (1) JPS62158265A (sh)
CN (1) CN86108260A (sh)
AT (1) AT394366B (sh)
AU (1) AU589725B2 (sh)
BE (1) BE905907A (sh)
BG (1) BG46004A3 (sh)
CA (1) CA1291133C (sh)
CH (1) CH670638A5 (sh)
CS (1) CS262681B2 (sh)
DD (1) DD256695A5 (sh)
DE (1) DE3643991A1 (sh)
DK (1) DK616886A (sh)
ES (1) ES2003994A6 (sh)
FI (1) FI83644C (sh)
FR (1) FR2592043B1 (sh)
GB (1) GB2184445B (sh)
HU (1) HU195491B (sh)
IT (1) IT1199821B (sh)
NL (1) NL8603236A (sh)
NO (1) NO865179L (sh)
PH (1) PH24385A (sh)
PL (1) PL263134A1 (sh)
PT (1) PT83979B (sh)
SE (1) SE466399B (sh)
SU (1) SU1470187A3 (sh)
YU (1) YU45814B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198194B (en) * 1986-12-30 1989-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of new derivatives of dioxazocin and medical compositions containing them
HU201318B (en) * 1987-12-31 1990-10-28 Egyt Gyogyszervegyeszeti Gyar Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same
ES2058761T3 (es) * 1989-10-20 1994-11-01 Akzo Nv Proceso para la preparacion de derivados de dibenzodioxazecina y dibenzodioxaazacicloundecina.
PT851865E (pt) * 1995-09-19 2002-11-29 Novo Nordisk As Derivados de 12h-dibenzo¬d,g|¬1,3|dioxina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2705M (fr) * 1963-04-18 1964-08-03 Rhone Poulenc Sa Nouvelles compositions anti-émétiques.
NL7202963A (sh) * 1972-03-07 1973-09-11
NL176458C (nl) * 1972-09-23 1985-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat en werkwijze voor de bereiding van daartoe geschikte actieve stoffen.
HU174126B (hu) * 1977-08-02 1979-11-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija novykh proizvodnykh dibenzo-kvadratnaja skobka-d,g-kvadratnaja skobka zakryta-kvadratnaja skobka-1,3,6-kvadratnaja skobka zakryta-dioksazocina
DE3426720A1 (de) * 1984-07-20 1986-01-23 Hoechst Ag, 6230 Frankfurt Benzthiazepinon- und benzthiazocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung

Also Published As

Publication number Publication date
HUT44247A (en) 1988-02-29
GB2184445A (en) 1987-06-24
US4906622A (en) 1990-03-06
PH24385A (en) 1990-06-13
DD256695A5 (de) 1988-05-18
NO865179L (no) 1987-06-22
PT83979A (en) 1987-01-01
AU6676586A (en) 1987-06-25
SE8605457L (sv) 1987-06-21
NL8603236A (nl) 1987-07-16
SE8605457D0 (sv) 1986-12-18
HU195491B (en) 1988-05-30
IT8622780A0 (it) 1986-12-19
JPS62158265A (ja) 1987-07-14
SE466399B (sv) 1992-02-10
BE905907A (fr) 1987-06-12
CS262681B2 (en) 1989-03-14
DK616886A (da) 1987-06-21
SU1470187A3 (ru) 1989-03-30
DE3643991A1 (de) 1987-06-25
CH670638A5 (sh) 1989-06-30
BG46004A3 (en) 1989-09-15
CS960686A2 (en) 1988-08-16
AT394366B (de) 1992-03-25
YU218886A (en) 1988-04-30
GB2184445B (en) 1989-10-18
FR2592043A1 (fr) 1987-06-26
DE3643991C2 (sh) 1990-08-09
ES2003994A6 (es) 1988-12-01
PT83979B (pt) 1989-01-17
FI83644B (fi) 1991-04-30
FI865244A (fi) 1987-06-21
FI865244A0 (fi) 1986-12-19
PL263134A1 (en) 1988-06-23
DK616886D0 (da) 1986-12-19
FI83644C (fi) 1991-08-12
CN86108260A (zh) 1987-09-09
AU589725B2 (en) 1989-10-19
FR2592043B1 (fr) 1991-10-11
NO865179D0 (no) 1986-12-19
CA1291133C (en) 1991-10-22
ATA326986A (de) 1991-09-15
IT1199821B (it) 1989-01-05
GB8630431D0 (en) 1987-01-28

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