AR044069A1 - Un metodo de diuresis mejorada en individuos con funcion renal deteriorada - Google Patents

Un metodo de diuresis mejorada en individuos con funcion renal deteriorada

Info

Publication number
AR044069A1
AR044069A1 ARP040101381A ARP040101381A AR044069A1 AR 044069 A1 AR044069 A1 AR 044069A1 AR P040101381 A ARP040101381 A AR P040101381A AR P040101381 A ARP040101381 A AR P040101381A AR 044069 A1 AR044069 A1 AR 044069A1
Authority
AR
Argentina
Prior art keywords
diuretic
individuals
renal function
metabolite
prodrug
Prior art date
Application number
ARP040101381A
Other languages
English (en)
Inventor
Scott Thomson
Kenneth J Widder
Lauren Otsuki
Roland Blantz
Howard C Dittrich
Original Assignee
Nova Cardia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nova Cardia Inc filed Critical Nova Cardia Inc
Publication of AR044069A1 publication Critical patent/AR044069A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composición farmacéutica que comprende una cantidad terapéuticamente efectiva de KW-3902, o una sal, éster, amida, metabolito o prodroga del mismo, y un diurético que no modifique la adenosina. Métodos para inducir un efecto diurético en un animal que comprenden el paso de administrar una cantidad terapéuticamente efectiva de KW-3902, o una sal, éster, amida, metabolito o prodroga del mismo, en combinación con una segunda composición farmacéutica capaz de inducir un efecto diurético. El KW- 3902 es un antagonista del receptor de adenosina A1 derivado de Xantina (AA1RA). Su nombre químico es 8-(3-noradamantil)-1,3-dipropilxantina, conocida también como 3,7-dihidro-1,3-dipropil-8-(3-triciclo[3.3.1.03,7]nonil)-1H-purina-2,6- diona. Reivindicación 5: La composición de acuerdo con la reivindicación 1, donde el diurético se selecciona dentro del grupo consistente en hidroclorotiazidas, furosemida, torsemida, bumetanida, ácido etacrínico, piretanida, norsemida, espironolactona, triamterene y amiloridetiazidas.
ARP040101381A 2003-04-25 2004-04-23 Un metodo de diuresis mejorada en individuos con funcion renal deteriorada AR044069A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46600703P 2003-04-25 2003-04-25

Publications (1)

Publication Number Publication Date
AR044069A1 true AR044069A1 (es) 2005-08-24

Family

ID=33418325

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101381A AR044069A1 (es) 2003-04-25 2004-04-23 Un metodo de diuresis mejorada en individuos con funcion renal deteriorada

Country Status (16)

Country Link
US (3) US7579331B2 (es)
EP (1) EP1620107A1 (es)
JP (1) JP2006524699A (es)
KR (1) KR20060004959A (es)
CN (1) CN1859913A (es)
AR (1) AR044069A1 (es)
AU (1) AU2004233852A1 (es)
BR (1) BRPI0409699A (es)
CA (1) CA2522971A1 (es)
MX (1) MXPA05011371A (es)
NO (1) NO20055536L (es)
NZ (1) NZ543109A (es)
RU (1) RU2367442C2 (es)
TW (1) TW200500070A (es)
WO (1) WO2004096228A1 (es)
ZA (1) ZA200509311B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
US20060293312A1 (en) * 2003-04-25 2006-12-28 Howard Dittrich Method of improved diuresis in individuals with impaired renal function
NZ543109A (en) 2003-04-25 2008-06-30 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
WO2005023183A2 (en) * 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use
US20050239759A1 (en) * 2004-04-16 2005-10-27 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist and an aldosterone inhibitor
JP2008531579A (ja) * 2005-02-24 2008-08-14 ニトロメッド インコーポレーティッド 酸化窒素増強利尿化合物、組成物および使用方法
EP1928414A2 (en) * 2005-04-22 2008-06-11 Novacardia, Inc. Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions
WO2007069675A1 (ja) * 2005-12-14 2007-06-21 Kyowa Hakko Kogyo Co., Ltd. キサンチン誘導体の易吸収性経口製剤
WO2007117549A2 (en) * 2006-04-06 2007-10-18 Novacardia, Inc. Co-administration of adenosine a1 receptor antagonists and anticonvulsants
CN101466383A (zh) * 2006-06-16 2009-06-24 美国诺华卡迪亚公司 包含低频率投与aa1ra的肾功能延长改善
JP2009539995A (ja) * 2006-06-16 2009-11-19 ノヴァカーディア，インク． うっ血性心不全および急性体液過剰の患者において入院期間を短縮するための方法
US20090197900A1 (en) * 2007-03-29 2009-08-06 Howard Dittrich Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
US20080242684A1 (en) * 2007-03-29 2008-10-02 Howard Dittrich Methods of administration of adenosine a1 receptor antagonists

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416810C (sv) 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
FR2531085A1 (fr) 1982-07-28 1984-02-03 Adir Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4769377A (en) 1983-02-18 1988-09-06 The Johns Hopkins University Adenosine receptor antagonists
DE3843117A1 (de) 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
US5290782A (en) 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
SE9000207L (sv) 1990-01-22 1991-07-23 Nobel Chemicals Ab Laekemedel samt anvaendningen av detsamma
DE4019892A1 (de) 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
WO1993000081A1 (en) 1991-06-28 1993-01-07 Sepracor, Inc. Optically pure s(-) nadolol for treatment of cardiovascular disorders
CA2093403C (en) 1992-04-08 1999-08-10 Fumio Suzuki Therapeutic agent for parkinson's disease
TW252044B (es) 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
DE4238367A1 (de) 1992-11-13 1994-05-19 Boehringer Ingelheim Kg Diuretisches Mittel
US5395836A (en) 1993-04-07 1995-03-07 Kyowa Hakko Kogyo Co., Ltd. 8-tricycloalkyl xanthine derivatives
US5736528A (en) 1993-10-28 1998-04-07 University Of Florida Research Foundation, Inc. N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
US5446046A (en) 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
CN1049117C (zh) 1994-09-16 2000-02-09 赵明玉 预防和治疗偏头痛的偏头痛片
ES2199289T3 (es) 1995-07-26 2004-02-16 Kyowa Hakko Kogyo Co., Ltd. Dispersion solida de derivados de xantina.
CN1227490A (zh) 1996-08-07 1999-09-01 协和发酵工业株式会社 含有黄嘌呤衍生物的脂肪乳剂
DE19816857A1 (de) 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6187780B1 (en) 1998-04-16 2001-02-13 Boehringer Ingelheim Pharma Kg Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity
ES2211079T3 (es) 1998-04-24 2004-07-01 Cv Therapeutics Composicion que contiene un antagonista del receptor a1 de adenosina y metodo para restablecer la funcion diuretica y renal.
US20020115687A1 (en) 1998-04-24 2002-08-22 Evan Beckman Method and composition for restoring diuretic and renal function
EP0970696A1 (en) 1998-05-05 2000-01-12 Kyowa Hakko Kogyo Co., Ltd. Combination of loop diuretics with adenosine A1-receptor antagonists
UA74141C2 (uk) 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
EP1775297A3 (en) 1999-11-12 2008-12-03 Biogen Idec MA Inc. Adenosine receptor antagonists and methods of making and using the same
CZ20021614A3 (cs) 1999-11-12 2002-07-17 Biogen, Inc. Polycykloalkylpuriny jako antagonisty adenosinového receptoru
US20050038017A1 (en) 1999-12-22 2005-02-17 Wolff Andrew A. Method and composition for restoring diuretic and renal function
YU42903A (sh) 2000-12-01 2006-05-25 Biogen Inc. Kondenzovani derivati purina kao antagonisti a1 receptora adenozina
BR0017386A (pt) 2000-12-18 2004-01-13 Novartis Ag Combinação terapêutica de amlodipina e benazepril
UA80258C2 (en) 2001-09-06 2007-09-10 Biogen Inc Methods of treating pulmonary disease
US20040229901A1 (en) 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
US20060293312A1 (en) 2003-04-25 2006-12-28 Howard Dittrich Method of improved diuresis in individuals with impaired renal function
NZ543109A (en) * 2003-04-25 2008-06-30 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
WO2005000294A1 (en) 2003-06-06 2005-01-06 Pharmacia Corporation Selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders
US20050239759A1 (en) 2004-04-16 2005-10-27 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist and an aldosterone inhibitor
CA2565037A1 (en) 2004-04-28 2005-11-10 Cv Therapeutics, Inc. Purine derivatives as a1 adenosine receptor antagonists
WO2007117549A2 (en) 2006-04-06 2007-10-18 Novacardia, Inc. Co-administration of adenosine a1 receptor antagonists and anticonvulsants
CN101466383A (zh) 2006-06-16 2009-06-24 美国诺华卡迪亚公司 包含低频率投与aa1ra的肾功能延长改善
JP2009539995A (ja) 2006-06-16 2009-11-19 ノヴァカーディア，インク． うっ血性心不全および急性体液過剰の患者において入院期間を短縮するための方法
WO2008024277A2 (en) 2006-08-22 2008-02-28 Novacardia, Inc. Kw-3902 conjugates that do not cross the blood-brain barrier

Also Published As

Publication number Publication date
US7579331B2 (en) 2009-08-25
US20060030572A1 (en) 2006-02-09
BRPI0409699A (pt) 2006-04-18
CA2522971A1 (en) 2004-11-11
JP2006524699A (ja) 2006-11-02
ZA200509311B (en) 2006-10-25
NO20055536L (no) 2005-12-29
NO20055536D0 (no) 2005-11-23
RU2005131938A (ru) 2006-06-27
US20050004145A1 (en) 2005-01-06
WO2004096228A1 (en) 2004-11-11
NZ543109A (en) 2008-06-30
EP1620107A1 (en) 2006-02-01
US20060035911A1 (en) 2006-02-16
CN1859913A (zh) 2006-11-08
AU2004233852A1 (en) 2004-11-11
KR20060004959A (ko) 2006-01-16
TW200500070A (en) 2005-01-01
MXPA05011371A (es) 2005-12-01
RU2367442C2 (ru) 2009-09-20

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