BR112013033797A2 - composição, célula isolada, mitocôndria isolada , métodos de preparo de um oócito, de fertilização in vitro, de melhora de fertilidade em um indivíduo, de sustentação de desenvolvimento embrionário, de recuperação ou aumento de função ovariana em um indivíduo, de preparo de um tecido ou célula do mesmo, e de produção de um oócito, oócito, e, agente bioenergético - Google Patents

composição, célula isolada, mitocôndria isolada , métodos de preparo de um oócito, de fertilização in vitro, de melhora de fertilidade em um indivíduo, de sustentação de desenvolvimento embrionário, de recuperação ou aumento de função ovariana em um indivíduo, de preparo de um tecido ou célula do mesmo, e de produção de um oócito, oócito, e, agente bioenergético

Info

Publication number
BR112013033797A2
BR112013033797A2 BR112013033797A BR112013033797A BR112013033797A2 BR 112013033797 A2 BR112013033797 A2 BR 112013033797A2 BR 112013033797 A BR112013033797 A BR 112013033797A BR 112013033797 A BR112013033797 A BR 112013033797A BR 112013033797 A2 BR112013033797 A2 BR 112013033797A2
Authority
BR
Brazil
Prior art keywords
oocyte
preparing
individual
cell
isolated
Prior art date
Application number
BR112013033797A
Other languages
English (en)
Inventor
A Sinclair David
Lee Tilly Jonathan
Original Assignee
Harvard College
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Massachusetts Gen Hospital filed Critical Harvard College
Publication of BR112013033797A2 publication Critical patent/BR112013033797A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0609—Oocytes, oogonia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
BR112013033797A 2011-06-29 2012-04-13 composição, célula isolada, mitocôndria isolada , métodos de preparo de um oócito, de fertilização in vitro, de melhora de fertilidade em um indivíduo, de sustentação de desenvolvimento embrionário, de recuperação ou aumento de função ovariana em um indivíduo, de preparo de um tecido ou célula do mesmo, e de produção de um oócito, oócito, e, agente bioenergético BR112013033797A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161502840P 2011-06-29 2011-06-29
US201261600529P 2012-02-17 2012-02-17
PCT/US2012/033672 WO2013002880A1 (en) 2011-06-29 2012-04-13 Compositions and methods for enhancing bioenergetic status in female germ cells

Publications (1)

Publication Number Publication Date
BR112013033797A2 true BR112013033797A2 (pt) 2017-02-14

Family

ID=47424472

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013033797A BR112013033797A2 (pt) 2011-06-29 2012-04-13 composição, célula isolada, mitocôndria isolada , métodos de preparo de um oócito, de fertilização in vitro, de melhora de fertilidade em um indivíduo, de sustentação de desenvolvimento embrionário, de recuperação ou aumento de função ovariana em um indivíduo, de preparo de um tecido ou célula do mesmo, e de produção de um oócito, oócito, e, agente bioenergético

Country Status (13)

Country Link
US (4) US9845482B2 (pt)
EP (2) EP2726601B1 (pt)
JP (3) JP6284475B2 (pt)
CN (1) CN103827293A (pt)
AU (2) AU2012276038B2 (pt)
BR (1) BR112013033797A2 (pt)
CA (1) CA2847292A1 (pt)
EA (1) EA201490050A1 (pt)
IL (2) IL230212B (pt)
MX (1) MX356815B (pt)
UA (1) UA117448C2 (pt)
WO (1) WO2013002880A1 (pt)
ZA (1) ZA201309707B (pt)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955846B2 (en) 2004-05-17 2011-06-07 The General Hospital Corporation Compositions comprising female germline stem cells and methods of use thereof
AP2013007229A0 (en) * 2011-04-14 2013-11-30 Gen Hospital Corp Compositions and methods for autologous germline mitochondrial energy transfer
WO2013035101A1 (en) 2011-09-11 2013-03-14 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
US10702556B2 (en) 2012-05-16 2020-07-07 Minovia Therpautices Ltd. Compositions and methods for inducing angiogenesis
WO2014146044A1 (en) 2013-03-15 2014-09-18 Washington University Administration of nicotinamide mononucleotide in the treatment of disease
WO2015089656A1 (en) * 2013-12-20 2015-06-25 Fertilify Inc. Compositions comprising vitamin c, vitamin e, and coenzyme q10 and use thereof for promoting female fertility and reproductive health
CN104188966B (zh) * 2014-07-14 2017-12-12 吴效科 小檗碱在制备治疗排卵障碍性不孕症的药物中的应用
US10323058B2 (en) 2014-07-24 2019-06-18 W. R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
CN104164401A (zh) * 2014-08-12 2014-11-26 沈阳洁瑞生物技术有限公司 精子洗涤液及其制备方法
EP2995948A1 (en) * 2014-09-09 2016-03-16 Ecole Polytechnique Federale de Lausanne (EPFL) Methods and compounds useful in hematopoietic stem cell medicine
BR112017003263A2 (pt) * 2014-09-16 2017-11-28 Ovascience Inc anticorpos anti-vasa, e métodos de produção e utilização dos mesmos
BR112017013420A2 (pt) * 2014-12-24 2018-02-06 Pf Medicament anticorpo adam17 humanizado
IL299482A (en) 2015-02-26 2023-02-01 Minovia Therapeutics Ltd Mammalian cells are enriched in active mitochondria
PL3268379T3 (pl) 2015-03-09 2024-03-18 W.R. Grace & Co. - Conn. Forma krystaliczna rybozydu nikotynamidu
CN104814974A (zh) * 2015-03-16 2015-08-05 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备抗衰老药物或保健品的应用
CN106244548B (zh) * 2015-06-09 2019-07-05 成都中医药大学 木犀草素在诱导间充质干细胞向神经细胞定向分化中的用途
US20180177703A1 (en) * 2015-06-25 2018-06-28 N.V. Perricone Llc Niacinamide Mononucleotide Formulations For Skin Aging
WO2017079428A1 (en) * 2015-11-04 2017-05-11 President And Fellows Of Harvard College Site specific germline modification
US20190290682A1 (en) 2016-07-15 2019-09-26 Alexander TARNAVA Composition for producing hydrogen rich water and other products
EP3517107B1 (en) * 2016-09-26 2023-11-01 St. Marianna University School of Medicine Agent for preventing or ameliorating reduction in ovarian function
US11633421B2 (en) 2016-11-29 2023-04-25 University Of Iowa Research Foundation Use of NAD precursors for improving maternal health and/or offspring health
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
WO2018143258A1 (ja) * 2017-01-31 2018-08-09 オリエンタル酵母工業株式会社 多分化能性幹細胞増殖促進剤
RU2662983C1 (ru) * 2017-01-31 2018-07-31 Алексей Юрьевич Грязнов Культуральная среда для ооцитов и эмбрионов
WO2018160920A1 (en) * 2017-03-02 2018-09-07 Orig3N, Inc. Systems and methods of assisted reproduction and prevention of genetic defects in offspring using induced pluripotent stem cells
WO2018200357A1 (en) * 2017-04-26 2018-11-01 Elysium Health, Inc. Methods and compositions of improving fertility
US20200179441A1 (en) * 2017-04-27 2020-06-11 H2 Water Technologies Ltd. Synergistic compositions for increasing mitochondrial function and energy
US11179423B2 (en) * 2017-05-31 2021-11-23 Palo Alto Investors Methods of enhancing female fertility
CN107308200A (zh) * 2017-06-19 2017-11-03 北正赛欧（北京）生物科技有限公司 用于治疗宫颈癌的组合物及其应用
CA3071561A1 (en) * 2017-07-31 2019-02-07 Newsouth Innovations Pty Limited Methods for increasing fertility
AU2018336171B2 (en) 2017-09-22 2023-01-05 Jubilant Epipad LLC Heterocyclic compounds as PAD inhibitors
IL272667B (en) 2017-10-18 2022-09-01 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
KR20200085836A (ko) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
US11459338B2 (en) 2017-11-24 2022-10-04 Jubilant Episcribe Llc Heterocyclic compounds as PRMT5 inhibitors
CN108384751A (zh) * 2018-03-12 2018-08-10 山大生殖研发中心有限公司 卵母细胞体外成熟培养方法和培养基
KR20200131845A (ko) 2018-03-13 2020-11-24 주빌런트 프로델 엘엘씨 Pd1/pd-l1 상호작용/활성화 억제제로서의 비사이클릭 화합물
CN108642001B (zh) * 2018-05-08 2022-09-02 中国农业科学院北京畜牧兽医研究所 一种提高牛性控冻精体外受精能力的方法
EP3794005A1 (en) * 2018-05-15 2021-03-24 Jumpstart Fertility Pty Ltd Inorganic salts of nicotinic acid mononucleotide as anti-aging agents
JP7458368B2 (ja) 2018-07-22 2024-03-29 ミノヴィア セラピューティクス リミテッド 筋疾患のミトコンドリア増強療法
WO2020028684A1 (en) * 2018-08-01 2020-02-06 Jumpstart Fertility Pty Ltd Salts of nicotinic acid and nicotinamide as anti-aging agents
EP3829715A1 (en) * 2018-08-01 2021-06-09 Jumpstart Fertility Pty Ltd Quaternary ammonium salts of nicotinic acid and nicotinamide mononucloetides and ribosides as anti-aging agents
US11013710B2 (en) * 2018-12-05 2021-05-25 Celagenex Research (India) Pvt. Ltd. Synergistic compositions of bioactive agents for optimizing cellular health
CN109674808A (zh) * 2019-01-30 2019-04-26 四川大学 β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途
CN111617093A (zh) * 2019-06-13 2020-09-04 中国科学院广州生物医药与健康研究院 化合物在制备药物中的用途
WO2020257285A1 (en) * 2019-06-17 2020-12-24 The Brigham And Women's Hospital, Inc. Materials and methods for generating functional oocytes
WO2020262325A1 (ja) * 2019-06-28 2020-12-30 国立大学法人広島大学 雌の抗老化剤
WO2021158601A1 (en) * 2020-02-03 2021-08-12 Blue California Methods and compositions related to the use of ergothioneine
EP4106649A4 (en) * 2020-02-20 2024-04-24 Univ Northeastern METHODS AND COMPOSITIONS FOR USING MITOCHONDRIAL THERAPIES TO IMPROVE FEMALE REPRODUCTIVE POTENTIAL
JP7289042B2 (ja) * 2020-03-04 2023-06-09 パナソニックＩｐマネジメント株式会社 洗濯機
TWI753404B (zh) * 2020-04-16 2022-01-21 國立屏東科技大學 輸卵管幹細胞促進卵母細胞體外成熟和胚發育之製劑、製備方法及其用途
CN111500531A (zh) * 2020-05-15 2020-08-07 扬州大学 一种鸡PGCs在体外长期培养的方法
WO2021247776A1 (en) * 2020-06-02 2021-12-09 Mediwel Labs, LLC Biologically active compositions and methods of using
CN116096376A (zh) * 2020-09-08 2023-05-09 未来生物科学实验室株式会社 精子运动性改善剂以及精子运动性改善方法
CN111925986B (zh) * 2020-09-24 2021-01-19 深圳市一五零生命科技有限公司 一种脐带间充质干细胞无血清培养基及其制备方法
CN114561342A (zh) * 2020-11-27 2022-05-31 童国庆 Nad信号通路激动剂在体外胚胎培养中的应用
CN117015406A (zh) * 2021-01-19 2023-11-07 嘉兰宠物有限公司 用于针对临床应用优化生殖组织衍生细胞产量和活力的方法
CN115074388B (zh) * 2021-06-29 2023-04-28 北京大学深圳医院 母源因子诱导的2c样全能干细胞及其转化应用
CN113403264A (zh) * 2021-07-21 2021-09-17 中国农业大学 一种gv期冷冻卵母细胞解冻后体外成熟培养液及其应用
CN113599371A (zh) * 2021-09-06 2021-11-05 郑州大学 二甲双胍在制备预防胸腺退化和/或促进胸腺组织再生药物中的应用
CN113797186A (zh) * 2021-10-27 2021-12-17 宁夏医科大学 二甲双胍在激活雌性生殖干细胞的应用
CN113750242A (zh) * 2021-10-28 2021-12-07 复旦大学附属中山医院 Nmn联合cd38抑制剂在制备预防或治疗阿霉素所致心脏毒性药物中的应用
TW202334089A (zh) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Ｐｐａｒｇ反向激動劑及其用途
CN115247146A (zh) * 2021-12-31 2022-10-28 温州医科大学 一种人类胚胎体外培养基及提高体外培养人类胚胎发育潜能的方法
JP2023156553A (ja) * 2022-04-13 2023-10-25 克昭 團 卵巣機能活性化剤、抗老化剤、医薬品、化粧品および食品または飲料
CN114917215B (zh) * 2022-04-27 2024-01-23 中国科学院生物物理研究所 活性化合物预防或治疗卵巢功能障碍性疾病的用途
CN115590017B (zh) * 2022-11-04 2023-09-12 中国农业大学 一种通过降低线粒体温度提高卵母细胞冷冻效果的方法
CN115956506B (zh) * 2023-02-16 2023-11-03 云南省农业科学院茶叶研究所 一种茶树离体再生组织的构建方法

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR475561A (pt) 1913-07-25
US3854470A (en) 1973-11-23 1974-12-17 L Augspurger Reproduction processes for cellular bodies
IT1057895B (it) 1975-02-17 1982-03-30 Serono Lab Gonadotropina corionica umana parzialmente desalinizzata per indurre l'ouvulazione
FR2322860A1 (fr) 1975-09-05 1977-04-01 Aron Sarl Procede de preparation de chlorhydrate de dimethylbiguanide
US4193392A (en) 1977-09-23 1980-03-18 Barnett Gordon R Method for removing ova from animals
US4326505A (en) 1980-01-07 1982-04-27 Occidental Petroleum Corporation Surgical procedure for embryo transplants on animals
US4339434A (en) 1981-08-17 1982-07-13 Gametrics Limited Method of increasing the incidence of female offspring
US4845077A (en) 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
FR2563726B1 (fr) 1984-05-04 1986-10-10 Robert Cassou Appareil d'insemination artificielle, notamment des carnivores
US4642094A (en) 1984-05-29 1987-02-10 North Jr Walter L Non-surgical embryo transfer device
US4589402A (en) 1984-07-26 1986-05-20 Serono Laboratories, Inc. Method of in vitro fertilization
US4725579A (en) 1985-02-21 1988-02-16 Serono Laboratories, Inc. Method of in vitro fertilization by a unique combination of gonadotropins
FR2580933B1 (fr) 1985-04-24 1987-08-07 Lenck Lucien Capacite trans-uterine pour fecondation " in vitro in vivo "
FR2589879B1 (fr) 1985-11-08 1989-05-12 Claude Ranoux Conteneur pour culture anaerobie d'embryons humains
AT387718B (de) 1986-04-09 1989-03-10 Fischl Franz H Dr Katheder zur kuenstlichen befruchtung
FR2608037A1 (fr) 1986-12-10 1988-06-17 Lenck Lucien Methode d'intubation destinee a permettre la transplantation de l'oeuf ou de la matiere embryonnaire, et moyens pour sa mise en oeuvre
FR2609885B1 (fr) 1987-01-22 1989-04-14 Cassou Robert Instrument pour l'insemination artificielle, le transfert d'embryons ou le prelevement de liquides folliculaires chez les mammiferes
US5538948A (en) 1987-01-30 1996-07-23 Novo Nordisk A/S Method for treating infertility comprising administering GnRH analog, gonadotrophins, and growth hormone
US4865589A (en) 1987-04-22 1989-09-12 Ludwig Simmet Instrument for the transfer of materials such as sperm and embryos
FR2614626B1 (fr) 1987-04-30 1989-07-21 Ranoux Claude Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal
US5160312A (en) 1990-02-09 1992-11-03 W. R. Grace & Co.-Conn. Cryopreservation process for direct transfer of embryos
US5147315A (en) 1990-04-06 1992-09-15 C. R. Bard, Inc. Access catheter and system for use in the female reproductive system
US5627066A (en) 1991-05-14 1997-05-06 Mount Sinai School Of Medicine Of The City University Of New York Method and apparatus for in vitro fertilization
JPH06507565A (ja) 1991-05-14 1994-09-01 マウント　シナイ　スクール　オヴ　メディスン　オヴ　ザ　シティー　ユニバーシティー　オヴ　ニューヨーク 体外受精方法および装置
FR2678506B1 (fr) 1991-07-01 2000-03-10 Claude Ranoux Procede de fecondation en cycle spontane.
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
GB9227123D0 (en) 1992-12-30 1993-02-24 Applied Research Systems Method
US5563059A (en) 1993-02-23 1996-10-08 Genentech, Inc. Use of human inhibin and human activin to increase the number of mature primate oocytes
GB9305984D0 (en) 1993-03-23 1993-05-12 Royal Free Hosp School Med Predictive assay
US5360389A (en) 1993-05-25 1994-11-01 Chenette Philip E Methods for endometrial implantation of embryos
US5541081A (en) 1994-03-22 1996-07-30 President And Fellows Of Harvard College Process for assessing oocyte and embryo quality
GB9410639D0 (en) 1994-05-27 1994-07-13 Queen Mary & Westfield College Method of improving fertilization
US5716928A (en) 1995-06-07 1998-02-10 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
JP3660026B2 (ja) 1995-09-04 2005-06-15 扶桑薬品工業株式会社 体外受精用培地組成物
US5827174A (en) 1995-09-26 1998-10-27 Reuss, Jr.; William Alexander Biological speciman containment and incubation pouch
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US6007839A (en) 1996-02-16 1999-12-28 The Liposome Company, Inc. Preparation of pharmaceutical compositions containing etherlipid-containing multiple lipid liposomes
US6040340A (en) 1996-05-07 2000-03-21 Schering Aktiengesellschaft Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors
US5824548A (en) 1996-05-29 1998-10-20 Wisconsin Alumni Research Foundation Method of increasing survival of cultured primate embryos in medium containing exogenous gonadotrophin releasor hormone
EP1983044B1 (en) * 1996-10-10 2016-08-10 Life Technologies Corporation Animal cell culture media comprising plant-derived nutrients
CA2199663C (en) 1997-03-11 2004-08-10 Ruth Miriam Moses In vitro maturation and fertilization of mammalian oocytes
US5935968A (en) 1997-03-17 1999-08-10 Merck & Co., Inc. Methods for treating polycystic ovary syndrome
CA2294900A1 (en) 1997-07-02 1999-01-14 Sdg, Inc. Targeted liposomal constructs for diagnostic and therapeutic uses
US6010448A (en) 1997-10-17 2000-01-04 Medworks Corp Embryo transfer arrangement
US5961444A (en) 1997-10-17 1999-10-05 Medworks Corporation In vitro fertilization procedure using direct vision
US6196965B1 (en) 1998-05-21 2001-03-06 Cryofacets, Inc. Compositions methods and devices for embryo implantation for in vitro fertilization
ES2258445T3 (es) 1999-02-24 2006-09-01 Novo Nordisk A/S Metodo in vitro para la sincronizacion de la maduracion de ovocitos.
AU2794000A (en) 1999-02-24 2000-09-14 Novo Nordisk A/S Treatment of infertility
AU1123301A (en) 1999-10-27 2001-05-08 General Hospital Corporation, The Methods and compositions for enhancing developmental potential of oocytes and zygotes
US6875854B1 (en) 1999-11-18 2005-04-05 The Brigham And Women's Hospital, Inc. Compositions and methods for the improved diagnosis and treatment of germ cell tumors
EP1233978A4 (en) 1999-11-18 2003-07-23 Brigham & Womens Hospital COMPOSITIONS AND METHODS FOR IMPROVED DIAGNOSIS AND TREATMENT OF GERM CELL TUMORS
US6544166B1 (en) 1999-11-25 2003-04-08 Groendahl Christian Treatment of human infertility
US6762053B2 (en) * 2000-06-09 2004-07-13 Vitrolife, Inc. Mammalian gamete and embryo culture media and culture media supplements
FR2812004B1 (fr) 2000-07-24 2002-12-27 Ccd Lab Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons
US7226994B2 (en) 2001-01-18 2007-06-05 Cambridge University Technical Services Limited Cell surface expressed marker of pluripotency
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
EP1648437A2 (en) 2003-07-01 2006-04-26 President And Fellows Of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
WO2005007687A1 (en) 2003-07-09 2005-01-27 Dana-Farber Cancer Institute, Inc Compositions and methods for modulating ovarian follicular initiation
US20050130302A1 (en) 2003-09-29 2005-06-16 Reprocell Inc. Method and composition for regulating expansion of stem cells
CA2548671C (en) 2003-12-29 2015-02-24 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
DK1765085T3 (en) 2004-05-17 2015-10-05 Gen Hospital Corp Compositions comprising female germline stem cells and methods of use thereof
US7955846B2 (en) 2004-05-17 2011-06-07 The General Hospital Corporation Compositions comprising female germline stem cells and methods of use thereof
PT3006040T (pt) * 2004-06-04 2018-03-28 Univ Washington Métodos e composições para o tratamento de neuropatias
US20060276393A1 (en) * 2005-01-13 2006-12-07 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
EP1877054A2 (en) * 2005-03-30 2008-01-16 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside and analogues thereof
WO2007084162A2 (en) 2005-04-08 2007-07-26 President And Fellows Of Harvard College Sirtuin inhibiting compounds
US20080050347A1 (en) * 2006-08-23 2008-02-28 Ichim Thomas E Stem cell therapy for cardiac valvular dysfunction
WO2008026018A1 (en) * 2006-09-01 2008-03-06 Topotarget Switzerland Sa New method for the treatment of inflammatory diseases
US20120135091A1 (en) * 2007-01-18 2012-05-31 Roth Mark B Methods and compositions for enhancing lifespan involving sirtuin-modulating compounds and chalcogenides
WO2008157398A1 (en) 2007-06-13 2008-12-24 Litron Laboratories Ltd. Method for measuring in vivo hematotoxicity with an emphasis on radiation exposure assessment
US20090111764A1 (en) 2007-10-25 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Mitochondrial selection
NO331476B1 (no) * 2007-12-21 2012-01-16 Jaffar Ali Bin M Abdullah Proteinfri gamete- og embryo-handtering samt dyrkningsmedieprodukter inneholdende metylcellulose
US8415094B2 (en) * 2007-12-21 2013-04-09 Jaffar Ali bin M. Abdullah Protein-free gamete and embryo handling and culture media products
WO2009087568A2 (en) 2008-01-10 2009-07-16 Universidade De Coimbra Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties
EP2213288A1 (en) 2009-01-30 2010-08-04 Karl Welte NAMPT and vitamin B3 for treating or preventing diseases
US8489337B2 (en) 2010-06-24 2013-07-16 The Invention Science Fund I, Llc Rejuvenation or preservation of germ cells
US8338178B2 (en) 2010-10-28 2012-12-25 The Invention Science Fund I, Llc Mitochondrial enhancement of cells
JP2012105585A (ja) * 2010-11-17 2012-06-07 Nippon Ika Kikai Seisakusho:Kk 人工受精用組成物
AP2013007229A0 (en) 2011-04-14 2013-11-30 Gen Hospital Corp Compositions and methods for autologous germline mitochondrial energy transfer
EP3345901A3 (en) 2011-06-29 2018-09-12 President and Fellows of Harvard College Small molecules as antiaging agents

Also Published As

Publication number Publication date
EP3495470A1 (en) 2019-06-12
CN103827293A (zh) 2014-05-28
IL230212B (en) 2018-08-30
JP2017206526A (ja) 2017-11-24
WO2013002880A1 (en) 2013-01-03
JP6496359B2 (ja) 2019-04-03
US9845482B2 (en) 2017-12-19
MX356815B (es) 2018-06-07
US20180100166A1 (en) 2018-04-12
UA117448C2 (uk) 2018-08-10
US20160024527A1 (en) 2016-01-28
JP2019030326A (ja) 2019-02-28
EP2726601A1 (en) 2014-05-07
US20130059384A1 (en) 2013-03-07
AU2012276038B2 (en) 2017-08-31
JP6284475B2 (ja) 2018-02-28
CA2847292A1 (en) 2013-01-03
MX2014000201A (es) 2014-06-11
EA201490050A1 (ru) 2014-07-30
EP2726601A4 (en) 2015-04-15
AU2017251852A1 (en) 2017-11-16
WO2013002880A4 (en) 2013-02-21
ZA201309707B (en) 2019-09-25
JP2014520526A (ja) 2014-08-25
EP2726601B1 (en) 2018-12-26
IL258129A (en) 2018-05-31
US20190002919A1 (en) 2019-01-03
AU2012276038A1 (en) 2014-02-20

Similar Documents

Publication Publication Date Title
BR112013033797A2 (pt) composição, célula isolada, mitocôndria isolada , métodos de preparo de um oócito, de fertilização in vitro, de melhora de fertilidade em um indivíduo, de sustentação de desenvolvimento embrionário, de recuperação ou aumento de função ovariana em um indivíduo, de preparo de um tecido ou célula do mesmo, e de produção de um oócito, oócito, e, agente bioenergético
MX2023001878A (es) Celulas modificadas geneticamente que comprenden un gen humano modificado de la region constante alfa del receptor de celulas t.
CY1119286T1 (el) Ανταγωνιστες των wnt και μεθοδοι αγωγης
HK1203559A1 (en) Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect rna
EP2885394A4 (en) METHODS, SYSTEMS, AND COMPOSITIONS FOR FUNCTIONAL IN VITRO CELLULAR MODELS OF MAMMALIAN SYSTEMS
BR112015007120A2 (pt) anticorpo biespecífico, composição farmacêutica, uso, célula hospedeira e método de produção de um anticorpo
BR112013018836A2 (pt) "métodos de manipulação, obtenção, elevação e aumento em uma planta que compreende a expressão de gene modificado"
HK1204677A1 (en) Methods and compositions for preparing biological specimens for microscopic analysis
EP2569704A4 (en) METHODS, APPARATUS AND MANUFACTURED PRODUCTS FOR UPDATING MODELS OF VIRTUAL MACHINES
BR112015030946A2 (pt) composição compreendendo uma célula ß pancreática não-nativa, método de diferenciação de células progenitoras em células ß pancreáticas in vitro e uso de uma célula ß pancreática não-nativa
SG11201508387WA (en) Polycaprolactone microcarriers for stem cell culture and fabrication thereof
EP2882846A4 (en) METHODS AND COMPOSITIONS FOR THE RAPID PRODUCTION OF RETINE PIGMENTED EPITHELIAL CELLS FROM MULTIPOTENT CELLS
BR112013024717A2 (pt) anticorpo isolado, ácido nucleico isolado, célula hospedeira, imunoconjugado, formulação farmacêutica, método de tratar um indivíduo que tem câncer e método de inibir proliferação celular em um indivíduo
EA201490636A1 (ru) Сконструированные с помощью рнк t-клетки для лечения злокачественных новообразований
EP2714099A4 (en) STERILIZED, ACELLULAR EXTRACELLULAR MATRIX COMPOSITIONS AND METHODS OF MAKING SAME
BR112014010455A2 (pt) Métodos para produzir um anticorpo, usos de il-e2 e/ou il-21, métodos para cultivar uma célula, usos de uma célula de mamífero e uso de sac no co- cultivo de células b
BR112013025862A2 (pt) composições de lignina, métodos de produzir as composições, métodos de utilizar composições de lignina e produtos produzidos desse modo
BR112013030830A2 (pt) processo de preparação de composto da fórmula (i) e estetrol obtido diretamente por meio do processo
IL228829A (en) Method for making an egg for in vitro fertilization and a method for in vitro fertilization
BR112014022817A2 (pt) Processo de aumento da criopreservação de células biológicas e composição de criopreservação
BR112015021586A2 (pt) formulações de morfina
MX362852B (es) Estructura auxiliar del vehiculo.
CL2013001129A1 (es) Composicion que comprende una celula madre gbm6-ad de glioblastoma purificada; metodo de generacion de anticuerpos especificos para gbm6-ad; dicho anticuerpo; metodo para producir una vacuna de celulas dendriticas; y su uso para el tratamiento de cancer.
EP3094956A4 (en) Preparation of cells, cell aggregates, and tissue fragments
DK201300530A (en) Vaccine relating to Pancreas disease in fish

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11T Dismissal of application maintained [chapter 11.20 patent gazette]