CA2626623C - Methode d'inhibition de la kinase flt3 - Google Patents

Methode d'inhibition de la kinase flt3 Download PDF

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Publication number
CA2626623C
CA2626623C CA2626623A CA2626623A CA2626623C CA 2626623 C CA2626623 C CA 2626623C CA 2626623 A CA2626623 A CA 2626623A CA 2626623 A CA2626623 A CA 2626623A CA 2626623 C CA2626623 C CA 2626623C
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CA
Canada
Prior art keywords
mmol
carboxylic acid
cyano
cyclohex
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2626623A
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English (en)
Other versions
CA2626623A1 (fr
Inventor
Shelley K. Ballentine
Christian Andrew Baumann
Jingsheng Chen
Carl R. Illig
Saneth Meegalla
M. Jonathan Rudolph
Robert W. Tuman
Mark J. Wall
Kenneth Wilson
Dana L. Johnson
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CA2626623A1 publication Critical patent/CA2626623A1/fr
Application granted granted Critical
Publication of CA2626623C publication Critical patent/CA2626623C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention porte sur une méthode de réduction ou d'inhibition de l'activité de kinase du récepteur FLT3 dans une cellule ou un patient, pour prévenir ou traiter chez un patient les troubles de prolifération cellulaire et/ou liés au FLT3, en utilisant le composé de l'invention (l) ou un de ses solvates, hydrate, tautomère ou sel pharmacocompatible. L'invention porte également sur des méthodes de traitement d'états tels que le cancer ou d'autres troubles de prolifération cellulaire.
CA2626623A 2005-10-18 2006-10-17 Methode d'inhibition de la kinase flt3 Expired - Fee Related CA2626623C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72768705P 2005-10-18 2005-10-18
US60/727,687 2005-10-18
PCT/US2006/060028 WO2007048088A2 (fr) 2005-10-18 2006-10-17 Methode d'inhibition de la kinase flt3

Publications (2)

Publication Number Publication Date
CA2626623A1 CA2626623A1 (fr) 2007-04-26
CA2626623C true CA2626623C (fr) 2016-08-30

Family

ID=37864477

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2626623A Expired - Fee Related CA2626623C (fr) 2005-10-18 2006-10-17 Methode d'inhibition de la kinase flt3

Country Status (19)

Country Link
US (1) US7795279B2 (fr)
EP (1) EP1951234A2 (fr)
JP (2) JP2009511628A (fr)
KR (1) KR101443651B1 (fr)
CN (1) CN101340909B (fr)
AU (1) AU2006304897B2 (fr)
BR (1) BRPI0617489A2 (fr)
CA (1) CA2626623C (fr)
CR (1) CR9984A (fr)
EA (1) EA200801118A1 (fr)
EC (1) ECSP088387A (fr)
GT (1) GT200800042A (fr)
IL (1) IL190727A (fr)
NO (1) NO20082223L (fr)
NZ (1) NZ595182A (fr)
SV (1) SV2008002880A (fr)
UA (1) UA94719C2 (fr)
WO (1) WO2007048088A2 (fr)
ZA (1) ZA200804253B (fr)

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ES2611604T3 (es) * 2004-10-22 2017-05-09 Janssen Pharmaceutica Nv Inhibidores de la c fms quinasa
US20060281788A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
AU2006304897B2 (en) * 2005-10-18 2012-07-12 Janssen Pharmaceutica N.V. Method of inhibiting FLT3 kinase
CN101454325A (zh) * 2006-03-09 2009-06-10 法马科皮亚公司 用于治疗代谢性疾病的8-杂芳基嘌呤mnk2抑制剂
EP2021335B1 (fr) * 2006-04-20 2011-05-25 Janssen Pharmaceutica N.V. Composés hétérocycliques inhibiteurs de c-fms kinase
AU2007240400B2 (en) * 2006-04-20 2013-08-22 Janssen Pharmaceutica N.V. Method of inhibiting C KIT kinase
MX2008013529A (es) 2006-04-20 2009-01-15 Janssen Pharmaceutica Nv Inhibidores de c-fms cinasa.
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
EP2521782B1 (fr) 2010-01-05 2019-04-10 INSERM - Institut National de la Santé et de la Recherche Médicale Antagonistes du récepteur flt3 pour le traitement ou la prévention de troubles de la douleur
WO2011113041A2 (fr) * 2010-03-12 2011-09-15 The Johns Hopkins University Neutralisation de ligand de flt3 comme thérapie de la leucémie
JP6046728B2 (ja) 2011-09-30 2016-12-21 オンコデザイン エス．ア． 大環状ｆｌｔ３キナーゼ阻害剤
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
ES2608628T3 (es) 2012-08-07 2017-04-12 Janssen Pharmaceutica Nv Procedimiento para la preparacion de derivados de ester heterociclicos
CN104370880A (zh) * 2013-01-24 2015-02-25 韩冰 一类蛋白酶抑制剂及其制备方法和用途
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
SG11201600504TA (en) 2013-07-22 2016-02-26 Actelion Pharmaceuticals Ltd 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives
CN107001283B (zh) 2014-07-31 2021-05-25 国家健康与医学研究院 Flt3受体拮抗剂
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
ES2709985T3 (es) 2015-01-15 2019-04-22 Idorsia Pharmaceuticals Ltd Derivados de hidroxialquil-piperazina como moduladores del receptor CXCR3
EP3254698A1 (fr) 2016-06-08 2017-12-13 Universite De Montpellier Inhibiteur du récepteur flt3 à faible dose pour le traitement d'une douleur neuropathique
WO2018118598A1 (fr) * 2016-12-23 2018-06-28 Arvinas, Inc. Composés et procédés pour la dégradation ciblée de polypeptides de kinase du foie fœtal
AU2018269678A1 (en) 2017-05-17 2019-12-12 Biodol Therapeutics FLT3 inhibitors for improving pain treatments by opioids
US11331313B2 (en) 2017-05-22 2022-05-17 Whitehead Institute For Biomedical Research KCC2 expression enhancing compounds and uses thereof
US11285131B2 (en) 2017-08-04 2022-03-29 Merck Sharp & Dohme Corp. Benzo[b]thiophene STING agonists for cancer treatment
AU2018311965A1 (en) 2017-08-04 2020-02-13 Merck Sharp & Dohme Llc Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment
WO2019057649A1 (fr) 2017-09-19 2019-03-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de la leucémie myéloïde aiguë

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CA2131528C (fr) 1992-03-05 2004-07-13 Philip E. Thorpe Agents diagnostiques et/ou therapeutiques cibles pour les cellules endotheliales neovasculaires
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Also Published As

Publication number Publication date
NZ595182A (en) 2012-12-21
GT200800042A (es) 2008-11-03
NO20082223L (no) 2008-07-02
WO2007048088A3 (fr) 2007-06-07
US20070149572A1 (en) 2007-06-28
EP1951234A2 (fr) 2008-08-06
AU2006304897B2 (en) 2012-07-12
BRPI0617489A2 (pt) 2011-07-26
KR20080064867A (ko) 2008-07-09
SV2008002880A (es) 2010-01-05
CR9984A (es) 2008-09-09
UA94719C2 (ru) 2011-06-10
JP2014129407A (ja) 2014-07-10
IL190727A (en) 2015-05-31
US7795279B2 (en) 2010-09-14
KR101443651B1 (ko) 2014-09-23
CN101340909B (zh) 2012-01-11
CA2626623A1 (fr) 2007-04-26
ZA200804253B (en) 2009-11-25
ECSP088387A (es) 2008-05-30
CN101340909A (zh) 2009-01-07
WO2007048088A2 (fr) 2007-04-26
EA200801118A1 (ru) 2008-10-30
JP2009511628A (ja) 2009-03-19
AU2006304897A1 (en) 2007-04-26
IL190727A0 (en) 2008-12-29

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