FR2635265B1 - Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation - Google Patents

Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation

Info

Publication number
FR2635265B1
FR2635265B1 FR8909767A FR8909767A FR2635265B1 FR 2635265 B1 FR2635265 B1 FR 2635265B1 FR 8909767 A FR8909767 A FR 8909767A FR 8909767 A FR8909767 A FR 8909767A FR 2635265 B1 FR2635265 B1 FR 2635265B1
Authority
FR
France
Prior art keywords
cyclosporin
preparation
pharmaceutical composition
active ingredient
intravenous pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8909767A
Other languages
English (en)
Other versions
FR2635265A1 (fr
Inventor
Orban Erno
Balogh Tibor
Ila Lajos
Ambrus Gabor
Jekkel Antonia
Elek Sandor
Tomori Eva
Siklosi Lajos
Sarudy Eva Toth
Moravcsik Imre
Elekes Istvan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of FR2635265A1 publication Critical patent/FR2635265A1/fr
Application granted granted Critical
Publication of FR2635265B1 publication Critical patent/FR2635265B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
FR8909767A 1988-07-21 1989-07-20 Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation Expired - Lifetime FR2635265B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU883796A HU201567B (en) 1988-07-21 1988-07-21 Process for production of intravenous medical compositions containing cyclosphorin

Publications (2)

Publication Number Publication Date
FR2635265A1 FR2635265A1 (fr) 1990-02-16
FR2635265B1 true FR2635265B1 (fr) 1995-03-17

Family

ID=10965544

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8909767A Expired - Lifetime FR2635265B1 (fr) 1988-07-21 1989-07-20 Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation

Country Status (26)

Country Link
US (1) US5047396A (fr)
JP (1) JPH07116051B2 (fr)
KR (1) KR0137674B1 (fr)
AR (1) AR243382A1 (fr)
AT (1) AT402258B (fr)
AU (1) AU614862B2 (fr)
BE (1) BE1004323A4 (fr)
CA (1) CA1332712C (fr)
CH (1) CH679120A5 (fr)
DD (1) DD283934A5 (fr)
DE (1) DE3924207A1 (fr)
DK (1) DK175540B1 (fr)
FI (1) FI92556C (fr)
FR (1) FR2635265B1 (fr)
GB (1) GB2221157B (fr)
GR (1) GR1002184B (fr)
HU (1) HU201567B (fr)
IL (1) IL91069A (fr)
IT (1) IT1231434B (fr)
LU (1) LU87560A1 (fr)
NL (1) NL194578C (fr)
NO (1) NO175287C (fr)
NZ (1) NZ230036A (fr)
PT (1) PT91246B (fr)
SE (1) SE509174C2 (fr)
ZA (1) ZA895588B (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
GB2251186A (en) * 1990-12-04 1992-07-01 Randall Neal Gatz Polypeptide for use in treatment of autoimmune disease
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
EP0642332B1 (fr) * 1992-05-13 1997-01-15 Sandoz Ltd. Compositions ophtalmiques contenant une cyclosporine
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
DE4412201A1 (de) * 1993-04-20 1994-11-10 Rentschler Arzneimittel Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
JP3833248B2 (ja) 1994-11-03 2006-10-11 ノバルティス・アクチエンゲゼルシャフト 簡単な組成及び高い生物有効性を有する経口投与のためのシクロスポリンの新規処方物及びその製造法
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
MX9702809A (es) * 1995-08-25 1998-02-28 Sangstat Medical Corp Formulaciones orales de ciclosporina.
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US20050053594A1 (en) * 1995-11-16 2005-03-10 Dario Alessi RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK
DE19544507B4 (de) * 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
KR20040004416A (ko) * 1997-01-30 2004-01-13 노파르티스 아게 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
ES2236891T3 (es) * 1997-03-12 2005-07-16 Abbott Laboratories Sistemas binarios hidrofilos para la administracion de ciclosporina.
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
AT408186B (de) * 1998-12-15 2001-09-25 Sanochemia Pharmazeutika Ag Wässerige zubereitung von beta-carotin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10015814A1 (de) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung
FR2826517B1 (fr) * 2001-06-20 2004-03-12 Somfy Dispositif d'alimentation pour store motorise ou similaire
PL206018B1 (pl) * 2001-10-19 2010-06-30 Isotechnika Inc Preparat farmaceutyczny, sposób jego wytwarzania, mikroemulsja i zastosowanie tego preparatu farmaceutycznego
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) * 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) * 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
GB2451811A (en) 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
JP4815418B2 (ja) * 2007-10-19 2011-11-16 カヤバ工業株式会社 空圧緩衝器
KR20110056516A (ko) * 2008-09-12 2011-05-30 크리티컬 파머수티컬스 리미티드 점막 또는 피부를 통한 치료제의 흡수 개선
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
US9987356B2 (en) 2011-03-11 2018-06-05 Beth Israel Deaconess Medical Center, Inc. Anti-CD40 antibodies and methods of administering thereof
EP3307322B1 (fr) 2015-09-04 2021-02-17 Primatope Therapeutics Inc. Anticorps humanisés anti-cd40 et leurs utilisations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3658M (fr) * 1964-02-18 1965-11-02 Michel Marie Andre Guerbet Composition huileuse pour l'injection intravasculaire.
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
AU534955B2 (en) * 1980-01-23 1984-02-23 Sandoz Ag Cyclosporin a to treat lymphoproliferative disorders
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE3339235A1 (de) * 1983-10-28 1985-05-09 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von polyurethanen
JPH02501389A (ja) * 1987-10-02 1990-05-17 フセソユズニ　カルディオロジチェスキ　ナウチニ　ツェントル　アカデミイ　メディツィンスキフ　ナウク　エスエスエスエル 多発性硬化症及び筋萎縮側索硬化症の治療用薬用製剤
GB8729153D0 (en) * 1987-12-14 1988-01-27 Efamol Ltd Fatty acid compositions
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
NO892995L (no) 1990-01-22
NZ230036A (en) 1991-02-26
CH679120A5 (fr) 1991-12-31
US5047396A (en) 1991-09-10
KR0137674B1 (ko) 1998-05-15
SE8902588D0 (sv) 1989-07-21
FI92556B (fi) 1994-08-31
JPH07116051B2 (ja) 1995-12-13
ATA176789A (de) 1996-08-15
NO175287B (no) 1994-06-20
GB2221157B (en) 1991-12-18
NL194578C (nl) 2002-08-05
GR890100467A (el) 1990-06-27
FI92556C (fi) 1994-12-12
AU3884589A (en) 1990-02-01
BE1004323A4 (fr) 1992-11-03
NO892995D0 (no) 1989-07-21
FI893520A (fi) 1990-01-22
JPH03115227A (ja) 1991-05-16
IT8921259A0 (it) 1989-07-21
NL8901902A (nl) 1990-02-16
AR243382A1 (es) 1993-08-31
CA1332712C (fr) 1994-10-25
ZA895588B (en) 1990-07-25
GB2221157A (en) 1990-01-31
DD283934A5 (de) 1990-10-31
DK362189A (da) 1990-01-22
IL91069A (en) 1993-07-08
GB8916679D0 (en) 1989-09-06
GR1002184B (en) 1996-03-12
DE3924207A1 (de) 1990-01-25
LU87560A1 (fr) 1991-02-18
NO175287C (no) 1994-09-28
FR2635265A1 (fr) 1990-02-16
SE8902588L (sv) 1990-01-22
HU201567B (en) 1990-11-28
IT1231434B (it) 1991-12-04
DK362189D0 (da) 1989-07-21
SE509174C2 (sv) 1998-12-14
HUT50851A (en) 1990-03-28
PT91246B (pt) 1995-05-04
KR900001364A (ko) 1990-02-27
FI893520A0 (fi) 1989-07-21
PT91246A (pt) 1990-02-08
AT402258B (de) 1997-03-25
DE3924207C2 (fr) 1992-07-09
DK175540B1 (da) 2004-11-29
AU614862B2 (en) 1991-09-12
NL194578B (nl) 2002-04-02

Similar Documents

Publication Publication Date Title
FR2635265B1 (fr) Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation
EP0221041A3 (fr) Dérivés de benzimidazole, leur préparation et leur application comme médicaments
FR2612187B1 (fr) Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant
FR2602141B1 (fr) Composition pharmaceutique a activite analgesique contenant de l'ibuprofene comme principe actif
FR2778406B1 (fr) Derives d'alpha-cetoamides, procede pour leur preparation, preparations pharmaceutiques les contenant, et leur utilisation en tant que medicaments anti-viraux
MC1915A1 (fr) Procédés pour la préparation de 2',3'-didésoxynucléosides et de formulations pharmaceutiques en contenant
FR2671086B1 (fr) Peptides opiouides, leur procede de preparation, et composition pharmaceutique contenant ces peptides.
NL8601838A (nl) Distamycinederivaten, werkwijze voor de bereiding ervan, alsmede farmaceutische preparaten, die deze derivaten bevatten.
FR2615512B1 (fr) Composes de benzamides substitues pharmacologiquement actifs, compositions pharmaceutiques contenant ces composes, et leur procede de preparation
FR2598320B1 (fr) Compositions pharmaceutiques hydrosolubles contenant de l'ubiquinone en tant que principe actif, utiles dans differentes applications therapeutiques
BE885555A (fr) Preparations pharmaceutiques a activite cytostatique, nouveaux derives de l'acide isocyanurique et procedes pour leur preparation
BE885605A (fr) Derives d'acide benzo(ij)quinolizine-carboxylique-2, utiles notamment comme medicaments antimicrobiens, procede de leur preparation et compositions therapeutiques et formes pharmaceutiques les contenant
FR2704857B1 (fr) Nouvelles benzodioxines substituées, leur procédé de préparation et les compositions pharmaceutiques les contenant.
IT1228437B (it) "derivati di 2,3,4,5,6,7 esaidro 2,7-metano-1,5 benzossazonina (rispettivamente 1,4 benzossazonina), procedimento per la loro preparazione e prodotti medicinali che contengono questi composti.
ATE57935T1 (de) 16,17-acetalsubstituierte pregnan-21-saeure, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
FR2621918B1 (fr) 2',3'-didesoxy-4-thio-uridines, procede de preparation de ces substances et medicaments qui en contiennent
FR2592043B1 (fr) 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12h-dibenzo-(d, g) (1, 3, 6)-dioxazocines optiquement actives, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2567402B1 (fr) Nouvelles compositions pharmaceutiques et cosmetiques contenant comme ingredient actif la dihydroxy-1,8 phenyl-10 anthrone-9, et procede de preparation de l'ingredient actif
ATE106883T1 (de) Azelastin-embonat, verfahren zu seiner herstellung und pharmazeutische zubereitungen, die als wirkstoff azelastin-embonat enthalten.
FR2649981B1 (fr) Derives de dihydropyrimidothiazine, leur procede de preparation et compositions pharmaceutiques les contenant
FR2584712B1 (fr) Phenylethanolamines a activite lipolytique, un procede pour leur preparation et compositions pharmaceutiques en contenant
FR2617164B1 (fr) Nouveaux derives de la decahydroquinoleine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
NL192385B (nl) 6-alkyl-4-fenyl-1,4-dihydro-3,5-pyridinecarbonzuuresters, werkwijze voor de bereiding daarvan en farmaceutische preparaten die deze esters bevat- ten.
FR2496658B1 (fr) Derives de l'acide nicotinique, leur preparation et medicament contenant ces substances
FR2597340B1 (fr) Compositions pharmaceutiques contenant de la vinburnine et leur procede de preparation.

Legal Events

Date Code Title Description
CD Change of name or company name
CD Change of name or company name