GR890100467A - Μεθοδος δια την παρασκευη ενδοφλεβιου φαρμακευτικης συνθεσεως. - Google Patents

Μεθοδος δια την παρασκευη ενδοφλεβιου φαρμακευτικης συνθεσεως.

Info

Publication number
GR890100467A
GR890100467A GR890100467A GR890100467A GR890100467A GR 890100467 A GR890100467 A GR 890100467A GR 890100467 A GR890100467 A GR 890100467A GR 890100467 A GR890100467 A GR 890100467A GR 890100467 A GR890100467 A GR 890100467A
Authority
GR
Greece
Prior art keywords
mass
preparating
pharmaceutical compositions
intravenous pharmaceutical
parts
Prior art date
Application number
GR890100467A
Other languages
English (en)
Other versions
GR1002184B (en
Inventor
Gabor Dr Ambrus
Tibor Dr Balogh
Sandor Dr Elek
Lajos Dr Ila
Elekes Dr Istvan
Antonia Dr Jekkel
Imre Moravcsik
Erno Dr Orban
Toth Eva Dr Sarudy
Lajos Dr Siklosi
Eva Dr Tomori
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of GR890100467A publication Critical patent/GR890100467A/el
Publication of GR1002184B publication Critical patent/GR1002184B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεσις αναφέρεται εις μέ?οδον δια την παρασκευήν ενδοφλεβίου φαρμακευτικής συν?έσεως περιλαμβανούσης κυκλοσπορίνη ως δραστικόν συστατικό. Η σύν?εσις συνίσταται εκ: α) 1 μέρους κατά μάζα μιας ή περισσοτέρων κυκλοσπορινών β) 8 έως 13 μερών κατά μάζα μονοεστέρος κεκορεσμένου υδροξυλιωμένου λιπαρού οξέος σχηματισ?έντος μετά πολυαι?υλιωμένης γλυκόλης, ή του μίγματος των ρη?έντων μονοεστέρων. γ) 4 έως 10 μερών κατά μάζα μιας ή περισσοτέρων μονο- ή πολυσΘενών αλκοολών δυναμένων να χορηγη?ούν ενδοφλεβίως. ω
GR890100467A 1988-07-21 1989-07-21 Method for preparating intravenous pharmaceutical compositions GR1002184B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU883796A HU201567B (en) 1988-07-21 1988-07-21 Process for production of intravenous medical compositions containing cyclosphorin

Publications (2)

Publication Number Publication Date
GR890100467A true GR890100467A (el) 1990-06-27
GR1002184B GR1002184B (en) 1996-03-12

Family

ID=10965544

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100467A GR1002184B (en) 1988-07-21 1989-07-21 Method for preparating intravenous pharmaceutical compositions

Country Status (26)

Country Link
US (1) US5047396A (el)
JP (1) JPH07116051B2 (el)
KR (1) KR0137674B1 (el)
AR (1) AR243382A1 (el)
AT (1) AT402258B (el)
AU (1) AU614862B2 (el)
BE (1) BE1004323A4 (el)
CA (1) CA1332712C (el)
CH (1) CH679120A5 (el)
DD (1) DD283934A5 (el)
DE (1) DE3924207A1 (el)
DK (1) DK175540B1 (el)
FI (1) FI92556C (el)
FR (1) FR2635265B1 (el)
GB (1) GB2221157B (el)
GR (1) GR1002184B (el)
HU (1) HU201567B (el)
IL (1) IL91069A (el)
IT (1) IT1231434B (el)
LU (1) LU87560A1 (el)
NL (1) NL194578C (el)
NO (1) NO175287C (el)
NZ (1) NZ230036A (el)
PT (1) PT91246B (el)
SE (1) SE509174C2 (el)
ZA (1) ZA895588B (el)

Families Citing this family (50)

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US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
GB2251186A (en) * 1990-12-04 1992-07-01 Randall Neal Gatz Polypeptide for use in treatment of autoimmune disease
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ES2098739T3 (es) * 1992-05-13 1997-05-01 Sandoz Ltd Composiciones oftalmicas conteniendo una cyclosporin.
EP0589843B1 (en) 1992-09-25 2001-11-28 Novartis AG Pharmaceutical compositions containing cyclosporins
DE4412201A1 (de) * 1993-04-20 1994-11-10 Rentschler Arzneimittel Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
RU2158601C2 (ru) * 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
PL319898A1 (en) * 1995-08-25 1997-09-01 Sangstat Medical Corp Cyclosporines containing compositions for oral administration
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US20050053594A1 (en) * 1995-11-16 2005-03-10 Dario Alessi RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK
DE19544507B4 (de) * 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
NZ336900A (en) * 1997-01-30 2001-06-29 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions comprising cyclosporin A and being substantially free of any oil
SI0969856T1 (en) * 1997-03-12 2005-06-30 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
AT408186B (de) * 1998-12-15 2001-09-25 Sanochemia Pharmazeutika Ag Wässerige zubereitung von beta-carotin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10015814A1 (de) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung
FR2826517B1 (fr) * 2001-06-20 2004-03-12 Somfy Dispositif d'alimentation pour store motorise ou similaire
KR100978836B1 (ko) * 2001-10-19 2010-08-30 이소테크니카 인코포레이티드 신규한 시클로스포린 유사체 미세유화액 예비농축물
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
GB2451811A (en) 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
JP4815418B2 (ja) * 2007-10-19 2011-11-16 カヤバ工業株式会社 空圧緩衝器
RU2519193C2 (ru) 2008-09-12 2014-06-10 Критикал Фармасьютикалс Лимитед Усовершенствование всасывания терапевтических средств через слизистые оболочки или кожу
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
CA3122934A1 (en) 2011-03-11 2012-09-20 Beth Israel Deaconess Medical Center, Inc. Fusion protein comprising a fragment of cd40 and method of producing same
SI3307322T1 (sl) 2015-09-04 2021-08-31 Primatope Therapeutics Inc. Humanizirana protitelesa proti CD40 in njihove uporabe

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2390420A1 (fr) * 1977-05-10 1978-12-08 Sandoz Sa Nouveaux derives cyclopeptidiques, leur preparation et leur application comme medicaments
GB2015339A (en) * 1978-03-07 1979-09-12 Sandoz Ltd Compositions comprising mono-cyclic peptides
AU534955B2 (en) * 1980-01-23 1984-02-23 Sandoz Ag Cyclosporin a to treat lymphoproliferative disorders
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
EP0143304A2 (de) * 1983-10-28 1985-06-05 Bayer Ag Verfahren zur Herstellung von Polyurethanen
EP0321128A1 (en) * 1987-12-14 1989-06-21 Efamol Holdings Plc Fatty acid compositions

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FR3658M (fr) * 1964-02-18 1965-11-02 Michel Marie Andre Guerbet Composition huileuse pour l'injection intravasculaire.
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
JPH02501389A (ja) * 1987-10-02 1990-05-17 フセソユズニ　カルディオロジチェスキ　ナウチニ　ツェントル　アカデミイ　メディツィンスキフ　ナウク　エスエスエスエル 多発性硬化症及び筋萎縮側索硬化症の治療用薬用製剤
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2390420A1 (fr) * 1977-05-10 1978-12-08 Sandoz Sa Nouveaux derives cyclopeptidiques, leur preparation et leur application comme medicaments
GB2015339A (en) * 1978-03-07 1979-09-12 Sandoz Ltd Compositions comprising mono-cyclic peptides
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
AU534955B2 (en) * 1980-01-23 1984-02-23 Sandoz Ag Cyclosporin a to treat lymphoproliferative disorders
EP0143304A2 (de) * 1983-10-28 1985-06-05 Bayer Ag Verfahren zur Herstellung von Polyurethanen
EP0321128A1 (en) * 1987-12-14 1989-06-21 Efamol Holdings Plc Fatty acid compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *

Also Published As

Publication number Publication date
NL8901902A (nl) 1990-02-16
FR2635265B1 (fr) 1995-03-17
AU3884589A (en) 1990-02-01
NZ230036A (en) 1991-02-26
NL194578B (nl) 2002-04-02
IL91069A (en) 1993-07-08
US5047396A (en) 1991-09-10
NO175287B (no) 1994-06-20
CH679120A5 (el) 1991-12-31
FR2635265A1 (fr) 1990-02-16
NO175287C (no) 1994-09-28
SE8902588D0 (sv) 1989-07-21
DE3924207A1 (de) 1990-01-25
NO892995L (no) 1990-01-22
DK175540B1 (da) 2004-11-29
JPH07116051B2 (ja) 1995-12-13
JPH03115227A (ja) 1991-05-16
GB2221157A (en) 1990-01-31
KR0137674B1 (ko) 1998-05-15
KR900001364A (ko) 1990-02-27
DE3924207C2 (el) 1992-07-09
DK362189D0 (da) 1989-07-21
AT402258B (de) 1997-03-25
DD283934A5 (de) 1990-10-31
FI92556C (fi) 1994-12-12
DK362189A (da) 1990-01-22
FI893520A (fi) 1990-01-22
NL194578C (nl) 2002-08-05
CA1332712C (en) 1994-10-25
FI893520A0 (fi) 1989-07-21
IT1231434B (it) 1991-12-04
GR1002184B (en) 1996-03-12
LU87560A1 (fr) 1991-02-18
ATA176789A (de) 1996-08-15
BE1004323A4 (fr) 1992-11-03
NO892995D0 (no) 1989-07-21
PT91246B (pt) 1995-05-04
GB2221157B (en) 1991-12-18
PT91246A (pt) 1990-02-08
IT8921259A0 (it) 1989-07-21
AR243382A1 (es) 1993-08-31
AU614862B2 (en) 1991-09-12
GB8916679D0 (en) 1989-09-06
SE8902588L (sv) 1990-01-22
FI92556B (fi) 1994-08-31
ZA895588B (en) 1990-07-25
HUT50851A (en) 1990-03-28
SE509174C2 (sv) 1998-12-14
HU201567B (en) 1990-11-28

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