ZA200804253B - Method of inhibiting FLT3 kinase - Google Patents

Method of inhibiting FLT3 kinase

Info

Publication number
ZA200804253B
ZA200804253B ZA200804253A ZA200804253A ZA200804253B ZA 200804253 B ZA200804253 B ZA 200804253B ZA 200804253 A ZA200804253 A ZA 200804253A ZA 200804253 A ZA200804253 A ZA 200804253A ZA 200804253 B ZA200804253 B ZA 200804253B
Authority
ZA
South Africa
Prior art keywords
flt3 kinase
inhibiting flt3
inhibiting
kinase
flt3
Prior art date
Application number
ZA200804253A
Other languages
English (en)
Inventor
Shelley K Ballentine
Chen Jinsheng
Sanath K Meegalla
Robert W Tuman
Wilson Kenneth
Baumann Christian Andrew
Carl R Illig
Rudolph M Jonathan
Mark J Wall
Dana L Johnson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200804253B publication Critical patent/ZA200804253B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
ZA200804253A 2005-10-18 2008-05-16 Method of inhibiting FLT3 kinase ZA200804253B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72768705P 2005-10-18 2005-10-18

Publications (1)

Publication Number Publication Date
ZA200804253B true ZA200804253B (en) 2009-11-25

Family

ID=37864477

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200804253A ZA200804253B (en) 2005-10-18 2008-05-16 Method of inhibiting FLT3 kinase

Country Status (19)

Country Link
US (1) US7795279B2 (fr)
EP (1) EP1951234A2 (fr)
JP (2) JP2009511628A (fr)
KR (1) KR101443651B1 (fr)
CN (1) CN101340909B (fr)
AU (1) AU2006304897B2 (fr)
BR (1) BRPI0617489A2 (fr)
CA (1) CA2626623C (fr)
CR (1) CR9984A (fr)
EA (1) EA200801118A1 (fr)
EC (1) ECSP088387A (fr)
GT (1) GT200800042A (fr)
IL (1) IL190727A (fr)
NO (1) NO20082223L (fr)
NZ (1) NZ595182A (fr)
SV (1) SV2008002880A (fr)
UA (1) UA94719C2 (fr)
WO (1) WO2007048088A2 (fr)
ZA (1) ZA200804253B (fr)

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AU2006304897B2 (en) * 2005-10-18 2012-07-12 Janssen Pharmaceutica N.V. Method of inhibiting FLT3 kinase
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EP2021335B1 (fr) * 2006-04-20 2011-05-25 Janssen Pharmaceutica N.V. Composés hétérocycliques inhibiteurs de c-fms kinase
AU2007240400B2 (en) * 2006-04-20 2013-08-22 Janssen Pharmaceutica N.V. Method of inhibiting C KIT kinase
MX2008013529A (es) 2006-04-20 2009-01-15 Janssen Pharmaceutica Nv Inhibidores de c-fms cinasa.
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
EP2521782B1 (fr) 2010-01-05 2019-04-10 INSERM - Institut National de la Santé et de la Recherche Médicale Antagonistes du récepteur flt3 pour le traitement ou la prévention de troubles de la douleur
WO2011113041A2 (fr) * 2010-03-12 2011-09-15 The Johns Hopkins University Neutralisation de ligand de flt3 comme thérapie de la leucémie
JP6046728B2 (ja) 2011-09-30 2016-12-21 オンコデザイン エス．ア． 大環状ｆｌｔ３キナーゼ阻害剤
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
ES2608628T3 (es) 2012-08-07 2017-04-12 Janssen Pharmaceutica Nv Procedimiento para la preparacion de derivados de ester heterociclicos
CN104370880A (zh) * 2013-01-24 2015-02-25 韩冰 一类蛋白酶抑制剂及其制备方法和用途
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
SG11201600504TA (en) 2013-07-22 2016-02-26 Actelion Pharmaceuticals Ltd 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives
CN107001283B (zh) 2014-07-31 2021-05-25 国家健康与医学研究院 Flt3受体拮抗剂
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
ES2709985T3 (es) 2015-01-15 2019-04-22 Idorsia Pharmaceuticals Ltd Derivados de hidroxialquil-piperazina como moduladores del receptor CXCR3
EP3254698A1 (fr) 2016-06-08 2017-12-13 Universite De Montpellier Inhibiteur du récepteur flt3 à faible dose pour le traitement d'une douleur neuropathique
WO2018118598A1 (fr) * 2016-12-23 2018-06-28 Arvinas, Inc. Composés et procédés pour la dégradation ciblée de polypeptides de kinase du foie fœtal
AU2018269678A1 (en) 2017-05-17 2019-12-12 Biodol Therapeutics FLT3 inhibitors for improving pain treatments by opioids
US11331313B2 (en) 2017-05-22 2022-05-17 Whitehead Institute For Biomedical Research KCC2 expression enhancing compounds and uses thereof
US11285131B2 (en) 2017-08-04 2022-03-29 Merck Sharp & Dohme Corp. Benzo[b]thiophene STING agonists for cancer treatment
AU2018311965A1 (en) 2017-08-04 2020-02-13 Merck Sharp & Dohme Llc Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment
WO2019057649A1 (fr) 2017-09-19 2019-03-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de la leucémie myéloïde aiguë

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Also Published As

Publication number Publication date
NZ595182A (en) 2012-12-21
GT200800042A (es) 2008-11-03
NO20082223L (no) 2008-07-02
WO2007048088A3 (fr) 2007-06-07
US20070149572A1 (en) 2007-06-28
EP1951234A2 (fr) 2008-08-06
AU2006304897B2 (en) 2012-07-12
BRPI0617489A2 (pt) 2011-07-26
KR20080064867A (ko) 2008-07-09
SV2008002880A (es) 2010-01-05
CA2626623C (fr) 2016-08-30
CR9984A (es) 2008-09-09
UA94719C2 (ru) 2011-06-10
JP2014129407A (ja) 2014-07-10
IL190727A (en) 2015-05-31
US7795279B2 (en) 2010-09-14
KR101443651B1 (ko) 2014-09-23
CN101340909B (zh) 2012-01-11
CA2626623A1 (fr) 2007-04-26
ECSP088387A (es) 2008-05-30
CN101340909A (zh) 2009-01-07
WO2007048088A2 (fr) 2007-04-26
EA200801118A1 (ru) 2008-10-30
JP2009511628A (ja) 2009-03-19
AU2006304897A1 (en) 2007-04-26
IL190727A0 (en) 2008-12-29

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