EA201171450A1 - Фитазы, кодирующие их нуклеиновые кислоты, и способы их получения и применения - Google Patents

Фитазы, кодирующие их нуклеиновые кислоты, и способы их получения и применения

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Publication number
EA201171450A1
EA201171450A1 EA201171450A EA201171450A EA201171450A1 EA 201171450 A1 EA201171450 A1 EA 201171450A1 EA 201171450 A EA201171450 A EA 201171450A EA 201171450 A EA201171450 A EA 201171450A EA 201171450 A1 EA201171450 A1 EA 201171450A1
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Prior art keywords
phytases
production
polypeptides
encoding
polynucleotides
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EA201171450A
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English (en)
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EA021178B1 (ru
Inventor
Дэвид П. Уэйнер
Арне И. мл. Солбак
Райан Макканн
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Верениум Корпорейшн
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43126780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201171450(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Верениум Корпорейшн filed Critical Верениум Корпорейшн
Publication of EA201171450A1 publication Critical patent/EA201171450A1/ru
Publication of EA021178B1 publication Critical patent/EA021178B1/ru

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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
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    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к фитазам, кодирующим их полинуклеотидам, применениям полинуклеотидов и полипептидов по изобретению, а также к получению и выделению таких полинуклеотидов и полипептидов. В частности, изобретение относится к полипептидам, обладающим фитазной активностью в условиях высоких температур, и фитазам, которые сохраняют активность после воздействия высоких температур. Изобретение дополнительно относится к фитазам, которые обладают повышенной лабильностью в желудке. Фитазы по изобретению можно применять в пищевых продуктах для повышения питательной ценности богатых фитатом ингредиентов. Фитазы по изобретению могут быть приготовлены в виде пищевых продуктов или кормов или пищевых или кормовых добавок, например, чтобы фитазы способствовали расщеплению фитата.
EA201171450A 2009-05-21 2010-05-20 Фитазы, кодирующие их нуклеиновые кислоты и способы их получения и применения EA021178B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18028309P 2009-05-21 2009-05-21
PCT/US2010/035667 WO2010135588A2 (en) 2009-05-21 2010-05-20 Phytases, nucleic acids encoding them and methods for making and using them

Publications (2)

Publication Number Publication Date
EA201171450A1 true EA201171450A1 (ru) 2012-06-29
EA021178B1 EA021178B1 (ru) 2015-04-30

Family

ID=43126780

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171450A EA021178B1 (ru) 2009-05-21 2010-05-20 Фитазы, кодирующие их нуклеиновые кислоты и способы их получения и применения

Country Status (17)

Country Link
US (3) US9695403B2 (ru)
EP (2) EP2432797B1 (ru)
JP (3) JP2012527247A (ru)
KR (1) KR101817253B1 (ru)
CN (2) CN102459303B (ru)
AU (1) AU2010249500B2 (ru)
BR (1) BRPI1011160A8 (ru)
CA (1) CA2763283C (ru)
DK (2) DK2432797T3 (ru)
EA (1) EA021178B1 (ru)
ES (2) ES2607688T3 (ru)
HU (2) HUE030948T2 (ru)
MX (1) MX355638B (ru)
NZ (1) NZ596459A (ru)
VN (1) VN30065A1 (ru)
WO (1) WO2010135588A2 (ru)
ZA (1) ZA201108491B (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2617818B1 (en) 2006-09-21 2016-03-23 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
DE102009038784B4 (de) 2009-08-25 2019-03-28 Siemens Healthcare Gmbh Vorbelegbares Sendedatenspeicherelement einer MR-Sendeeinheit in Array-Anwendungen
CN104471071B (zh) * 2012-07-20 2021-05-28 青岛蔚蓝生物集团有限公司 作为基因表达诱导剂的糖酯
GB201308828D0 (en) * 2013-03-12 2013-07-03 Verenium Corp Phytase
GB201308843D0 (en) 2013-03-14 2013-07-03 Verenium Corp Phytase formulation
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
TW201504259A (zh) * 2013-07-25 2015-02-01 Verenium Corp 植酸酶
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
EP3018203A1 (en) * 2014-11-06 2016-05-11 Fertinagro Nutrientes, S.L. Novel phytase, method for obtaining the same and use thereof
US10386315B2 (en) 2016-04-19 2019-08-20 Malvern Panalytical Inc. Differential scanning calorimetry method and apparatus
JP7054523B2 (ja) 2016-06-28 2022-04-14 国立研究開発法人農業・食品産業技術総合研究機構 細胞封入用デバイス及びその使用
JP7051504B2 (ja) * 2018-03-14 2022-04-11 昭和産業株式会社 家禽の筋胃増大用飼料、家禽の筋胃増大用混合飼料、及び家禽の筋胃を増大させる方法
US11278670B2 (en) 2018-04-26 2022-03-22 Carefusion 303, Inc. Semi-autonomous hot-swap infusion module
KR20210005665A (ko) * 2018-04-26 2021-01-14 다니스코 유에스 인크. 고형 조성물 중 파이타아제의 안정성의 증가 방법과 포스페이트 및 파이타아제를 포함하는 과립 조성물
WO2020168943A1 (zh) * 2019-02-18 2020-08-27 青岛蔚蓝生物集团有限公司 植酸酶突变体
CN111363775B (zh) * 2020-03-18 2022-08-05 浙江工业大学 一种生物酶法去消旋化制备l-草铵膦的方法、草铵膦脱氢酶突变体及应用
CN113699134B (zh) * 2020-05-22 2024-04-05 潍坊康地恩生物科技有限公司 植酸酶突变体
CN111653310B (zh) * 2020-06-29 2023-06-20 北京大学深圳研究生院 含二硫键多肽的结构预测方法及装置
EP4119660A1 (en) * 2021-07-16 2023-01-18 AB Enzymes Oy Phytase variants
EP4119661A1 (en) * 2021-07-16 2023-01-18 AB Enzymes Oy Phytase variants with improved stability and ip4 activity
CN115154331B (zh) * 2022-06-16 2024-01-16 武汉大学 一种具有介孔核壳结构的牙本质矿化脱敏材料及其制备方法
CN115011739B (zh) * 2022-08-03 2022-11-01 南京邦康生物技术有限公司 一种益生菌的生产控制方法与系统

Family Cites Families (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966971A (en) 1975-01-02 1976-06-29 Grain Processing Corporation Separation of protein from vegetable sources
US5366558A (en) 1979-03-23 1994-11-22 Brink David L Method of treating biomass material
JPS56501231A (ru) 1979-09-28 1981-09-03
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4535060A (en) 1983-01-05 1985-08-13 Calgene, Inc. Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase, production and use
NL8300698A (nl) 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
JPS59166049A (ja) 1983-03-09 1984-09-19 Nippon Shinyaku Co Ltd 豆乳の製法
JPS60140506A (ja) 1983-12-28 1985-07-25 Hitachi Ltd 磁気ヘツド
US5087571A (en) 1984-06-22 1992-02-11 President And Fellows Of Harvard College Method for providing a cell culture from a transgenic non-human mammal
US4943674A (en) 1987-05-26 1990-07-24 Calgene, Inc. Fruit specific transcriptional factors
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3590766T (ru) 1985-03-30 1987-04-23
CA1313830C (en) 1985-08-07 1993-02-23 Dilip Maganlal Shah Glyphosate-resistant plants
US5107065A (en) 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5780292A (en) 1987-04-29 1998-07-14 Alko Group Ltd. Production of phytate degrading enzymes in trichoderma
DE3623533A1 (de) 1986-07-12 1988-01-21 Beiersdorf Ag Pyrido(1,8)naphthyridinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
NZ221259A (en) 1986-07-31 1990-05-28 Calgene Inc Seed specific transcriptional regulation
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
CA1340522C (en) 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
US5573933A (en) 1987-04-14 1996-11-12 Luminis Pty, Ltd. Transgenic pigs
DE3725946A1 (de) 1987-08-05 1989-02-16 Boehringer Ingelheim Vetmed Stabilisierter futtermittelzusatz und verfahren zu seiner herstellung
NL8702735A (nl) 1987-11-17 1989-06-16 Dorr Oliver Inc Werkwijze voor het weken van granen met een nieuw enzympreparaat.
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
NZ230375A (en) 1988-09-09 1991-07-26 Lubrizol Genetics Inc Synthetic gene encoding b. thuringiensis insecticidal protein
US5162215A (en) 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5316770A (en) 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
BR9007159A (pt) 1989-02-24 1991-12-10 Monsanto Co Genes sinteticos de plantas e processo para a preparacao dos mesmos
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
JPH0376529A (ja) 1989-08-17 1991-04-02 Kyowa Hakko Kogyo Co Ltd 生地およびそれを用いるパンの製造法
US4940935A (en) 1989-08-28 1990-07-10 Ried Ashman Manufacturing Automatic SMD tester
UA27702C2 (ru) 1989-09-27 2000-10-16 Гіст-Брокейдс Н.В. Фрагмент геномной днк, которая кодирует фитазу aspergillus niger, фрагмент кднк, которая кодирует фитазу aspergillus niger, рекомбинантная плазмидная днк для экспрессии фитазы в aspergillus (варианты), штамм aspergillus продуцент фитазы aspergillus (варианты), способ получения
US5641876A (en) 1990-01-05 1997-06-24 Cornell Research Foundation, Inc. Rice actin gene and promoter
ATE157702T1 (de) 1990-02-07 1997-09-15 Abbott Lab Alkalische phosphatase mit verbesserter spezifischer aktivität zur verwendung in indikatorreagenzien
US5543576A (en) 1990-03-23 1996-08-06 Mogen International Production of enzymes in seeds and their use
KR100225087B1 (ko) 1990-03-23 1999-10-15 한스 발터라벤 피타아제의 식물내 발현
US5593963A (en) 1990-09-21 1997-01-14 Mogen International Expression of phytase in plants
WO1991016427A1 (en) 1990-04-24 1991-10-31 Stratagene Methods for phenotype creation from multiple gene populations
WO1991019810A1 (en) 1990-06-15 1991-12-26 California Biotechnology Inc. Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
US5639949A (en) 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
AU8914291A (en) 1990-11-23 1992-06-25 Plant Genetic Systems N.V. Process for transforming monocotyledonous plants
JP3298879B2 (ja) 1990-12-20 2002-07-08 イグジス，インコーポレイテッド 結合タンパク質の最適化
JP2509824B2 (ja) 1991-02-23 1996-06-26 正美 星野 ミネラル吸収促進剤
US6110700A (en) 1991-03-11 2000-08-29 The General Hospital Corporation PRAD1 cyclin and its cDNA
US5922854A (en) 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
GB9114259D0 (en) 1991-07-02 1991-08-21 Ici Plc Plant derived enzyme and dna sequences
CA2075135A1 (en) 1991-08-02 1993-02-03 David E. Ellis Particle-mediated transformation of gymnosperms
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
US5994629A (en) 1991-08-28 1999-11-30 Novartis Ag Positive selection
UA48104C2 (ru) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, содержащий последовательность, которая кодирует инсектицидный протеин, оптимизированную для кукурузы, фрагмент днк, обеспечивающий направленную желательную для сердцевины стебля экспрессию связанного с ней структурного гена в растении, фрагмент днк, обеспечивающий специфическую для пыльцы экспрессию связанного с ней структурного гена в растении, рекомбинантная молекула днк, способ получения оптимизированной для кукурузы кодирующей последовательности инсектицидного протеина, способ защиты растений кукурузы по меньшей мере от одного насекомого-вредителя
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
IL104704A0 (en) 1992-02-13 1993-06-10 Gist Brocades Nv Stabilized aqueous liquid formulation of phytase
JPH05236997A (ja) 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
GB9216151D0 (en) 1992-07-29 1992-09-09 Ici Plc Containment of plant germplasm
JPH0670749A (ja) 1992-08-27 1994-03-15 Nishinomiya Shuzo Kk 麹菌及びその育種方法
JPH06153896A (ja) 1992-08-27 1994-06-03 Nishinomiya Shuzo Kk 清酒の製造方法
PT686197E (pt) 1993-02-26 2000-11-30 Calgene Llc Sistema de expressao de genes baseado em geminivirus
EP0619369B2 (en) 1993-04-05 2009-09-30 Aveve N.V. Phytate hydrolysis and enzyme composition for hydrolyzing phytate
EP0670670A4 (en) 1993-09-30 1996-04-24 Agracetus HETEROLOGICAL PEROXIDASE PROCESSING TRANSGENIC COTTON PLANTS.
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6468742B2 (en) 1993-11-01 2002-10-22 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
US5492813A (en) 1993-11-01 1996-02-20 Boehringer Mannheim Corporation Muteins of β-galactosidase fragments having increased activity
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
NZ279676A (en) 1994-03-09 1998-04-27 Abbott Lab Humanized milk produced by non-human transgenic mammal transformed with a heterologous gene coding for human enzyme producing human oligosaccharides and glycoconjugates
EP0750671A1 (en) 1994-03-09 1997-01-02 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
JPH07277865A (ja) 1994-04-14 1995-10-24 Ebara Res Co Ltd 堆肥およびその製造方法
EP1142485B1 (en) 1994-04-22 2008-02-27 Novozymes A/S A method for improving the solubility of vegetable proteins
US5437992A (en) 1994-04-28 1995-08-01 Genencor International, Inc. Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp
GB9409336D0 (en) 1994-05-10 1994-06-29 Finnfeeds Int Ltd Use of an enzyme for manufacturing an agent for the treatment and/or prophylaxis of coccidiosis
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5750870A (en) 1994-06-17 1998-05-12 Agritope, Inc. Plant genetic transformation methods and transgenic plants
US5830732A (en) 1994-07-05 1998-11-03 Mitsui Toatsu Chemicals, Inc. Phytase
US5959171A (en) 1994-08-17 1999-09-28 Pharming B.V. Method for the production of biologically active polypeptides in a mammal's
WO1996006927A1 (en) 1994-09-01 1996-03-07 Merck & Co., Inc. Transgenic animal expressing a familial form of human amyloid precursor protein
US5795737A (en) 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
US6111166A (en) 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
US5880327A (en) 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5786316A (en) 1994-10-27 1998-07-28 The Procter & Gamble Company Cleaning compositions comprising xylanases
US5770012A (en) 1994-11-18 1998-06-23 P. H. Glatfelter Co. Process for treating paper machine stock containing bleached hardwood pulp with an enzyme mixture to reduce vessel element picking
US6187992B1 (en) 1994-12-05 2001-02-13 Merck & Co., Inc. Transgenic mouse having a disrupted amyloid precursor protein gene
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5705369A (en) 1994-12-27 1998-01-06 Midwest Research Institute Prehydrolysis of lignocellulose
ATE210180T1 (de) 1995-01-26 2001-12-15 Novozymes As Xylanase beinhaltende futterzusätze für tiere
JPH08205785A (ja) 1995-02-03 1996-08-13 Ii M Kenkyu Kiko:Kk フィチン分解性飼料
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
CA2213340C (en) 1995-03-03 2011-07-26 Novartis Ag Control of gene expression in plants by receptor mediated transactivation in the presence of a chemical ligand
CA2223103A1 (en) 1995-06-06 1996-12-12 Isis Pharmaceuticals Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5720971A (en) 1995-07-05 1998-02-24 Her Majesty The Queen In Right Of Canada, As Represented By The Department Of Agriculture And Agri-Food Canada Enzyme additives for ruminant feeds
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
US6057103A (en) 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US5721118A (en) 1995-10-31 1998-02-24 The Regents Of The University Of California, San Diego Mammalian artificial chromosomes and methods of using same
DK172530B1 (da) 1995-11-10 1998-11-23 Leo Pharm Prod Ltd Tilsætningsprodukt til drikkevand og foder til dyr samt fremgangsmåde for tilsætning
US6764835B2 (en) 1995-12-07 2004-07-20 Diversa Corporation Saturation mutageneis in directed evolution
US6361974B1 (en) 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US6562594B1 (en) 1999-09-29 2003-05-13 Diversa Corporation Saturation mutagenesis in directed evolution
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
KR0169913B1 (ko) 1996-03-14 1999-01-15 김은영 신균주 바실러스속 ds11과 이로부터 생산되는 신규 파이타아제
AU2077197A (en) 1996-03-18 1997-10-10 Novo Nordisk Biotech, Inc. Polypeptides having phytase activity and nucleic acids encoding same
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US6025155A (en) 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US5697987A (en) 1996-05-10 1997-12-16 The Trustees Of Princeton University Alternative fuel
US6057100A (en) 1996-06-07 2000-05-02 Eos Biotechnology, Inc. Oligonucleotide arrays
US5939303A (en) 1996-06-14 1999-08-17 Her Majesty The Queen In Right Of Canada, As Represented By The Dept. Of Agriculture & Agri-Food Canada Phytases of ruminal microorganisms
US5759840A (en) 1996-09-09 1998-06-02 National Research Council Of Canada Modification of xylanase to improve thermophilicity, alkalophilicity and thermostability
EP0925362B1 (en) 1996-09-12 2005-07-20 Syngenta Participations AG Transgenic plants expressing cellulolytic enzymes
US6039942A (en) 1996-12-20 2000-03-21 Novo Nordick A/S Phytase polypeptides
WO1998030681A1 (en) 1997-01-09 1998-07-16 Novo Nordisk A/S Phytase combinations
DK1717322T3 (da) 1997-01-17 2012-10-22 Codexis Mayflower Holdings Llc Udvikling af hele celler og organismer ved rekursiv sekvensrekombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
ATE418608T1 (de) 1997-03-18 2009-01-15 Novozymes As Methode zur herstellung einer bibliothek mittels dna-shuffling
BR9808368A (pt) 1997-03-18 2000-05-23 Novo Nordisk As Processos para a construção de uma biblioteca de polinucleotideos homólogos recombinados, para a identificação um polipeptìdeo de interesse, e, para a produção de um polipeptìdeo de interesse.
US5948653A (en) 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6153410A (en) 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
KR100206453B1 (ko) 1997-03-27 1999-07-01 박원훈 신규한플라즈미드를이용하여형질전환시킨균주 이.채씨오엘아이.피와이로부터생산된피타제
US6333181B1 (en) 1997-04-07 2001-12-25 University Of Florida Research Foundation, Inc. Ethanol production from lignocellulose
US5916780A (en) 1997-06-09 1999-06-29 Iogen Corporation Pretreatment process for conversion of cellulose to fuel ethanol
NZ330940A (en) 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6855365B2 (en) 1997-08-13 2005-02-15 Diversa Corporation Recombinant bacterial phytases and uses thereof
US20040091968A1 (en) * 1997-08-13 2004-05-13 Short Jay M. Recombinant phytases and methods of making and using them
US6183740B1 (en) 1997-08-13 2001-02-06 Diversa Corporation Recombinant bacterial phytases and uses thereof
US6720014B1 (en) 1997-08-13 2004-04-13 Diversa Corporation Phytase-containing foodstuffs and methods of making and using them
US7078035B2 (en) 1997-08-13 2006-07-18 Diversa Corporation Phytases, nucleic acids encoding them and methods for making and using them
US5876997A (en) 1997-08-13 1999-03-02 Diversa Corporation Phytase
WO1999009217A1 (en) 1997-08-15 1999-02-25 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
ATE319986T1 (de) 1997-09-11 2006-03-15 Bioventures Inc Verfahren zur herstellung von arrays hoher dichte
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
WO1999021979A1 (en) 1997-10-28 1999-05-06 Maxygen, Inc. Human papillomavirus vectors
EP1030861A4 (en) 1997-10-31 2001-09-05 Maxygen Inc MODIFICATION OF VIRAL TROPISM AND THE DIVERSITY OF HOST SPECIES BY RECOMBINATION OF THE VIRAL GENOME
EP0921189B1 (en) 1997-11-14 2005-01-12 Sankyo Company Limited Transgenic animal allergy models and methods for their use
EP1036198B1 (en) 1997-12-08 2012-09-26 California Institute Of Technology Method for creating polynucleotide and polypeptide sequences
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP1053343A2 (en) 1998-02-11 2000-11-22 Maxygen, Inc. Targeting of genetic vaccine vectors
EP1054973A1 (en) 1998-02-11 2000-11-29 Maxygen, Inc. Antigen library immunization
US6514495B1 (en) * 1998-03-23 2003-02-04 Novozymes A/S Phytase varinats
ATE340870T1 (de) 1998-04-03 2006-10-15 Compound Therapeutics Inc Adressierbare protein arrays
DE69918091D1 (de) 1998-04-08 2004-07-22 Nutreco Aquaculture Res Ct As Verfahren zur modifizierung der proteinstruktur in endgeformten futterpellets, baellen oder aehnlichen, zur erreichung von formstabilitaet
US6156952A (en) 1998-04-09 2000-12-05 Constituent Institution Of The University Of Maryland System HIV transgenic animals and uses therefor
US6048695A (en) 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
CN1308683A (zh) 1998-06-29 2001-08-15 菲洛斯公司 用于产生高多样性文库的方法
FR2782323B1 (fr) 1998-08-12 2002-01-11 Proteus Procede de production in vitro de sequences polynucleotidiques recombinees, banques de sequences et sequences ainsi obtenues
GB2340755B (en) 1998-08-24 2002-09-25 Cannon Rubber Ltd Breast pump insert
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
FR2788782B1 (fr) 1999-01-25 2003-01-31 Gie Agro Ind Produit multienzymatique a activites glucoamylasique, proteolytique et xylanasique et procede pour sa production par fermentation a l'etat solide de son de ble avec aspergillus niger
US6511824B1 (en) 1999-03-17 2003-01-28 Exelixis, Inc. Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use
ES2248067T3 (es) 1999-03-31 2006-03-16 Cornell Research Foundation, Inc. Fosfatasas con actividad de fitasa mejorada.
CN100379860C (zh) 1999-04-23 2008-04-09 圭尔夫大学 表达唾液蛋白的转基因动物
US6221653B1 (en) 1999-04-27 2001-04-24 Agilent Technologies, Inc. Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids
DE19922753A1 (de) 1999-05-18 2000-11-23 Basf Ag Enzym-Instantformulierungen für die Tierernährung
DE19929257A1 (de) 1999-06-25 2000-12-28 Basf Ag Polymerbeschichtete, granulierte enzymhaltige Futtermittelzusätze und Verfahren zu deren Herstellung
ES2436602T3 (es) 1999-07-09 2014-01-03 Novozymes A/S Proceso para la preparación de un gránulo que contiene enzimas
US6653151B2 (en) 1999-07-30 2003-11-25 Large Scale Proteomics Corporation Dry deposition of materials for microarrays using matrix displacement
EP1889904A3 (en) 1999-10-01 2008-07-09 Novozymes A/S Enzyme granulate
US6409841B1 (en) 1999-11-02 2002-06-25 Waste Energy Integrated Systems, Llc. Process for the production of organic products from diverse biomass sources
KR100790918B1 (ko) 1999-11-18 2008-01-03 코넬 리서치 파운데이션 인코포레이티드 에스케리챠 콜리 피타아제의 부위-지향성 돌연변이유발
EP1106603A3 (en) 1999-12-06 2003-11-19 Fuji Photo Film Co., Ltd. DNA chip and reactive solid carrier
US6531644B1 (en) 2000-01-14 2003-03-11 Exelixis, Inc. Methods for identifying anti-cancer drug targets
WO2001052620A2 (en) 2000-01-21 2001-07-26 The Scripps Research Institute Methods and compositions to modulate expression in plants
EP1259630A1 (en) 2000-02-23 2002-11-27 Novozymes A/S Fermentation with a phytase
ES2166316B1 (es) 2000-02-24 2003-02-16 Ct Investig Energeticas Ciemat Procedimiento de produccion de etanol a partir de biomasa lignocelulosica utilizando una nueva levadura termotolerante.
US6423145B1 (en) 2000-08-09 2002-07-23 Midwest Research Institute Dilute acid/metal salt hydrolysis of lignocellulosics
CA2425671A1 (en) 2000-10-12 2002-04-18 Exelixis, Inc. Human ect2 and methods of use
AU2002251724B2 (en) 2000-10-24 2007-06-21 Syngenta Participations Ag Control of gene expression in plants
US6309872B1 (en) 2000-11-01 2001-10-30 Novozymes Biotech, Inc Polypeptides having glucoamylase activity and nucleic acids encoding same
AU2002356511A1 (en) 2001-07-30 2003-04-01 Immunex Corporation T. reesei phytase enyzmes, polynucleides encoding the enzymes, vectors and host cells thereof, and methods of using
ATE488585T1 (de) 2001-08-27 2010-12-15 Syngenta Participations Ag Selbstprozessierende pflanzen und pflanzenteile
MY139056A (en) * 2001-12-28 2009-08-28 Ab Enzymes Gmbh Microbially-expressed thermotolerant phytase for animal feed
TW200305430A (en) * 2001-12-28 2003-11-01 Syngenta Participations Ag Thermotolerant phytase for animal feed
CN101792749B (zh) 2002-08-12 2012-09-05 金克克国际有限公司 大肠杆菌AppA肌醇六磷酸酶突变体
US7884261B2 (en) 2004-06-30 2011-02-08 CERES,Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant growth rate and biomass in plants
JP2007527726A (ja) 2004-03-08 2007-10-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 自己プロセシング植物および植物部分
JP4587691B2 (ja) 2004-03-30 2010-11-24 アサヒビール株式会社 イノシトール含量の高いビール、発泡酒、麦芽発酵飲料およびその製造方法
US20050227930A1 (en) 2004-04-08 2005-10-13 Kgk Synergize Inc. Cholesterol lowering combination
US20060014260A1 (en) 2004-05-07 2006-01-19 Zhiliang Fan Lower cellulase requirements for biomass cellulose hydrolysis and fermentation
CN1706941A (zh) 2004-06-10 2005-12-14 安徽固源生物工程有限责任公司 高比活植酸酶的热稳定性改良及其高效表达
DE102004050410A1 (de) 2004-10-15 2006-06-08 Ab Enzymes Gmbh Polypeptid mit Phytaseaktivität und dieses codierende Nucleotidsequenz
ES2387203T3 (es) * 2006-04-04 2012-09-17 Novozymes A/S Variantes de fitasa
EP2069486A2 (en) * 2006-08-03 2009-06-17 Cornell Research Foundation, Inc. Phytases with improved thermal stability
EP2617818B1 (en) * 2006-09-21 2016-03-23 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
DE102006053059A1 (de) 2006-11-10 2008-05-15 Ab Enzymes Gmbh Polypeptid mit Phytaseaktivität und erhöhter Temperaturstabilität der Enzymaktivität sowie dieses codierende Nukleotidsequenz
US9476078B2 (en) 2007-07-31 2016-10-25 Basf Enzymes Llc Tailored multi-site combinatorial assembly
AU2008331564B2 (en) * 2007-12-03 2014-01-09 Agrivida, Inc. Engineering enzymatically susceptible proteins

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