AT510866A3 - Stabiles pharmazeutisches kombinationspräparat - Google Patents
Stabiles pharmazeutisches kombinationspräparat Download PDFInfo
- Publication number
- AT510866A3 AT510866A3 ATA9359/2009A AT93592009A AT510866A3 AT 510866 A3 AT510866 A3 AT 510866A3 AT 93592009 A AT93592009 A AT 93592009A AT 510866 A3 AT510866 A3 AT 510866A3
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical combination
- combination preparation
- stable pharmaceutical
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 abstract 1
- 229960000528 amlodipine Drugs 0.000 abstract 1
- VHYCDWMUTMEGQY-UHFFFAOYSA-N bisoprolol Chemical compound CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 VHYCDWMUTMEGQY-UHFFFAOYSA-N 0.000 abstract 1
- 229960002781 bisoprolol Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Packages (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Stabile, feste pharmazeutische Zusammensetzung enthaltendAmlodipin oder pharmazeutisch annehmbare Salze davon undBisoprolol oder pharmazeutisch annehmbare Salze davon sowiepharmazeutisch annehmbare Hilfsstoffe, verpackt in einerfeuchtigkeitsbeständigen Verpackung, und die weiters wenigerals 0,5% der Verbindung gemäß Formel (3), bezogen auf dasGewicht der Wirkstoffe, umfasst.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ATGM8014/2015U AT14769U1 (de) | 2008-09-30 | 2009-09-30 | Stabiles pharmazeutisches Kombinationspräparat |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0800591A HU230877B1 (hu) | 2008-09-30 | 2008-09-30 | Stabil kombinációs gyógyszerkészítmény |
PCT/HU2009/000085 WO2010038091A2 (en) | 2008-09-30 | 2009-09-30 | Stable combination pharmaceutical composition |
Publications (2)
Publication Number | Publication Date |
---|---|
AT510866A2 AT510866A2 (de) | 2012-07-15 |
AT510866A3 true AT510866A3 (de) | 2014-06-15 |
Family
ID=89988527
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ATA9359/2009A AT510866A3 (de) | 2008-09-30 | 2009-09-30 | Stabiles pharmazeutisches kombinationspräparat |
ATGM8014/2015U AT14769U1 (de) | 2008-09-30 | 2009-09-30 | Stabiles pharmazeutisches Kombinationspräparat |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ATGM8014/2015U AT14769U1 (de) | 2008-09-30 | 2009-09-30 | Stabiles pharmazeutisches Kombinationspräparat |
Country Status (31)
Country | Link |
---|---|
EP (2) | EP2359815B1 (de) |
KR (1) | KR101772619B1 (de) |
CN (1) | CN102164585B (de) |
AT (2) | AT510866A3 (de) |
BG (1) | BG66274B1 (de) |
CH (1) | CH702345B1 (de) |
CY (1) | CY1122084T1 (de) |
CZ (2) | CZ30825U1 (de) |
DE (1) | DE202009019152U1 (de) |
DK (1) | DK2344141T3 (de) |
EA (2) | EA026238B9 (de) |
EE (1) | EE05723B1 (de) |
ES (2) | ES2385988B2 (de) |
GE (1) | GEP20135859B (de) |
HK (1) | HK1155976A1 (de) |
HR (3) | HRP20110162B1 (de) |
HU (3) | HU230877B1 (de) |
LT (3) | LT2359815T (de) |
ME (1) | ME03774B (de) |
MX (1) | MX2011003407A (de) |
MY (1) | MY175270A (de) |
PL (3) | PL2344141T3 (de) |
PT (3) | PT2359815T (de) |
RO (1) | RO127490B1 (de) |
RS (3) | RS60686B1 (de) |
RU (2) | RU2549437C2 (de) |
SG (1) | SG194392A1 (de) |
SI (2) | SI2344141T1 (de) |
SK (2) | SK288593B6 (de) |
UA (1) | UA101407C2 (de) |
WO (1) | WO2010038091A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU230877B1 (hu) | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stabil kombinációs gyógyszerkészítmény |
CN101766611B (zh) * | 2010-02-09 | 2011-10-12 | 施慧达药业集团(吉林)有限公司 | 一种左旋氨氯地平或其可药用盐和β受体阻滞剂的药物组合物及其应用 |
CN104254321A (zh) | 2012-02-17 | 2014-12-31 | 埃吉斯药物私人有限公司 | 稳定性提高的药物制剂 |
CN114404414A (zh) * | 2013-06-13 | 2022-04-29 | 阿克比治疗有限公司 | 用于治疗贫血症的组合物和方法 |
HUP1300496A2 (hu) | 2013-08-16 | 2015-03-02 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Stabil kombinációs gyógyszerkészítmény |
FR3027803B1 (fr) * | 2014-11-05 | 2018-02-09 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant et un inhibiteur de l'enzyme de conversion |
FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
WO2024052498A1 (en) | 2022-09-07 | 2024-03-14 | Kinast Lasse | An immediate-release oral pharmaceutical form of amlodipine with increased api content |
CN116687926B (zh) * | 2023-07-27 | 2023-12-12 | 石家庄四药有限公司 | 一种比索洛尔氨氯地平复方片剂及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005099699A1 (en) * | 2004-04-07 | 2005-10-27 | Sepracor Inc. | Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension |
IN224215B (de) * | 2004-08-05 | 2009-02-06 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU221810B1 (hu) * | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
GB0001621D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
WO2002053538A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine fumarate |
AT5874U1 (de) * | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
AU2001100431A4 (en) * | 2001-10-03 | 2001-11-01 | Pfizer Limited | Pharmaceutical compositions comprising amlodipine maleate |
WO2003032954A1 (en) | 2001-10-17 | 2003-04-24 | Dr. Reddy's Laboratories Ltd. | Stabilized pharmaceutical formulations containing amlodipine maleate |
WO2004075825A2 (en) * | 2003-02-28 | 2004-09-10 | Ranbaxy Laboratories Limited | Dosage forms of amlodipine and processes for their preparation |
WO2005051350A2 (en) * | 2003-10-28 | 2005-06-09 | Torrent Pharmaceuticals Limited | Water dispersible tablet |
WO2006059217A1 (en) * | 2004-12-01 | 2006-06-08 | Ranbaxy Laboratories Limited | Stable solid dosage forms of amlodipine besylate and processes for their preparation |
CZ2005141A3 (cs) * | 2005-03-07 | 2006-04-12 | Lunaria, Spol. S. R. O. | Lécivý prípravek na bázi amlodipin-besilátu se zvýsenou stabilitou |
IES20070122A2 (en) * | 2006-12-05 | 2008-05-28 | Michael Hilary Burke | A process for the preparation of an orally administered unit dose tablet |
HU230877B1 (hu) | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stabil kombinációs gyógyszerkészítmény |
-
2008
- 2008-09-30 HU HU0800591A patent/HU230877B1/hu unknown
-
2009
- 2009-09-30 HU HUE11003486A patent/HUE049948T2/hu unknown
- 2009-09-30 LT LTEP11003486.5T patent/LT2359815T/lt unknown
- 2009-09-30 CZ CZ2017-33281U patent/CZ30825U1/cs not_active IP Right Cessation
- 2009-09-30 WO PCT/HU2009/000085 patent/WO2010038091A2/en active Application Filing
- 2009-09-30 CH CH00567/11A patent/CH702345B1/de unknown
- 2009-09-30 EP EP11003486.5A patent/EP2359815B1/de active Active
- 2009-09-30 MY MYPI2011001388A patent/MY175270A/en unknown
- 2009-09-30 UA UAA201105446A patent/UA101407C2/ru unknown
- 2009-09-30 KR KR1020117009405A patent/KR101772619B1/ko active IP Right Grant
- 2009-09-30 RS RS20110136A patent/RS60686B1/sr unknown
- 2009-09-30 DE DE202009019152.4U patent/DE202009019152U1/de not_active Expired - Lifetime
- 2009-09-30 MX MX2011003407A patent/MX2011003407A/es not_active Application Discontinuation
- 2009-09-30 EE EEP201100029A patent/EE05723B1/et unknown
- 2009-09-30 EP EP09748467.9A patent/EP2344141B1/de not_active Revoked
- 2009-09-30 CZ CZ2011-252A patent/CZ308237B6/cs unknown
- 2009-09-30 RS RSP20190990 patent/RS59201B1/sr unknown
- 2009-09-30 RU RU2011112047/15A patent/RU2549437C2/ru active
- 2009-09-30 SI SI200931990T patent/SI2344141T1/sl unknown
- 2009-09-30 SI SI200932053T patent/SI2359815T1/sl unknown
- 2009-09-30 CN CN200980138060.7A patent/CN102164585B/zh active Active
- 2009-09-30 EA EA201100430A patent/EA026238B9/ru not_active IP Right Cessation
- 2009-09-30 SK SK5023-2011A patent/SK288593B6/sk unknown
- 2009-09-30 GE GEAP200912210A patent/GEP20135859B/en unknown
- 2009-09-30 PT PT110034865T patent/PT2359815T/pt unknown
- 2009-09-30 PT PT09748467T patent/PT2344141T/pt unknown
- 2009-09-30 PT PT2009000085A patent/PT2010038091Y/pt active IP Right Grant
- 2009-09-30 RU RU2014139476A patent/RU2687282C2/ru active
- 2009-09-30 PL PL09748467T patent/PL2344141T3/pl unknown
- 2009-09-30 EA EA201691869A patent/EA038392B1/ru unknown
- 2009-09-30 PL PL394605A patent/PL394605A1/pl unknown
- 2009-09-30 LT LTEP09748467.9T patent/LT2344141T/lt unknown
- 2009-09-30 DK DK09748467.9T patent/DK2344141T3/da active
- 2009-09-30 ES ES201190015A patent/ES2385988B2/es active Active
- 2009-09-30 AT ATA9359/2009A patent/AT510866A3/de active IP Right Grant
- 2009-09-30 RS RS20200397A patent/RS60784B1/sr unknown
- 2009-09-30 PL PL11003486T patent/PL2359815T3/pl unknown
- 2009-09-30 ME MEP-2020-76A patent/ME03774B/de unknown
- 2009-09-30 RO RO201100274A patent/RO127490B1/ro unknown
- 2009-09-30 ES ES09748467T patent/ES2739900T3/es active Active
- 2009-09-30 AT ATGM8014/2015U patent/AT14769U1/de not_active IP Right Cessation
- 2009-09-30 SG SG2013073382A patent/SG194392A1/en unknown
- 2009-09-30 SK SK7-2017U patent/SK7997Y1/sk unknown
- 2009-09-30 HU HUE09748467A patent/HUE045326T2/hu unknown
-
2011
- 2011-02-24 LT LT2011012A patent/LT5815B/lt unknown
- 2011-03-04 HR HRP20110162AA patent/HRP20110162B1/hr active IP Right Grant
- 2011-04-29 BG BG10110927A patent/BG66274B1/bg unknown
- 2011-10-03 HK HK11110411.7A patent/HK1155976A1/zh unknown
-
2019
- 2019-07-30 CY CY20191100810T patent/CY1122084T1/el unknown
- 2019-07-31 HR HRP20191373 patent/HRP20191373T1/hr unknown
-
2020
- 2020-04-08 HR HRP20200614TT patent/HRP20200614T1/hr unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005099699A1 (en) * | 2004-04-07 | 2005-10-27 | Sepracor Inc. | Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension |
IN224215B (de) * | 2004-08-05 | 2009-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UW | Change of intellectual property right |
Effective date: 20160515 |