KR850003533A - 1,3-디옥산 유도체의 제조방법 - Google Patents
1,3-디옥산 유도체의 제조방법 Download PDFInfo
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- KR850003533A KR850003533A KR1019840007065A KR840007065A KR850003533A KR 850003533 A KR850003533 A KR 850003533A KR 1019840007065 A KR1019840007065 A KR 1019840007065A KR 840007065 A KR840007065 A KR 840007065A KR 850003533 A KR850003533 A KR 850003533A
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- hydroxy
- alkyl
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- benzene ring
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- 238000000034 method Methods 0.000 title claims 7
- 150000000093 1,3-dioxanes Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 17
- -1 polymethylene Polymers 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- 229910052783 alkali metal Inorganic materials 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000002009 diols Chemical class 0.000 claims 3
- 125000000532 dioxanyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 239000007858 starting material Substances 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 125000005236 alkanoylamino group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 claims 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 claims 1
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 claims 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
- GCXNJAXHHFZVIM-UHFFFAOYSA-N 2-phenylfuran Chemical compound C1=COC(C=2C=CC=CC=2)=C1 GCXNJAXHHFZVIM-UHFFFAOYSA-N 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical class CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- PSZDOEIIIJFCFE-UHFFFAOYSA-N Oleanolic alcohol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C)(C)CC5C4=CCC3C21C PSZDOEIIIJFCFE-UHFFFAOYSA-N 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
- 238000010306 acid treatment Methods 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- PSZDOEIIIJFCFE-OSQDELBUSA-N erythrodiol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PSZDOEIIIJFCFE-OSQDELBUSA-N 0.000 claims 1
- HTZRWCSRPTWJCT-UHFFFAOYSA-N erythrodiol Natural products CC1(C)CCC2(CO)CCC3C(CCC4C3(C)CCC5C(C)(C)C(O)CCC45C)C2C1 HTZRWCSRPTWJCT-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002373 hemiacetals Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 229940014800 succinic anhydride Drugs 0.000 claims 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pyrane Compounds (AREA)
- Television Signal Processing For Recording (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (18)
- 식(Ⅱ)의 에리트로-4-하이드록시-하이드록시메틸-4-페닐부틸알데히드 유도체와 식(Rd)3p=CH.Y.CO.Q의일리드를 반응시켜 반응물을 산성화하는 것을 특징으로 하는 식(Ⅲ)의 에리트로-디올의 제조방법.
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- 여기서 Y는 치환체로서(1-4C)알킬을 포함하는 2-5탄소원자의 폴리메틸렌 : 벤젠고리 B는 할로게노, (1-6C)알킬, (1-6C)알콕시, 하이드록시(1-6C)알카노일옥시, (1-6C)알카노일아미노, 트리후로로메틸과 니트로로부터 선택된 하나또는 두 개의 치환체를 포함하며: Rf는 하이드록시 또는 (1-6C)알칸설폰아미도이고; 하이드록시와 하이드록시 메틸기는 시스-상대적 입체 화학이성질체 또는 그것의 알카리 금속염을 갖으며 일리드식의 Rd는 (1-6C)알킬 또는 알릴, Q는 -OM 또는 -NM.SO2Re를 대신하고 여기서 M은 알카리 금속이고, Re는 (1-6C)알킬이다.
- 제1항에 있어서, 식(Ⅱ)의 부틸알데히드 유도체는 벤젠고리 B의 의미가 제1항과 같은 식(Ⅱa)의 대응하는 [2,3-트랜스]-테트라하이드로-5-하이드록시메틸-2-페닐후란으로부터 생성되는 것을 특징으로 하는 방법.
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- 식(Ⅱ)의-4-하이드록시-3-하이드록시-메틸-4-페닐부틸알데히드 또는 그것의 알카리 금속염 또는 대응하는 식(Ⅱa)의 [2,3-]-테트라하이드로-5-하이드록시-3-하이드록시메틸-2-페닐후란을 산성화후에 식(Ⅲ)의-디올을 얻기위해 반응시키며(i)여기서 벤젠고리 B는 할로게노, (1-6C)알킬, (1-6C)알콕시, 하이드록시, (1-6C)알카노일옥시, (1-6C)알카노일아미노, 트리후로로메틸과 니트로로부터 선택된 하나 또는 두 개의 치환체를 포함하며 하이드록시와 식(Ⅱ)의 하이드록시메틸기는 시스-상대적 입체화학 이성질체를 나타내며 식(Rd)3P=CH.Y.CO.Q의 일리드에 있어서 Rd는 (1-6C)알킬 또는 알릴이고 Q는 -OM 또는 -NM.SO2Re를 대신하며 여기서 M은 알카리금속, Re는 (1-6C)알킬이고 Y는 치환체로서(1-4C)알킬을 포함하는 2-5탄소의 폴리메틸렌이며 Rf는 하이드록시 또는 (1-6C)알칸설폰아미도이며 식(Ⅲ)의 디올 또는 모노 (1-6C)알칸설포닐 또는 그것의 알렌설포닐 에스테르와 식 Ra.Rb.O의 카모닐 화합물 또는 그것의 아세탈, 헤미아세탈 또는 하이드레이트를 반응시키는(ii)단계로 구성되는 것을 특징으로 하며 A가 에틸렌인 식(Ⅰ)의 화합물이 필요할 때, A가 비닐렌인식(Ⅰ)을 대응하는 화합물은 적당한 촉매 존재에서 수소화되며; Ra 또는 Rb가 하이드록시페닐이거나 벤젠고리 B가 하이드록시 치환체를 포함하는 식(Ⅰ)의 화합물이 필요할때, 하이드록시기가 트리메틸실일, (1-6C)알킬, 아실 또는 벤질보호기에 의해 보호된 식(Ⅰ)의 대응하는 화합물은 탈보호화되며; 광학적으로 활성형태가 필요할 때 (i)과 (ii)단계는 식(Ⅱ)의 광학적 활성의 알데히드나 식(Ⅱa)의 후란으로 개시하여 수행하고 Rc가 하이드록시인 식(Ⅰ)의 라세믹형태는 통상적인 공정에 의해 적당한 유기염기의 광학적 활성형태와 반응하여 분해되며; 약학적으로 허용될 수 있는 염이 필요할 때 Rc가 하이드록시인 식(Ⅰ)의 화합물을 생리적으로 허용될 수 있는 양이온을 생성하는 염기와 반응시키거나: (1-6C)알킬에스테르 또는 (1-6C)알설칸폰아마이드가 필요할 때 Rc가 라세믹의 하이드록시 또는 광학적 활성형태인 식(Ⅰ)의 대응하는 화합물 또는 그것의 반응성 유도체를 (1-6C)알카놀 또는 (1-6C)알칸설폰아마이드 또는 그것의 알카리 금속염과 반응시키는 것을 특징으로 하는 식(Ⅰ)의 (4-페닐-1.3-디옥산-시스-5-일)알케노산의 제조방법.
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- 상기식에서 Ra와 Rb는 각각 수소,(2-6C)알케닐, 3이하의 할로게노 치환체를 포함하는 (1-8C)알킬, 펜타후로로페닐, 알릴 또는 알릴-(1-4C)알킬이며 후자의 2개는 할로게노, (1-6C)알킬, (1-6C)알콕시, (1-4C)알킬렌디옥시, 트리후로로메틸, 시아노, 니트로, 하이드록시, (2-6C)알카노일옥시, (1-6C)알킬티오, (1-6C)알칸설포닐,(1-6C)알카일아미노로부터 선택되는 3이하의 치환체를 포함하며 2-4탄소 원자의 옥사폴리메틸렌이고, Ra와 Rb가 모두 알킬 또는 알케닐일 때 Ra와 Rb의 총탄소수는 8 또는 그 이하이거나; Ra와 Rb는 함께 2-7탄소원자의 폴리메틸렌을 형성하며 임의적으로 하나 또는 두 개의 (1-4C)알킬치환체를 포함하며 Rc는 하이드록시, (1-6C)알콕시 또는 (1-6C)알칸설폰아미도이고; n은 1; A는 에틸렌 또는 비닐렌이고; Y와 벤젠고리 B는 상기에서 언급대로이고 디옥산 고리의 4와 5위치에 있는 치환체는 시스-상대적 입체화학 이성질체를 갖거나 이러한 화합물의 Rc가 하이드록시시기인 경우 그 염은 염기와 함께 생리적으로 허용될 수 있는 양이온을 생성한다.
- 제3항에 있어서, 개시물질의 Ra와 Rb는 모두 수소, 메틸, 에틸, 프로필, 부틸 또는 트리후로로메틸이고; Ra와 Rb는 함께 트리메틸렌, 테트라메틸렌, 펜타메틸렌, 헥사메틸렌, 또는 식 : CH2CH2.CHCH3.CH2CH2-의 기를 형성하거나; Ra는 (3-8C)알킬, 트리후로로메틸, 크로로메틸, 2-크로로에틸, 펜타후로로페닐, 페닐, 벤질, 또는 나프틸이고 마지막 3개는 1또는 2의 할로게노, (1-4C)알킬, (1-4C)알콕시, 트리후로로메틸, 하이드록시, 시아노(1-4C)알킬티오 또는 (1-4C)알카노일아미노 치환체를 포함하며 메틸렌디옥시 또는 메틸렌옥시메틸렌 치환체이고 Rb는 수소이며; 벤젠고리 B는 치환되지 않거나 2-할로게노-, 2-(1-4C)알킬-, 2-(1-4C)알콕시-, 2-하이드록시-또는 3-할로게노-페닐이며; Ra와 디옥산고리의 4-,5-위치의 치환체는 시스-상대적 입체화학이성질체를 갖으며; n은 1이고; A는 트리메틸렌인 것을 특징으로 하는 방법.
- 제3항에 있어서, 개시물질의 Ra는 메틸, 에틸, 이소프로필, 2-크로로페닐, 2-메틸페닐, 2-에틸페닐, 3-후로로페닐, 3-크로로페닐, 3-메틸티오페닐, 4-후로로페닐, 4-크로로페닐, 4-메톡시페닐, 3.4-메틸렌디옥시페닐 또는 3.4(메틸렌 옥시메틸렌)페닐과 Rb는 수소이거나; Ra와 Rb는 모두 메틸 또는 메틸이거나 함께 펜타메틸렌, 헥사메틸렌 또는 (3-메틸)펜타메틸렌을 형성하며; 벤젠고리 B는 치환되지 않거나 0-메톡시, 0-하이드록시, 0-메틸, 0-후로로 또는 0-크로로치환체이고; Ra와 디옥산고리의 4와 5위치의 치환체는 시스-상대적 입체화학이 성질체를 갖으며; n은 1이고; A는 트리메틸렌인 것을 특징으로 하는 방법.
- 벤젠고리 B가 할로게노, (1-6C)알킬, (1-6C)알콕시, 하이드록시(1-6C)알카노일옥시, (1-6C)알카노일아미노, 트리후로로메틸과 니트로로부터 선택되는 하나 또는 두 개의 치환체를 포함하는 식(Ⅳ)의 [2.3-트랜스]-락톤을 선택적으로 환원시키는 것을 특징으로 하는 라세믹 또는 광학적 활성 형태의 식(Ⅱa)화합물의 제조방법.
-
- 식(Ⅴ)의-페닐파리콘산 또는 그것의 적당한 유도체를 선택적으로 환원시키는 것을 특징으로 하는 라세믹 또는 광학적 활성 형태의 식(Ⅳ)의 [2.3-]-락톤의 제조방법.
-
- 제7항에 있어서, 식(Ⅴ)의-페닐파라콘산 개시물질은 식(Ⅴa)의-페닐파라콘산과 식(Ⅴ)의 트랜스-페닐파라콘산의 혼합물을 강산 처리하여 제조하며 숙시닉안하이드라이드와 벤젠고리 B의 의미가 제6항과 같은 식(Ⅵ)의 벤즈알데히드의 염기촉매 축합에 의해 얻어지는 것을 특징으로 하는 방법.
-
- 제3,4 또는 5항에 있어서, 식(Ⅱa)의 [2.3-트랜스]-후란은 식(Ⅴ)의-페닐파라콘산을 선택적으로 환원하여 얻는 식(Ⅳ)의 [2.3-트랜스]-락톤을 다시 선택적으로 환원하여 얻는 것을 특징으로 하는 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
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| GB838330120A GB8330120D0 (en) | 1983-11-11 | 1983-11-11 | Chemical process |
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| DE3685775T2 (de) * | 1985-05-10 | 1993-01-21 | Ici Plc | Alkenderivate. |
| GB8511890D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Benzene derivatives |
| HU198706B (en) * | 1985-05-10 | 1989-11-28 | Ici Plc | Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them |
| GB8511891D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Alkenoic acids |
| GB8511894D0 (en) | 1985-05-10 | 1985-06-19 | Ici Plc | Phenol derivatives |
| GB8611174D0 (en) * | 1986-05-08 | 1986-06-18 | Ici Plc | Amide derivatives |
| GB8626297D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Pharmaceutical compositions |
| GB8626296D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Therapeutic agents |
| GB8709794D0 (en) * | 1987-04-24 | 1987-05-28 | Ici Plc | Heterocyclic acids |
| US5248780A (en) * | 1988-02-16 | 1993-09-28 | Imperial Chemical Industries, Plc | Pyridyl substituted alkenoic acid derivatives |
| GB8901201D0 (en) * | 1988-02-16 | 1989-03-15 | Ici Plc | Pyridine derivatives |
| GB8814340D0 (en) * | 1988-06-16 | 1988-07-20 | Ici Plc | Process |
| GB9021571D0 (en) * | 1990-10-04 | 1990-11-21 | Ici Plc | Heterocyclic acids |
| WO2002085833A1 (fr) * | 2001-04-18 | 2002-10-31 | Kuraray Co., Ltd. | Procede de preparation d'acide 2-benzyl-succinique a activite optique et de monamides de l'acide 2-benzyl-succinique a activite optique |
| RU2449999C2 (ru) * | 2006-01-18 | 2012-05-10 | Эвольва Са | Модуляторы ppar |
| WO2008089461A1 (en) | 2007-01-18 | 2008-07-24 | Evolva Sa | Substituted 1,3-dioxanes useful as ppar modulators |
| ES2609825T3 (es) * | 2007-01-18 | 2017-04-24 | Evolva Sa | 1,3-Dioxanos sustituidos útiles como moduladores de PPAR |
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