ATE405669T1 - Remodellierung von glycoproteinen unter verwendung von endoglycanasen - Google Patents
Remodellierung von glycoproteinen unter verwendung von endoglycanasenInfo
- Publication number
- ATE405669T1 ATE405669T1 AT02786845T AT02786845T ATE405669T1 AT E405669 T1 ATE405669 T1 AT E405669T1 AT 02786845 T AT02786845 T AT 02786845T AT 02786845 T AT02786845 T AT 02786845T AT E405669 T1 ATE405669 T1 AT E405669T1
- Authority
- AT
- Austria
- Prior art keywords
- glycoproteins
- endoglycanases
- remodeling
- provides methods
- recombinantly produced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33430101P | 2001-11-28 | 2001-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE405669T1 true ATE405669T1 (de) | 2008-09-15 |
Family
ID=23306575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02786845T ATE405669T1 (de) | 2001-11-28 | 2002-11-27 | Remodellierung von glycoproteinen unter verwendung von endoglycanasen |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1461445B1 (de) |
JP (1) | JP2005535280A (de) |
AT (1) | ATE405669T1 (de) |
AU (1) | AU2002351199A1 (de) |
CA (1) | CA2468295C (de) |
DE (1) | DE60228492D1 (de) |
WO (1) | WO2003046150A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
JP2006523211A (ja) | 2003-03-14 | 2006-10-12 | ネオス テクノロジーズ インコーポレイテッド | 分岐水溶性ポリマーとその複合物 |
EP2338333B1 (de) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylierungsverfahren und durch die Verfahren hergestellte Proteine/Peptide |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
ES2560657T3 (es) | 2004-01-08 | 2016-02-22 | Ratiopharm Gmbh | Glicosilación con unión en O de péptidos G-CSF |
CA2565414A1 (en) | 2004-05-04 | 2005-11-24 | Novo Nordisk Health Care Ag | O-linked glycoforms of polypeptides and method to manufacture them |
WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
EP1799249A2 (de) | 2004-09-10 | 2007-06-27 | Neose Technologies, Inc. | Glycopegyliertes interferon alpha |
EP1797192A1 (de) * | 2004-09-29 | 2007-06-20 | Novo Nordisk Health Care AG | Modifizierte proteine |
SI2586456T1 (sl) | 2004-10-29 | 2016-05-31 | Ratiopharm Gmbh | Preoblikovanje in glikopegliacija fibroblastnega rastnega faktorja (FGF) |
EP1858543B1 (de) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylierten Granulocyten-Kolonie-stimulierender Faktor |
JP4910091B2 (ja) * | 2005-02-16 | 2012-04-04 | 国立大学法人北海道大学 | 4位ハロゲン化ガラクトース含有糖鎖及びその応用 |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
EP1987068B1 (de) | 2006-02-10 | 2018-08-08 | Life Technologies Corporation | Modifizierung von oligosacchariden und etikettierung von proteinen |
CN101516388B (zh) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
EP2054521A4 (de) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Verfahren zur reinigung von polypeptid-konjugate |
DK2101821T3 (da) | 2006-12-15 | 2014-10-06 | Baxter Healthcare Sa | Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo |
ES2406267T3 (es) | 2007-04-03 | 2013-06-06 | Biogenerix Ag | Métodos de tratamiento usando G-CSF glicopegilado |
WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
PL2257311T3 (pl) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
US8815580B2 (en) | 2008-08-08 | 2014-08-26 | Vib Vzw | Cells producing glycoproteins having altered glycosylation patterns and method and use thereof |
SI2889043T1 (sl) * | 2008-12-16 | 2019-08-30 | Genzyme Corporation | Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein |
KR20170124619A (ko) | 2009-03-27 | 2017-11-10 | 아카데미아 시니카 | 바이러스에 대한 면역을 위한 방법 및 조성물 |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
WO2011012850A2 (en) | 2009-07-27 | 2011-02-03 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
HUE028056T2 (en) | 2009-07-27 | 2016-11-28 | Baxalta GmbH | Blood coagulation protein conjugates |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
JP5908401B2 (ja) | 2009-07-27 | 2016-04-26 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 血液凝固タンパク質複合体 |
TWI537385B (zh) * | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
CA2822591C (en) | 2010-12-22 | 2020-12-29 | Baxter International Inc. | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
US10851174B2 (en) | 2011-03-03 | 2020-12-01 | University Of Maryland, Baltimore | Core fucosylated glycopeptides and glycoproteins: chemoenzymatic synthesis and uses thereof |
CA2862925C (en) | 2012-02-10 | 2020-01-21 | University Of Maryland, Baltimore | Chemoenzymatic glycoengineering of antibodies and fc fragments thereof |
US11293012B2 (en) | 2015-07-09 | 2022-04-05 | Vib Vzw | Cells producing glycoproteins having altered N- and O-glycosylation patterns and methods and use thereof |
AU2018322943B2 (en) | 2017-09-04 | 2020-06-04 | 89Bio Ltd. | Mutant FGF-21 peptide conjugates and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
US5876980A (en) | 1995-04-11 | 1999-03-02 | Cytel Corporation | Enzymatic synthesis of oligosaccharides |
US6030815A (en) | 1995-04-11 | 2000-02-29 | Neose Technologies, Inc. | Enzymatic synthesis of oligosaccharides |
US5728554A (en) | 1995-04-11 | 1998-03-17 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
US5922577A (en) | 1995-04-11 | 1999-07-13 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
IL130964A0 (en) | 1997-01-16 | 2001-01-28 | Cytel Corp | Practical in vitro sialylation of recombinant glycoproteins |
JP2004528001A (ja) * | 2000-05-12 | 2004-09-16 | ネオーズ テクノロジーズ, インコーポレイテッド | インビトロにおけるフコシル化組換えグリコペプチド |
-
2002
- 2002-11-27 DE DE60228492T patent/DE60228492D1/de not_active Expired - Lifetime
- 2002-11-27 EP EP02786845A patent/EP1461445B1/de not_active Expired - Lifetime
- 2002-11-27 AU AU2002351199A patent/AU2002351199A1/en not_active Abandoned
- 2002-11-27 CA CA2468295A patent/CA2468295C/en not_active Expired - Fee Related
- 2002-11-27 WO PCT/US2002/038442 patent/WO2003046150A2/en active Application Filing
- 2002-11-27 AT AT02786845T patent/ATE405669T1/de not_active IP Right Cessation
- 2002-11-27 JP JP2003547585A patent/JP2005535280A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2003046150A3 (en) | 2003-11-27 |
WO2003046150A2 (en) | 2003-06-05 |
EP1461445B1 (de) | 2008-08-20 |
EP1461445A4 (de) | 2005-08-17 |
DE60228492D1 (de) | 2008-10-02 |
CA2468295C (en) | 2010-08-03 |
CA2468295A1 (en) | 2003-06-05 |
AU2002351199A1 (en) | 2003-06-10 |
JP2005535280A (ja) | 2005-11-24 |
EP1461445A2 (de) | 2004-09-29 |
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Legal Events
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---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |