DK3045176T3 - Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion - Google Patents

Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion Download PDF

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Publication number
DK3045176T3
DK3045176T3 DK15199540.4T DK15199540T DK3045176T3 DK 3045176 T3 DK3045176 T3 DK 3045176T3 DK 15199540 T DK15199540 T DK 15199540T DK 3045176 T3 DK3045176 T3 DK 3045176T3
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Prior art keywords
oxo
amino
representative
isoindol
dione
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DK15199540.4T
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English (en)
Inventor
Roger Shen-Chu Chen
George W Muller
Markian S Jaworsky
Manohar T Saindane
Louise Cameron
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Celgene Corp
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Publication of DK3045176T3 publication Critical patent/DK3045176T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2857—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by displacing or removing an element enclosing it
    • B65D51/2864—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by displacing or removing an element enclosing it the element being a plug or like element closing a passage between the auxiliary container and the main container
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Claims (4)

1. Farmaceutisk sammensætning eller enkelt enhedsdoseringsform, der omfatter krystallinsk 3-(4-amino-l-oxo-l,3-dihydro-isoindol-2-yl)-piperidin-2,6-dion og eventuelt én eller flere excipienser eller fortyndere, hvilket krystallinsk 3-(4-amino-l-oxo-1,3 dihydro-isoindol-2-yl)-piperidin-2,6-dion haret røntgenpulverdiffraktionsmønster, der omfatter peaks ved 20, 24,5 og 29 grader 2Θ.
2. Farmaceutisk sammensætning eller enkelt enhedsdoseringsform ifølge krav 1 til anvendelse i en fremgangsmåde til behandling eller forebyggelse af en sygdom valgt fra gruppen bestående af sygdomme forbundet med uønsket angiogenese, cancer, inflammatoriske sygdomme, autoimmune sygdomme og immunsygdomme.
3. Farmaceutisk sammensætning eller enkelt enhedsdoseringsform til anvendelse ifølge krav 2, hvor sygdommen er en solid tumor, en blodbåren tumor, et myelodysplastisk syndrom eller en myeloproliferativ sygdom.
4. Farmaceutisk sammensætning eller enkelt enhedsdoseringsform til anvendelse ifølge krav 2 eller 3, hvor fremgangsmåden indebærer indgivelse af det krystallinske 3-(4-amino-l-oxo-l,3-dihydro-isoindol-2-yl)-piperidin-2,6-dion ad oral, parenteral eller sublingual indgivelsesvej.
DK15199540.4T 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion DK3045176T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49972303P 2003-09-04 2003-09-04
EP20110185757 EP2425836A1 (en) 2003-09-04 2004-09-03 Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione

Publications (1)

Publication Number Publication Date
DK3045176T3 true DK3045176T3 (da) 2019-02-25

Family

ID=34272860

Family Applications (5)

Application Number Title Priority Date Filing Date
DK15199540.4T DK3045176T3 (da) 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion
DK15199521.4T DK3042659T3 (da) 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion
DK15199526.3T DK3045175T3 (da) 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion
DK11185767T DK2426118T3 (da) 2003-09-04 2004-09-03 Fremgangsmåder til fremstilling af polymorfe former af 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidin-2,6-dion
DK04783095.5T DK1667682T3 (da) 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidin-2,6-dion

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK15199521.4T DK3042659T3 (da) 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion
DK15199526.3T DK3045175T3 (da) 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidin-2,6-dion
DK11185767T DK2426118T3 (da) 2003-09-04 2004-09-03 Fremgangsmåder til fremstilling af polymorfe former af 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidin-2,6-dion
DK04783095.5T DK1667682T3 (da) 2003-09-04 2004-09-03 Polymorfe former af 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidin-2,6-dion

Country Status (37)

Country Link
US (20) US7465800B2 (da)
EP (7) EP2425836A1 (da)
JP (6) JP4733037B2 (da)
KR (3) KR101005991B1 (da)
CN (7) CN102060843B (da)
AP (1) AP2324A (da)
AR (2) AR047994A1 (da)
AT (1) ATE531369T1 (da)
AU (2) AU2004270211B2 (da)
BR (1) BRPI0414084A (da)
CA (9) CA2741575C (da)
CR (2) CR8291A (da)
CY (1) CY1112017T1 (da)
DK (5) DK3045176T3 (da)
EA (1) EA009922B1 (da)
EC (1) ECSP066467A (da)
ES (5) ES2718926T3 (da)
GE (1) GEP20104958B (da)
HK (6) HK1092388A1 (da)
HR (1) HRP20110836T1 (da)
HU (3) HUE041282T2 (da)
IL (5) IL174067A (da)
IS (1) IS8340A (da)
MA (1) MA28084A1 (da)
ME (3) ME01572B (da)
MX (6) MX346260B (da)
NO (4) NO336898B1 (da)
NZ (1) NZ546054A (da)
OA (1) OA13250A (da)
PE (1) PE20060284A1 (da)
PL (5) PL3042659T3 (da)
PT (5) PT1667682E (da)
RS (3) RS20060158A (da)
SI (2) SI1667682T1 (da)
UA (1) UA83504C2 (da)
WO (1) WO2005023192A2 (da)
ZA (1) ZA200601858B (da)

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