IL88989A - 16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL88989A
IL88989A IL88989A IL8898989A IL88989A IL 88989 A IL88989 A IL 88989A IL 88989 A IL88989 A IL 88989A IL 8898989 A IL8898989 A IL 8898989A IL 88989 A IL88989 A IL 88989A
Authority
IL
Israel
Prior art keywords
dehydro
vitamin
derivatives
preparation
pharmaceutical compositions
Prior art date
Application number
IL88989A
Other versions
IL88989A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL88989A0 publication Critical patent/IL88989A0/en
Publication of IL88989A publication Critical patent/IL88989A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
IL88989A 1988-01-20 1989-01-18 16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them IL88989A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20

Publications (2)

Publication Number Publication Date
IL88989A0 IL88989A0 (en) 1989-08-15
IL88989A true IL88989A (en) 1993-08-18

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
IL88989A IL88989A (en) 1988-01-20 1989-01-18 16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
EP (1) EP0325279B1 (en)
JP (1) JPH0764806B2 (en)
KR (1) KR960009119B1 (en)
AR (1) AR247551A1 (en)
AT (1) ATE74350T1 (en)
AU (1) AU622139B2 (en)
BG (1) BG60530B2 (en)
CA (1) CA1337529C (en)
DE (1) DE58901056D1 (en)
DK (1) DK169945B1 (en)
ES (1) ES2033467T3 (en)
FI (1) FI90764C (en)
GR (1) GR3004786T3 (en)
HU (1) HU201007B (en)
IE (1) IE60921B1 (en)
IL (1) IL88989A (en)
MC (1) MC1998A1 (en)
NO (1) NO175429C (en)
NZ (1) NZ227641A (en)
PH (1) PH25605A (en)
PT (1) PT89486B (en)
YU (1) YU47298B (en)
ZA (1) ZA8923B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (en) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferol derivatives
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
ATE141914T1 (en) * 1992-05-20 1996-09-15 Hoffmann La Roche FLUORINATED ANALOGUE VITAMINS D3
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
TW267161B (en) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
DK0884308T3 (en) * 1997-05-02 2003-07-21 Duphar Int Res Process for Preparation of 16-Dehydro Vitamin D Compounds
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US9221753B2 (en) * 2004-02-03 2015-12-29 Chugai Seiyaku Kabushiki Kaisha Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
JP5449767B2 (en) * 2005-04-25 2014-03-19 サイトクロマ インコーポレイテッド Low plasma calcium-elevating 16,23-diene-25-oxime analog of 1α, 25-dihydroxyvitamin D3
CA2619311A1 (en) * 2005-08-18 2007-02-22 Bioxell S.P.A. Synthesis of 1.alpha.-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7803154A (en) * 1977-03-24 1978-09-26 Wisconsin Alumni Res Found VITAMIN D ANTAGONISTS, METHOD OF PREPARATION THEREOF, AND PREPARATIONS CONTAINING THEY.
DE2920092A1 (en) * 1978-05-19 1979-11-29 Wisconsin Alumni Res Found ANTIVITAMIN D COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (en) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferol derivatives

Also Published As

Publication number Publication date
JPH0764806B2 (en) 1995-07-12
EP0325279B1 (en) 1992-04-01
YU11789A (en) 1991-04-30
ZA8923B (en) 1989-09-27
FI90764C (en) 1994-03-25
PT89486B (en) 1993-12-31
AU2864489A (en) 1989-07-20
ES2033467T3 (en) 1993-03-16
AR247551A1 (en) 1995-01-31
GR3004786T3 (en) 1993-04-28
IE890157L (en) 1989-07-20
NO175429C (en) 1994-10-12
IL88989A0 (en) 1989-08-15
DE58901056D1 (en) 1992-05-07
HUT49317A (en) 1989-09-28
EP0325279A1 (en) 1989-07-26
HU201007B (en) 1990-09-28
FI890283A (en) 1989-07-21
NO175429B (en) 1994-07-04
DK19789A (en) 1989-07-21
KR890011838A (en) 1989-08-22
JPH029861A (en) 1990-01-12
FI890283A0 (en) 1989-01-19
PH25605A (en) 1991-08-08
YU47298B (en) 1995-01-31
MC1998A1 (en) 1990-01-26
KR960009119B1 (en) 1996-07-13
NO890239L (en) 1989-07-21
DK169945B1 (en) 1995-04-10
IE60921B1 (en) 1994-09-07
BG60530B2 (en) 1995-07-28
AU622139B2 (en) 1992-04-02
NO890239D0 (en) 1989-01-19
ATE74350T1 (en) 1992-04-15
FI90764B (en) 1993-12-15
NZ227641A (en) 1991-06-25
DK19789D0 (en) 1989-01-17
CA1337529C (en) 1995-11-07
PT89486A (en) 1989-10-04

Similar Documents

Publication Publication Date Title
IL91129A0 (en) Aminomethyloxooxazolidinyl arylbenzene derivatives,their preparation and pharmaceutical compositions containing them
IL90245A0 (en) Ethenediamine derivatives,their preparation and pharmaceutical compositions containing them
IL95045A0 (en) Thienodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL100262A0 (en) Alpha-oxoacetamide derivatives,their preparation and pharmaceutical compositions containing them
IL92544A0 (en) Piperazine derivatives,their preparation and pharmaceutical compositions containing them
IL86798A (en) 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them
IL94082A0 (en) 3-n-substituted carbamoyl-indole derivatives,their preparation and pharmaceutical compositions containing them
IL97050A0 (en) 4-isoxazolecarboxamide derivatives,pharmaceutical compositions containing them and their preparation
IL83432A (en) N-phenylcarboxamide derivatives,their preparation and pharmaceutical compositions containing them
IL88989A (en) 16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them
IL92633A0 (en) Piperidine derivatives,their preparation and pharmaceutical compositions containing them
IL92710A (en) 2-iminobenzothiazoline derivatives, their preparation and pharmaceutical compositions containing them
IL88314A0 (en) Indane derivatives,their preparation and pharmaceutical compositions containing them
IL89084A0 (en) Benzodioxole derivatives,their preparation and pharmaceutical compositions containing them
IL84128A0 (en) 3-propenylcephem derivatives,their preparation and pharmaceutical compositions containing them
IL88002A0 (en) 2,2-dimethylchromene derivatives,their preparation and pharmaceutical compositions containing them
IL91245A0 (en) Benzopyranol derivatives,their preparation and pharmaceutical compositions containing them
IL90002A0 (en) Phosphonoalkylpurine derivatives,their preparation and pharmaceutical compositions containing them
IL91709A0 (en) Substituted thienopyrans,their preparation and pharmaceutical compositions containing them
IL92889A0 (en) Benzene derivatives,their preparation and pharmaceutical compositions containing them
IL83753A (en) Sulphonamidoethyl derivatives,their preparation and pharmaceutical compositions containing them
IL92634A0 (en) Adenosine derivatives,their preparation and pharmaceutical compositions containing them
IL92326A0 (en) Substituted oxadiamino-butanes,their preparation and pharmaceutical compositions containing them
IL90324A0 (en) 2-aminoethanol derivatives,their preparation and pharmaceutical compositions containing them
IL89533A0 (en) Benzocycloheptene derivatives,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees