EP1948193A4 - Aminopyrimidines utiles en tant qu'inhibiteurs de kinases - Google Patents
Aminopyrimidines utiles en tant qu'inhibiteurs de kinasesInfo
- Publication number
- EP1948193A4 EP1948193A4 EP06836890A EP06836890A EP1948193A4 EP 1948193 A4 EP1948193 A4 EP 1948193A4 EP 06836890 A EP06836890 A EP 06836890A EP 06836890 A EP06836890 A EP 06836890A EP 1948193 A4 EP1948193 A4 EP 1948193A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- kinase inhibitors
- aminopyrimidines useful
- aminopyrimidines
- useful
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73295105P | 2005-11-03 | 2005-11-03 | |
US73355705P | 2005-11-04 | 2005-11-04 | |
PCT/US2006/042994 WO2007056164A2 (fr) | 2005-11-03 | 2006-11-03 | Aminopyrimidines utiles en tant qu'inhibiteurs de kinases |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1948193A2 EP1948193A2 (fr) | 2008-07-30 |
EP1948193A4 true EP1948193A4 (fr) | 2011-11-09 |
EP1948193B1 EP1948193B1 (fr) | 2015-01-07 |
Family
ID=38023840
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06827465.3A Not-in-force EP1951715B1 (fr) | 2005-11-03 | 2006-11-03 | Aminopyrimidines utiles en tant qu'inhibiteurs de kinases |
EP06836890.1A Not-in-force EP1948193B1 (fr) | 2005-11-03 | 2006-11-03 | Aminopyrimidines utiles en tant qu'inhibiteurs de kinases |
EP06836938.8A Not-in-force EP1954277B1 (fr) | 2005-11-03 | 2006-11-03 | Aminopyrimidines utiles en tant qu'inhibiteurs de kinases |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06827465.3A Not-in-force EP1951715B1 (fr) | 2005-11-03 | 2006-11-03 | Aminopyrimidines utiles en tant qu'inhibiteurs de kinases |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06836938.8A Not-in-force EP1954277B1 (fr) | 2005-11-03 | 2006-11-03 | Aminopyrimidines utiles en tant qu'inhibiteurs de kinases |
Country Status (18)
Country | Link |
---|---|
US (7) | US7767672B2 (fr) |
EP (3) | EP1951715B1 (fr) |
JP (5) | JP5328361B2 (fr) |
KR (3) | KR20080066069A (fr) |
CN (3) | CN101316843B (fr) |
AR (3) | AR056764A1 (fr) |
AU (3) | AU2006311830B2 (fr) |
BR (3) | BRPI0619704A2 (fr) |
CA (3) | CA2627857A1 (fr) |
ES (2) | ES2435081T3 (fr) |
IL (3) | IL191044A0 (fr) |
MX (3) | MX2008005814A (fr) |
NO (3) | NO20082514L (fr) |
NZ (4) | NZ606259A (fr) |
RU (5) | RU2423361C2 (fr) |
SG (2) | SG166827A1 (fr) |
TW (3) | TW200734327A (fr) |
WO (3) | WO2007056163A2 (fr) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6638926B2 (en) | 2000-09-15 | 2003-10-28 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
SE0104140D0 (sv) * | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
WO2004072029A2 (fr) | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Compositions utiles en tant qu'inhibiteurs de proteine kinases |
PT1853588E (pt) * | 2005-02-16 | 2008-08-25 | Astrazeneca Ab | Compostos químicos |
CA2608009A1 (fr) * | 2005-05-16 | 2006-11-23 | Astrazeneca Ab | Composes chimiques |
CA2626623C (fr) * | 2005-10-18 | 2016-08-30 | Janssen Pharmaceutica N.V. | Methode d'inhibition de la kinase flt3 |
ES2391783T3 (es) * | 2005-10-28 | 2012-11-29 | Astrazeneca Ab | Derivados de 4-(3-aminopirazol)pirimidina para su uso como agentes inhibidores de las tirosina cinasas en el tratamiento del cáncer |
AU2006311830B2 (en) | 2005-11-03 | 2013-03-14 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
DE602006021776D1 (de) * | 2005-11-16 | 2011-06-16 | Vertex Pharma | Als kinaseinhibitoren geeignete aminopyrimidine |
EP2016070B1 (fr) * | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibiteurs de la c-fms kinase |
US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
AU2007317435A1 (en) | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
WO2008077086A1 (fr) | 2006-12-19 | 2008-06-26 | Vertex Pharmaceuticals Incorporated | Aminopyridines utiles comme inhibiteurs de protéine kinases |
NZ579483A (en) | 2007-03-09 | 2012-07-27 | Vertex Pharma | Aminopyridines useful as inhibitors of protein kinases |
JP5393489B2 (ja) * | 2007-03-09 | 2014-01-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | 蛋白キナーゼの阻害剤として有用なアミノピリミジン |
JP5520057B2 (ja) | 2007-03-09 | 2014-06-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | 蛋白キナーゼの阻害剤として有用なアミノピリミジン |
MX2009011059A (es) | 2007-04-13 | 2009-11-26 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasas. |
JP2010524911A (ja) * | 2007-04-18 | 2010-07-22 | アストラゼネカ アクチボラグ | 5−アミノピラゾール−3−イル−3H−イミダゾ[4,5−b]ピリジン誘導体と癌の治療のためのその使用 |
MX2009011811A (es) * | 2007-05-02 | 2010-01-14 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasa. |
WO2008137621A1 (fr) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines servant d'inhibiteurs de kinases |
CA2685876A1 (fr) | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Thiazoles et pyrazoles qui s'utilisent comme inhibiteurs de kinase |
UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
JP2010526048A (ja) * | 2007-05-04 | 2010-07-29 | アストラゼネカ アクチボラグ | アミノ−チアゾリル−ピリミジン誘導体、および癌の治療のための該誘導体の使用 |
EP2164842A2 (fr) * | 2007-05-24 | 2010-03-24 | Vertex Pharmaceuticals Incorporated | Thiazoles et pyrazoles utiles en tant qu'inhibiteurs de kinase |
JP2010529193A (ja) * | 2007-06-11 | 2010-08-26 | ミイカナ セラピューティクス インコーポレイテッド | 置換ピラゾール化合物 |
CA2694499A1 (fr) | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Procede de preparation de la 5-fluoro-1h-pyrazolo[3,4-b]pyridin-3-amine et des derives de celle-ci |
EP2190849B1 (fr) * | 2007-08-15 | 2013-11-20 | Vertex Pharmceuticals Incorporated | Dérivés 4-(9-(3,3-difluorocyclopentyl)-5,7,7-triméthyl-6-oxo-6,7,8,9-tetrahydro-5h-pyrimido[4,5-b[1,4]diazépin-2-ylamino)-3-méthoxybenzamide en tant que inhibiteurs des protéines kinases humaines plk1 a plk4 pour le traitement de maladies prolifératives |
MX2010002772A (es) | 2007-09-21 | 2010-03-31 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazol como activadores de glucocinasa para el tratamiento de diabetes mellitus. |
WO2009086012A1 (fr) * | 2007-12-20 | 2009-07-09 | Curis, Inc. | Inhibiteurs d'aurore contenant une fraction de liaison de zinc |
WO2009114703A2 (fr) * | 2008-03-12 | 2009-09-17 | Fox Chase Cancer Center | Thérapie combinée pour le traitement d'un cancer |
US8324199B2 (en) * | 2008-03-13 | 2012-12-04 | Bristol-Myers Squibb Company | Pyridazine derivatives as factor xia inhibitors |
EP2955222B1 (fr) * | 2008-03-17 | 2018-09-12 | The Scripps Research Institute | Approches chimiques et génétiques combinées pour la génération de cellules souches pluripotentes induites |
UY31885A (es) * | 2008-06-11 | 2010-01-29 | Astrazeneca Ab | Derivados de las 1, 3, 5-triazina-2, 4-diaminas-6-sustituidas-n-sustituidas y sales farmacéuticamente aceptables de los mismos, composiciones y aplicaciones. |
KR101341876B1 (ko) * | 2008-09-05 | 2013-12-20 | 셀진 아빌로믹스 리서치, 인코포레이티드 | 비가역 인히비터 디자인을 위한 알고리즘 |
RU2011116928A (ru) * | 2008-09-30 | 2012-11-20 | Астразенека Аб (Se) | Гетероциклические ингибиторы jак киназы |
MX2011006725A (es) | 2008-12-22 | 2011-09-15 | Millennium Pharm Inc | Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20. |
CA2765050A1 (fr) * | 2009-06-09 | 2010-12-16 | California Capital Equity, Llc | Derives de la triazine substituee a l'ureidophenyle et leurs applications therapeutiques |
AU2010295690B2 (en) * | 2009-09-16 | 2016-07-28 | Celgene Avilomics Research, Inc. | Protein kinase conjugates and inhibitors |
WO2011082285A1 (fr) | 2009-12-30 | 2011-07-07 | Avila Therapeutics, Inc. | Modification covalente de protéine, dirigée sur un ligand |
ES2706066T3 (es) | 2010-07-02 | 2019-03-27 | Univ Health Network | Procedimiento dirigido a enfermedades mutantes con PTEN y composiciones para las mismas |
SG10201505951VA (en) * | 2010-07-30 | 2015-08-28 | Oncotherapy Science Inc | Quinoline derivatives and melk inhibitors containing the same |
WO2012112674A2 (fr) | 2011-02-15 | 2012-08-23 | The Johns Hopkins University | Composés et procédés d'utilisation de ceux-ci dans le traitement de troubles neurodégénératifs |
SI2736895T1 (sl) | 2011-07-27 | 2016-03-31 | Astrazeneca Ab | Derivati 2-(2,4,5-substituiranega-anilino) pirimidina, kot modulatorji EGFR uporabni za zdravljenje raka |
RU2014109897A (ru) | 2011-08-25 | 2015-09-27 | Ф.Хоффманн-Ля Рош Аг | Ингибиторы серин/треонин киназы рак1 |
JP2014525418A (ja) * | 2011-09-05 | 2014-09-29 | 浙江海正薬業股▲ふん▼有限公司 | タンパク質キナーゼ阻害活性を有する4−置換−(3−置換−1h−ピラゾール−5−アミノ)−ピリミジン誘導体及びその使用 |
CA2856722C (fr) | 2011-11-30 | 2022-11-22 | Emory University | Inhibiteurs de jak antiviraux utiles dans le traitement ou la prevention d'infections retrovirales et autres infections virales |
US8815877B2 (en) | 2011-12-22 | 2014-08-26 | Genentech, Inc. | Serine/threonine kinase inhibitors |
RU2014141674A (ru) | 2012-03-16 | 2016-05-10 | Аксикин Фармасьютикалз, Инк. | 3,5-диаминопиразоловые ингибиторы киназы |
RS61664B1 (sr) | 2012-04-24 | 2021-04-29 | Vertex Pharma | Inhibitori dna-pk |
US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
WO2013177367A2 (fr) | 2012-05-23 | 2013-11-28 | The Johns Hopkins University | Composés et méthodes d'utilisation de ceux-ci pour traiter des troubles neurodégénératifs |
SG10201610869TA (en) | 2012-06-26 | 2017-02-27 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti |
JP6277198B2 (ja) * | 2012-11-05 | 2018-02-07 | ナント ホールディングス アイピー,エルエルシー | 置換インドール−5−オール誘導体及びそれらの治療適用 |
RS58374B1 (sr) | 2013-03-12 | 2019-03-29 | Vertex Pharma | Inhibitori dnk-pk |
JP2016514703A (ja) | 2013-03-15 | 2016-05-23 | ナントバイオサイエンス、インコーポレイテッド | 置換インドール−5−オール誘導体及びそれらの治療適用 |
AU2014251038A1 (en) | 2013-04-08 | 2015-11-26 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
EP3057953B1 (fr) | 2013-10-17 | 2018-08-15 | Vertex Pharmaceuticals Incorporated | Co-cristaux de (s)-n-méthyl-8-(1-((2'-méthyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide et leurs dérivés deutérés utilisés comme inhibiteurs de protéine kinase dépendante de l'adn (dna-pk) |
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- 2011-04-04 RU RU2011112948/15A patent/RU2011112948A/ru not_active Application Discontinuation
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2012
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004000833A1 (fr) * | 2002-06-20 | 2003-12-31 | Vertex Pharmaceuticals Incorporated | Procedes pour la preparation de pyrimidines substituees et derives de pyrimidines utilises comme inhibiteurs des proteine-kinases |
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