ATE117296T1 - Pyridazinamin-derivate. - Google Patents
Pyridazinamin-derivate.Info
- Publication number
- ATE117296T1 ATE117296T1 AT88202572T AT88202572T ATE117296T1 AT E117296 T1 ATE117296 T1 AT E117296T1 AT 88202572 T AT88202572 T AT 88202572T AT 88202572 T AT88202572 T AT 88202572T AT E117296 T1 ATE117296 T1 AT E117296T1
- Authority
- AT
- Austria
- Prior art keywords
- 6alkyl
- hydrogen
- compounds
- formula
- 6alkyloxy
- Prior art date
Links
- LETVJWLLIMJADE-UHFFFAOYSA-N pyridazin-3-amine Chemical class NC1=CC=CN=N1 LETVJWLLIMJADE-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 hydroxy, mercapto Chemical class 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940121357 antivirals Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12453087A | 1987-11-23 | 1987-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE117296T1 true ATE117296T1 (de) | 1995-02-15 |
Family
ID=22415413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88202572T ATE117296T1 (de) | 1987-11-23 | 1988-11-17 | Pyridazinamin-derivate. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0320032B1 (de) |
| JP (1) | JPH0629255B2 (de) |
| KR (1) | KR0125280B1 (de) |
| CN (1) | CN1021328C (de) |
| AT (1) | ATE117296T1 (de) |
| AU (1) | AU611504B2 (de) |
| BG (1) | BG60676B1 (de) |
| CA (1) | CA1327573C (de) |
| DE (1) | DE3852816T2 (de) |
| DK (1) | DK651288A (de) |
| ES (1) | ES2070126T3 (de) |
| FI (1) | FI92584C (de) |
| GR (1) | GR3015816T3 (de) |
| HU (1) | HU200762B (de) |
| IE (1) | IE65768B1 (de) |
| IL (1) | IL88429A (de) |
| JO (1) | JO1552B1 (de) |
| MA (1) | MA21446A1 (de) |
| MY (1) | MY104343A (de) |
| NO (1) | NO171980C (de) |
| NZ (1) | NZ226920A (de) |
| PH (1) | PH26670A (de) |
| PT (1) | PT89047B (de) |
| SU (1) | SU1724013A3 (de) |
| TN (1) | TNSN88128A1 (de) |
| ZA (1) | ZA888744B (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106973A (en) * | 1987-11-23 | 1992-04-21 | Janssen Pharmaceutica N.V. | Pyridzainamine derivatives |
| GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
| US5070090A (en) * | 1989-05-15 | 1991-12-03 | Janssen Pharmaceutica N.V. | Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers |
| JO1645B1 (en) * | 1989-12-26 | 1991-11-27 | شركة جانسين فارماسوتيكا ان. في | Pyridazine compounds are antibacterial viruses |
| US5169855A (en) * | 1990-03-28 | 1992-12-08 | Du Pont Merck Pharmaceutical Company | Piperidine ether derivatives as psychotropic drugs or plant fungicides |
| MX9100513A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
| FR2668151A1 (fr) * | 1990-10-23 | 1992-04-24 | Rhone Poulenc Agrochimie | Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant. |
| HU214320B (hu) * | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| CA2099630A1 (en) * | 1992-07-02 | 1994-01-03 | Guy Dominic Diana | Heterocyclyl-phenoxyalkyl-piperidinylpyridazines as antiviral agents |
| US5242924A (en) * | 1992-07-02 | 1993-09-07 | Sterling Winthrop Inc. | Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents |
| US5364865A (en) * | 1992-12-30 | 1994-11-15 | Sterling Winthrop Inc. | Phenoxy- and phenoxyalkyl-piperidines as antiviral agents |
| US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
| US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
| GB9406144D0 (en) * | 1993-03-29 | 1994-05-18 | Zeneca Ltd | Heterocyclic compounds |
| US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
| WO1994022834A1 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic derivatives as platelet aggregation inhibitors |
| AU744539B2 (en) * | 1997-10-27 | 2002-02-28 | Neurosearch A/S | Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors |
| US6683100B2 (en) | 1999-01-19 | 2004-01-27 | Novartis Ag | Organic compounds |
| EP1057819A4 (de) | 1998-02-19 | 2003-02-05 | Eisai Co Ltd | Phthalazinderivate und mittel gegen erektionstörungen |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US6316500B1 (en) * | 1999-01-05 | 2001-11-13 | Isp Investments Inc. | Aliphatically unsaturated hydroxy benzoates and preservative compositions thereof |
| AUPR213700A0 (en) | 2000-12-18 | 2001-01-25 | Biota Scientific Management Pty Ltd | Antiviral agents |
| CA2456985A1 (en) | 2001-08-15 | 2003-02-27 | Icos Corporation | 2h-phthalazin-1-ones and methods for use thereof |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| JP4544999B2 (ja) * | 2002-11-25 | 2010-09-15 | 持田製薬株式会社 | ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤 |
| EP3042895A1 (de) | 2003-07-30 | 2016-07-13 | Xenon Pharmaceuticals Inc. | Pyridazinderivate und deren verwendung als therapeutische wirkstoffe |
| US7754711B2 (en) | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| AU2004261249B2 (en) * | 2003-07-30 | 2008-09-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| JP4852540B2 (ja) * | 2004-06-30 | 2012-01-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐ阻害剤としてのフタラジン誘導体 |
| JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
| EP1799667B1 (de) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe |
| EP2289510A1 (de) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten |
| MX2007003319A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| EP2269610A3 (de) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| CN1887875B (zh) * | 2005-06-30 | 2011-04-06 | 深圳市东阳光实业发展有限公司 | 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途 |
| NZ564759A (en) * | 2005-06-30 | 2011-08-26 | Prosidion Ltd | GPCR agonists |
| EP2386554A1 (de) | 2005-07-04 | 2011-11-16 | High Point Pharmaceuticals, LLC | Histamine H3 Rezeptor aktive Verbindungen |
| EP2079732B9 (de) | 2006-05-29 | 2012-03-21 | High Point Pharmaceuticals, LLC | 3-(1,3-benyodioxol-5-yl)-6- (4-cyclopropylpiperazin-1-yl)-pyridazin, dessen salze und solvate und dessen verwendung als histamin-h3-rezeptorantagonist |
| EP2014656A3 (de) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | Neue heterocyclische H3-Antagonisten |
| CN101864003B (zh) * | 2010-06-11 | 2012-05-02 | 漆又毛 | 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法 |
| CN102344416B (zh) * | 2010-08-02 | 2015-09-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 哒嗪衍生物及其作为抗小rna病毒感染药物的用途 |
| CN102485717B (zh) * | 2010-12-06 | 2015-12-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑胺衍生物及其作为抗小rna病毒感染药物的用途 |
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| EP3749697A4 (de) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | Chromatografieharz mit einem liganden mit anionenaustausch-hydrophobem mischmodus |
| CN118047485B (zh) * | 2024-04-08 | 2024-06-25 | 西安文理学院 | 一种污水治理的复合微生物菌剂及其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8802151A1 (es) * | 1985-07-31 | 1988-04-01 | Janssen Pharmaceutica Nv | Un procedimiento para la preparacion de nuevos piridazinaminas. |
-
1988
- 1988-10-26 MY MYPI88001214A patent/MY104343A/en unknown
- 1988-11-02 CA CA000581965A patent/CA1327573C/en not_active Expired - Fee Related
- 1988-11-09 NZ NZ226920A patent/NZ226920A/xx unknown
- 1988-11-17 DE DE3852816T patent/DE3852816T2/de not_active Expired - Fee Related
- 1988-11-17 EP EP88202572A patent/EP0320032B1/de not_active Expired - Lifetime
- 1988-11-17 ES ES88202572T patent/ES2070126T3/es not_active Expired - Lifetime
- 1988-11-17 AT AT88202572T patent/ATE117296T1/de not_active IP Right Cessation
- 1988-11-18 AU AU25751/88A patent/AU611504B2/en not_active Ceased
- 1988-11-21 TN TNTNSN88128A patent/TNSN88128A1/fr unknown
- 1988-11-21 BG BG86132A patent/BG60676B1/bg unknown
- 1988-11-21 IL IL88429A patent/IL88429A/xx not_active IP Right Cessation
- 1988-11-22 JO JO19881552A patent/JO1552B1/en active
- 1988-11-22 HU HU885991A patent/HU200762B/hu not_active IP Right Cessation
- 1988-11-22 PT PT89047A patent/PT89047B/pt not_active IP Right Cessation
- 1988-11-22 NO NO885190A patent/NO171980C/no unknown
- 1988-11-22 MA MA21689A patent/MA21446A1/fr unknown
- 1988-11-22 ZA ZA888744A patent/ZA888744B/xx unknown
- 1988-11-22 SU SU884356881A patent/SU1724013A3/ru active
- 1988-11-22 FI FI885409A patent/FI92584C/fi not_active IP Right Cessation
- 1988-11-22 DK DK651288A patent/DK651288A/da not_active Application Discontinuation
- 1988-11-22 JP JP63293739A patent/JPH0629255B2/ja not_active Expired - Fee Related
- 1988-11-22 IE IE348688A patent/IE65768B1/en not_active IP Right Cessation
- 1988-11-23 KR KR1019880015415A patent/KR0125280B1/ko not_active Expired - Fee Related
- 1988-11-23 PH PH37851A patent/PH26670A/en unknown
- 1988-11-23 CN CN88108173A patent/CN1021328C/zh not_active Expired - Fee Related
-
1995
- 1995-04-17 GR GR950400946T patent/GR3015816T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |