DK652689A - Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse - Google Patents

Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse Download PDF

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Publication number
DK652689A
DK652689A DK652689A DK652689A DK652689A DK 652689 A DK652689 A DK 652689A DK 652689 A DK652689 A DK 652689A DK 652689 A DK652689 A DK 652689A DK 652689 A DK652689 A DK 652689A
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DK
Denmark
Prior art keywords
substd
opt
alkyl
cycloalkyl
alkenyl
Prior art date
Application number
DK652689A
Other languages
Danish (da)
English (en)
Other versions
DK652689D0 (da
Inventor
Ulrike Kuefner-Muehl
Karl-Heinz Weber
Gerhard Walther
Werner Stransky
Helmut Ensinger
Guenter Schingnitz
Franz Josef Kuhn
Erich Lehr
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DK652689D0 publication Critical patent/DK652689D0/da
Publication of DK652689A publication Critical patent/DK652689A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK652689A 1988-12-22 1989-12-21 Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse DK652689A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3843117A DE3843117A1 (de) 1988-12-22 1988-12-22 Neue xanthinderivate mit adenosin-antagonistischer wirkung

Publications (2)

Publication Number Publication Date
DK652689D0 DK652689D0 (da) 1989-12-21
DK652689A true DK652689A (da) 1990-06-23

Family

ID=6369764

Family Applications (1)

Application Number Title Priority Date Filing Date
DK652689A DK652689A (da) 1988-12-22 1989-12-21 Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse

Country Status (32)

Country Link
US (4) US5175291A (US20050026921A1-20050203-C00071.png)
EP (1) EP0374808B1 (US20050026921A1-20050203-C00071.png)
JP (1) JP2565576B2 (US20050026921A1-20050203-C00071.png)
KR (1) KR0165666B1 (US20050026921A1-20050203-C00071.png)
AT (1) ATE136897T1 (US20050026921A1-20050203-C00071.png)
BG (1) BG61669B2 (US20050026921A1-20050203-C00071.png)
BR (1) BR1100527A (US20050026921A1-20050203-C00071.png)
CA (1) CA2006387C (US20050026921A1-20050203-C00071.png)
CZ (1) CZ286230B6 (US20050026921A1-20050203-C00071.png)
DD (1) DD290421A5 (US20050026921A1-20050203-C00071.png)
DE (3) DE3843117A1 (US20050026921A1-20050203-C00071.png)
DK (1) DK652689A (US20050026921A1-20050203-C00071.png)
ES (1) ES2086313T3 (US20050026921A1-20050203-C00071.png)
FI (1) FI96513C (US20050026921A1-20050203-C00071.png)
GR (1) GR3019733T3 (US20050026921A1-20050203-C00071.png)
HR (1) HRP940724A2 (US20050026921A1-20050203-C00071.png)
HU (1) HU218674B (US20050026921A1-20050203-C00071.png)
IE (1) IE74205B1 (US20050026921A1-20050203-C00071.png)
IL (1) IL92829A (US20050026921A1-20050203-C00071.png)
MX (1) MX9203618A (US20050026921A1-20050203-C00071.png)
NO (1) NO173502C (US20050026921A1-20050203-C00071.png)
NZ (1) NZ231901A (US20050026921A1-20050203-C00071.png)
PH (2) PH31107A (US20050026921A1-20050203-C00071.png)
PL (1) PL162877B1 (US20050026921A1-20050203-C00071.png)
PT (1) PT92658B (US20050026921A1-20050203-C00071.png)
RU (1) RU2057752C1 (US20050026921A1-20050203-C00071.png)
SG (1) SG46380A1 (US20050026921A1-20050203-C00071.png)
SI (1) SI8912423B (US20050026921A1-20050203-C00071.png)
SK (1) SK279525B6 (US20050026921A1-20050203-C00071.png)
UA (1) UA26427A (US20050026921A1-20050203-C00071.png)
YU (1) YU47934B (US20050026921A1-20050203-C00071.png)
ZA (1) ZA899881B (US20050026921A1-20050203-C00071.png)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
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DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
CA2061544A1 (en) * 1991-02-25 1992-08-26 Fumio Suzuki Xanthine compounds
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
EP0541120B1 (en) * 1991-11-08 1999-05-26 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives for the treatment of dementia
IT1260444B (it) * 1992-01-24 1996-04-09 Mario Brufani Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
EP0556778A3 (en) * 1992-02-17 1993-11-24 Kyowa Hakko Kogyo Kk Xanthine derivatives
US5484920A (en) * 1992-04-08 1996-01-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for Parkinson's disease
CA2093403C (en) * 1992-04-08 1999-08-10 Fumio Suzuki Therapeutic agent for parkinson's disease
WO1994003173A1 (de) * 1992-08-01 1994-02-17 Boehringer Ingelheim Kg Verwendung von 8-(3-oxocyclopentyl)-1,3-dipropyl-7h-purin-2,6-dion zur symptomatischen behandlung der zystischen fibrose
TW252044B (US20050026921A1-20050203-C00071.png) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
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JP3769737B2 (ja) * 1994-03-30 2006-04-26 味の素株式会社 シクロプロパン誘導体及びその製造法
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US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
US6545002B1 (en) 1999-06-01 2003-04-08 University Of Virginia Patent Foundation Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
NZ519427A (en) 1999-11-12 2003-08-29 Biogen Inc Polycycloalkylpurine derivative useful as an adenosine receptor antagonist
PL206890B1 (pl) * 1999-11-12 2010-10-29 Biogen Idec Ma Pochodna bicykloalkilopuryny, jej zastosowanie i kompozycja leku
WO2001051490A1 (en) 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
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US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
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Also Published As

Publication number Publication date
DD290421A5 (de) 1991-05-29
SG46380A1 (en) 1998-02-20
DE58909657D1 (de) 1996-05-23
ES2086313T3 (es) 1996-07-01
HRP940724A2 (en) 1997-06-30
CZ286230B6 (cs) 2000-02-16
FI96513C (fi) 1996-07-10
BR1100527A (pt) 2000-08-01
ZA899881B (en) 1991-08-28
NZ231901A (en) 1993-12-23
MX9203618A (es) 1992-09-01
IL92829A (en) 1995-12-31
PT92658A (pt) 1990-06-29
NO895168D0 (no) 1989-12-21
NO173502B (no) 1993-09-13
SK719789A3 (en) 1998-12-02
UA26427A (uk) 1999-08-30
NO895168L (no) 1990-06-25
PH31111A (en) 1998-02-23
ATE136897T1 (de) 1996-05-15
US5532368A (en) 1996-07-02
PL282878A1 (en) 1992-03-09
FI96513B (fi) 1996-03-29
HU218674B (hu) 2000-10-28
YU47934B (sh) 1996-05-20
CZ719789A3 (cs) 1999-10-13
HU896736D0 (en) 1990-02-28
PT92658B (pt) 1995-09-12
US5688802A (en) 1997-11-18
SK279525B6 (sk) 1998-12-02
RU2057752C1 (ru) 1996-04-10
DK652689D0 (da) 1989-12-21
GR3019733T3 (en) 1996-07-31
HUT52503A (en) 1990-07-28
IE894147L (en) 1990-06-22
US5175291A (en) 1992-12-29
PH31107A (en) 1998-02-23
KR0165666B1 (ko) 1999-01-15
JPH02247180A (ja) 1990-10-02
NO173502C (no) 1993-12-22
CA2006387A1 (en) 1990-06-22
AU637990B2 (en) 1993-06-17
KR900009646A (ko) 1990-07-05
PL162877B1 (pl) 1994-01-31
YU242389A (en) 1991-10-31
CA2006387C (en) 2000-02-08
EP0374808B1 (de) 1996-04-17
IE74205B1 (en) 1997-07-16
DE3843117A1 (de) 1990-06-28
DE8817122U1 (de) 1993-02-04
BG61669B2 (bg) 1998-02-27
US5696124A (en) 1997-12-09
EP0374808A3 (de) 1991-05-15
AU4707289A (en) 1990-06-28
SI8912423B (sl) 1998-12-31
IL92829A0 (en) 1990-09-17
FI896117A0 (fi) 1989-12-20
JP2565576B2 (ja) 1996-12-18
EP0374808A2 (de) 1990-06-27
SI8912423A (sl) 1998-04-30

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