SU1573021A1 - 14 @ -Окси-7,8-метилендиоксиаллобербан, обладающий антидепрессивной активностью - Google Patents
14 @ -Окси-7,8-метилендиоксиаллобербан, обладающий антидепрессивной активностью Download PDFInfo
- Publication number
- SU1573021A1 SU1573021A1 SU864028190A SU4028190A SU1573021A1 SU 1573021 A1 SU1573021 A1 SU 1573021A1 SU 864028190 A SU864028190 A SU 864028190A SU 4028190 A SU4028190 A SU 4028190A SU 1573021 A1 SU1573021 A1 SU 1573021A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- sup
- sub
- group
- yohimbine
- mri
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Emergency Protection Circuit Devices (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Изобретение относитс к гетероциклическим соединени м, в частности к 14Α-окси-7,8-метилендиоксиаллобербану, обладающему антидепрессивной активностью. Цель - вы вление более активных соединений. Получение ведут реакцией металлического натри в ксилоле с 7,8-метилендиокси-14-оксоаллобербана при нагревании. Выход 84%. Т.пл. 214 - 217°С. Новые соединени обладают высоким селективным антагонизмом по отношению к α-адренергическим рецепторам и не оказывают какого-либо отрицательного воздействи на допамин-, серотонин-, гистамин- или мускаринрецепторы. 5 табл.
Description
R виде гидрохлорида
Таблиц
14о/-окси-7,8-метилендиоксиаллобербана гидрохлорвд. Р 0,01. Р 0,001.
Claims (3)
- Формула изобретения
1 4 (X -Окси-7,8-метилендиоксиаллобербан формулы нНГЛ'Н hDl λ. он обладающий антидепрессивной активностью.,8Таблица 1Соединение------------— — Деференсные сосуды крыс Продольные гладкие мышцы (приготовления) из илеума Относительная активность Диференсные Продольные морских свинок сосуды гладкие мышцы (приготовления) илеума II ηйохимбин Фентоламин Идазоксан Имилоксан (1^Л!7,22 +7,78 +8,07 +8,17 +6,840,110,050,040,080,01 (4) (4) (4) (3)СССС (12) С7,52 + 0,458,82 +7,49 +8,26 + (4)NC0,220,040,46 (6) (4)1,01,15 - 2,230,132,821,00,794,68Таблица 2
Деференсные сосуды рдинение крыс pAj Легочная артерия кролика рА г 'йохимбин ентоламинItIIФ<Идазоксан ^милоксан (I)*7,05 +8,026,007,28 +4,95 +0,19 (4) NC0,25 .(4) С0,16 (4) NC0,64 (14) NC0,11 (4) NC - 5,59 + 0,4 (4) : * В виде гидрохлорида.Таблица 3
Соединения Легочные артерии кро- ликов ’рА2 Йохимбин 5,81 + 0,37 (4) СИдазоксан 6,03 +0,11 (4) С (I)*5,29 + 0,20 (8) NC * В виде гидрохлоридаТаблица 4Соединение Селективность Йохимбин 4,67 Фентоламин 0,57 Идазоксан 117,5 Имилоксан· 0,36 (D* 1659 * В виде I гидрохлорида Таблица 5Часть головного Содержание NE/DA, Kf, TR Μ /1 4. мозга Катехоламин Обработка нмоль/г Ч-’ НМОЛь/г·Ч ’’ ч Фронтальная NE d -MPT 0,91 * 0,04 (4) 0,445 0,40 + 0,01 2,24 Кортекс с/-МРТ+ 0,87 + 0,05 (4) 0,740 0,64 + 0,03** 1,35 с/ -MFT+иохимбнн 0,99 + 0,07 (4) 0,880 0,87 + 0,06*** 1,13 Стриатум DA и -МРТ 50,65 + 3,52 (4) 0,592 29,98+2,08 1,68 ci -МРТ+* 48,03 + 4,66 (4) 0,776 37,27+3,62 1,28 с/ -МРТ+иохимбин 64,46 + 6,04 (4) 0,906 58,40+5,47** 1,10 * 14в/-окси-7,8-метилендиоксиаллобербана гидрохлорид.** Р <0,01. .*** Р <0,001 .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU851982A HU195505B (en) | 1985-05-24 | 1985-05-24 | Process for producing 7,8-methylendioxy-14-hydroxy-berban derivatives and pharmaceuticals comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1573021A1 true SU1573021A1 (ru) | 1990-06-23 |
Family
ID=10957145
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU864027562A SU1508958A3 (ru) | 1985-05-24 | 1986-05-23 | Способ получени производных бербана или их солей |
| SU864028190A SU1573021A1 (ru) | 1985-05-24 | 1986-09-29 | 14 @ -Окси-7,8-метилендиоксиаллобербан, обладающий антидепрессивной активностью |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU864027562A SU1508958A3 (ru) | 1985-05-24 | 1986-05-23 | Способ получени производных бербана или их солей |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4851416A (ru) |
| EP (1) | EP0202950B1 (ru) |
| JP (1) | JPS61280492A (ru) |
| KR (1) | KR870001742B1 (ru) |
| CN (1) | CN1010779B (ru) |
| AT (1) | ATE95180T1 (ru) |
| AU (1) | AU599030B2 (ru) |
| CA (1) | CA1294964C (ru) |
| CS (1) | CS266586B2 (ru) |
| DD (1) | DD251289A5 (ru) |
| DE (1) | DE3689080T2 (ru) |
| DK (1) | DK242886A (ru) |
| ES (1) | ES8800938A1 (ru) |
| FI (1) | FI85023C (ru) |
| GR (1) | GR861348B (ru) |
| HU (1) | HU195505B (ru) |
| IE (1) | IE60479B1 (ru) |
| IL (1) | IL78722A (ru) |
| NO (1) | NO164098C (ru) |
| NZ (1) | NZ216280A (ru) |
| PH (1) | PH24053A (ru) |
| PL (1) | PL148617B1 (ru) |
| PT (1) | PT82634B (ru) |
| SU (2) | SU1508958A3 (ru) |
| YU (1) | YU46956B (ru) |
| ZA (1) | ZA863869B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5122504A (en) * | 1990-02-27 | 1992-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Superconducting ribbon process using laser heating |
| WO1992020678A1 (en) * | 1991-05-22 | 1992-11-26 | Chinoin Gyógyszer- És Vegyészeti Gyár R.T. | New berbane derivatives, pharmaceutical compositions containing these compounds and process for the preparation of same |
| US5492907A (en) * | 1992-12-09 | 1996-02-20 | The United States Of America As Represented By The Department Of Health & Human Services | Antipsychotic composition and method of treatment |
| US5663167A (en) * | 1992-12-09 | 1997-09-02 | The United States Of America As Represented By The Department Of Health And Human Services | Antipsychotic composition and method of treatment |
-
1985
- 1985-05-24 HU HU851982A patent/HU195505B/hu unknown
-
1986
- 1986-05-08 IL IL78722A patent/IL78722A/xx not_active IP Right Cessation
- 1986-05-21 YU YU84886A patent/YU46956B/sh unknown
- 1986-05-21 JP JP61114973A patent/JPS61280492A/ja active Pending
- 1986-05-22 ES ES555206A patent/ES8800938A1/es not_active Expired
- 1986-05-23 SU SU864027562A patent/SU1508958A3/ru active
- 1986-05-23 NO NO862054A patent/NO164098C/no unknown
- 1986-05-23 PT PT82634A patent/PT82634B/pt not_active IP Right Cessation
- 1986-05-23 DD DD86290542A patent/DD251289A5/de not_active IP Right Cessation
- 1986-05-23 KR KR1019860004054A patent/KR870001742B1/ko not_active IP Right Cessation
- 1986-05-23 IE IE137386A patent/IE60479B1/en not_active IP Right Cessation
- 1986-05-23 FI FI862174A patent/FI85023C/fi not_active IP Right Cessation
- 1986-05-23 NZ NZ216280A patent/NZ216280A/xx unknown
- 1986-05-23 CS CS863767A patent/CS266586B2/cs unknown
- 1986-05-23 US US06/867,323 patent/US4851416A/en not_active Expired - Fee Related
- 1986-05-23 CA CA000509814A patent/CA1294964C/en not_active Expired - Lifetime
- 1986-05-23 AU AU57853/86A patent/AU599030B2/en not_active Ceased
- 1986-05-23 GR GR861348A patent/GR861348B/el unknown
- 1986-05-23 CN CN85104693A patent/CN1010779B/zh not_active Expired
- 1986-05-23 PL PL1986259689A patent/PL148617B1/pl unknown
- 1986-05-23 EP EP86303947A patent/EP0202950B1/en not_active Expired - Lifetime
- 1986-05-23 ZA ZA863869A patent/ZA863869B/xx unknown
- 1986-05-23 DE DE86303947T patent/DE3689080T2/de not_active Expired - Fee Related
- 1986-05-23 PH PH33811A patent/PH24053A/en unknown
- 1986-05-23 AT AT86303947T patent/ATE95180T1/de not_active IP Right Cessation
- 1986-05-23 DK DK242886A patent/DK242886A/da not_active Application Discontinuation
- 1986-09-29 SU SU864028190A patent/SU1573021A1/ru active
Non-Patent Citations (1)
| Title |
|---|
| J. Meg. Chenu, 1984, 27, 1411. Drugs of the Future, 1985, 10, 841. * |
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