DK2805716T3 - Farmaceutisk sammensætning omfattende buprenorfin med hurtigvirkning - Google Patents

Farmaceutisk sammensætning omfattende buprenorfin med hurtigvirkning Download PDF

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DK2805716T3
DK2805716T3 DK14175085.1T DK14175085T DK2805716T3 DK 2805716 T3 DK2805716 T3 DK 2805716T3 DK 14175085 T DK14175085 T DK 14175085T DK 2805716 T3 DK2805716 T3 DK 2805716T3
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Anders Pettersson
Christer Nyström
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Orexo Ab
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Claims (14)

1. En i det væsentlige vandfri farmaceutisk sammensætning til sublingual administration indeholdende en effektiv mængde buprenorfin i form af mikropartikler vedhæftet til overfladen af bærerpartikler, der er større end mikropartiklerne og er vand-opløselige; og et bioadhæsions- og/eller slimhindeadhæsionsfremmende middel.
2. Sammensætning ifølge krav 1, hvor mikropartiklerne af buprenorfin har en vægtbaseret gennemsnitsdiameter på mindre end 10 pm.
3. Sammensætning ifølge krav 1 eller 2, hvor middelsigtediameteren af bærerpartiklerne er mindre end 750 pm.
4. Sammensætning ifølge krav 1 eller 2, hvor middelsigtediameteren er fra 100 til 600 pm.
5. Sammensætning ifølge et hvilket som helst af kravene 1-4, hvor bærerpartiklerne omfatter et sprødt materiale der vil fragmentere let når det komprimeres.
6. Sammensætning ifølge et hvilket som helst af kravene 1-5, hvor det bio/slimhindeadhæsionsfremmende middel er valgt fra gruppen bestående af acrylpolymerer, cellulosederivater, naturlige polymerer med bio/slimhindeadhæsiv-egenskaber, og blandinger deraf.
7. Sammensætning ifølge krav 6, hvor det bio/slimhindeadhæsionsfremmende middel er valgt fra gruppen bestående af cellulosederivater og omfattende hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, natriumcarboxymethylcellulose, methylcellulose, ethylhydroxyethylcellulose, carboxymethylcellulose og modificeret cellulosegummi; crosscarmellose; modificeret stivelse; acrylpolymerer omfattende carbomer og dets derivater; polyethylenoxid; chitosan; gelatin; natriumalginat; pektin; scleroglucan; xanthangummi; guargummi; poly-co-(rnethylvinylether-maleinsyreanhydrid); og blandinger deraf.
8. Sammensætning ifølge et hvilket som helst af kravene 1-7, hvor bærerpartiklerne omfatter et vand-opløseligt, farmaceutisk acceptabelt kulhydrat og/eller et uorganisk salt.
9. Sammensætning ifølge krav 8, hvor bærerpartiklerne omfatter mindst ét af materialerne mannitol, lactose, calciumphosphat og sukker.
10. Sammensætning ifølge et hvilket som helst af kravene 1-9, hvor bærerpartiklerne indeholder mindst ét farmaceutisk opløsningsmiddel der fremmer fordelingen af mikropartiklerne af det aktive middel eller midler over den sublinguale slimhinde.
11. Sammensætning ifølge krav 10, hvor opløsningsmidlet er valgt fra gruppen bestående af tværbundet polyvinylpyrrolidon, carboxymethylstivelse, naturlig stivelse, mikrokrystallinsk cellulose, cellulosegummi, og blandinger deraf.
12. Sammensætning ifølge krav 10 eller 11, hvor opløsningsmidlet er til stede i en mængde fra 1 til 10 vægtprocent af sammensætningen.
13. Sammensætning ifølge et hvilket som helst af kravene 1 til 12, til anvendelse i den sublinguale administration af buprenorfin til en patient.
14. Sammensætning ifølge et hvilket som helst af kravene 1 til 12, til anvendelse i en fremgangsmåde til at reducere uregelmæssig lægemiddelabsorption via nedsvælget spyt.
DK14175085.1T 1998-09-24 1999-09-24 Farmaceutisk sammensætning omfattende buprenorfin med hurtigvirkning DK2805716T3 (da)

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SE9803240A SE9803240D0 (sv) 1998-09-24 1998-09-24 A pharmaceutical composition having a rapid action
EP10001408.3A EP2236133B1 (en) 1998-09-24 1999-09-24 Pharmaceutical composition comprising fentanyl for the treatment of acute or breakthrough pain by sublingual administration

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DK99952867T DK1115383T3 (da) 1998-09-24 1999-09-24 Behandling af akutte lidelser ved sublingual indgivelse af at farmaceutisk præparat
DK10001406.7T DK2236132T3 (da) 1998-09-24 1999-09-24 Farmaceutisk sammensætning til behandlingen af søvnløshed ved sublingual administration
DK05077875.2T DK1652518T3 (da) 1998-09-24 1999-09-24 Farmaceutisk sammensætning til sublingval administration
DK14175085.1T DK2805716T3 (da) 1998-09-24 1999-09-24 Farmaceutisk sammensætning omfattende buprenorfin med hurtigvirkning
DK10001408.3T DK2236133T3 (da) 1998-09-24 1999-09-24 Farmaceutisk sammensætning omfattende fentanyl til behandlingen af akut- eller gennembrydningssmerte ved sublingual administration

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DK99952867T DK1115383T3 (da) 1998-09-24 1999-09-24 Behandling af akutte lidelser ved sublingual indgivelse af at farmaceutisk præparat
DK10001406.7T DK2236132T3 (da) 1998-09-24 1999-09-24 Farmaceutisk sammensætning til behandlingen af søvnløshed ved sublingual administration
DK05077875.2T DK1652518T3 (da) 1998-09-24 1999-09-24 Farmaceutisk sammensætning til sublingval administration

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