DZ3236A1 - Procédé pour la purification de proteines actives pharmacologiquement par chromatographie d'échange de cations - Google Patents

Procédé pour la purification de proteines actives pharmacologiquement par chromatographie d'échange de cations

Info

Publication number
DZ3236A1
DZ3236A1 DZ020153A DZ020153A DZ3236A1 DZ 3236 A1 DZ3236 A1 DZ 3236A1 DZ 020153 A DZ020153 A DZ 020153A DZ 020153 A DZ020153 A DZ 020153A DZ 3236 A1 DZ3236 A1 DZ 3236A1
Authority
DZ
Algeria
Prior art keywords
purification
cation exchange
exchange chromatography
pharmacologically active
active proteins
Prior art date
Application number
DZ020153A
Other languages
English (en)
French (fr)
Inventor
Giuseppe Claudio Viscomi
Lucia Scapol
Original Assignee
Alfa Waddermann S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Waddermann S P A filed Critical Alfa Waddermann S P A
Application granted granted Critical
Publication of DZ3236A1 publication Critical patent/DZ3236A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DZ020153A 2001-07-06 2002-06-26 Procédé pour la purification de proteines actives pharmacologiquement par chromatographie d'échange de cations DZ3236A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001BO000426A ITBO20010426A1 (it) 2001-07-06 2001-07-06 Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico

Publications (1)

Publication Number Publication Date
DZ3236A1 true DZ3236A1 (fr) 2005-04-20

Family

ID=11439471

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ020153A DZ3236A1 (fr) 2001-07-06 2002-06-26 Procédé pour la purification de proteines actives pharmacologiquement par chromatographie d'échange de cations

Country Status (27)

Country Link
US (1) US6866782B2 (en:Method)
EP (1) EP1273592B1 (en:Method)
JP (1) JP3940037B2 (en:Method)
KR (1) KR100771252B1 (en:Method)
CN (1) CN100484954C (en:Method)
AR (1) AR034663A1 (en:Method)
AT (1) ATE307824T1 (en:Method)
BG (1) BG65748B1 (en:Method)
BR (1) BR0202431A (en:Method)
CA (1) CA2388716C (en:Method)
CU (1) CU23149A3 (en:Method)
DE (1) DE60206847T2 (en:Method)
DK (1) DK1273592T3 (en:Method)
DZ (1) DZ3236A1 (en:Method)
EG (1) EG23150A (en:Method)
ES (1) ES2250544T3 (en:Method)
HR (1) HRP20020480B1 (en:Method)
HU (1) HUP0202124A2 (en:Method)
IT (1) ITBO20010426A1 (en:Method)
ME (1) MEP3408A (en:Method)
MX (1) MXPA02006303A (en:Method)
PL (1) PL209954B1 (en:Method)
RS (1) RS51512B (en:Method)
RU (1) RU2274471C2 (en:Method)
SI (1) SI1273592T1 (en:Method)
SK (1) SK287827B6 (en:Method)
UY (1) UY27354A1 (en:Method)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500852A (ja) * 2003-05-16 2007-01-18 クリオバイオフィジカ， インコーポレイテッド 外部勾配クロマトフォーカシング
JP3920913B2 (ja) * 2004-03-30 2007-05-30 寛 柳澤 タンパク質の分離方法
US7449116B2 (en) * 2004-10-01 2008-11-11 Agilent Technologies, Inc. Methods and systems for protein separation
US7943046B2 (en) * 2004-10-01 2011-05-17 Agilent Technologies, Inc Methods and systems for on-column protein delipidation
ES2532804T3 (es) * 2006-04-12 2015-03-31 Crealta Pharmaceuticals Llc Purificación de proteínas con tensioactivo catiónico
WO2009073975A1 (en) * 2007-12-10 2009-06-18 National Research Council Of Canada Production of recombinant interferon proteins
DE102009032179A1 (de) 2009-07-07 2011-01-13 Biogenerix Ag Verfahren zur Reinigung von Interferon beta
CN101768601B (zh) * 2010-02-01 2013-08-07 山东泉港药业有限公司 一种重组人血白蛋白—干扰素α2b的生产方法
SG10201605397PA (en) * 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
US8921113B2 (en) 2012-12-21 2014-12-30 Dionex Corporation Buffer kit and method of generating a linear pH gradient
US9650412B2 (en) * 2013-03-08 2017-05-16 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
CN104236983A (zh) * 2013-06-14 2014-12-24 中国科学院大连化学物理研究所 溶液样品中含长烷基链的离子液体的去除方法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
WO2016079598A1 (en) * 2014-11-18 2016-05-26 Unichem Laboratories Limited An improved process for the preparation of pharmacopoeial grade interferon alpha 2b
CN106496302B (zh) * 2015-09-08 2021-12-10 三生国健药业（上海）股份有限公司 一种用离子交换层析纯化蛋白质的方法
GB201517450D0 (en) * 2015-10-02 2015-11-18 Ipsen Biopharm Ltd Method
JP2018536418A (ja) * 2015-12-09 2018-12-13 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 脱離条件下で発酵固体からタンパク質を精製する方法
GB2568936B (en) 2017-12-01 2019-12-25 Ford Global Tech Llc Liquid cooled injector
BR112021003420A2 (pt) 2018-08-31 2021-05-18 Genzyme Corporation resina cromatográfica estéril e uso da mesma em processos de manufatura
US11022585B2 (en) 2019-06-09 2021-06-01 Dionex Corporation Methods and systems for optimizing buffer conditions with liquid chromatography
CN111138523A (zh) * 2019-12-10 2020-05-12 天津生机集团股份有限公司 一种从重组鸡干扰素α复性液中纯化制备重组鸡干扰素α的方法
CN113968900B (zh) * 2020-07-23 2023-07-25 中元汇吉生物技术股份有限公司 一种纯化C1q蛋白的方法
CN115918902A (zh) * 2022-12-19 2023-04-07 新疆农业科学院农业质量标准与检测技术研究所 一种通过微水波扩散重力法预处理葡萄脱水并获取高酚葡萄提取物的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617401A1 (de) * 1966-05-02 1972-02-17 Centre Nat Rech Scient Verfahren zur Herstellung von Interferon-Praeparaten
US4228154A (en) * 1979-02-26 1980-10-14 Armour Pharmaceutical Company Purification of plasma albumin by ion exchange chromatography
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
US5037644A (en) * 1986-10-27 1991-08-06 Cetus Corporation Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
US4732683A (en) * 1986-12-02 1988-03-22 Biospectrum, Inc. Purification method for alpha interferon
US4765903A (en) * 1987-10-06 1988-08-23 Interferon Sciences, Inc. Purification of monomeric interferon
US5250662A (en) * 1989-10-05 1993-10-05 Alpha Therapeutic Corporation Albumin purification
US5849874A (en) * 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
IT1262899B (it) * 1992-03-27 1996-07-22 Sclavo Spa Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
US5367054A (en) * 1993-04-12 1994-11-22 Stolle Research & Development Corp. Large-scale purification of egg immunoglobulin
ES2161793T3 (es) * 1994-04-09 2001-12-16 Hoffmann La Roche Proceso para la produccion de alfa-interferona.
JP3702474B2 (ja) * 1994-06-01 2005-10-05 三菱ウェルファーマ株式会社 血清アルブミン製剤の製造方法
RU2081122C1 (ru) * 1994-06-16 1997-06-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН Способ выделения и очистки инсулина или его биотехнологических предшественников
US5486470A (en) * 1994-07-21 1996-01-23 Merck & Co., Inc. Purified herpes simplex virus protease and methods of purification
CA2157219C (en) 1994-08-31 2010-10-05 Munehiro Noda Process for purifying recombinant human serum albumin
EP1736483A3 (en) * 1995-09-07 2008-07-30 Pharming Intellectual Property BV Purification of alpha-1 proteinase inhibitor
RU2132386C1 (ru) * 1997-06-20 1999-06-27 Государственный научный центр вирусологии и биотехнологии "Вектор" Способ получения рекомбинантного интерферона-гамма человека
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process

Also Published As

Publication number Publication date
ES2250544T3 (es) 2006-04-16
JP3940037B2 (ja) 2007-07-04
CN1396176A (zh) 2003-02-12
PL209954B1 (pl) 2011-11-30
HRP20020480B1 (en) 2006-11-30
AR034663A1 (es) 2004-03-03
RS51512B (sr) 2011-06-30
EG23150A (en) 2004-05-31
BG65748B1 (bg) 2009-09-30
EP1273592B1 (en) 2005-10-26
SK8592002A3 (en) 2003-01-09
BR0202431A (pt) 2003-09-09
HUP0202124A2 (hu) 2003-10-28
US6866782B2 (en) 2005-03-15
RU2002117383A (ru) 2004-01-27
MXPA02006303A (es) 2003-02-10
SK287827B6 (sk) 2011-11-04
KR100771252B1 (ko) 2007-10-30
YU50502A (sh) 2005-09-19
CN100484954C (zh) 2009-05-06
UY27354A1 (es) 2003-04-30
MEP3408A (en) 2010-10-10
EP1273592A2 (en) 2003-01-08
JP2003096092A (ja) 2003-04-03
BG106768A (en) 2003-05-30
SI1273592T1 (sl) 2006-02-28
RU2274471C2 (ru) 2006-04-20
US20030010715A1 (en) 2003-01-16
CA2388716C (en) 2008-01-08
DE60206847D1 (de) 2005-12-01
ATE307824T1 (de) 2005-11-15
EP1273592A3 (en) 2003-03-19
CU23149A3 (es) 2006-06-29
KR20030005005A (ko) 2003-01-15
DE60206847T2 (de) 2006-07-06
DK1273592T3 (da) 2006-01-02
CA2388716A1 (en) 2003-01-06
ITBO20010426A1 (it) 2003-01-06
ITBO20010426A0 (it) 2001-07-06
HU0202124D0 (en:Method) 2002-09-28
PL354769A1 (en) 2003-01-13
HRP20020480A2 (en) 2003-02-28

Similar Documents

Publication Publication Date Title
DZ3236A1 (fr) Procédé pour la purification de proteines actives pharmacologiquement par chromatographie d'échange de cations
DE69925804D1 (de) Kompensator/Phasenverzögerer für die einstellbare Ausrichtung des Strahls
MA25223A1 (fr) Procede pour la preparation de 4-carboxy-amino-2-substitue-1,2,3,4 tetrahydroquinoleine
EP1416052A4 (en) PROCESS FOR THE PREPARATION OF 1,4-DIHYDROXY-2-NAPHTHOIC ACID
EP1473082A4 (en) METHOD FOR PRODUCING HYDROGEN CLEANING CATALYST
EP1572638A4 (en) IMPROVED METHOD FOR THE PRODUCTION OF AMORPHIC ATORVASTATIN CALCIUM SALT (2: 1)
EP1401472A4 (en) ALTERNATIVE SPLICE FORMS OF PROTEINS AS A BASIS FOR MULTIPLE THERAPEUTIC MODALITIES
FR2808272B1 (fr) Procede de fabrication d'olefines sulfurees
FR2818979B1 (fr) Procede de preparation d'imidaclopride
FR2829134B1 (fr) Procede de preparation de (meth) acrylates d'alkylimidazolidone
MA24831A1 (fr) Procede pour la preparation d'acides hydroxamiques
MA25412A1 (fr) Procede pour la preparation d'acides 2-(n-phenylamino) benzoiques.
FR2829131B1 (fr) Procede pour la dimerisation de l'isobutene
FR2829133B1 (fr) Procede d'alkylation des olefines par les isoparaffines
FR2732689B1 (fr) Procede de purification de tensio-actifs amphoteres par electrodialyse
FR2843110B1 (fr) Procede d'isomerisation d'olefines
FR2775478B1 (fr) Procede utile pour la silylation de l'acide triflique
FR2829152B1 (fr) Procede enzymatique pour la resolution enantiomerique d'acides amines
FR2808273B1 (fr) Procede de fabrication d'olefines sulfurees
FR2758137B1 (fr) Procede de purification du pentafluoroethane par distillation extractive
FR2822459B1 (fr) Procede de preparation d'une olefine halogenee
FR2829132B1 (fr) Procede pour l'oligomerisation des olefines
FR2807041B1 (fr) Procede semi-continu de preparation d'amides d'acides carboxyliques bis-silyles
FR2800376B1 (fr) Procede pour la production d'alkylhalogenosilanes
FR2830013B1 (fr) Procede d'obtention de monoorganoxysilanes halogenes utilisables notamment en tant qu'intermediaires de synthese