CZ719789A3 - Nové xanthinové deriváty a způsob jejich výroby - Google Patents
Nové xanthinové deriváty a způsob jejich výrobyInfo
- Publication number
- CZ719789A3 CZ719789A3 CS897197A CS719789A CZ719789A3 CZ 719789 A3 CZ719789 A3 CZ 719789A3 CS 897197 A CS897197 A CS 897197A CS 719789 A CS719789 A CS 719789A CZ 719789 A3 CZ719789 A3 CZ 719789A3
- Authority
- CZ
- Czechia
- Prior art keywords
- substd
- opt
- alkyl
- cycloalkyl
- alkenyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- CJVFIJXEPCVCTK-LWMBYGOMSA-N (2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)C(C)C CJVFIJXEPCVCTK-LWMBYGOMSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3843117A DE3843117A1 (de) | 1988-12-22 | 1988-12-22 | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ719789A3 true CZ719789A3 (cs) | 1999-10-13 |
| CZ286230B6 CZ286230B6 (cs) | 2000-02-16 |
Family
ID=6369764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS19897197A CZ286230B6 (cs) | 1988-12-22 | 1989-12-19 | Nové xanthinové deriváty a způsob jejich výroby |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US5175291A (cs) |
| EP (1) | EP0374808B1 (cs) |
| JP (1) | JP2565576B2 (cs) |
| KR (1) | KR0165666B1 (cs) |
| AT (1) | ATE136897T1 (cs) |
| BG (1) | BG61669B2 (cs) |
| BR (1) | BR1100527A (cs) |
| CA (1) | CA2006387C (cs) |
| CZ (1) | CZ286230B6 (cs) |
| DD (1) | DD290421A5 (cs) |
| DE (3) | DE3843117A1 (cs) |
| DK (1) | DK652689A (cs) |
| ES (1) | ES2086313T3 (cs) |
| FI (1) | FI96513C (cs) |
| GR (1) | GR3019733T3 (cs) |
| HR (1) | HRP940724A2 (cs) |
| HU (1) | HU218674B (cs) |
| IE (1) | IE74205B1 (cs) |
| IL (1) | IL92829A (cs) |
| MX (1) | MX9203618A (cs) |
| NO (1) | NO173502C (cs) |
| NZ (1) | NZ231901A (cs) |
| PH (2) | PH31107A (cs) |
| PL (1) | PL162877B1 (cs) |
| PT (1) | PT92658B (cs) |
| RU (1) | RU2057752C1 (cs) |
| SG (1) | SG46380A1 (cs) |
| SI (1) | SI8912423B (cs) |
| SK (1) | SK279525B6 (cs) |
| UA (1) | UA26427A (cs) |
| YU (1) | YU47934B (cs) |
| ZA (1) | ZA899881B (cs) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| US5047534A (en) * | 1990-03-26 | 1991-09-10 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine receptor agents |
| GB2244487B (en) * | 1990-05-29 | 1994-02-02 | Ici Plc | Azole derivatives |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| CA2061544A1 (en) * | 1991-02-25 | 1992-08-26 | Fumio Suzuki | Xanthine compounds |
| GB9111130D0 (en) * | 1991-05-23 | 1991-07-17 | Ici Plc | Azole derivatives |
| GB9111131D0 (en) * | 1991-05-23 | 1991-07-17 | Ici Plc | Heterocyclic compounds |
| ATE180482T1 (de) * | 1991-11-08 | 1999-06-15 | Kyowa Hakko Kogyo Kk | Xanthinderivate zur behandlung der demenz |
| IT1260444B (it) * | 1992-01-24 | 1996-04-09 | Mario Brufani | Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti |
| JPH05294966A (ja) * | 1992-02-17 | 1993-11-09 | Kyowa Hakko Kogyo Co Ltd | キサンチン誘導体 |
| US5484920A (en) * | 1992-04-08 | 1996-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for Parkinson's disease |
| CA2093403C (en) * | 1992-04-08 | 1999-08-10 | Fumio Suzuki | Therapeutic agent for parkinson's disease |
| WO1994003173A1 (de) * | 1992-08-01 | 1994-02-17 | Boehringer Ingelheim Kg | Verwendung von 8-(3-oxocyclopentyl)-1,3-dipropyl-7h-purin-2,6-dion zur symptomatischen behandlung der zystischen fibrose |
| TW252044B (cs) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| US5288721A (en) * | 1992-09-22 | 1994-02-22 | Cell Therapeutics, Inc. | Substituted epoxyalkyl xanthines |
| JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
| US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
| DE4236331A1 (de) * | 1992-10-28 | 1994-05-05 | Boehringer Ingelheim Kg | Synergistische Kombination |
| AU6087894A (en) * | 1993-01-14 | 1994-08-15 | Cell Therapeutics, Inc. | Acetal or ketal substituted therapeutic compounds |
| ATE169019T1 (de) * | 1993-02-26 | 1998-08-15 | Merrell Pharma Inc | Xanthinderivate als adenosin-a1 rezeptor antagonisten |
| WO1994025462A1 (en) * | 1993-05-03 | 1994-11-10 | The United States Of America, Represented By The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
| DE4316576A1 (de) * | 1993-05-18 | 1994-11-24 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin |
| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
| JP3769737B2 (ja) * | 1994-03-30 | 2006-04-26 | 味の素株式会社 | シクロプロパン誘導体及びその製造法 |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| CA2206804C (en) * | 1994-12-13 | 2002-03-19 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| CA2206287C (en) * | 1994-12-13 | 2001-03-20 | Mark Chasin | Aryl thioxanthines |
| US5864037A (en) | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
| US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| US5786360A (en) * | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
| DE69834500T2 (de) * | 1997-09-05 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | Xanthinderivative zur behandlung von hirnischämie |
| US6248746B1 (en) | 1998-01-07 | 2001-06-19 | Euro-Celtique S.A. | 3-(arylalkyl) xanthines |
| DE19816857A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU754094B2 (en) * | 1998-06-01 | 2002-11-07 | Astellas Pharma Inc. | Remedies for male sterility |
| WO2000002861A1 (en) | 1998-07-10 | 2000-01-20 | The United States Of America, Represented By Secretary, Department Of Health And Human Services | A3 adenosine receptor antagonists |
| US6025362A (en) * | 1998-08-31 | 2000-02-15 | Fukunaga; Atsuo F. | Uses of xanthine compounds |
| US6576619B2 (en) | 1999-05-24 | 2003-06-10 | Cv Therapeutics, Inc. | Orally active A1 adenosine receptor agonists |
| US6545002B1 (en) * | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
| HK1049153B (en) | 1999-11-12 | 2007-09-28 | Biogen Idec Ma Inc. | Adenosine receptor antagonists and methods of making and using the same |
| US6649600B1 (en) * | 1999-11-12 | 2003-11-18 | Biogen, Inc. | Adenosine receptor antagonists and methods of making and using the same |
| DE60122285D1 (de) | 2000-01-14 | 2006-09-28 | Us Gov Health & Human Serv | Methonocarbacycloalkylanaloga von nucleosiden |
| US20020115635A1 (en) * | 2001-02-21 | 2002-08-22 | Pnina Fishman | Modulation of GSK-3beta activity and its different uses |
| DK1444233T3 (da) * | 2001-11-09 | 2011-10-17 | Gilead Palo Alto Inc | A2B-adenosinreceptorantagonister |
| US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
| US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US6977300B2 (en) * | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| AU2003261206A1 (en) * | 2002-07-19 | 2004-02-09 | Aryx Therapeutics | Xanthine derivatives having adenosine a1-receptor antagonist properties |
| WO2004074247A2 (en) * | 2003-02-19 | 2004-09-02 | Endacea, Inc. | A1 adenosine receptor antagonists |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| BRPI0409699A (pt) * | 2003-04-25 | 2006-04-18 | Novacardia Inc | métodos de indução do efeito diurético, de indução, manutenção ou restauração do efeito diurético de diurético não modificador de adenosina, de manutenção, restauração ou melhoria da função renal em paciente, de indução de diurese, de prevenção do inìcio de deficiência renal em paciente com sobrecarga de fluidos ou chf, de tratamento de paciente que sofre de chf e de melhoria dos resultados globais da saúde, composição farmacêutica e seus usos |
| DE60322748D1 (de) * | 2003-05-06 | 2008-09-18 | Cv Therapeutics Inc | Xanthinderivate als a2b-adenosinrezeptorantagonisten |
| EP1636229A4 (en) * | 2003-06-06 | 2008-07-30 | Endacea Inc | ADENOSINE A1 RECEPTOR ANTAGONISTS |
| CA2528367A1 (en) * | 2003-06-09 | 2004-12-23 | Endacea, Inc. | A1 adenosine receptor antagonists |
| TW200507882A (en) * | 2003-07-17 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Solid formulations |
| DK2295434T3 (en) * | 2003-08-25 | 2015-12-14 | Dogwood Pharmaceuticals Inc | Substituted 8-heteroaryl xanthines |
| US6847249B1 (en) * | 2003-10-09 | 2005-01-25 | Analog Devices, Inc. | Highest available voltage selector circuit |
| EP1755594A1 (en) * | 2004-04-16 | 2007-02-28 | Novacardia, Inc. | Combination therapy comprising an adenosine a1 receptor antagonist and an aldosterone inhibitor |
| DK1789053T3 (da) * | 2004-09-01 | 2012-08-06 | Gilead Sciences Inc | Fremgangsmåde til sårheling under anvendelse af a2b-adenosinreceptor-antagonister |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| US8193200B2 (en) | 2007-01-04 | 2012-06-05 | University Of Virginia Patent Foundation | Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease |
| WO2008121893A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| CN102015712A (zh) * | 2008-03-26 | 2011-04-13 | 阿德维纳斯治疗私人有限公司 | 作为腺苷受体拮抗剂的杂环化合物 |
| US8129862B2 (en) * | 2009-10-23 | 2012-03-06 | Analog Devices, Inc. | Scalable highest available voltage selector circuit |
| JP5843778B2 (ja) * | 2009-11-09 | 2016-01-13 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物、その調製およびその使用 |
| EP2507241A1 (en) | 2009-12-02 | 2012-10-10 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives and dendrimer conjugates thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1201997A (en) * | 1967-08-04 | 1970-08-12 | Yissum Res Dev Co | New substituted purines and purine derivatives |
| US3624216A (en) * | 1970-06-25 | 1971-11-30 | Abbott Lab | 8-substituted theophyllines as anti-inflammatory agents |
| US3624215A (en) * | 1970-06-25 | 1971-11-30 | Abbott Lab | 8-substituted theophyllines as anti-anxiety agents |
| DE3028273A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate |
| ES8401072A1 (es) * | 1982-11-23 | 1983-12-16 | Faes | Procedimiento de preparacion de un nuevo espirodecano. |
| US4593095A (en) * | 1983-02-18 | 1986-06-03 | The Johns Hopkins University | Xanthine derivatives |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| US4755517A (en) * | 1986-07-31 | 1988-07-05 | Warner-Lambert Company | Derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
| US5175290A (en) * | 1988-09-16 | 1992-12-29 | Marion Merrell Dow Inc. | 8-(oxo-substituted cycloalkyl)xanthines |
| DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| US4957921A (en) * | 1989-12-06 | 1990-09-18 | Warner-Lambert Company | Substituted cyclohexanols as central nervous system agents |
| ATE180482T1 (de) * | 1991-11-08 | 1999-06-15 | Kyowa Hakko Kogyo Kk | Xanthinderivate zur behandlung der demenz |
-
1988
- 1988-12-22 DE DE3843117A patent/DE3843117A1/de not_active Ceased
- 1988-12-22 DE DE8817122U patent/DE8817122U1/de not_active Expired - Lifetime
-
1989
- 1989-12-19 EP EP89123412A patent/EP0374808B1/de not_active Expired - Lifetime
- 1989-12-19 AT AT89123412T patent/ATE136897T1/de not_active IP Right Cessation
- 1989-12-19 SG SG1996003965A patent/SG46380A1/en unknown
- 1989-12-19 DE DE58909657T patent/DE58909657D1/de not_active Expired - Fee Related
- 1989-12-19 CZ CS19897197A patent/CZ286230B6/cs not_active IP Right Cessation
- 1989-12-19 SK SK7197-89A patent/SK279525B6/sk unknown
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1992
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20001219 |