EA029303B1 - Антитела к cd38 - Google Patents

Антитела к cd38 Download PDF

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Publication number
EA029303B1
EA029303B1 EA201390993A EA201390993A EA029303B1 EA 029303 B1 EA029303 B1 EA 029303B1 EA 201390993 A EA201390993 A EA 201390993A EA 201390993 A EA201390993 A EA 201390993A EA 029303 B1 EA029303 B1 EA 029303B1
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EA
Eurasian Patent Office
Prior art keywords
zeg
tng
antibody
rgo
azr
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Application number
EA201390993A
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English (en)
Russian (ru)
Other versions
EA201390993A1 (ru
Inventor
Кэтлин Энн Элиас
Грегори Ландес
Швета Сингх
Ваутер Корвер
Эндрю Уоллинг Дрэйк
Мэри Хаак-Френдшо
Гиорги Пэл Снелл
Винай Бхаскар
Original Assignee
Такеда Фармасьютикал Компани Лимитед
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Publication of EA201390993A1 publication Critical patent/EA201390993A1/ru
Publication of EA029303B1 publication Critical patent/EA029303B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201390993A 2010-12-30 2011-12-30 Антитела к cd38 EA029303B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061428699P 2010-12-30 2010-12-30
US201161470382P 2011-03-31 2011-03-31
US201161470406P 2011-03-31 2011-03-31
US201161485104P 2011-05-11 2011-05-11
PCT/US2011/068235 WO2012092612A1 (en) 2010-12-30 2011-12-30 Anti-cd38 antibodies

Publications (2)

Publication Number Publication Date
EA201390993A1 EA201390993A1 (ru) 2013-12-30
EA029303B1 true EA029303B1 (ru) 2018-03-30

Family

ID=45498158

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201390993A EA029303B1 (ru) 2010-12-30 2011-12-30 Антитела к cd38
EA201791186A EA201791186A1 (ru) 2010-12-30 2011-12-30 Антитела к cd38

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201791186A EA201791186A1 (ru) 2010-12-30 2011-12-30 Антитела к cd38

Country Status (38)

Country Link
US (11) US9102744B2 (OSRAM)
EP (6) EP3789404A1 (OSRAM)
JP (10) JP6148984B2 (OSRAM)
KR (5) KR102070326B1 (OSRAM)
CN (4) CN107365385A (OSRAM)
AR (1) AR084747A1 (OSRAM)
AU (3) AU2011351921B2 (OSRAM)
BR (1) BR112013017009B1 (OSRAM)
CA (1) CA2822061C (OSRAM)
CO (1) CO6761368A2 (OSRAM)
CR (1) CR20130313A (OSRAM)
CY (3) CY1122161T1 (OSRAM)
DK (3) DK2658871T3 (OSRAM)
EA (2) EA029303B1 (OSRAM)
EC (1) ECSP13012794A (OSRAM)
ES (3) ES2690095T3 (OSRAM)
GE (1) GEP20166493B (OSRAM)
HR (3) HRP20181245T1 (OSRAM)
HU (3) HUE038535T2 (OSRAM)
IL (1) IL226973A (OSRAM)
JO (2) JOP20210044A1 (OSRAM)
LT (3) LT3284754T (OSRAM)
MA (1) MA34763B1 (OSRAM)
MX (2) MX350903B (OSRAM)
MY (1) MY160499A (OSRAM)
NZ (2) NZ612272A (OSRAM)
PE (1) PE20140247A1 (OSRAM)
PL (3) PL3284754T3 (OSRAM)
PT (3) PT2658871T (OSRAM)
RS (3) RS61280B1 (OSRAM)
SG (1) SG191211A1 (OSRAM)
SI (3) SI2658871T1 (OSRAM)
SM (2) SMT201800388T1 (OSRAM)
TR (1) TR201808709T4 (OSRAM)
TW (1) TWI564304B (OSRAM)
UY (1) UY33850A (OSRAM)
WO (2) WO2012092612A1 (OSRAM)
ZA (1) ZA201304696B (OSRAM)

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US10342869B2 (en) 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
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US20140155584A1 (en) 2014-06-05
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KR102070326B1 (ko) 2020-01-29
SI3284754T1 (sl) 2021-03-31
WO2012092616A1 (en) 2012-07-05
SMT201800405T1 (it) 2018-09-13
HK1245284A1 (en) 2018-08-24
JP2018019689A (ja) 2018-02-08
US20180066069A1 (en) 2018-03-08
AU2011351921A1 (en) 2013-07-11
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JP6621447B2 (ja) 2019-12-18
KR101945002B1 (ko) 2019-02-07
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DK2658870T3 (en) 2018-08-06
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DK2658871T3 (en) 2018-08-13
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AU2011351921B2 (en) 2017-04-13
KR102602640B1 (ko) 2023-11-16
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US20250171561A1 (en) 2025-05-29
HUE038727T2 (hu) 2018-11-28
KR102294213B1 (ko) 2021-08-27
CN103282383A (zh) 2013-09-04
CN119775422A (zh) 2025-04-08
SG191211A1 (en) 2013-07-31
EP2658871A1 (en) 2013-11-06
CN113480649B (zh) 2025-01-28
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PT3284754T (pt) 2020-12-21
JP6148984B2 (ja) 2017-06-14
MA34763B1 (fr) 2013-12-03
KR102451597B1 (ko) 2022-10-06
US9676869B2 (en) 2017-06-13
BR112013017009B1 (pt) 2022-07-26
NZ705848A (en) 2016-07-29
JP2014509837A (ja) 2014-04-24
JP2016121139A (ja) 2016-07-07
CY1122165T1 (el) 2020-07-31
MX350903B (es) 2017-09-25
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GEP20166493B (en) 2016-06-27
PL3284754T3 (pl) 2021-04-06
HRP20181245T1 (hr) 2018-10-05
HRP20201996T1 (hr) 2021-02-05
JOP20210044A1 (ar) 2017-06-16
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WO2012092612A1 (en) 2012-07-05
JP2014509187A (ja) 2014-04-17
ES2690095T3 (es) 2018-11-19
TWI564304B (zh) 2017-01-01
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US20150203587A1 (en) 2015-07-23
JP7315598B2 (ja) 2023-07-26
MX2020012426A (es) 2021-02-18
AU2017204571A1 (en) 2017-07-27
CN113480649A (zh) 2021-10-08
RS61280B1 (sr) 2021-02-26
TW201247705A (en) 2012-12-01
KR20200009142A (ko) 2020-01-29
RS57494B1 (sr) 2018-10-31
JP6425635B2 (ja) 2018-11-21
SI2658871T1 (sl) 2018-11-30
US8926969B2 (en) 2015-01-06
TR201808709T4 (tr) 2018-07-23
KR20210107892A (ko) 2021-09-01
JP2018029581A (ja) 2018-03-01
US20200040105A1 (en) 2020-02-06
JOP20110402B1 (ar) 2021-08-17

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