DK169945B1 - 25-Hydroxy-vitamin-D3-derivater, fremgangsmåde til fremstilling deraf samt lægemiddel indeholdende disse forbindelser - Google Patents

25-Hydroxy-vitamin-D3-derivater, fremgangsmåde til fremstilling deraf samt lægemiddel indeholdende disse forbindelser Download PDF

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Publication number
DK169945B1
DK169945B1 DK019789A DK19789A DK169945B1 DK 169945 B1 DK169945 B1 DK 169945B1 DK 019789 A DK019789 A DK 019789A DK 19789 A DK19789 A DK 19789A DK 169945 B1 DK169945 B1 DK 169945B1
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Prior art keywords
compound
formula
mixture
treatment
compounds
Prior art date
Application number
DK019789A
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Danish (da)
English (en)
Other versions
DK19789D0 (da
DK19789A (da
Inventor
Bernard Michael Hennessy
Shian-Jan Shiuey
Gary Arthur Truitt
Milan Radoje Uskokovic
Enrico Giuseppe Baggiolini
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK19789D0 publication Critical patent/DK19789D0/da
Publication of DK19789A publication Critical patent/DK19789A/da
Application granted granted Critical
Publication of DK169945B1 publication Critical patent/DK169945B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
DK019789A 1988-01-20 1989-01-17 25-Hydroxy-vitamin-D3-derivater, fremgangsmåde til fremstilling deraf samt lægemiddel indeholdende disse forbindelser DK169945B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20
US14593288 1988-01-20

Publications (3)

Publication Number Publication Date
DK19789D0 DK19789D0 (da) 1989-01-17
DK19789A DK19789A (da) 1989-07-21
DK169945B1 true DK169945B1 (da) 1995-04-10

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
DK019789A DK169945B1 (da) 1988-01-20 1989-01-17 25-Hydroxy-vitamin-D3-derivater, fremgangsmåde til fremstilling deraf samt lægemiddel indeholdende disse forbindelser

Country Status (23)

Country Link
EP (1) EP0325279B1 (fr)
JP (1) JPH0764806B2 (fr)
KR (1) KR960009119B1 (fr)
AR (1) AR247551A1 (fr)
AT (1) ATE74350T1 (fr)
AU (1) AU622139B2 (fr)
BG (1) BG60530B2 (fr)
CA (1) CA1337529C (fr)
DE (1) DE58901056D1 (fr)
DK (1) DK169945B1 (fr)
ES (1) ES2033467T3 (fr)
FI (1) FI90764C (fr)
GR (1) GR3004786T3 (fr)
HU (1) HU201007B (fr)
IE (1) IE60921B1 (fr)
IL (1) IL88989A (fr)
MC (1) MC1998A1 (fr)
NO (1) NO175429C (fr)
NZ (1) NZ227641A (fr)
PH (1) PH25605A (fr)
PT (1) PT89486B (fr)
YU (1) YU47298B (fr)
ZA (1) ZA8923B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DK0398217T3 (da) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferolderivater
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
DE69304279T2 (de) * 1992-05-20 1997-02-20 Hoffmann La Roche Fluorierte Analoge Vitamins D3
CA2096105A1 (fr) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Analogues fluores de vitamine d3
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
TW267161B (fr) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
ES2196476T3 (es) * 1997-05-02 2003-12-16 Duphar Int Res Un metodo de preparar compuestos de 16-deshidro-vitamina d.
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US9221753B2 (en) * 2004-02-03 2015-12-29 Chugai Seiyaku Kabushiki Kaisha Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
EP1883626B1 (fr) * 2005-04-25 2017-10-11 OPKO Ireland Global Holdings, Ltd. Analogues d'oxime 16,23-diene 25 a calcemie basse de 1alpha,25-dihydroxy-vitamine d3
JP2009508813A (ja) * 2005-08-18 2009-03-05 ビオクセル エッセ ピ ア １α−フルオロー２５−ヒドロキシ−１６−２３Ｅ−ジエン−２６，２７−ビスホモ−２０−エピ−コレカルシフェロールの合成

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7803154A (nl) * 1977-03-24 1978-09-26 Wisconsin Alumni Res Found Vitamine d-antagonisten, werkwijze voor de be- reiding daarvan, en preparaten die ze bevatten.
NL7903929A (nl) * 1978-05-19 1979-11-21 Wisconsin Alumni Res Found Verbindingen met anti-vitamine d activiteit, farmaceutisch preparaat, dat een dergelijke verbinding bevat, alsmede werkwijze voor de toepassing van dergelijke verbindingen.
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DK0398217T3 (da) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferolderivater

Also Published As

Publication number Publication date
NO175429B (no) 1994-07-04
AR247551A1 (es) 1995-01-31
BG60530B2 (bg) 1995-07-28
GR3004786T3 (fr) 1993-04-28
JPH0764806B2 (ja) 1995-07-12
MC1998A1 (fr) 1990-01-26
KR960009119B1 (en) 1996-07-13
PT89486A (pt) 1989-10-04
YU47298B (sh) 1995-01-31
DE58901056D1 (de) 1992-05-07
FI90764C (fi) 1994-03-25
NO890239D0 (no) 1989-01-19
NO890239L (no) 1989-07-21
KR890011838A (ko) 1989-08-22
EP0325279B1 (fr) 1992-04-01
CA1337529C (fr) 1995-11-07
YU11789A (en) 1991-04-30
ES2033467T3 (es) 1993-03-16
ZA8923B (en) 1989-09-27
PH25605A (en) 1991-08-08
FI890283A0 (fi) 1989-01-19
IL88989A (en) 1993-08-18
IE890157L (en) 1989-07-20
JPH029861A (ja) 1990-01-12
ATE74350T1 (de) 1992-04-15
HU201007B (en) 1990-09-28
IL88989A0 (en) 1989-08-15
AU2864489A (en) 1989-07-20
EP0325279A1 (fr) 1989-07-26
FI890283A (fi) 1989-07-21
NO175429C (no) 1994-10-12
IE60921B1 (en) 1994-09-07
DK19789D0 (da) 1989-01-17
DK19789A (da) 1989-07-21
HUT49317A (en) 1989-09-28
NZ227641A (en) 1991-06-25
AU622139B2 (en) 1992-04-02
FI90764B (fi) 1993-12-15
PT89486B (pt) 1993-12-31

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B1 Patent granted (law 1993)
PBP Patent lapsed

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