EA200970335A1 - Композиции и способы для диагностики и лечения рака - Google Patents

Композиции и способы для диагностики и лечения рака

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Publication number
EA200970335A1
EA200970335A1 EA200970335A EA200970335A EA200970335A1 EA 200970335 A1 EA200970335 A1 EA 200970335A1 EA 200970335 A EA200970335 A EA 200970335A EA 200970335 A EA200970335 A EA 200970335A EA 200970335 A1 EA200970335 A1 EA 200970335A1
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EA
Eurasian Patent Office
Prior art keywords
cancer
diagnosis
compositions
treatment
methods
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Application number
EA200970335A
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English (en)
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EA018260B1 (ru
Inventor
Остин Герни
Тимоти Хэуи
Санджив Сатиал
Фумико Аксельрод
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Онкомед Фармасьютикалз, Инк.
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Application filed by Онкомед Фармасьютикалз, Инк. filed Critical Онкомед Фармасьютикалз, Инк.
Publication of EA200970335A1 publication Critical patent/EA200970335A1/ru
Publication of EA018260B1 publication Critical patent/EA018260B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Описано выделенное антитело, которое специфически связывается с внеклеточным доменом DLL4 человека и влияет на рост опухоли, содержащей раковые стволовые клетки. Описан также способ лечения рака, включающий в себя введение терапевтически эффективного количества антитела против DLL4.
EA200970335A 2006-09-29 2007-09-28 Антитела к дельта-подобному лиганду 4 человека и их применение EA018260B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84790406P 2006-09-29 2006-09-29
US88626007P 2007-01-23 2007-01-23
US94254207P 2007-06-07 2007-06-07
PCT/US2007/020889 WO2008042236A2 (en) 2006-09-29 2007-09-28 Compositions and methods for diagnosing and treating cancer

Publications (2)

Publication Number Publication Date
EA200970335A1 true EA200970335A1 (ru) 2009-10-30
EA018260B1 EA018260B1 (ru) 2013-06-28

Family

ID=39268983

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970335A EA018260B1 (ru) 2006-09-29 2007-09-28 Антитела к дельта-подобному лиганду 4 человека и их применение

Country Status (28)

Country Link
US (5) US7750124B2 (ru)
EP (3) EP2066694B1 (ru)
JP (3) JP5535633B2 (ru)
KR (1) KR101477824B1 (ru)
AU (1) AU2007305443B2 (ru)
BR (1) BRPI0717431A2 (ru)
CA (1) CA2664738C (ru)
CO (1) CO6180466A2 (ru)
CR (1) CR10667A (ru)
CY (1) CY1117154T1 (ru)
DK (1) DK2066694T3 (ru)
EA (1) EA018260B1 (ru)
ES (1) ES2557953T3 (ru)
HK (1) HK1133268A1 (ru)
HR (1) HRP20160082T1 (ru)
HU (1) HUE028379T2 (ru)
IL (1) IL197721A (ru)
MA (1) MA30808B1 (ru)
ME (1) ME02371B (ru)
MX (1) MX2009003229A (ru)
NO (1) NO20091635L (ru)
NZ (1) NZ576404A (ru)
PL (1) PL2066694T3 (ru)
PT (1) PT2066694E (ru)
RS (1) RS54452B1 (ru)
SI (1) SI2066694T1 (ru)
WO (1) WO2008042236A2 (ru)
ZA (1) ZA200901615B (ru)

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US20140147443A9 (en) 2014-05-29
DK2066694T3 (en) 2016-02-08
CA2664738A1 (en) 2008-04-10
HRP20160082T1 (hr) 2016-02-26
CR10667A (es) 2009-05-25
AU2007305443A1 (en) 2008-04-10
PT2066694E (pt) 2016-01-27
MX2009003229A (es) 2009-06-18
US20160367667A1 (en) 2016-12-22
EP2562188A2 (en) 2013-02-27
EP3357932A1 (en) 2018-08-08
CA2664738C (en) 2017-03-07
RS54452B1 (en) 2016-06-30
NZ576404A (en) 2012-02-24
EP2562188A3 (en) 2013-03-06
AU2007305443B2 (en) 2012-08-23
KR20090078334A (ko) 2009-07-17
EP2066694A2 (en) 2009-06-10
JP5997194B2 (ja) 2016-09-28
US9376497B2 (en) 2016-06-28
US20100316637A1 (en) 2010-12-16
HK1133268A1 (en) 2010-03-19
JP2010504755A (ja) 2010-02-18
WO2008042236A3 (en) 2008-07-31
SI2066694T1 (sl) 2016-02-29
CO6180466A2 (es) 2010-07-19
JP2014158469A (ja) 2014-09-04
EP2066694B1 (en) 2015-11-04
US9228020B2 (en) 2016-01-05
EA018260B1 (ru) 2013-06-28
NO20091635L (no) 2009-06-26
ES2557953T3 (es) 2016-01-29
IL197721A0 (en) 2011-08-01
HUE028379T2 (en) 2016-12-28
US7750124B2 (en) 2010-07-06
IL197721A (en) 2015-03-31
ZA200901615B (en) 2009-12-30
CY1117154T1 (el) 2017-04-05
US20190060453A1 (en) 2019-02-28
EP2066694A4 (en) 2010-05-05
JP5535633B2 (ja) 2014-07-02
KR101477824B1 (ko) 2015-01-02

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