EA025172B9 - Способ оценки способности достижения одним или более эмбрионами человека стадии бластоцисты - Google Patents

Способ оценки способности достижения одним или более эмбрионами человека стадии бластоцисты

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Publication number
EA025172B9
EA025172B9 EA201270300A EA201270300A EA025172B9 EA 025172 B9 EA025172 B9 EA 025172B9 EA 201270300 A EA201270300 A EA 201270300A EA 201270300 A EA201270300 A EA 201270300A EA 025172 B9 EA025172 B9 EA 025172B9
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EA
Eurasian Patent Office
Prior art keywords
time
blastocyst stage
human embryos
mitosis
developmental potential
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Application number
EA201270300A
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English (en)
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EA201270300A1 (ru
EA025172B1 (ru
Inventor
Конни С. Вонг
Кевин Э. Лоуке
Томас М. Баэр
Рене А. Реййо-Пера
Барри Бер
Original Assignee
Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA025172(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити filed Critical Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити
Publication of EA201270300A1 publication Critical patent/EA201270300A1/ru
Publication of EA025172B1 publication Critical patent/EA025172B1/ru
Publication of EA025172B9 publication Critical patent/EA025172B9/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • G01N15/1433—
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G01N2015/1029—
    • G01N2015/103—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1493—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1497—Particle shape
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10004—Still image; Photographic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
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    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30044—Fetus; Embryo

Abstract

В изобретении предложен способ оценки способности достижения одним или более эмбрионами человека стадии бластоцисты, включающий культивирование одного или более эмбрионов человека в условиях, подходящих для развития эмбриона; цейтраферную съемку у одного или более эмбрионов длительности по меньшей мере одного явления цитокинеза или клеточного цикла; измерение по меньшей мере одного клеточного параметра, включающего (а) длительность первого цитокинеза; или (б) время между первым и вторым митозом; или (в) время между вторым и третьим митозом; и идентификацию эмбриона, который обладает способностью достижения стадии бластоцисты, когда указанный по меньшей мере один клеточный параметр для указанного эмбриона соответствует (i) длительности первого цитокинеза, составляющей до 33 мин; или (ii) времени между первым и вторым митозом, составляющим от около 7,8 до 14,3 ч; или (iii) времени между вторым и третьим митозом, составляющим до 5,8 ч.
EA201270300A 2009-08-22 2010-08-23 Способ оценки способности достижения одним или более эмбрионами человека стадии бластоцисты EA025172B9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23608509P 2009-08-22 2009-08-22
US33265110P 2010-05-07 2010-05-07
PCT/US2010/046343 WO2011025736A1 (en) 2009-08-22 2010-08-23 Imaging and evaluating embryos, oocytes, and stem cells

Publications (3)

Publication Number Publication Date
EA201270300A1 EA201270300A1 (ru) 2013-01-30
EA025172B1 EA025172B1 (ru) 2016-11-30
EA025172B9 true EA025172B9 (ru) 2017-01-30

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EA201270300A EA025172B9 (ru) 2009-08-22 2010-08-23 Способ оценки способности достижения одним или более эмбрионами человека стадии бластоцисты

Country Status (24)

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US (9) US8721521B2 (ru)
EP (4) EP2615460B1 (ru)
JP (2) JP5951487B2 (ru)
KR (1) KR101747983B1 (ru)
CN (2) CN104293646A (ru)
AU (1) AU2010286740B2 (ru)
BR (1) BR112012003847B1 (ru)
CA (1) CA2761231C (ru)
CL (1) CL2012000456A1 (ru)
DK (4) DK2615460T3 (ru)
EA (1) EA025172B9 (ru)
ES (3) ES2500057T3 (ru)
HK (3) HK1166521A1 (ru)
HU (1) HUE052071T2 (ru)
IL (1) IL218239A (ru)
IN (1) IN2012DN02452A (ru)
MX (1) MX2012002266A (ru)
MY (1) MY180473A (ru)
NZ (1) NZ598293A (ru)
PL (1) PL2827150T6 (ru)
PT (1) PT2827150T (ru)
SG (1) SG178536A1 (ru)
WO (1) WO2011025736A1 (ru)
ZA (1) ZA201201363B (ru)

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WO2011025736A1 (en) 2011-03-03
PL2827150T3 (pl) 2021-05-31
US8323177B2 (en) 2012-12-04
US20130162795A1 (en) 2013-06-27
MY180473A (en) 2020-11-30
CA2761231C (en) 2021-07-13
AU2010286740A1 (en) 2011-11-24
HK1166521A1 (en) 2012-11-02
AU2010286740B2 (en) 2016-03-10
BR112012003847A2 (pt) 2016-03-22
EP2430454A1 (en) 2012-03-21
MX2012002266A (es) 2012-09-07
US7963906B2 (en) 2011-06-21
EP2615460B1 (en) 2014-06-25
US20110105834A1 (en) 2011-05-05
US8989475B2 (en) 2015-03-24
PL2827150T6 (pl) 2021-05-31
ES2838698T7 (es) 2022-02-18
US20170089820A1 (en) 2017-03-30
IL218239A (en) 2017-03-30
US8721521B2 (en) 2014-05-13
US8951184B2 (en) 2015-02-10
NZ598293A (en) 2014-06-27
SG178536A1 (en) 2012-03-29
KR20120066023A (ko) 2012-06-21
US20120094326A1 (en) 2012-04-19
JP2016104018A (ja) 2016-06-09
HK1186521A1 (en) 2014-03-14
IN2012DN02452A (ru) 2015-08-21
EP3805762B1 (en) 2024-02-07
EP2827150B3 (en) 2021-08-18
ES2500057T3 (es) 2014-09-29
US20150160117A1 (en) 2015-06-11
US20120095287A1 (en) 2012-04-19
DK2827150T6 (da) 2021-11-22
ES2399711T3 (es) 2013-04-02
JP2013502233A (ja) 2013-01-24
ZA201201363B (en) 2013-05-29
CA2761231A1 (en) 2011-03-03
EP2430454B1 (en) 2013-01-23
EA025172B1 (ru) 2016-11-30
US8337387B2 (en) 2012-12-25
DK2615460T3 (da) 2014-08-25
US9228931B2 (en) 2016-01-05
CN102576027B (zh) 2014-10-01
AU2010286740A2 (en) 2011-12-15
HK1201915A1 (en) 2015-09-11
CN102576027A (zh) 2012-07-11
ES2838698T3 (es) 2021-07-02
HUE052071T2 (hu) 2021-04-28
CN104293646A (zh) 2015-01-21
PT2827150T (pt) 2020-12-09

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