EA201270300A1 - Визуализация и оценка эмбрионов, яйцеклеток и стволовых клеток - Google Patents

Визуализация и оценка эмбрионов, яйцеклеток и стволовых клеток

Info

Publication number
EA201270300A1
EA201270300A1 EA201270300A EA201270300A EA201270300A1 EA 201270300 A1 EA201270300 A1 EA 201270300A1 EA 201270300 A EA201270300 A EA 201270300A EA 201270300 A EA201270300 A EA 201270300A EA 201270300 A1 EA201270300 A1 EA 201270300A1
Authority
EA
Eurasian Patent Office
Prior art keywords
embryos
eggs
visualization
assessment
stem cells
Prior art date
Application number
EA201270300A
Other languages
English (en)
Other versions
EA025172B1 (ru
EA025172B9 (ru
Inventor
Конни С. Вонг
Кевин Э. Лоуке
Томас М. Баэр
Рене А. Реййо-Пера
Барри Бер
Original Assignee
Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201270300(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити filed Critical Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити
Publication of EA201270300A1 publication Critical patent/EA201270300A1/ru
Publication of EA025172B1 publication Critical patent/EA025172B1/ru
Publication of EA025172B9 publication Critical patent/EA025172B9/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1029—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/103—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10004—Still image; Photographic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30044—Fetus; Embryo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Theoretical Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Computer Hardware Design (AREA)
  • Multimedia (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)

Abstract

Предложены способы, композиции и наборы для определения способности к развитию одного или нескольких эмбрионов или плюрипотентных клеток и/или наличия хромосомных нарушений в одном или нескольких эмбрионах или плюрипотентных клетках. Данные способы, композиции и наборы находят применение при идентификации in vitro эмбрионов и яйцеклеток, которые наиболее полезны для применения при лечении бесплодия у человека.
EA201270300A 2009-08-22 2010-08-23 Способ оценки способности достижения одним или более эмбрионами человека стадии бластоцисты EA025172B9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23608509P 2009-08-22 2009-08-22
US33265110P 2010-05-07 2010-05-07
PCT/US2010/046343 WO2011025736A1 (en) 2009-08-22 2010-08-23 Imaging and evaluating embryos, oocytes, and stem cells

Publications (3)

Publication Number Publication Date
EA201270300A1 true EA201270300A1 (ru) 2013-01-30
EA025172B1 EA025172B1 (ru) 2016-11-30
EA025172B9 EA025172B9 (ru) 2017-01-30

Family

ID=42799722

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270300A EA025172B9 (ru) 2009-08-22 2010-08-23 Способ оценки способности достижения одним или более эмбрионами человека стадии бластоцисты

Country Status (24)

Country Link
US (9) US8721521B2 (ru)
EP (4) EP2827150B3 (ru)
JP (2) JP5951487B2 (ru)
KR (1) KR101747983B1 (ru)
CN (2) CN104293646A (ru)
AU (1) AU2010286740B2 (ru)
BR (1) BR112012003847B1 (ru)
CA (1) CA2761231C (ru)
CL (1) CL2012000456A1 (ru)
DK (4) DK2827150T6 (ru)
EA (1) EA025172B9 (ru)
ES (4) ES2972747T3 (ru)
HK (3) HK1166521A1 (ru)
HU (1) HUE052071T2 (ru)
IL (1) IL218239A (ru)
IN (1) IN2012DN02452A (ru)
MX (1) MX2012002266A (ru)
MY (1) MY180473A (ru)
NZ (1) NZ598293A (ru)
PL (1) PL2827150T6 (ru)
PT (1) PT2827150T (ru)
SG (1) SG178536A1 (ru)
WO (1) WO2011025736A1 (ru)
ZA (1) ZA201201363B (ru)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879666A (en) * 1996-10-24 1999-03-09 The Procter & Gamble Company Methods and compositions for reducing body odor
HUP0900431A2 (en) * 2009-07-10 2011-01-28 Cryo Innovation Kft Sample imaging system and pocedure for transmitting imager of cells or tissues located in breeder space towards a data processing device
SG178536A1 (en) 2009-08-22 2012-03-29 Univ Leland Stanford Junior Imaging and evaluating embryos, oocytes, and stem cells
US8621943B2 (en) * 2009-09-30 2014-01-07 Weyerhaeuser Nr Company Method of singulating embryos
DE102010009853B4 (de) * 2010-03-02 2012-12-06 Bruker Daltonik Gmbh Bestimmung von Gewebezuständen mittels bildgebender Massenspektrometrie
US9482659B2 (en) * 2010-09-27 2016-11-01 Progyny, Inc. Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes and stem cells
US20130217061A1 (en) * 2010-10-25 2013-08-22 Masahiko Sato Apparatus for Systematic Single Cell Tracking of Distinctive Cellular Events
JP2014507664A (ja) * 2011-02-23 2014-03-27 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ヒト胚における異数性の検出方法
WO2012163363A1 (en) * 2011-05-31 2012-12-06 Unisense Fertilitech A/S Embryo quality assessment based on blastomere cleavage and morphology
WO2012178069A1 (en) * 2011-06-22 2012-12-27 The Johns Hopkins University System and device for characterizing cells
DK2726865T3 (en) * 2011-07-01 2017-03-20 Cambridge Entpr Ltd Methods for predicting viability of mammalian embryos
JP5887766B2 (ja) * 2011-08-31 2016-03-16 株式会社ニコン 顕微鏡制御装置、画像処理装置、顕微鏡装置およびプログラム
WO2013056002A1 (en) * 2011-10-12 2013-04-18 University Of Iowa Research Foundation Use of microrna for assessing embryos grown in vitro and improving culture media
DK2778231T3 (en) * 2011-11-08 2019-04-15 Hamamatsu Photonics Kk PROCEDURE FOR TEMPERATURE OF STEM CELLS, PROCEDURE FOR REMOVAL OF CELL AREA IN STANDING TENDING AGAINST DIFFERENTIALIZATION, AND DEVICE FOR TEMPERATURE OF STEM CELLS
KR101697512B1 (ko) * 2011-12-15 2017-01-19 한국전자통신연구원 영상 정합 장치 및 방법
US9282995B2 (en) * 2011-12-22 2016-03-15 Previvo Genetics, Llc Recovery and processing of human embryos formed in vivo
US9216037B2 (en) 2013-06-21 2015-12-22 Previvo Genetics, Llc Uterine lavage for embryo retrieval
US20160151090A1 (en) * 2011-12-22 2016-06-02 Previvo Genetics, Llc Recovery and processing of human embryos formed in vivo
US20150272622A1 (en) 2011-12-22 2015-10-01 Previvo Genetics, Llc Recovery and processing of human embryos formed in vivo
US9179935B2 (en) 2012-01-13 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Mechanical biomarkers for oocyte and embryo viability
KR20140120321A (ko) * 2012-02-01 2014-10-13 벤타나 메디컬 시스템즈, 인코포레이티드 조직 샘플들에 있어서의 유전자들을 검출하는 시스템
US20130225431A1 (en) * 2012-02-23 2013-08-29 The Board Of Trustees Of The Leland Stanford Junior University Assessment of cellular fragmentation dynamics for detection of human embryonic aneuploidy
JP2013230145A (ja) * 2012-04-30 2013-11-14 Masahiko Sato 細胞集団の状態を評価するための方法、候補化合物の発癌性を評価するための方法、潜在的な抗癌化合物の抗癌活性を評価するための方法及び治療用細胞集団の品質を評価するための方法
EP2855664B1 (en) * 2012-05-31 2017-10-04 Unisense Fertilitech A/S Embryo quality assessment based on blastocyst development
US20140017717A1 (en) * 2012-05-31 2014-01-16 Auxogyn, Inc. In vitro embryo blastocyst prediction methods
ITRM20120257A1 (it) * 2012-06-05 2013-12-06 Advanced Comp Systems A C S S P A Metodo per la quantificazione del grado di regolarità morfologica della zona pellucida in embrioni e ovociti.
CN104411817A (zh) * 2012-06-25 2015-03-11 尤尼森斯繁殖技术公司 方法和设备
CN104755608A (zh) * 2012-08-30 2015-07-01 尤尼森斯繁殖技术公司 体外培养胚胎的自动化监控
US9829482B2 (en) * 2012-09-13 2017-11-28 Purdue Research Foundation Motility-contrast imaging for oocyte and embryo viability assessment
WO2014121200A1 (en) * 2013-02-01 2014-08-07 Auxogyn, Inc. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential
PT2951574T (pt) * 2013-02-01 2019-07-05 Ares Trading Sa Medição do desenvolvimento de embriões e potencial de implantação com a ajuda de parâmetros de tempo e fenótipo de primeira citocinese
US9177192B2 (en) * 2013-02-28 2015-11-03 Progyny, Inc. Apparatus, method, and system for image-based human embryo cell classification
BR112015022446B1 (pt) * 2013-03-14 2022-05-17 Fujifilm Irvine Scientific, Inc Método e ensaio com embrião de camundongo em base molecular para controle de qualidade destinado a uso com tecnologia de fertilização in vitro
US10667499B2 (en) 2013-03-14 2020-06-02 FUJIFILM Irvine Scientific, Inc. Method and quality control molecular based mouse embryo assay for use with in vitro fertilization technology
WO2014172607A1 (en) * 2013-04-19 2014-10-23 The Board Of Trustees Of The University Of Arkansas Amphibian oocyte or embryo bioassay
US9404908B2 (en) 2013-04-29 2016-08-02 The Board of Truestees of the Leland Stanford Junior University Non-invasive imaging to the blastocyst stage for the detection of human embryonic aneuploidy
GB201312032D0 (en) * 2013-07-04 2013-08-21 Vitrolife Kft Embryo assessment method
ES2979017T3 (es) 2013-07-05 2024-09-23 Esco Medical Tech Uab Un dispositivo para monitorizar del desarrollo de un material biológico
JP2015029431A (ja) * 2013-07-31 2015-02-16 大日本印刷株式会社 細胞培養容器
US10123697B2 (en) * 2013-09-10 2018-11-13 University Of Rochester Apparatus and method for automatic alignment in an optical system and applications
JP6303347B2 (ja) * 2013-09-11 2018-04-04 大日本印刷株式会社 検体画像管理システム及び検体画像管理プログラム
WO2015045012A1 (ja) * 2013-09-24 2015-04-02 富士通株式会社 コロニー検査プログラム、コロニー検査装置およびコロニー検査方法
WO2015045183A1 (ja) * 2013-09-30 2015-04-02 富士通株式会社 コロニー画像検査プログラム、コロニー画像検査方法及びコロニー画像検査装置
US9519823B2 (en) * 2013-10-04 2016-12-13 The University Of Manchester Biomarker method
US9953417B2 (en) 2013-10-04 2018-04-24 The University Of Manchester Biomarker method
US10540783B2 (en) * 2013-11-01 2020-01-21 Illumina, Inc. Image analysis useful for patterned objects
US20150125899A1 (en) * 2013-11-07 2015-05-07 Rebecca Willits Fluorescence-assisted counting apparatus for qualitative and/or quantitative measurement of fluorescently tagged particles
US9469650B2 (en) 2013-11-08 2016-10-18 Board Of Trustees Of The University Of Arkansas Melampomagnolide B derivatives
US9487536B2 (en) 2013-11-08 2016-11-08 Board Of Trustees Of The University Of Arkansas Melampomagnolide B derivatives
US9395346B2 (en) * 2013-11-18 2016-07-19 Zoetis Services Llc Non-contact egg identification system for determining egg viability, and associated method
WO2015101886A1 (en) * 2014-01-03 2015-07-09 Copan Italia S.P.A. Apparatus and method for treatment of diagnostic information relating to samples of microbiological material
JP6343934B2 (ja) * 2014-01-09 2018-06-20 大日本印刷株式会社 成育情報管理システム及び成育情報管理プログラム
JP6343935B2 (ja) * 2014-01-09 2018-06-20 大日本印刷株式会社 成育情報管理システム及び成育情報管理プログラム
GB2524082A (en) 2014-03-14 2015-09-16 Unisense Fertilitech As Methods and apparatus for analysing embryo development
ES2837840T3 (es) 2014-03-20 2021-07-01 Ares Trading Sa Medida cuantitativa de la cinética de desarrollo de la morfología de mórula y blastocisto humanos
US9723831B2 (en) * 2014-07-30 2017-08-08 The Governing Council Of The University Of Toronto System and methods for automated vitrification of biological materials
JP6775911B2 (ja) * 2014-11-14 2020-10-28 キヤノンメディカルシステムズ株式会社 細胞特性を判定する方法および装置、並びに疾患の検査方法
WO2016090166A1 (en) 2014-12-03 2016-06-09 Board Of Trustees Of The University Of Arkansas Melampomagnolide b dimers
US9723989B2 (en) * 2015-01-19 2017-08-08 Purdue Research Foundation Ex vivo motility contrast imaging
US20180023149A1 (en) * 2015-02-17 2018-01-25 Genea Ip Holdings Pty Limited Method and apparatus for dynamically culturing a biological sample
CN107533217A (zh) 2015-03-13 2018-01-02 格尼亚Ip控股私人有限公司 用于显微技术的方法与装置
CN107667178A (zh) * 2015-03-26 2018-02-06 休斯敦大学系统 细胞的整合功能和分子概况
US10420626B2 (en) 2015-06-30 2019-09-24 Canon U.S.A., Inc. Fiducial markers, systems, and methods of registration
JP6609330B2 (ja) * 2015-06-30 2019-11-20 キヤノン ユーエスエイ，インコーポレイテッド レジストレーションの基準マーカー、システム、および方法
JP6746945B2 (ja) * 2015-06-30 2020-08-26 ソニー株式会社 情報処理装置、情報処理システム及び情報処理方法
US10510143B1 (en) * 2015-09-21 2019-12-17 Ares Trading S.A. Systems and methods for generating a mask for automated assessment of embryo quality
US11494578B1 (en) * 2015-09-21 2022-11-08 Ares Trading S.A. Systems and methods for automated assessment of embryo quality using image based features
US10428082B2 (en) 2016-01-29 2019-10-01 Bioventures, Llc Triazole derivatives of melampomagnolide B and methods of use thereof
US11300766B2 (en) * 2016-06-13 2022-04-12 Sony Corporation Apparatus, information processing apparatus, program, and information processing method
US10872414B2 (en) 2016-06-15 2020-12-22 Sony Corporation Information processing apparatus, observation system, observation method, and program
WO2018001437A1 (en) * 2016-06-30 2018-01-04 Esco Medical Aps An apparatus for the incubation of a biological material
JP6776672B2 (ja) * 2016-07-08 2020-10-28 住友電気工業株式会社 品質評価方法及び品質評価装置
JP2018014991A (ja) * 2016-07-13 2018-02-01 ソニー株式会社 情報処理装置、情報処理方法及び情報処理システム
JP2018022216A (ja) 2016-08-01 2018-02-08 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
CN107058455B (zh) * 2016-08-10 2021-09-17 黑龙江省农业科学院畜牧研究所 猪2细胞胚胎体积的测量方法
US20190225923A1 (en) * 2016-09-30 2019-07-25 Nanyang Technological University Apparatus for embryo biopsy
ES2907811T3 (es) * 2016-11-10 2022-04-26 Becton Dickinson Co Sistema de línea de tiempo para supervisar un protocolo de medio de cultivo
EP3550009A4 (en) * 2016-11-29 2019-12-18 Sony Corporation INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD, PROGRAM, AND OBSERVATION SYSTEM
AU2017368974A1 (en) * 2016-11-30 2019-06-13 Sony Corporation Information processing device, observation system, information processing method, and program
EP3611696A4 (en) 2017-02-16 2021-02-17 Kyoto University CELL EVALUATION PROCESS, CELL EVALUATION DEVICE AND CELL EVALUATION PROGRAM
EP3640319A4 (en) * 2017-06-13 2020-06-03 Sony Corporation INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING PROCESS AND PROGRAM
CN107312861B (zh) * 2017-08-01 2020-08-18 北京大学人民医院 一种b-all患者预后风险评估标记物
US11202652B2 (en) 2017-08-11 2021-12-21 Canon U.S.A., Inc. Registration and motion compensation for patient-mounted needle guide
US11227386B2 (en) * 2017-08-15 2022-01-18 Siemens Healthcare Gmbh Identifying the quality of the cell images acquired with digital holographic microscopy using convolutional neural networks
CN111279421B (zh) * 2017-09-29 2024-04-09 布里格姆妇女医院 人类胚胎的自动评价
JP6414310B1 (ja) * 2017-10-26 2018-10-31 ソニー株式会社 受精卵品質評価方法、プログラム及び情報処理装置
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
US10893911B2 (en) 2017-11-26 2021-01-19 Canon U.S.A., Inc. Automated image cropping for enhanced automatic device-to-image registration
JP2019100940A (ja) * 2017-12-06 2019-06-24 東ソー株式会社 未分化細胞を高感度に検出および回収する方法
FR3077136A1 (fr) * 2018-01-19 2019-07-26 I2S Dispositif d'observation d'une cellule ou d'un ensemble de cellules vivantes
JPWO2019172112A1 (ja) * 2018-03-06 2021-02-18 ゼノアックリソース株式会社 細胞凍結保存用溶液およびその利用
US10552957B2 (en) * 2018-03-24 2020-02-04 Dan Nayot Methods and systems for determining quality of an oocyte
JP6960053B2 (ja) 2018-06-07 2021-11-05 オリンパス株式会社 画像処理装置および培養評価システム
GB2589763B (en) * 2018-06-28 2023-05-24 Nikon Corp Device, system, and program
TWI669616B (zh) * 2018-08-13 2019-08-21 行政院原子能委員會核能研究所 圓柱狀和圓餅狀數位模型之模擬切割方法
WO2020058931A1 (en) 2018-09-20 2020-03-26 Aivf Ltd Image feature detection
EP3644228B1 (en) * 2018-10-23 2024-08-14 The Chinese University Of Hong Kong Method and apparatus for segmenting cellular image
US10748290B2 (en) * 2018-10-31 2020-08-18 Fei Company Smart metrology on microscope images
TWI664582B (zh) * 2018-11-28 2019-07-01 靜宜大學 細胞檢測方法、裝置與系統
EP3909015B1 (en) * 2019-01-08 2024-08-14 Novocure GmbH Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
US11274800B2 (en) * 2019-01-11 2022-03-15 Valeo North America, Inc. IR illuminator with asymetric radiation pattern
CN109829898B (zh) * 2019-01-17 2023-05-16 柳州康云互联科技有限公司 一种用于互联网检测中基于神经网络的测量检测系统及方法
US11386559B2 (en) * 2019-04-03 2022-07-12 The Regents Of The University Of California System and method for tissue viability screening
WO2020198779A1 (en) * 2019-04-04 2020-10-08 Presagen Pty Ltd Method and system for selecting embryos
WO2020223157A1 (en) * 2019-04-29 2020-11-05 Animated Dynamics, Inc. Interferometric method and apparatus for non-invasive assessment of oocyte maturity and competency
CN110363218B (zh) * 2019-06-06 2023-07-11 张孝东 一种胚胎无创评估方法及装置
CN110129201B (zh) * 2019-06-13 2024-06-14 济南国科医工科技发展有限公司 胚胎时差培养装置
WO2020261555A1 (ja) * 2019-06-28 2020-12-30 オリンパス株式会社 画像生成システムおよび画像生成方法
JP2022546398A (ja) * 2019-08-30 2022-11-04 クーパーサージカル・インコーポレイテッド 生殖検体を処理するシステムおよび方法
JP2022551683A (ja) * 2019-09-25 2022-12-13 プレサーゲン プロプライアトリー リミテッド 人工知能（ａｉ）モデルを使用した非侵襲的遺伝子検査を行う方法及びシステム
BR112022010586A2 (pt) * 2019-12-19 2022-08-16 Pioneer Hi Bred Int Geração e uso de modelo preditivo de cultura de micrósporo
US20210302710A1 (en) * 2020-02-24 2021-09-30 Massachusetts Institute Of Technology Bragg light source for dark-field imaging devices
EP4211459A4 (en) * 2020-09-08 2024-10-09 Aivf Ltd SYSTEM AND METHOD FOR REPRESENTING A BIOLOGICAL PROCESS VIA NON-VOICE AUDIO
CN112382339B (zh) * 2020-11-17 2024-08-13 中国人民解放军军事科学院军事医学研究院 一种识别合子型基因激活zga基因的方法及装置
CN112481273B (zh) * 2020-12-29 2023-11-24 南通大学附属医院 结直肠癌抑癌基因及其启动子区高dna甲基化的验证方法
US11481900B2 (en) 2021-03-09 2022-10-25 Thread Robotics Inc. System and method for automated gamete selection
WO2022260740A1 (en) * 2021-06-10 2022-12-15 Alife Health Inc. Machine learning for optimizing ovarian stimulation
CN113834936A (zh) * 2021-08-20 2021-12-24 李竞宇 生长分化因子9在预测胚胎发育潜力中的应用
WO2023081446A1 (en) * 2021-11-05 2023-05-11 Thread Robotics Inc. System and method for automated cell positioning
WO2023225121A1 (en) * 2022-05-17 2023-11-23 Overture Life, Inc. Methods, computer programs, and systems for automated microinjection

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0430881A3 (en) 1989-11-29 1991-10-23 Ciba-Geigy Ag Photochromic compounds, process for their preparation and their use
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
GB9401833D0 (en) 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
US5541081A (en) * 1994-03-22 1996-07-30 President And Fellows Of Harvard College Process for assessing oocyte and embryo quality
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
WO1996030496A1 (en) 1995-03-24 1996-10-03 University Of Alabama At Birmingham Research Foundation Human embryo co-culture system and uses thereof
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
JP3660026B2 (ja) 1995-09-04 2005-06-15 扶桑薬品工業株式会社 体外受精用培地組成物
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
EP0882225B1 (en) 1995-11-22 2004-02-04 Unisense APS Microsensor and use of such microsensor
EP0953354A4 (en) 1996-08-13 2002-10-23 Fujisawa Pharmaceutical Co HEMATOPOIETIC STEM CELLS PROLIFERING ACTIVE SUBSTANCES
US6008010A (en) * 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
DK172855B1 (da) 1996-11-12 1999-08-16 Unisense Aps Fremgangsmåde til måling af koncentrationen af et medium i et miljø, mikrosensor til brug ved fremgangsmåden og anvendelse
US6166761A (en) * 1997-01-09 2000-12-26 Interface Multigrad Technology Method and apparatus for monitoring a biological sample
CA2199663C (en) 1997-03-11 2004-08-10 Ruth Miriam Moses In vitro maturation and fertilization of mammalian oocytes
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US5961444A (en) * 1997-10-17 1999-10-05 Medworks Corporation In vitro fertilization procedure using direct vision
ATE361091T1 (de) 1999-02-24 2007-05-15 Novo Nordisk As Behandlung von unfruchtbarkeit
FR2812004B1 (fr) 2000-07-24 2002-12-27 Ccd Lab Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons
JP4497923B2 (ja) * 2001-12-05 2010-07-07 ザ ジェイ． デビッド グラッドストーン インスティテューツ ロボット顕微鏡検査システム
WO2003055385A1 (en) 2001-12-21 2003-07-10 Unisense A/S Multifibre sensor for measuring perfusion
US7015031B2 (en) * 2002-01-24 2006-03-21 Genx International, Inc. Biological specimen-culturing system and method with onboard specimen development sensors
US7672369B2 (en) 2002-02-13 2010-03-02 Reify Corporation Method and apparatus for acquisition, compression, and characterization of spatiotemporal signals
GB0215668D0 (en) 2002-07-06 2002-08-14 Weatherford Lamb Coupling tubulars
AU2003287934A1 (en) 2002-12-23 2004-07-14 Unisense Fertilitech Aps Device and method for non-invasive measurement of the individual metabolic rate of a substantially spherical metabolizing particle
CN2610349Y (zh) * 2003-04-01 2004-04-07 北京舒尔德科技发展有限公司 多功能显微成像仪
US7042639B1 (en) * 2003-08-21 2006-05-09 The United States Of America As Represented By The Administrator Of Nasa Identification of cells with a compact microscope imaging system with intelligent controls
CA2537938C (en) * 2003-09-09 2013-01-22 Cryo-Innovation Kft. Improving post-thaw survival of cryopreserved biological material by hydrostatic pressure challenge
HU0302888D0 (en) * 2003-09-09 2003-11-28 Pribenszky Csaba Dr In creasing of efficacity of stable storage by freezing of embryos in preimplantation stage with pretreatment by pressure
GB2409029A (en) 2003-12-11 2005-06-15 Sony Uk Ltd Face detection
US20070054289A1 (en) * 2004-03-29 2007-03-08 Michigan State University Identification of genes involved in fertility, ovarian function and/or fetal/newborn viability
US7572601B2 (en) * 2004-10-15 2009-08-11 Northwestern University Compositions and methods for determining oocyte development potential
CA2585784A1 (en) 2004-11-17 2006-05-26 Mosaic Reproductive Health And Genetics, Llc Methods of determining human egg competency
JP5451073B2 (ja) 2005-10-14 2014-03-26 ユニセンス・ファーティリテック・アクティーゼルスカブ 細胞集団における変化の決定
US8048999B2 (en) 2005-12-13 2011-11-01 Kyoto University Nuclear reprogramming factor
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
JP4921858B2 (ja) * 2006-06-07 2012-04-25 オリンパス株式会社 画像処理装置および画像処理プログラム
ATE477499T1 (de) 2006-06-16 2010-08-15 Unisense Fertilitech As Embryonenqualitätsbeurteilung auf der grundlage von blastomerenteilung und bewegung
US8428331B2 (en) * 2006-08-07 2013-04-23 Northeastern University Phase subtraction cell counting method
WO2008031226A1 (en) * 2006-09-15 2008-03-20 UNIVERSITé LAVAL Mammalian oocyte development competency granulosa markers and uses thereof
US7940978B2 (en) * 2007-06-05 2011-05-10 General Electric Company Automatic characterization of cellular motion
DK2173853T3 (da) 2007-06-29 2011-07-04 Unisense Fertilitech As Indretning, system og fremgangsmåde til at overvåge og/eller dyrke mikroskopiske objekter
GB0806281D0 (en) 2008-04-07 2008-05-14 Univ Leeds Markers of Oocyte viability
WO2009146335A1 (en) 2008-05-27 2009-12-03 Gene Security Network, Inc. Methods for embryo characterization and comparison
JP2010004789A (ja) * 2008-06-26 2010-01-14 Nikon Corp 胚観察装置
JP2011526782A (ja) * 2008-07-05 2011-10-20 ウニセンス フェルティリテック アー／エス １対１識別システム
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
HUP0900431A2 (en) 2009-07-10 2011-01-28 Cryo Innovation Kft Sample imaging system and pocedure for transmitting imager of cells or tissues located in breeder space towards a data processing device
CN102497774A (zh) 2009-07-16 2012-06-13 Bwt生物测定有限责任公司 评估胚胎结果的方法
SG178536A1 (en) * 2009-08-22 2012-03-29 Univ Leland Stanford Junior Imaging and evaluating embryos, oocytes, and stem cells
WO2011071551A1 (en) 2009-12-08 2011-06-16 Molecular Biometrics, Inc. Sample cell for spectroscopic analysis, systems and uses thereof
EP2348318A1 (en) 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Diagnostic method for endometrial receptivity
GB2484457B (en) 2010-10-02 2015-04-15 Univ Plymouth Method and system for determining characteristics of an embryo and uses thereof
WO2012163363A1 (en) 2011-05-31 2012-12-06 Unisense Fertilitech A/S Embryo quality assessment based on blastomere cleavage and morphology
US20140017717A1 (en) 2012-05-31 2014-01-16 Auxogyn, Inc. In vitro embryo blastocyst prediction methods

Also Published As

Publication number Publication date
IL218239A (en) 2017-03-30
IL218239A0 (en) 2012-04-30
ES2399711T3 (es) 2013-04-02
EP2615460B1 (en) 2014-06-25
US7963906B2 (en) 2011-06-21
US20150160117A1 (en) 2015-06-11
AU2010286740B2 (en) 2016-03-10
HK1166521A1 (en) 2012-11-02
EP3805762A1 (en) 2021-04-14
US20110105834A1 (en) 2011-05-05
US20170089820A1 (en) 2017-03-30
EP2430454B1 (en) 2013-01-23
US8951184B2 (en) 2015-02-10
WO2011025736A1 (en) 2011-03-03
EA025172B1 (ru) 2016-11-30
ES2838698T3 (es) 2021-07-02
NZ598293A (en) 2014-06-27
US8721521B2 (en) 2014-05-13
EP3805762B1 (en) 2024-02-07
MY180473A (en) 2020-11-30
CL2012000456A1 (es) 2012-08-03
EP2430454A1 (en) 2012-03-21
US20110092762A1 (en) 2011-04-21
EP2615460A1 (en) 2013-07-17
EP3805762C0 (en) 2024-02-07
US8337387B2 (en) 2012-12-25
DK201200196A (en) 2012-03-22
IN2012DN02452A (ru) 2015-08-21
ES2500057T3 (es) 2014-09-29
CN102576027B (zh) 2014-10-01
KR101747983B1 (ko) 2017-06-15
CA2761231C (en) 2021-07-13
JP2013502233A (ja) 2013-01-24
US9228931B2 (en) 2016-01-05
US20120094326A1 (en) 2012-04-19
ES2972747T3 (es) 2024-06-14
DK2430454T3 (da) 2013-02-11
US8323177B2 (en) 2012-12-04
PL2827150T3 (pl) 2021-05-31
US20120095287A1 (en) 2012-04-19
DK2827150T3 (da) 2020-11-16
HUE052071T2 (hu) 2021-04-28
KR20120066023A (ko) 2012-06-21
JP2016104018A (ja) 2016-06-09
JP5951487B2 (ja) 2016-07-13
CN102576027A (zh) 2012-07-11
US20150125890A1 (en) 2015-05-07
EP2827150B3 (en) 2021-08-18
PT2827150T (pt) 2020-12-09
EA025172B9 (ru) 2017-01-30
CA2761231A1 (en) 2011-03-03
US20130162795A1 (en) 2013-06-27
SG178536A1 (en) 2012-03-29
EP2827150B1 (en) 2020-10-21
HK1201915A1 (en) 2015-09-11
US20130165745A1 (en) 2013-06-27
EP2827150A1 (en) 2015-01-21
PL2827150T6 (pl) 2021-05-31
HK1186521A1 (en) 2014-03-14
ES2838698T7 (es) 2022-02-18
AU2010286740A1 (en) 2011-11-24
CN104293646A (zh) 2015-01-21
MX2012002266A (es) 2012-09-07
DK2827150T6 (da) 2021-11-22
BR112012003847B1 (pt) 2020-12-01
ZA201201363B (en) 2013-05-29
US8989475B2 (en) 2015-03-24
AU2010286740A2 (en) 2011-12-15
BR112012003847A2 (pt) 2016-03-22
DK2615460T3 (da) 2014-08-25

Similar Documents

Publication Publication Date Title
EA201270300A1 (ru) Визуализация и оценка эмбрионов, яйцеклеток и стволовых клеток
WO2013181549A3 (en) In vitro embryo blastocyst prediction methods
CR20110470A (es) Proteínas de union a il-17
AR090339A1 (es) Metodos de pronostico, diagnostico y tratamiento de la fibrosis pulmonar idiopatica
CY1117833T1 (el) Νεες συνθεσεις και μεθοδοι για την αγωγη του καρκινου
EA201590630A1 (ru) Способы лечения и диагностики, связанные с лизилоксидазоподобным белком 2 (loxl2)
EA201391154A2 (ru) Способы и композиции для нацеливания на адипоциты у млекопитающих
WO2015195949A3 (en) Methods, compositions, and devices for rapid analysis of biological markers
EA201101520A1 (ru) Способы диагностики онкологических заболеваний, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
IN2015DN02634A (ru)
EA201590247A1 (ru) Антитела к siglec-15
IN2012DN02485A (ru)
GB2511221A (en) Methods and compositions for classification of samples
EP2373784A4 (en) GENERATION AND MAINTENANCE OF STEM CELLS
EA201200323A1 (ru) Соединения и композиции, как ингибиторы протеинкиназы
EA201200118A1 (ru) Дифференцировка мезенхемальных стволовых клеток
SG196784A1 (en) Stem cell cultures
IN2012DN00852A (ru)
MD20130098A2 (ru) Тест для определения лизил-оксидазы-2 и методы его использования
EA201400748A1 (ru) Композиция для обработки семян
UY34243A (es) Marcadores y metodos para evaluación del riesgo de enfermedades cardiovasculares
WO2010083215A3 (en) Composition and method for the treatment of diseases affected by apoptosis
PH12014502711A1 (en) Compositions and methods for enhancing mobilization and proliferation of blastomere-like stem cells
WO2011106785A3 (en) Methods of identifying agents effective to treat cognitive decline and diseases associated therewith
WO2014155105A3 (en) Assessment of risk of aneuploidy

Legal Events

Date Code Title Description
TH4A Publication of the corrected specification to eurasian patent
TH4A Publication of the corrected specification to eurasian patent