EP0639364B1 - Poche dotee de chambres multiples - Google Patents

Poche dotee de chambres multiples Download PDF

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Publication number
EP0639364B1
EP0639364B1 EP93911945A EP93911945A EP0639364B1 EP 0639364 B1 EP0639364 B1 EP 0639364B1 EP 93911945 A EP93911945 A EP 93911945A EP 93911945 A EP93911945 A EP 93911945A EP 0639364 B1 EP0639364 B1 EP 0639364B1
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EP
European Patent Office
Prior art keywords
container
film
chambers
cover
portions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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EP93911945A
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German (de)
English (en)
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EP0639364A1 (fr
EP0639364A4 (fr
Inventor
Fujio Inoue
Masamitsu Izumi
Shigetoshi Kashiyama
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Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
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Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Publication of EP0639364A4 publication Critical patent/EP0639364A4/fr
Publication of EP0639364A1 publication Critical patent/EP0639364A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments
    • B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals

Definitions

  • the present invention relates to containers having a plurality of chambers chiefly for use in the field of medicine, and more particularly to flexible containers of plastics having a plurality of chambers for accommodating liquid preparations, powder preparations or solid preparations, and partition means dividing the container into the chambers and permitting communication between the chambers when required.
  • the desiccant which absorbs water from the liquid preparation, fails to fully dry up the hygroscopic medicinal and further causes concentration of the liquid preparation. Because of this drawback, it has not been practice to preserve the hygroscopic and unstable antibiotic or like medicinal and the liquid preparation as separately accommodated in the flexible container of plastics.
  • medicinals such as antibiotics
  • the medicinal is mixed or diluted with, or dissolved in, physiological saline, glucose solution or like dissolving liquid or diluent which is preserved separately.
  • Containers have therefore been developed which comprise a glass vial having enclosed therein an unstable antibiotic and a dissolving liquid-containing flexible container portion of plastics joined to the vial in combination therewith, with a piercing needle provided therebetween (see, for example, Unexamined Japanese Patent Publication HEI 2-1277).
  • These containers have the advantage that the contents can be mixed together with ease aseptically, whereas difficulties are encountered in discarding the container because a very complicated procedure is needed for separating the container into the glass vial, flexible container portion and piercing implement for disposal.
  • the container has a problem as the disposal of medical wastes which has attracted attention presently, i.e., the problem of failing to fulfill the requirement of easy disposal.
  • containers having a plurality of chambers for accommodating other medicinal which is readily oxidizable such as amino acid solution containing tryptophan, and a sugar or electrolytic solution
  • the container of this type must be preserved as placed in an expensive moisture- and gas-barrier outer bag together with an oxygen absorber.
  • the latter preparation sugar or electrolyte solution
  • the outer bag therefore requires a larger capacity, an oxygen absorber having an increased capacity to absorb oxygen or an increased amount of absorber, and a larger amount of moisture- and gas-barrier material, hence the drawback of an increased cost.
  • EP-A-263571 and EP-A-109983 do also disclose plastic containers having one or a plurality of chambers which are entirely covered with cover means exhibiting moisture- and gas-barrier properties.
  • non-prepublished European Patent Application EP-A-513364 discloses a plastic container having container portions which form a plurality of chambers, at least one container portion having no cover and at least one container portion having a cover, the cover being made of a flexible film having moisture- and gas-barrier properties and forming a closed space around the covered container portion, said closed space containing a desiccant and/or an oxygen absorber.
  • An object of the present invention is to provide a flexible container of plastics having a plurality of chambers and usable for accommodating and preserving liquid preparations, powder preparations or solid preparations which are hygroscopic or susceptible to oxidation.
  • Another object of the present invention is to provide such a container which can be prepared with use of a reduced amount of expensive moisture- and gas-barrier film and which is therefore inexpensive.
  • Still another object of the present invention is to provide a container of the type mentioned which need not include a glass vial and which is therefore easy to dispose of.
  • Another object of the present invention is to provide such a container wherein at least one of the chambers contains a liquid, powder or solid medicinal preparation which is hygroscopic or susceptible to oxidation, only this chamber being separated from outside moisture and oxygen and adapted to prevent the preparation from oxidation or absorbing moisture without enclosing any oxygen absorber nor desiccant therein.
  • the present invention provides a container having a plurality of chambers for accommodating a liquid, powder or solid preparation and partition means dividing the container into the chambers and permitting communication between the chambers when required, the container comprising a flexible body made of plastics and having container portions which form said plurality of chambers, at least one but not all of said chambers being enclosed within a cover made of a flexible film having moisture- and gas-barrier properties to form a closed space around said covered chamber(s), said closed space containing an inert gas and/or dry gas but not accommodating a desiccant and/or an oxygen absorber, the other chamber(s) being coverless.
  • the container is characterized in that it comprises a flexible plastics container body forming the plurality of chambers, at least one of the chambers being enclosed with a cover having a sealed periphery to form a closed space therein around the chamber, the other chamber or chambers being coverless, the cover being made of a flexible film having moisture- and gas-barrier properties, the partition means being formed by at least one weak seal portion easily openable by pressing the chamber to give an increased internal pressure.
  • a usual substance such as a liquid, powder or solid preparation which is not susceptible to oxidation or hygroscopic
  • This chamber is not enclosed with a moisture- and gas-impermeable cover and is therefore low in moisture- and gas-barrier properties, whereas the substance contained therein can be preserved for a long period of time as in common plastics containers since the substance is a usual one.
  • a special substance such as a liquid, powder or solid preparation which is susceptible to oxidation and/or hygroscopic, is accommodated in the chamber enclosed with the cover.
  • the container body forming the chamber is made of plastics, has moisture- and gas-permeability inherent to plastics although very slight and is low in moisture- and gas-barrier properties.
  • the cover enclosing the chamber is made of a special film which is impermeable to moisture and gas, so that the special substance can be preserved for a long period of time free of degradation despite the low moisture- and gas-barrier properties of the plastics container body.
  • the container of the present invention is usable free of any trouble for accommodating medicinals, such as antibiotics, which are hygroscopic and become unstable with time, and liquid preparations such as dissolving solutions or diluents.
  • the container of the present invention has the gas-impermeable cover of expensive special film, whereas the cover is provided on the container only locally and can therefore be formed with use of a small amount of the expensive special film. This serves to minimize the rise in the cost of packaging. A further cost reduction can be achieved since there is no need to enclose an oxygen absorber or desiccant in the cover around the container body.
  • the plurality of chambers of the container of the invention are separated by at least one weak seal portion, which can be opened by a pressure applied from outside to cause the chambers to communicate with each other.
  • Medicinal components can therefore be mixed together aseptically while being held out of contact with outside air.
  • the plastics container body and the cover constituting the container are both flexible and readily deformable, so that the container can be disposed of without the necessity of separation more easily than containers wherein glass or metal is used.
  • FIGS. 1 and 2 show an embodiment of the invention of the type having two weak seal portions.
  • FIG. 1 showing the embodiment, indicated at 1 is a flexible plastics container body which has a discharge port 2.
  • the plastics container body 1 is prepared from two superposed sheets of flexible plastics film 3 by heat seal the sheets together along the outer peripheral edges thereof.
  • the film 3 is not a special one but is an inexpensive plastics film which is generally used for making flexible plastics containers in the field of medicine.
  • FIG. 3 shows an example of film 3 comprising two layers, i.e., an outer layer 3a of polyethylene (hereinafter referred to simply as "PE”), and an inner layer 3b of a blend of PE and polypropylene (hereinafter referred to simply as "PP").
  • PE polyethylene
  • PP polypropylene
  • the plastics container body 1 has two weak seal portions 8a, 8b extending transversely of the container at an intermediate portion of its height and formed by heat sealing.
  • the weak seal portions 8a, 8b are so adapted that the opposed sheets of film can be separated from each other when required by utilizing the internal pressure of the container which is increased as by pressing the container.
  • the seal strength of the weak seal portions must be smaller than that of the peripheral edge portion of the container body 1.
  • the interior of the plastics container body 1 is divided into upper and lower two chambers 1a, 1b by the weak seal portions 8a, 8b.
  • the upper container portion 1A forming the upper chamber 1a is enclosed with a cover 5, while the lower container portion 1B forming the lower chamber 1b is not provided with such a cover 5.
  • the cover 5 is made of a special film 6 which is impermeable to moisture and gas.
  • FIG. 5 shows an example of special film 6, i.e., a multi-layer film comprising an outer layer 6a and an inner layer 6b of PE.
  • the outer layer 6a is an aluminum-covered film such as aluminum-laminated film, an aluminum-deposited film having high moisture- and gas-impermeability or a two-layer film composed of polyvinylidene chloride and polypropylene (PP).
  • the polyvinylidene chloride forming the outer layer 6a may be replaced by a silica-deposited film of polyvinyl alcohol.
  • the cover 5 comprises two sheets of special film 6 which are so arranged as to surround the upper container portion 1A.
  • the parts which are out of contact with the upper container portion 1A are heat sealed to each other, while the parts in contact with the portion 1A are heat sealed to the outer surface of the portion 1A as indicated at 6c, 6c.
  • the bonded lower edge portions 6c, 6c are positioned between the weak seal portions 8a, 8b.
  • FIG. 4 shows the heat sealed joint on an enlarged scale.
  • the lower edge portion 6c of the cover 5 is heat sealed to the space portion 9 between the seal portions 8a, 8b. This obviates the likelihood that the heat sealing operation will give an increased seal strength to the weak seal portions 8a, 8b.
  • the lower edge portion of the cover 5 is heat sealed to the container body 1 over the weak seal portion. Accordingly, it is desired to seal the edge portion under such a condition that the seal strength of the weak seal portion is prevented from increasing to the greatest possible extent, or the seal portion can be easily separated free of trouble even if the seal strength is increased.
  • Such a condition can be determined by suitably selecting the material for the cover and determining the heat sealing conditions as to temperature, time and pressure, whereas this involves considerable limitations.
  • the lower edge portion 6c of the cover 5 can be sealed to the container body 1 without adversely affecting the seal strength of the weak seal portions 8a, 8b. This leads to the advantage that the material for the cover 5 and the sealing conditions are selectable with greater freedom than in the case of the single seal portion.
  • the sealed joint of the lower edge portion 6c is positioned at a greater distance from the chambers 1a, 1b of the container body as will be apparent from FIG. 4. This eliminates the likelihood that the heat of the sealing operation will thermally degrade the medicinal preparations accommodated in the chambers 1a, 1b.
  • Medicinal preparations which are hygroscopic or susceptible to oxidation include many that are susceptible to thermal degradation, whereas the cover 5 lower edge portion can be heat sealed to the container body without the likelihood of thermally degrading such a preparation. Even if one of the two weak seal portions is opened, the other portion prevents the two chambers from communicating with each other.
  • a powder preparation 10 which is hygroscopic and/or susceptible to oxidation is accommodated within the covered upper container portion 1A, while a usual liquid preparation 11, for example, is accommodated within the coverless lower container portion 1B.
  • the temperature at which the seals are formed is the highest for the entire peripheral portion of the plastics container body 1 and the upper edge portion and side edge portions of the cover 5, less high for the lower edge portions of the cover 5 sealed to the container body 1, and lowest for the weak seal portions 8a, 8b. Consequently, the weak seal portions 8a, 8b are the lowest of all the seals in bond strength.
  • FIG. 6 shows a preferred example of process for producing the present container shown in FIGS. 1 and 2. The process will be described below with reference to FIG. 6, (a) to (e).
  • FIG. 6 First as shown in FIG. 6, (a), two sheets of plastics film shown in FIG. 3 are placed over each other so that the inner layers 3b, 3b are brought into contact with each other, and three sides of the assembly are heat-sealed at a temperature about 170 to about 200°C to make a plastics container body 1.
  • weak seal portions 8a, 8b are formed at an intermediate portion of the container body at a temperature about 110 to about 130°C, and a discharge port 2 is attached to the body. Consequently formed are an upper container portion 1A providing an upper chamber, and a lower container portion 1B separated from the portion 1A and providing a lower chamber.
  • a liquid preparation 11 is filled into the lower container portion 1B through the unsealed part thereof.
  • the unsealed parts of the two container portions 1A, 1B are sealed, followed by heating for sterilization with use of high-pressure steam, hot water or the like.
  • one side of the upper container portion 1A is then cut in an aseptic atmosphere as seen in FIG. 6, (c) to open this portion, which is thereafter dried when so required.
  • a cover 5 is provided over the upper container portion 1A using the special film shown in FIG. 5 and is heat-sealed on its three sides.
  • the lower edge portions 6c extending along the weak seal portions 8a, 8b are heat-sealed at a temperature about 130 to 135°C at an intermediate area between the two portions 8a, 8b to avoid heat-sealing of the lower edge portions as superimposed on the weak seal portions.
  • One side of the cover 5 corresponding to the open side of the upper container portion 1A is similarly left open.
  • FIG. 6 (e) shows the container thus obtained and having the two chambers.
  • the weak seal portions can be formed, for example, by pressing a heated seal forming die against the container body by a cylinder device.
  • the die can be of a structure having two ridges spaced apart by a predetermined distance and heatable to a controlled temperature by an electric heater.
  • a liquid preparation can be placed into the covered container portion 1A and a liquid or powder preparation into the coverless container portion 1B, for example, by a process similar to the foregoing exemplary process.
  • the container accommodating these preparations can be prepared by attaching a discharge port 2 to the container body, then placing the specified preparations into the respective container portions 1A, 1B, closing the filling openings, sterilizing the contents by autoclave, then attaching a cover 5 to the upper container portion 1A, and thereafter sealing the side opening of the cover.
  • the upper container portion 1A is formed by a plastics film comprising an outer layer of PE and an inner layer of blend of PE and PP, so that the container portion 1A permits passage of moisture and gas (e.g. oxygen) although in a very small amount.
  • the upper container portion 1A is provided with the cover 5 of special film having moisture- and gas-barrier properties, with the result that the cover 5 functions to overcome the above disadvantage of the upper container portion 1A. Accordingly, a powder preparation which is hygroscopic and/or susceptible to oxidation can be preserved for a long period of time as accommodated in the upper container portion 1A although this portion is formed by plastics.
  • the weak seal portions 8a, 8b separating the upper and lower container portions 1A, 1B are the lowest in seal strength of all the seals. Therefore, when the container portion is pressed to increase the internal pressure of the container portion, the increased pressure separates the weak seal portions 8a, 8b permitting the two container portions 1A, 1B to communicate with each other, whereby the liquid preparation and the powder preparation within the respective container portions 1A, 1B can be mixed together under an aseptic condition into a solution as contemplated.
  • powder preparations for use in the above embodiment are antibiotic, anti-cancer, steroid, antithrombotic, fibrinolytic, vitamin and like preparations which are hygroscopic and susceptible to oxidation and to thermal degradation.
  • useful liquid preparations are physiological saline, glucose solution and like dissolving solutions or diluents.
  • the usual film for making the plastics container body is a multi-layer film of the construction shown in FIG. 3, also usable is a single-layer or multi-layer film prepared from at least one combination of resins selected from among PE, PP and blends of these resins.
  • FIG. 7 shows as an example a three-layer film 35 which comprises an outer layer 31 of linear low-density polyethylene (hereinafter referred to briefly as "LLDPE"), an intermediate layer 33 of resin mixture of LLDPE and low-crystalline (or amorphous) ethylene/ ⁇ -olefin elastomer, and an inner layer 34 of resin mixture of LLDPE and PP.
  • LLDPE linear low-density polyethylene
  • the LLDPE to be used for the inner layer 34 is pretreated at a high temperature in a vacuum as by the devolatilization and stripping process to thereby reduce the content of low-molecular-weight substances with up to about 30 carbon atoms to not higher than a specified value, whereby the interaction between the medicinal preparation and the inner-layer can be prevented favorably.
  • containers can be formed with high stability to withstand sterilization at a high temperature of at least 121°C, for example, with use of high-pressure steam or hot water.
  • high-density polyethylene HDPE
  • a silica-deposited film is used to form at least a layer of the sheet because of its transparency and high impermeability to moisture and gas.
  • FIG. 8 shows a moisture- and gas-impermeable barrier film as an example of such film, i.e., a three-layer film 46 which comprises an outer layer 43 of biaxially oriented PET film, an intermediate layer 44 of silica-deposited PVA film and an inner layer 45 of low-density polyethylene (LDPE) and in which these layers are bonded to one another with a urethane adhesive resin.
  • a multi-layer film at least for the cover so that the material of the innermost layer of the cover is the same as the material of the outermost layer of the plastics container body, whereby a satisfactory heat seal can be formed.
  • LLDPE low-density polyethylene
  • a powder preparation is enclosed in the chamber of the covered container portion and a liquid in the chamber of the coverless container portion according to the foregoing embodiment, the powder preparation and the liquid preparation can be replaced by each other depending on the contemplated purpose.
  • a liquid preparation is accommodated in the covered container portion with a powder preparation enclosed in the other container portion, for example, in the case where the liquid preparation is an amino acid preparation or the like containing cysteine or tryptophan added thereto and susceptible to oxidation, and the powder preparation is a sugar, an electrolyte or a mixture thereof.
  • a liquid preparation is enclosed in the covered container portion with other liquid preparation in the other container portion, for example, in the case where the former liquid preparation is susceptible to oxidation, such as an amino acid preparation containing cysteine or tryptophan, or a vitamin preparation, and the latter liquid preparation is a sugar or electrolytic preparation.
  • the former liquid preparation is susceptible to oxidation, such as an amino acid preparation containing cysteine or tryptophan, or a vitamin preparation
  • the latter liquid preparation is a sugar or electrolytic preparation.
  • the former liquid preparation is a readily oxidizable fat emulsion or the like, and the latter preparation is a sugar or electrolytic preparation.
  • a solid preparation in one of the container portions and a liquid preparation in the other container portion.
  • Other examples of such powder, liquid and solid preparations are various nutrient preparations and curing agents which are given intravenously or enterally (tube or oral feeding).
  • Further cover may be made locally or entirely of an aluminum-covered film to shield the interior from light.
  • the aluminum-covered film used for the cover may be made peelable locally or entirely when the preparation is to be used, if so desired.
  • While the foregoing embodiment is a container having two chambers for accommodating a liquid preparation and one kind of powder preparation individually, such a container can be provided with more than two chambers, for example, as shown in FIG. 9.
  • Disposed inside the cover 5 is a container portion 1A' having chambers 1a 1 , 1a 2 for accommodating two kinds of powder preparations (or a powder preparation and a solid preparation).
  • a liquid preparation is accommodated in the coverless container portion 1B. It is possible to provide a plurality of chambers for liquid preparations besides powder or solid preparations. Weak seal portions are provided between these chambers.
  • an inert gas such as nitrogen gas, carbon dioxide gas or argon gas
  • an inert gas such as nitrogen gas, carbon dioxide gas or argon gas
  • the inert gas When a liquid, powder or solid preparation which is hygroscopic is enclosed in the chambers la, it is desired to enclose dry air, dry nitrogen gas or like dry gas in the space.
  • the inert gas When the inert gas is enclosed, the air in the space is replaced by the inert gas. This ensures a greater effect to prevent oxidation.
  • the dry gas is enclosed, the air in the space is replaced by the dry gas, which therefore assures an enhanced moistureproof effect.
  • the medicinal preparations contained in the container can be given high stability despite the lapse of time by the moisture- and gas-impermeable film covering the chamber or chambers which must be moisture-proof and free of oxidation, and further by enclosing the inert gas or dry gas in the space inside the cover around the container body, without placing an oxygen absorber and/or desiccant into the space unlike the conventional practice.
  • Two weak seal portions need not always be formed, but more than two seal portions or a single seal portion can be provided. Further the weak seal portion need not always be linear but can be V-shaped so as to project approximately toward the center of the covered chamber. When a pressure is applied to one chamber with hand in this case, the force acting to open the weak seal portion will concentrate on the V-shaped portion, with the result that the medicinal components can be mixed together by opening the weak seal portion with a relatively small pressure. In this case, however, there is a likelihood that separation will inadvertently occur in the seal portion during storage or transport of the container, so that it is desirable to carefully determine the heat-sealing condition.
  • the weak seal portion is formed by directly bonding together the inner layers of two sheets forming the container body.
  • the weak seal portion may be formed by heat seal the two sheets together with a multi-layer insert film held therebetween.
  • FIG. 10 shows a modification wherein two-layer insert film is used.
  • Indicated at 3 is a container forming film which is a single-layer or multi-layer film
  • at 18 is a sheet having a high heat seal strength on the innermost layer of the film 3 at one side
  • at 19 is a sheet having a low heat seal strength on the innermost layer of the film 3 on the other side.
  • the film portion 3 and the sheet 19 form a weak seal portions 21a, 21b.
  • the sheet 18 is made of the same material as the film 3, i.e., PE or PP, and the sheet 19 is made of a blend of PE and PP.
  • Two insert films can be used which are each provided for the two weak seal portions respectively.
  • the cover 5 may be heat-sealed in register with the weak seal portion provided that the weak seal portion is held weak, alternatively, the cover can be attached to the container body using an adhesive or the like.
  • the container of the invention is preferably stored or transported as folded in two at the weak seal portions 8a, 8b and as enclosed with an outer bag 50.
  • the seal portion is prevented from opening due to a pressure under the weight of superimposed containers or due to impact on falling.
  • the discharging port 2' may be formed at one end the chamber 1a' which contains a powder preparation 10 such as antibiotic.
  • the chamber 1b' containing a liquid such as a dissolving solution is closed. If a discharging port is formed at a chamber containing a liquid such as dissolving solution, there is a risk of inadvertently administering only the liquid without mixing with the powder preparation especially in an emergency. Such risk can be eliminated by forming the discharging port at the chamber containing the powder preparation such as antibiotic.
  • a discharge port hole 2a is formed in a two-layer plastics film 3 like the one shown in FIG. 3.
  • a discharge port 2 is attached by heat seal to the outer layer, i.e., the PE layer, of the film 3 in register with the hole 2a.
  • the film 3 is then folded in two along a line through the discharge port 2 as shown in FIG. 13, (c).
  • the two flaps of film 3 are heat sealed together at their peripheral portions at a temperature of about 170 to about 200°C except at filling openings 35, 36 for a medicinal preparation and powder preparation to obtain a plastic container body 1.
  • the filling opening 35 may be sealed and the filling opening 36 only may be left unsealed.
  • two parallel weak seal portions 8a, 8b are formed at an intermediate portion of the container body, with a space portion 9 provided therebetween, at a heat sealing temperature of about 110 to about 130°C.
  • the weak seal portion 8b is 10 mm and the weak seal portion 8a is about 5 mm in width.
  • upper and lower container portions 1A, 1B are formed as partitioned by the weak seal portions 8a, 8b.
  • the medicinal preparation 11 is subsequently filled into the lower container portion 1B through the opening 36, and the two filling openings 35, 36 are thereafter sealed off as seen in FIG. 13, (f), followed by sterilization with autoclave.
  • the sterilized body is externally dried, the portion of the opening 35 is cut in an aseptic atmosphere to open the opening 35 again, and clean air is applied to the interior of the upper container portion 1A through the opening 35 for drying and cleaning.
  • the powder preparation 10 is filled into the upper container portion 1A through the opening 35 under an aseptic condition, and the filling opening 35 is thereafter sealed off.
  • a cover 5 is provided to enclose the upper container portion 1A therewith using two sheets of special film 6 shown in FIG. 5.
  • one of the two film sheets is transparent, and the other sheet is nontransparent.
  • the joint 1A 1 (see FIG. 13, (h)) of the periphery of the upper container portion 1A, especially at opposite side portions thereof, needs to have a width greater than 5 mm. Usually this width is about 7 to about 10 mm in view of the sealing width of the film 6.
  • the lower edge portion 6c of the cover 5 is sealed at the position of the space portion 9 between the two weak seal portions 8a, 8b.
  • the sealing temperature is about 150 to about 170°C when the film 6 used is transparent, or 130 to 150°C when the film used is a nontransparent aluminum-covered film.
  • FIG. 13 (i) the cover 5 provided around the upper container portion 1A is initially partly open at one side thereof as indicated at 40.
  • An inert gas or dry gas is injected into the space 7 between the cover 5 and the upper container portion 1A through the opening 40, and the opening 40 is thereafter sealed off.
  • FIG. 13, (j) shows the container of the invention having the two chambers and two weak seal portions thus obtained.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Bag Frames (AREA)
  • Package Specialized In Special Use (AREA)
  • Catching Or Destruction (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Refuse Receptacles (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Table Equipment (AREA)
  • Packages (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)

Claims (11)

  1. Récipient comprenant une pluralité de chambres (1A,1B)pour recevoir une préparation liquide, en poudre ou solide (10,11) et des moyens de séparation divisant le récipient en lesdites chambres et permettant une communication entre les chambres lorsque c'est nécessaire, la poche comprenant un corps souple (1) enmatière plastique et ayant des parties de récipient qui définissent ladite pluralité de chambres (1A,1B), au moins une chambre (1A) mais non toutes lesdites chambres (1A,1B) étant enfermée à l'intérieur d'une enveloppe (5) fabriquée en un film souple (6) ayant des propriétés d'arrêt de l'humidité et des gaz de manière a définir un espace fermé (7) autour de la chambre ou des chambres enveloppées (1A), ledit espace fermé (7) contenant un gaz inerte et/ou un gaz sec mais ne contenant pas un produit dessicateur et/ou un produit d'absorption de l'oxygène, la ou les autres chambres (1B) étant sans enveloppe.
  2. Récipient selon la revendication 1,dans lequel les moyens de séparation sont constitués par au moins une partie de jonction faible (8a,8b) qui peut être facilement ouverte par compression de la chambre (1A,1B)pour engendrer une plus grande pression intérieure.
  3. Récipient selon la revendication 2, dans lequel au moins deux parties de jonction faible (8a,8b) sont prévues à un certain espacement (9), et l'enveloppe (5) comporte un bord thermosoudé (6c) entre les parties de jonction faible adjacentes.
  4. Récipient selon la revendication 1, dans lequel la chambre enveloppée (1A) contient une préparation liquide, en poudre ou solide (10,11) sensible a l'oxydation et/ou hygroscopique.
  5. Récipient selon la revendication 1, dans lequel la ou les parties de jonction faible (8a,8b) sont formées par thermosoudage direct mutuel des surfaces intérieures opposées d'un film de matière plastique souple (3) formant le corps de récipient (1).
  6. Récipient selon la revendication 1, dans lequel la ou les parties de jonction faible (8a,8b) sont formées par thermosoudage mutuel des surfaces intérieures opposées d'un film en matière plastique souple (3) formant le corps de récipient (1), avec un insert de film tenu entre les surfaces intérieures opposées.
  7. Récipient selon la revendication 1, dans lequel le corps de récipient (1) est formé d'un film en matière plastique (35) comprenant une couche extérieure (31) de polyéthylène linéaire basse densité, une couche intermédiaire (33) de mélange de résine de polyéthylène linéaire basse densité et d'élastomère de type éthylène /α-oléfine, et une couche intérieure (34) de mélange de résine de polyéthylène linéaire basse densité et de polypropylène.
  8. Récipient selon la revendication 1, dans lequel l'enveloppe (5) comprend une couche de film de résine à dépôt de silice.
  9. Récipient selon la revendication 1, dans lequel l'enveloppe (5) comprend une couche extérieure (43) de film de téréphtalate de polyéthylène biaxialement orienté, une couche intermédiaire (44) de film d'alcool polyvinylique à dépôt de silice et une couche intérieure (45) de polyéthylène basse densité.
  10. Récipient selon la revendication 1, dans lequel l'enveloppe (5) présente une surface extérieure cosntituée par un film à couche d'aluminium.
  11. Récipient selon la revendication 4, dans lequel la substance (10,11) sensible à l'oxydation et/ou hygroscopique est un antibiotique.
EP93911945A 1992-05-03 1993-04-28 Poche dotee de chambres multiples Expired - Lifetime EP0639364B1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP14011392 1992-05-03
JP14011392 1992-05-03
JP140113/92 1992-05-03
JP6466993A JP3079403B2 (ja) 1992-05-03 1993-02-28 複室容器
JP6466993 1993-02-28
JP64669/93 1993-02-28
PCT/JP1993/000558 WO1993021890A1 (fr) 1992-05-03 1993-04-28 Poche dotee de chambres multiples

Publications (3)

Publication Number Publication Date
EP0639364A4 EP0639364A4 (fr) 1994-10-24
EP0639364A1 EP0639364A1 (fr) 1995-02-22
EP0639364B1 true EP0639364B1 (fr) 1999-07-28

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EP93911945A Expired - Lifetime EP0639364B1 (fr) 1992-05-03 1993-04-28 Poche dotee de chambres multiples

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EP (1) EP0639364B1 (fr)
JP (1) JP3079403B2 (fr)
CN (1) CN1065742C (fr)
AT (1) ATE182464T1 (fr)
AU (1) AU654442B2 (fr)
CA (1) CA2112661C (fr)
DE (1) DE69325801T2 (fr)
DK (1) DK0639364T3 (fr)
EG (1) EG20103A (fr)
ES (1) ES2133399T3 (fr)
FI (1) FI107694B (fr)
GR (1) GR3031088T3 (fr)
HU (1) HU216406B (fr)
NO (1) NO303815B1 (fr)
PH (1) PH31343A (fr)
PL (1) PL172973B1 (fr)
PT (1) PT101262B (fr)
RU (1) RU2103987C1 (fr)
SG (1) SG44684A1 (fr)
TW (1) TW216768B (fr)
WO (1) WO1993021890A1 (fr)

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US7770611B2 (en) 1999-11-12 2010-08-10 Baxter International Inc. Peelable seal closure assembly
US8343129B2 (en) 2006-06-15 2013-01-01 Metpro Ab Container, system and method for providing a solution
US9004761B2 (en) 2006-05-01 2015-04-14 Baxter International Inc. Multiple chamber container with mistake proof administration system

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US7678097B1 (en) 1999-11-12 2010-03-16 Baxter International Inc. Containers and methods for manufacturing same
US7770611B2 (en) 1999-11-12 2010-08-10 Baxter International Inc. Peelable seal closure assembly
US9004761B2 (en) 2006-05-01 2015-04-14 Baxter International Inc. Multiple chamber container with mistake proof administration system
US8343129B2 (en) 2006-06-15 2013-01-01 Metpro Ab Container, system and method for providing a solution
US9254357B2 (en) 2006-06-15 2016-02-09 Metpro Ab Container, system and method for providing a solution

Also Published As

Publication number Publication date
HUT68420A (en) 1995-06-28
WO1993021890A1 (fr) 1993-11-11
RU2103987C1 (ru) 1998-02-10
JP3079403B2 (ja) 2000-08-21
JPH0614975A (ja) 1994-01-25
PL298768A1 (en) 1994-03-21
CN1082881A (zh) 1994-03-02
PT101262B (pt) 1999-10-29
EG20103A (en) 1997-07-31
ATE182464T1 (de) 1999-08-15
HU216406B (hu) 1999-06-28
PH31343A (en) 1998-07-17
AU4270993A (en) 1993-11-29
SG44684A1 (en) 1997-12-19
EP0639364A1 (fr) 1995-02-22
CA2112661A1 (fr) 1993-11-11
NO934910D0 (no) 1993-12-30
GR3031088T3 (en) 1999-12-31
CN1065742C (zh) 2001-05-16
ES2133399T3 (es) 1999-09-16
PL172973B1 (pl) 1997-12-31
NO934910L (no) 1994-01-26
PT101262A (pt) 1994-06-30
DK0639364T3 (da) 1999-11-29
FI935972A (fi) 1994-02-24
FI107694B (fi) 2001-09-28
DE69325801T2 (de) 1999-11-18
NO303815B1 (no) 1998-09-07
TW216768B (en) 1993-12-01
FI935972A0 (fi) 1993-12-31
EP0639364A4 (fr) 1994-10-24
HU9400012D0 (en) 1994-05-30
CA2112661C (fr) 2002-02-26
AU654442B2 (en) 1994-11-03
DE69325801D1 (de) 1999-09-02

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