EA201490050A1 - Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток - Google Patents

Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток

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Publication number
EA201490050A1
EA201490050A1 EA201490050A EA201490050A EA201490050A1 EA 201490050 A1 EA201490050 A1 EA 201490050A1 EA 201490050 A EA201490050 A EA 201490050A EA 201490050 A EA201490050 A EA 201490050A EA 201490050 A1 EA201490050 A1 EA 201490050A1
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EA
Eurasian Patent Office
Prior art keywords
bioenergy
compositions
methods
women
increasing
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EA201490050A
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English (en)
Inventor
Джонэсэн Ли Тилли
Дэвид А. Синклер
Original Assignee
Зе Дженерэл Хоспитэл Корпорейшн
Президент Энд Феллоус Оф Харвард Колледж
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Publication of EA201490050A1 publication Critical patent/EA201490050A1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer

Abstract

Описаны композиции и способы, предусматривающие биоэнергетические средства для восстановления качества старых ооцитов, улучшения стволовых клеток оогониев или улучшения их производных (например, цитоплазмы или выделенных митохондрий) для применения в методиках улучшения фертильности.
EA201490050A 2011-06-29 2012-04-13 Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток EA201490050A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161502840P 2011-06-29 2011-06-29
US201261600529P 2012-02-17 2012-02-17
PCT/US2012/033672 WO2013002880A1 (en) 2011-06-29 2012-04-13 Compositions and methods for enhancing bioenergetic status in female germ cells

Publications (1)

Publication Number Publication Date
EA201490050A1 true EA201490050A1 (ru) 2014-07-30

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EA201490050A EA201490050A1 (ru) 2011-06-29 2012-04-13 Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток

Country Status (13)

Country Link
US (4) US9845482B2 (ru)
EP (2) EP2726601B1 (ru)
JP (3) JP6284475B2 (ru)
CN (1) CN103827293A (ru)
AU (2) AU2012276038B2 (ru)
BR (1) BR112013033797A2 (ru)
CA (1) CA2847292A1 (ru)
EA (1) EA201490050A1 (ru)
IL (2) IL230212B (ru)
MX (1) MX356815B (ru)
UA (1) UA117448C2 (ru)
WO (1) WO2013002880A1 (ru)
ZA (1) ZA201309707B (ru)

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