DK2654794T3 - Materialer og fremgangsmåder til konjugering af et vandopløseligt fedtsyrederivat til et protein - Google Patents
Materialer og fremgangsmåder til konjugering af et vandopløseligt fedtsyrederivat til et protein Download PDFInfo
- Publication number
- DK2654794T3 DK2654794T3 DK11806103.5T DK11806103T DK2654794T3 DK 2654794 T3 DK2654794 T3 DK 2654794T3 DK 11806103 T DK11806103 T DK 11806103T DK 2654794 T3 DK2654794 T3 DK 2654794T3
- Authority
- DK
- Denmark
- Prior art keywords
- conjuging
- protein
- procedures
- materials
- water soluble
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 239000000463 material Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426356P | 2010-12-22 | 2010-12-22 | |
| PCT/US2011/065591 WO2012087838A1 (en) | 2010-12-22 | 2011-12-16 | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2654794T3 true DK2654794T3 (da) | 2020-06-08 |
Family
ID=45464916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11806103.5T DK2654794T3 (da) | 2010-12-22 | 2011-12-16 | Materialer og fremgangsmåder til konjugering af et vandopløseligt fedtsyrederivat til et protein |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8945897B2 (enExample) |
| EP (2) | EP2654794B8 (enExample) |
| JP (1) | JP6138052B2 (enExample) |
| KR (1) | KR102025442B1 (enExample) |
| CN (1) | CN103269723B (enExample) |
| AR (1) | AR084576A1 (enExample) |
| AU (2) | AU2011349574B9 (enExample) |
| BR (1) | BR112013015898A2 (enExample) |
| CA (1) | CA2822591C (enExample) |
| DK (1) | DK2654794T3 (enExample) |
| EA (1) | EA032056B1 (enExample) |
| ES (1) | ES2800983T3 (enExample) |
| HU (1) | HUE049352T2 (enExample) |
| MX (1) | MX345608B (enExample) |
| NZ (1) | NZ612320A (enExample) |
| PL (1) | PL2654794T3 (enExample) |
| PT (1) | PT2654794T (enExample) |
| SG (1) | SG191298A1 (enExample) |
| TW (1) | TWI546279B (enExample) |
| WO (1) | WO2012087838A1 (enExample) |
Families Citing this family (30)
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| US20150233903A1 (en) * | 2012-09-10 | 2015-08-20 | The Johns Hopkins University | Solid phase glycan and glycopeptide analysis and microfluidic chip for glycomic extraction, analysis and methods for using same |
| CN103897031A (zh) * | 2012-12-25 | 2014-07-02 | 深圳先进技术研究院 | 化学修饰的胸腺五肽及其合成方法 |
| WO2014131011A1 (en) * | 2013-02-25 | 2014-08-28 | J Craig Venter Institute | Metaproteomic method to identify secreted pattern recognition molecules and adhesive antimicrobial factors for detection of microbial agents eliciting inflammation in the human host |
| AU2014234271A1 (en) * | 2013-03-20 | 2015-10-08 | Fresenius Kabi Deutschland Gmbh | Process for the preparation of thiol functionalized hydroxyalkyl starch derivatives |
| CN103636918B (zh) * | 2013-12-13 | 2015-11-04 | 东北农业大学 | 一种富含亚油酸的改性分离蛋白制备方法 |
| EP3102224B1 (en) * | 2013-12-20 | 2019-02-20 | NephroGenesis, LLC. | Apparatuses for kidney dialysis and lipocalin protein for use in the prevention or treatment of uremia by dialysis |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
| KR20180031775A (ko) * | 2015-08-12 | 2018-03-28 | 셀 머신스, 인크. | 긴 반감기 응집 복합체와 관련된 방법 및 조성물 |
| CN106554425B (zh) * | 2015-09-18 | 2018-10-30 | 沈阳药科大学 | 一种聚唾液酸的脂质接枝衍生物及其应用 |
| CN109069569B (zh) * | 2015-12-02 | 2023-02-14 | 韩美药品株式会社 | 使用脂肪酸衍生物的蛋白缀合物及其制备方法 |
| CN108147990B (zh) * | 2016-12-02 | 2023-01-24 | 上海中医药大学 | 一种膜锚定元件及其应用 |
| ES2963839T3 (es) | 2017-02-08 | 2024-04-02 | Bristol Myers Squibb Co | Polipéptidos de relaxina modificados que comprenden un potenciador farmacocinético y usos de los mismos |
| CN107141354A (zh) * | 2017-05-05 | 2017-09-08 | 李斯文 | 一种融合蛋白及光敏剂复合物及其制备方法和应用 |
| WO2019023295A1 (en) | 2017-07-27 | 2019-01-31 | Saint Louis University | Fatty acid modified human epidermal growth factor |
| CA3151394C (en) * | 2017-09-19 | 2023-10-03 | Immunwork Inc. | Pharmaceutical constructs with enhanced binding affinity with albumin |
| US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| SG11202107497XA (en) | 2019-01-23 | 2021-08-30 | Regeneron Pharma | Treatment of ophthalmic conditions with angiopoietin-like 7 (angptl7) inhibitors |
| EP3819307A1 (en) * | 2019-11-07 | 2021-05-12 | CytoKi Pharma ApS | Therapeutic derivatives of interleukin-22 |
| US11692020B2 (en) | 2019-11-20 | 2023-07-04 | Anwita Biosciences, Inc. | Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| CN113967267B (zh) * | 2020-07-21 | 2022-10-25 | 四川大学 | 脂肪酸修饰的白蛋白的内质网靶向作用及其用途 |
| EP4298219A1 (en) | 2021-02-26 | 2024-01-03 | Regeneron Pharmaceuticals, Inc. | Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors |
| EP4337680A1 (en) * | 2021-05-11 | 2024-03-20 | Cytoki Pharma ApS | Therapeutic derivatives of interleukin-22 |
| EP4089107A1 (en) * | 2021-05-11 | 2022-11-16 | CytoKi Pharma ApS | Therapeutic derivatives of interleukin-22 |
| EP4089108A1 (en) * | 2021-05-11 | 2022-11-16 | CytoKi Pharma ApS | Therapeutic derivatives of interleukin-22 |
| CN114990175B (zh) * | 2021-10-22 | 2023-03-31 | 岩唐生物科技(杭州)有限责任公司 | 一种岩藻糖衍生物的合成方法 |
| CA3263628A1 (en) * | 2022-07-29 | 2024-02-01 | The Trustees Of The University Of Pennsylvania | ANTICOAGULANT TARGETING THE LYMPH FOR THE PREVENTION OF LYMPHATOUS THROMBOSIS |
| CN115894719B (zh) * | 2022-11-24 | 2023-10-20 | 武汉禾元生物科技股份有限公司 | 一种人血清白蛋白胰岛素偶联物及其制备方法 |
| WO2025133203A1 (en) * | 2023-12-22 | 2025-06-26 | Pam Theragnostics Gmbh | Compounds and methods for a long-lasting pam |
| CN118209737B (zh) * | 2024-05-22 | 2024-08-09 | 国科大杭州高等研究院 | 一种用于鉴定检测脂肪酸与蛋白质相互作用的方法 |
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- 2011-12-16 PL PL11806103T patent/PL2654794T3/pl unknown
- 2011-12-16 ES ES11806103T patent/ES2800983T3/es active Active
- 2011-12-16 HU HUE11806103A patent/HUE049352T2/hu unknown
- 2011-12-16 KR KR1020137019066A patent/KR102025442B1/ko active Active
- 2011-12-16 SG SG2013048194A patent/SG191298A1/en unknown
- 2011-12-16 DK DK11806103.5T patent/DK2654794T3/da active
- 2011-12-16 CN CN201180062472.4A patent/CN103269723B/zh active Active
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- 2011-12-16 CA CA2822591A patent/CA2822591C/en active Active
- 2011-12-16 BR BR112013015898-0A patent/BR112013015898A2/pt not_active Application Discontinuation
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- 2011-12-16 WO PCT/US2011/065591 patent/WO2012087838A1/en not_active Ceased
- 2011-12-16 NZ NZ612320A patent/NZ612320A/en unknown
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- 2011-12-16 PT PT118061035T patent/PT2654794T/pt unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2654794B1 (en) | 2020-03-04 |
| CN103269723A (zh) | 2013-08-28 |
| KR20130129254A (ko) | 2013-11-27 |
| AU2011349574B2 (en) | 2017-06-01 |
| EP2654794B8 (en) | 2020-04-22 |
| AU2011349574B9 (en) | 2017-06-15 |
| WO2012087838A1 (en) | 2012-06-28 |
| AU2017204019A1 (en) | 2017-07-06 |
| CN103269723B (zh) | 2017-04-05 |
| EA201390940A1 (ru) | 2014-04-30 |
| ES2800983T3 (es) | 2021-01-07 |
| KR102025442B1 (ko) | 2019-09-25 |
| JP2014501262A (ja) | 2014-01-20 |
| BR112013015898A2 (pt) | 2018-06-26 |
| SG191298A1 (en) | 2013-07-31 |
| CA2822591C (en) | 2020-12-29 |
| AR084576A1 (es) | 2013-05-29 |
| US8945897B2 (en) | 2015-02-03 |
| TWI546279B (zh) | 2016-08-21 |
| MX345608B (es) | 2017-02-07 |
| EA032056B1 (ru) | 2019-04-30 |
| EP3673921A1 (en) | 2020-07-01 |
| PT2654794T (pt) | 2020-06-11 |
| AU2011349574A1 (en) | 2013-07-11 |
| HUE049352T2 (hu) | 2020-09-28 |
| US20120190096A1 (en) | 2012-07-26 |
| EP2654794A1 (en) | 2013-10-30 |
| CA2822591A1 (en) | 2012-06-28 |
| PL2654794T3 (pl) | 2020-07-27 |
| TW201305090A (zh) | 2013-02-01 |
| MX2013007369A (es) | 2013-09-26 |
| JP6138052B2 (ja) | 2017-05-31 |
| NZ612320A (en) | 2015-06-26 |
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