DK172074B1 - Fremgangsmåde til krystallisation af iopamidol og anvendelse af butanol dertil - Google Patents

Fremgangsmåde til krystallisation af iopamidol og anvendelse af butanol dertil Download PDF

Info

Publication number
DK172074B1
DK172074B1 DK089294A DK89294A DK172074B1 DK 172074 B1 DK172074 B1 DK 172074B1 DK 089294 A DK089294 A DK 089294A DK 89294 A DK89294 A DK 89294A DK 172074 B1 DK172074 B1 DK 172074B1
Authority
DK
Denmark
Prior art keywords
butanol
iopamidol
water
sec
isobutanol
Prior art date
Application number
DK089294A
Other languages
Danish (da)
English (en)
Other versions
DK89294A (da
Inventor
Marco Villa
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931720A external-priority patent/IT1257001B/it
Priority claimed from IT000760 external-priority patent/IT1269339B/it
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of DK89294A publication Critical patent/DK89294A/da
Application granted granted Critical
Publication of DK172074B1 publication Critical patent/DK172074B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK089294A 1993-07-30 1994-07-29 Fremgangsmåde til krystallisation af iopamidol og anvendelse af butanol dertil DK172074B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI931720A IT1257001B (it) 1993-07-30 1993-07-30 Processo per la cristalizzazione dello iopamidolo
ITMI931720 1993-07-30
ITMI940760 1994-04-20
IT000760 IT1269339B (it) 1994-04-20 1994-04-20 Processo per la cristallizzazione dello iopamidolo

Publications (2)

Publication Number Publication Date
DK89294A DK89294A (da) 1995-01-31
DK172074B1 true DK172074B1 (da) 1997-10-13

Family

ID=26331032

Family Applications (1)

Application Number Title Priority Date Filing Date
DK089294A DK172074B1 (da) 1993-07-30 1994-07-29 Fremgangsmåde til krystallisation af iopamidol og anvendelse af butanol dertil

Country Status (29)

Country Link
US (3) US5571941A (ru)
JP (1) JP3299045B2 (ru)
KR (1) KR100355211B1 (ru)
CN (1) CN1035940C (ru)
AT (1) AT404832B (ru)
AU (1) AU690138B2 (ru)
BE (1) BE1008403A4 (ru)
CA (1) CA2128942C (ru)
CH (1) CH686783A5 (ru)
CZ (1) CZ289300B6 (ru)
DE (1) DE4426818A1 (ru)
DK (1) DK172074B1 (ru)
ES (1) ES2102312B1 (ru)
FI (1) FI960400A0 (ru)
FR (1) FR2708601B1 (ru)
GB (1) GB2280436B (ru)
GR (1) GR940100366A (ru)
HU (1) HU217023B (ru)
IE (1) IE80675B1 (ru)
IL (1) IL110391A (ru)
NL (1) NL194272C (ru)
NO (1) NO304226B1 (ru)
NZ (1) NZ271632A (ru)
PT (1) PT101554B (ru)
RU (1) RU2135462C1 (ru)
SE (1) SE9402595L (ru)
SI (1) SI9420046B (ru)
WO (1) WO1995004031A1 (ru)
ZA (1) ZA945472B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
AU6516196A (en) * 1995-07-04 1997-02-05 Recordati S.A. A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylene-glycol
BR9606624A (pt) * 1995-09-08 1997-11-11 Bracco Int Bv Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
CZ299420B6 (cs) * 1997-02-11 2008-07-23 Bracco International B. V. Zpusob krystalizace iopamidolu
GB9720969D0 (en) 1997-10-02 1997-12-03 Nycomed Imaging As Process
KR20000031642A (ko) * 1998-11-09 2000-06-05 강재헌 이오파미돌의 결정화 방법
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319671B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
DE102005059191B4 (de) * 2005-12-05 2008-02-07 Bayer Schering Pharma Ag Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen
KR100976097B1 (ko) * 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
AU2010232556A1 (en) * 2009-04-02 2011-11-03 Allergan, Inc. Prostaglandin E receptor antagonists
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
DE102012104679A1 (de) 2011-05-30 2012-12-06 Westfälische Wilhelms-Universität Münster Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli
SG11201504201RA (en) 2012-12-19 2015-07-30 Ge Healthcare As Purification of x-ray contrast agents
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (ru) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
KR960016747B1 (ko) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol

Also Published As

Publication number Publication date
CA2128942A1 (en) 1995-01-31
ATA150594A (de) 1998-07-15
USRE36433E (en) 1999-12-07
ES2102312A1 (es) 1997-07-16
NL194272C (nl) 2001-11-05
GB9414912D0 (en) 1994-09-14
GR940100366A (en) 1996-03-31
CZ183194A3 (en) 1995-02-15
IE940609A1 (en) 1995-02-08
HU217023B (hu) 1999-11-29
SI9420046B (sl) 2003-10-31
FI960400A (fi) 1996-01-29
ZA945472B (en) 1995-03-03
FI960400A0 (fi) 1996-01-29
DK89294A (da) 1995-01-31
SE9402595D0 (sv) 1994-07-29
GB2280436B (en) 1997-08-13
NL194272B (nl) 2001-07-02
CA2128942C (en) 2003-07-15
SI9420046A (en) 1996-10-31
IL110391A0 (en) 1994-10-21
WO1995004031A1 (en) 1995-02-09
ES2102312B1 (es) 1998-04-01
AU7532194A (en) 1995-02-28
SE9402595L (sv) 1995-01-31
KR960703842A (ko) 1996-08-31
HU9600191D0 (en) 1996-11-28
JP3299045B2 (ja) 2002-07-08
AT404832B (de) 1999-03-25
CN1128020A (zh) 1996-07-31
US5571941A (en) 1996-11-05
PT101554A (pt) 1995-05-04
NL9401229A (nl) 1995-02-16
IE80675B1 (en) 1998-11-18
JPH07145125A (ja) 1995-06-06
FR2708601B1 (fr) 1995-12-08
AU690138B2 (en) 1998-04-23
CH686783A5 (it) 1996-06-28
RU2135462C1 (ru) 1999-08-27
IL110391A (en) 1998-12-06
DE4426818A1 (de) 1995-02-02
KR100355211B1 (ko) 2003-04-10
CN1035940C (zh) 1997-09-24
US6506938B1 (en) 2003-01-14
FR2708601A1 (fr) 1995-02-10
NO304226B1 (no) 1998-11-16
NO960376D0 (no) 1996-01-29
GB2280436A (en) 1995-02-01
PT101554B (pt) 2000-01-31
CZ289300B6 (cs) 2001-12-12
HUP9774567A2 (en) 1997-01-28
NZ271632A (en) 1997-07-27
BE1008403A4 (fr) 1996-05-07
NO960376L (no) 1996-01-29

Similar Documents

Publication Publication Date Title
DK172074B1 (da) Fremgangsmåde til krystallisation af iopamidol og anvendelse af butanol dertil
FI87768C (fi) Foerfarande foer framstaellning av 1,6-di(n3-cyan-n1-guanidino)hexan
EP0747344B1 (en) Process for the purification and crystallisation of iopamidol
US6037494A (en) Process for the crystallization from a linear or branched (C5-C6) alcohol or their mixtures of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyy l)amino]-2,4,6-triiodo-1,3-benzendicarboxamide
CN112409182A (zh) 一种乳酸薄荷酯的合成及提纯分离方法
JPH04290877A (ja) 対称的な２，２’−メチレンビスベンゾトリアゾリル　フェノール類の製造方法
HUT56050A (en) Process for resolving 2-amino-4phenyl-butane
JP3130396B2 (ja) 光学異性体分離法
RU2154628C2 (ru) СПОСОБ ПОЛУЧЕНИЯ γ-АМИНОМАСЛЯНОЙ КИСЛОТЫ
KR970008311B1 (ko) 3-피롤린의 제조방법
KR20170039071A (ko) 광학 활성 2-메틸피페라진의 제조 방법
NO331657B1 (no) Fremgangsmate for fremstilling av iohexol
BE579146A (ru)
BE579144A (ru)
JPS60243051A (ja) ｄ，ｄ′‐２，２′‐（エチレンジイミノ）ジ‐１‐ブタノールを製造する方法
JPS60197647A (ja) 光学活性酸アミドの取得方法

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired

Expiry date: 20140729