EA010299B1 - Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортёра - Google Patents

Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортёра Download PDF

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Publication number
EA010299B1
EA010299B1 EA200600351A EA200600351A EA010299B1 EA 010299 B1 EA010299 B1 EA 010299B1 EA 200600351 A EA200600351 A EA 200600351A EA 200600351 A EA200600351 A EA 200600351A EA 010299 B1 EA010299 B1 EA 010299B1
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EA
Eurasian Patent Office
Prior art keywords
group
compound
ring
lower alkyl
bromo
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EA200600351A
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English (en)
Russian (ru)
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EA200600351A1 (ru
Inventor
Сумихиро Номура
Ийдзи Каваниси
Киитиро Уита
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Мицубиси Танабе Фарма Корпорейшн
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Application filed by Мицубиси Танабе Фарма Корпорейшн filed Critical Мицубиси Танабе Фарма Корпорейшн
Publication of EA200600351A1 publication Critical patent/EA200600351A1/ru
Publication of EA010299B1 publication Critical patent/EA010299B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA200600351A 2003-08-01 2004-07-30 Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортёра EA010299B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49153403P 2003-08-01 2003-08-01
PCT/JP2004/011312 WO2005012326A1 (en) 2003-08-01 2004-07-30 Novel compounds having inhibitory activity against sodium-dependant transporter

Publications (2)

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EA200600351A1 EA200600351A1 (ru) 2006-08-25
EA010299B1 true EA010299B1 (ru) 2008-08-29

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ID=34115515

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Application Number Title Priority Date Filing Date
EA200600351A EA010299B1 (ru) 2003-08-01 2004-07-30 Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортёра
EA200800924A EA015104B1 (ru) 2003-08-01 2004-07-30 Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера

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EA200800924A EA015104B1 (ru) 2003-08-01 2004-07-30 Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера

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US (3) US7943788B2 (cg-RX-API-DMAC7.html)
EP (4) EP2896397B2 (cg-RX-API-DMAC7.html)
JP (2) JP4130466B2 (cg-RX-API-DMAC7.html)
KR (2) KR100778988B1 (cg-RX-API-DMAC7.html)
CN (4) CN1829729A (cg-RX-API-DMAC7.html)
AR (1) AR045173A1 (cg-RX-API-DMAC7.html)
AU (1) AU2004260761B2 (cg-RX-API-DMAC7.html)
BE (1) BE2014C027I2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0413232B8 (cg-RX-API-DMAC7.html)
CA (1) CA2534024C (cg-RX-API-DMAC7.html)
CR (2) CR8188A (cg-RX-API-DMAC7.html)
CY (3) CY1113813T1 (cg-RX-API-DMAC7.html)
DK (2) DK2896397T4 (cg-RX-API-DMAC7.html)
EA (2) EA010299B1 (cg-RX-API-DMAC7.html)
ES (4) ES2649737T5 (cg-RX-API-DMAC7.html)
FR (1) FR14C0034I2 (cg-RX-API-DMAC7.html)
HR (2) HRP20130124T4 (cg-RX-API-DMAC7.html)
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NZ (2) NZ575711A (cg-RX-API-DMAC7.html)
PL (2) PL1651658T5 (cg-RX-API-DMAC7.html)
PT (2) PT1651658E (cg-RX-API-DMAC7.html)
RS (1) RS53365B (cg-RX-API-DMAC7.html)
SG (1) SG145694A1 (cg-RX-API-DMAC7.html)
SI (2) SI1651658T2 (cg-RX-API-DMAC7.html)
TW (2) TWI385177B (cg-RX-API-DMAC7.html)
UA (1) UA83243C2 (cg-RX-API-DMAC7.html)
WO (1) WO2005012326A1 (cg-RX-API-DMAC7.html)
ZA (5) ZA200601685B (cg-RX-API-DMAC7.html)

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CN1020944C (zh) 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
EP1609785B1 (en) 2003-03-14 2016-02-03 Astellas Pharma Inc. C-glycoside derivatives and salts thereof
ES2649737T5 (es) † 2003-08-01 2021-07-07 Mitsubishi Tanabe Pharma Corp Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio
NZ549629A (en) * 2004-03-04 2010-06-25 Kissei Pharmaceutical Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
CN103435581B (zh) 2004-03-16 2015-08-19 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
WO2006010557A1 (de) * 2004-07-27 2006-02-02 Boehringer Ingelheim International Gmbh D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
CA2581922A1 (en) * 2004-09-29 2006-04-06 Kissei Pharmaceutical Co., Ltd. 1-(.beta.-d-glycopyranosyl)-3-substituted nitrogenous heterocyclic compound, medicinal composition containing the same, and medicinal use thereof
EP1828216B1 (en) 2004-12-16 2008-09-10 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200637869A (en) 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
MY147375A (en) * 2005-01-31 2012-11-30 Mitsubishi Tanabe Pharma Corp Indole derivatives
AR053329A1 (es) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
JP4496174B2 (ja) * 2005-01-31 2010-07-07 田辺三菱製薬株式会社 医薬組成物
CA2595257A1 (en) 2005-02-23 2006-08-31 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors
WO2006108842A1 (en) 2005-04-15 2006-10-19 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors
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