DK652689A - Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse - Google Patents

Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse Download PDF

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Publication number
DK652689A
DK652689A DK652689A DK652689A DK652689A DK 652689 A DK652689 A DK 652689A DK 652689 A DK652689 A DK 652689A DK 652689 A DK652689 A DK 652689A DK 652689 A DK652689 A DK 652689A
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DK
Denmark
Prior art keywords
substd
opt
alkyl
cycloalkyl
alkenyl
Prior art date
Application number
DK652689A
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English (en)
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DK652689D0 (da
Inventor
Ulrike Kuefner-Muehl
Karl-Heinz Weber
Gerhard Walther
Werner Stransky
Helmut Ensinger
Guenter Schingnitz
Franz Josef Kuhn
Erich Lehr
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DK652689D0 publication Critical patent/DK652689D0/da
Publication of DK652689A publication Critical patent/DK652689A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
DK652689A 1988-12-22 1989-12-21 Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse DK652689A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3843117A DE3843117A1 (de) 1988-12-22 1988-12-22 Neue xanthinderivate mit adenosin-antagonistischer wirkung

Publications (2)

Publication Number Publication Date
DK652689D0 DK652689D0 (da) 1989-12-21
DK652689A true DK652689A (da) 1990-06-23

Family

ID=6369764

Family Applications (1)

Application Number Title Priority Date Filing Date
DK652689A DK652689A (da) 1988-12-22 1989-12-21 Xanthinderivater med adenosin-antagonistisk aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse

Country Status (32)

Country Link
US (4) US5175291A (da)
EP (1) EP0374808B1 (da)
JP (1) JP2565576B2 (da)
KR (1) KR0165666B1 (da)
AT (1) ATE136897T1 (da)
BG (1) BG61669B2 (da)
BR (1) BR1100527A (da)
CA (1) CA2006387C (da)
CZ (1) CZ286230B6 (da)
DD (1) DD290421A5 (da)
DE (3) DE8817122U1 (da)
DK (1) DK652689A (da)
ES (1) ES2086313T3 (da)
FI (1) FI96513C (da)
GR (1) GR3019733T3 (da)
HR (1) HRP940724A2 (da)
HU (1) HU218674B (da)
IE (1) IE74205B1 (da)
IL (1) IL92829A (da)
MX (1) MX9203618A (da)
NO (1) NO173502C (da)
NZ (1) NZ231901A (da)
PH (2) PH31107A (da)
PL (1) PL162877B1 (da)
PT (1) PT92658B (da)
RU (1) RU2057752C1 (da)
SG (1) SG46380A1 (da)
SI (1) SI8912423B (da)
SK (1) SK279525B6 (da)
UA (1) UA26427A (da)
YU (1) YU47934B (da)
ZA (1) ZA899881B (da)

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US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
CA2061544A1 (en) * 1991-02-25 1992-08-26 Fumio Suzuki Xanthine compounds
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
EP0541120B1 (en) * 1991-11-08 1999-05-26 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives for the treatment of dementia
IT1260444B (it) * 1992-01-24 1996-04-09 Mario Brufani Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
US5336769A (en) * 1992-02-17 1994-08-09 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
CA2093403C (en) * 1992-04-08 1999-08-10 Fumio Suzuki Therapeutic agent for parkinson's disease
US5484920A (en) * 1992-04-08 1996-01-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for Parkinson's disease
WO1994003173A1 (de) * 1992-08-01 1994-02-17 Boehringer Ingelheim Kg Verwendung von 8-(3-oxocyclopentyl)-1,3-dipropyl-7h-purin-2,6-dion zur symptomatischen behandlung der zystischen fibrose
TW252044B (da) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
JP2613355B2 (ja) * 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
US5877179A (en) * 1992-09-29 1999-03-02 The United States Of America As Represented By The Department Of Health And Human Services Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
WO1994015605A1 (en) * 1993-01-14 1994-07-21 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
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DE4316576A1 (de) * 1993-05-18 1994-11-24 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin
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US5736528A (en) * 1993-10-28 1998-04-07 University Of Florida Research Foundation, Inc. N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
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US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
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DE69531555T2 (de) * 1994-12-13 2004-06-17 Euroceltique S.A. Dreifachsubstituierte thioxanthine
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US5786360A (en) 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
WO1999012546A1 (fr) * 1997-09-05 1999-03-18 Kyowa Hakko Kogyo Co., Ltd. Remede contre la degenerescence neurale
US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
DE19816857A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2333947C (en) * 1998-06-01 2010-09-21 Fujisawa Pharmaceutical Co., Ltd. Pyrazolopyridine compounds as adenosine a1 antagonist for male sterility
CA2336967C (en) 1998-07-10 2010-06-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor antagonists
US6025362A (en) * 1998-08-31 2000-02-15 Fukunaga; Atsuo F. Uses of xanthine compounds
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
US6545002B1 (en) 1999-06-01 2003-04-08 University Of Virginia Patent Foundation Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
WO2001034604A2 (en) * 1999-11-12 2001-05-17 Biogen, Inc. Adenosine receptor antagonists and methods of making and using the same
MEP42208A (en) * 1999-11-12 2011-02-10 Biogen Idec Inc Polycycloalkylpurines as adenosine receptor antagonists
AU2001230913B2 (en) 2000-01-14 2005-06-30 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
US20080318983A1 (en) * 2001-11-09 2008-12-25 Rao Kalla A2b adenosine receptor antagonists
AU2002359365B2 (en) * 2001-11-09 2008-07-10 Gilead Sciences, Inc. A2B adenosine receptor antagonists
US7317017B2 (en) * 2002-11-08 2008-01-08 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
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US6977300B2 (en) * 2001-11-09 2005-12-20 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US20040106797A1 (en) * 2002-07-19 2004-06-03 Pascal Druzgala Novel xanthines having adenosine A1-receptor antagonist properties
JP2006518390A (ja) * 2003-02-19 2006-08-10 エンダシア，インコーポレイテッド Ａ１アデノシンレセプターアンタゴニスト
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
US20060293312A1 (en) * 2003-04-25 2006-12-28 Howard Dittrich Method of improved diuresis in individuals with impaired renal function
NZ543109A (en) * 2003-04-25 2008-06-30 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
DE60322748D1 (de) * 2003-05-06 2008-09-18 Cv Therapeutics Inc Xanthinderivate als a2b-adenosinrezeptorantagonisten
US7247639B2 (en) * 2003-06-06 2007-07-24 Endacea, Inc. A1 adenosine receptor antagonists
CA2528367A1 (en) * 2003-06-09 2004-12-23 Endacea, Inc. A1 adenosine receptor antagonists
TW200507882A (en) * 2003-07-17 2005-03-01 Kyowa Hakko Kogyo Kk Solid formulations
US6847249B1 (en) * 2003-10-09 2005-01-25 Analog Devices, Inc. Highest available voltage selector circuit
BRPI0509753A (pt) * 2004-04-16 2007-10-16 Novacardia Inc composição farmacêutica e método de tratamento de doença cardiovascular
RU2385322C2 (ru) * 2004-09-01 2010-03-27 Си Ви Терапьютикс, Инк. Способ заживления ран с применением антагонистов аденозинового рецептора a2b
EP2035009A1 (en) * 2006-06-16 2009-03-18 Novacardia, Inc. Prolonged improvement of renal function comprising infrequent administration of an aa1ra
US8193200B2 (en) 2007-01-04 2012-06-05 University Of Virginia Patent Foundation Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease
US20090197900A1 (en) * 2007-03-29 2009-08-06 Howard Dittrich Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
US20080242684A1 (en) * 2007-03-29 2008-10-02 Howard Dittrich Methods of administration of adenosine a1 receptor antagonists
JP5460690B2 (ja) * 2008-03-26 2014-04-02 アドヴィナス・セラピューティックス・リミテッド アデノシンレセプターアンタゴニストとしてのヘテロ環化合物
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Also Published As

Publication number Publication date
HRP940724A2 (en) 1997-06-30
SK719789A3 (en) 1998-12-02
DE3843117A1 (de) 1990-06-28
US5175291A (en) 1992-12-29
MX9203618A (es) 1992-09-01
HU218674B (hu) 2000-10-28
PT92658B (pt) 1995-09-12
PH31111A (en) 1998-02-23
DK652689D0 (da) 1989-12-21
ES2086313T3 (es) 1996-07-01
RU2057752C1 (ru) 1996-04-10
SG46380A1 (en) 1998-02-20
EP0374808A3 (de) 1991-05-15
YU242389A (en) 1991-10-31
CA2006387C (en) 2000-02-08
UA26427A (uk) 1999-08-30
ZA899881B (en) 1991-08-28
FI96513B (fi) 1996-03-29
PL282878A1 (en) 1992-03-09
DE58909657D1 (de) 1996-05-23
US5688802A (en) 1997-11-18
KR0165666B1 (ko) 1999-01-15
IE74205B1 (en) 1997-07-16
DD290421A5 (de) 1991-05-29
CA2006387A1 (en) 1990-06-22
NO895168L (no) 1990-06-25
FI896117A0 (fi) 1989-12-20
ATE136897T1 (de) 1996-05-15
BR1100527A (pt) 2000-08-01
SI8912423A (sl) 1998-04-30
US5532368A (en) 1996-07-02
SK279525B6 (sk) 1998-12-02
PH31107A (en) 1998-02-23
US5696124A (en) 1997-12-09
EP0374808A2 (de) 1990-06-27
DE8817122U1 (da) 1993-02-04
FI96513C (fi) 1996-07-10
YU47934B (sh) 1996-05-20
NO173502C (no) 1993-12-22
AU637990B2 (en) 1993-06-17
NZ231901A (en) 1993-12-23
IL92829A0 (en) 1990-09-17
HUT52503A (en) 1990-07-28
PT92658A (pt) 1990-06-29
EP0374808B1 (de) 1996-04-17
BG61669B2 (bg) 1998-02-27
IE894147L (en) 1990-06-22
NO173502B (no) 1993-09-13
KR900009646A (ko) 1990-07-05
GR3019733T3 (en) 1996-07-31
CZ286230B6 (cs) 2000-02-16
JP2565576B2 (ja) 1996-12-18
CZ719789A3 (cs) 1999-10-13
HU896736D0 (en) 1990-02-28
NO895168D0 (no) 1989-12-21
IL92829A (en) 1995-12-31
JPH02247180A (ja) 1990-10-02
PL162877B1 (pl) 1994-01-31
AU4707289A (en) 1990-06-28
SI8912423B (sl) 1998-12-31

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