UA117448C2 - Середовище клітинної культури для культивування ооцита - Google Patents

Середовище клітинної культури для культивування ооцита

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UA117448C2
UA117448C2 UAA201400826A UAA201400826A UA117448C2 UA 117448 C2 UA117448 C2 UA 117448C2 UA A201400826 A UAA201400826 A UA A201400826A UA A201400826 A UAA201400826 A UA A201400826A UA 117448 C2 UA117448 C2 UA 117448C2
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osc
oocyte
inhibitor
stem cell
nad
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UAA201400826A
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English (en)
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Джонатан Лі Тіллі
Девід А. Сінклер
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Зе Дженерел Хоспітел Корпорейшн
Президент Енд Феллоус Оф Харвард Колледж
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Publication of UA117448C2 publication Critical patent/UA117448C2/uk

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Винахід стосується середовища клітинної культури для культивування ооцита, стовбурової клітини оогоніїв (OSC), потомка OSC або передімплантаційної зіготи, де зазначена OSC, одержана з оваріальної тканини, являє собою виділену стовбурову клітину, що не є ембріональною та є мітотично компетентною і експресує Vasa, Oct-4, Dazl i Stella, де зазначене середовище клітинної культури містить інгібітор CD38 та попередник нікотинамідаденіндинуклеотиду (NAD), де зазначений інгібітор CD38 являє собою сполуку, вибрану з групи, що складається з апігеніну, лютеоліну, тирфостину-8, берберину і SRT-1720, та де зазначені інгібітор CD38 і попередник NAD присутні у зазначеному середовищі у кількості, ефективній для покращення біоенергетичного стану зазначених ооцита, OSC, потомка OSC або передімплантаційної зиготи, культивованих у зазначеному середовищі. Винахід також стосується композиції, що містить виділений ооцит, стовбурову клітину оогоніїв (OSC), потомок OSC або препарат мітохондрій, та зазначені інгібітор CD38 і попередник NAD; способу культивування ооцита та способу одержання ооцита для застосування у заплідненні in vitro.
UAA201400826A 2011-06-29 2012-04-13 Середовище клітинної культури для культивування ооцита UA117448C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161502840P 2011-06-29 2011-06-29
US201261600529P 2012-02-17 2012-02-17
PCT/US2012/033672 WO2013002880A1 (en) 2011-06-29 2012-04-13 Compositions and methods for enhancing bioenergetic status in female germ cells

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UA117448C2 true UA117448C2 (uk) 2018-08-10

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US (4) US9845482B2 (uk)
EP (2) EP3495470A1 (uk)
JP (3) JP6284475B2 (uk)
CN (1) CN103827293A (uk)
AU (2) AU2012276038B2 (uk)
BR (1) BR112013033797A2 (uk)
CA (1) CA2847292A1 (uk)
EA (1) EA201490050A1 (uk)
IL (2) IL230212B (uk)
MX (1) MX356815B (uk)
UA (1) UA117448C2 (uk)
WO (1) WO2013002880A1 (uk)
ZA (1) ZA201309707B (uk)

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