EE05723B1 - Stabiilse koostisega ravimkoostis, mis sisaldab amlodipiini ja bisoprolooli, ning meetod selle valmistamiseks - Google Patents

Stabiilse koostisega ravimkoostis, mis sisaldab amlodipiini ja bisoprolooli, ning meetod selle valmistamiseks

Info

Publication number
EE05723B1
EE05723B1 EEP201100029A EEP201100029A EE05723B1 EE 05723 B1 EE05723 B1 EE 05723B1 EE P201100029 A EEP201100029 A EE P201100029A EE P201100029 A EEP201100029 A EE P201100029A EE 05723 B1 EE05723 B1 EE 05723B1
Authority
EE
Estonia
Prior art keywords
pharmaceutical composition
bisoprolol
amlodipine
preparation
combination pharmaceutical
Prior art date
Application number
EEP201100029A
Other languages
English (en)
Inventor
László Wagner
Zsolt Zsigmond
György Ujfalussy
Huszár Magdolna Leventiszné
Péter Tonka-Nagy
Erzsébet Bárczay
Lászlóné Góra
Edit Szeleczki
Ágnes Fülöp
Original Assignee
EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság filed Critical EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság
Publication of EE201100029A publication Critical patent/EE201100029A/et
Publication of EE05723B1 publication Critical patent/EE05723B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Packages (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Stabiilne tahke ravimkoostis sisaldab amlodipiinalust või selle farmatseutiliselt aktsepteeritavat soola, bisoproloolfumaraati ning farmatseutiliselt aktsepteeritavaid ekstsipiente. Ravimkoostis on pakendatud niiskuskindlasse pakendisse ja sisaldab aktiivainete massi alusel vähem kui 0,5% ühendit valemiga 3, milles amlodipiinalus või selle farmatseutiliselt aktsepteeritav sool ja bisoproloolfumaraat ei ole koostises eraldatud.
EEP201100029A 2008-09-30 2009-09-30 Stabiilse koostisega ravimkoostis, mis sisaldab amlodipiini ja bisoprolooli, ning meetod selle valmistamiseks EE05723B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0800591A HU230877B1 (hu) 2008-09-30 2008-09-30 Stabil kombinációs gyógyszerkészítmény
PCT/HU2009/000085 WO2010038091A2 (en) 2008-09-30 2009-09-30 Stable combination pharmaceutical composition

Publications (2)

Publication Number Publication Date
EE201100029A EE201100029A (et) 2011-06-15
EE05723B1 true EE05723B1 (et) 2014-10-15

Family

ID=89988527

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP201100029A EE05723B1 (et) 2008-09-30 2009-09-30 Stabiilse koostisega ravimkoostis, mis sisaldab amlodipiini ja bisoprolooli, ning meetod selle valmistamiseks

Country Status (31)

Country Link
EP (2) EP2359815B1 (et)
KR (1) KR101772619B1 (et)
CN (1) CN102164585B (et)
AT (2) AT510866A3 (et)
BG (1) BG66274B1 (et)
CH (1) CH702345B1 (et)
CY (1) CY1122084T1 (et)
CZ (2) CZ30825U1 (et)
DE (1) DE202009019152U1 (et)
DK (1) DK2344141T3 (et)
EA (2) EA026238B9 (et)
EE (1) EE05723B1 (et)
ES (2) ES2739900T3 (et)
GE (1) GEP20135859B (et)
HK (1) HK1155976A1 (et)
HR (3) HRP20110162B1 (et)
HU (3) HU230877B1 (et)
LT (3) LT2344141T (et)
ME (1) ME03774B (et)
MX (1) MX2011003407A (et)
MY (1) MY175270A (et)
PL (3) PL2359815T3 (et)
PT (3) PT2359815T (et)
RO (1) RO127490B1 (et)
RS (3) RS60784B1 (et)
RU (2) RU2549437C2 (et)
SG (1) SG194392A1 (et)
SI (2) SI2344141T1 (et)
SK (2) SK288593B6 (et)
UA (1) UA101407C2 (et)
WO (1) WO2010038091A2 (et)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230877B1 (hu) 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény
CN101766611B (zh) * 2010-02-09 2011-10-12 施慧达药业集团(吉林)有限公司 一种左旋氨氯地平或其可药用盐和β受体阻滞剂的药物组合物及其应用
US20150094345A1 (en) 2012-02-17 2015-04-02 Egis Gyogyszergyar Zrt. Pharmaceutical formulation having improved stability
CN114404414A (zh) * 2013-06-13 2022-04-29 阿克比治疗有限公司 用于治疗贫血症的组合物和方法
HUP1300496A2 (hu) 2013-08-16 2015-03-02 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Stabil kombinációs gyógyszerkészítmény
FR3027803B1 (fr) * 2014-11-05 2018-02-09 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant et un inhibiteur de l'enzyme de conversion
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
WO2024052498A1 (en) 2022-09-07 2024-03-14 Kinast Lasse An immediate-release oral pharmaceutical form of amlodipine with increased api content
CN116687926B (zh) * 2023-07-27 2023-12-12 石家庄四药有限公司 一种比索洛尔氨氯地平复方片剂及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
AT5874U1 (de) * 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
EP1309556B1 (en) 2000-12-29 2004-11-24 Pfizer Limited Amlodipine fumarate
AU2001100431A4 (en) * 2001-10-03 2001-11-01 Pfizer Limited Pharmaceutical compositions comprising amlodipine maleate
WO2003032954A1 (en) 2001-10-17 2003-04-24 Dr. Reddy's Laboratories Ltd. Stabilized pharmaceutical formulations containing amlodipine maleate
WO2004075825A2 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Dosage forms of amlodipine and processes for their preparation
WO2005051350A2 (en) * 2003-10-28 2005-06-09 Torrent Pharmaceuticals Limited Water dispersible tablet
WO2005099699A1 (en) * 2004-04-07 2005-10-27 Sepracor Inc. Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension
IN224215B (et) * 2004-08-05 2009-02-06
WO2006059217A1 (en) * 2004-12-01 2006-06-08 Ranbaxy Laboratories Limited Stable solid dosage forms of amlodipine besylate and processes for their preparation
CZ2005141A3 (cs) * 2005-03-07 2006-04-12 Lunaria, Spol. S. R. O. Lécivý prípravek na bázi amlodipin-besilátu se zvýsenou stabilitou
IES20070122A2 (en) * 2006-12-05 2008-05-28 Michael Hilary Burke A process for the preparation of an orally administered unit dose tablet
HU230877B1 (hu) 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény

Also Published As

Publication number Publication date
CZ308237B6 (cs) 2020-03-18
EA026238B9 (ru) 2017-05-31
EP2359815A1 (en) 2011-08-24
RS60686B1 (sr) 2020-09-30
PT2344141T (pt) 2019-08-06
MY175270A (en) 2020-06-17
HUE045326T2 (hu) 2019-12-30
EA026238B1 (ru) 2017-03-31
WO2010038091A3 (en) 2010-09-23
PT2010038091Y (pt) 2020-02-10
EP2359815B1 (en) 2020-01-08
HU230877B1 (hu) 2018-11-29
EP2344141B1 (en) 2019-05-01
ME03774B (me) 2021-04-20
HUE049948T2 (hu) 2020-11-30
RS60784B1 (sr) 2020-10-30
LT5815B (lt) 2012-02-27
HU0800591D0 (en) 2008-11-28
SK7997Y1 (sk) 2018-02-05
HRP20110162A2 (hr) 2011-06-30
GEP20135859B (en) 2013-06-25
RO127490A2 (ro) 2012-06-29
AT510866A3 (de) 2014-06-15
ES2385988B2 (es) 2013-12-11
RU2687282C2 (ru) 2019-05-13
EA038392B1 (ru) 2021-08-20
RU2549437C2 (ru) 2015-04-27
AT14769U1 (de) 2016-05-15
LT2011012A (lt) 2011-10-25
EP2344141A2 (en) 2011-07-20
AT510866A2 (de) 2012-07-15
DK2344141T3 (da) 2019-08-05
CN102164585A (zh) 2011-08-24
EA201100430A1 (ru) 2011-10-31
RU2014139476A (ru) 2015-06-20
SK50232011A3 (sk) 2011-08-04
DE202009019152U1 (de) 2017-03-06
KR101772619B1 (ko) 2017-08-29
HRP20110162A8 (hr) 2019-03-22
CZ30825U1 (cs) 2017-07-11
HUP0800591A2 (en) 2010-10-28
LT2359815T (lt) 2020-04-27
CY1122084T1 (el) 2020-11-25
EA201691869A1 (ru) 2017-04-28
KR20110063563A (ko) 2011-06-10
SK288593B6 (sk) 2018-09-03
EE201100029A (et) 2011-06-15
RS59201B1 (sr) 2019-10-31
RO127490B1 (ro) 2022-01-28
UA101407C2 (ru) 2013-03-25
BG66274B1 (bg) 2012-12-28
BG110927A (bg) 2011-09-30
WO2010038091A2 (en) 2010-04-08
LT2344141T (lt) 2019-08-26
PL394605A1 (pl) 2011-09-26
HRP20110162B1 (hr) 2019-09-20
PL2359815T3 (pl) 2020-11-30
PL2344141T3 (pl) 2019-10-31
RU2011112047A (ru) 2012-11-10
WO2010038091A9 (en) 2011-04-07
SK72017U1 (sk) 2017-08-02
HK1155976A1 (zh) 2012-06-01
MX2011003407A (es) 2011-06-20
HRP20200614T1 (hr) 2020-10-02
ES2739900T3 (es) 2020-02-04
ES2385988A1 (es) 2012-08-06
RS20110136A1 (en) 2012-08-31
SG194392A1 (en) 2013-11-29
SI2344141T1 (sl) 2019-09-30
HRP20191373T1 (hr) 2019-11-01
CZ2011252A3 (cs) 2011-07-07
PT2359815T (pt) 2020-04-16
SI2359815T1 (sl) 2020-10-30
CH702345B1 (de) 2014-05-15
CN102164585B (zh) 2016-04-27

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