IL88989A - 16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL88989A
IL88989A IL88989A IL8898989A IL88989A IL 88989 A IL88989 A IL 88989A IL 88989 A IL88989 A IL 88989A IL 8898989 A IL8898989 A IL 8898989A IL 88989 A IL88989 A IL 88989A
Authority
IL
Israel
Prior art keywords
dehydro
vitamin
derivatives
preparation
pharmaceutical compositions
Prior art date
Application number
IL88989A
Other versions
IL88989A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL88989A0 publication Critical patent/IL88989A0/en
Publication of IL88989A publication Critical patent/IL88989A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL88989A 1988-01-20 1989-01-18 16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them IL88989A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20

Publications (2)

Publication Number Publication Date
IL88989A0 IL88989A0 (en) 1989-08-15
IL88989A true IL88989A (en) 1993-08-18

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
IL88989A IL88989A (en) 1988-01-20 1989-01-18 16-dehydro-vitamin d3 derivatives, their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
EP (1) EP0325279B1 (en)
JP (1) JPH0764806B2 (en)
KR (1) KR960009119B1 (en)
AR (1) AR247551A1 (en)
AT (1) ATE74350T1 (en)
AU (1) AU622139B2 (en)
BG (1) BG60530B2 (en)
CA (1) CA1337529C (en)
DE (1) DE58901056D1 (en)
DK (1) DK169945B1 (en)
ES (1) ES2033467T3 (en)
FI (1) FI90764C (en)
GR (1) GR3004786T3 (en)
HU (1) HU201007B (en)
IE (1) IE60921B1 (en)
IL (1) IL88989A (en)
MC (1) MC1998A1 (en)
NO (1) NO175429C (en)
NZ (1) NZ227641A (en)
PH (1) PH25605A (en)
PT (1) PT89486B (en)
YU (1) YU47298B (en)
ZA (1) ZA8923B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DE69005897D1 (en) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferol derivatives.
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
ES2091515T3 (en) * 1992-05-20 1996-11-01 Hoffmann La Roche FLUORATED ANALOGS OF VITAMIN D3.
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
TW267161B (en) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
JPH10316652A (en) * 1997-05-02 1998-12-02 Duphar Internatl Res Bv Production of 16-dehydro-vitamin d compound
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US9221753B2 (en) * 2004-02-03 2015-12-29 Chugai Seiyaku Kabushiki Kaisha Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
WO2006113990A2 (en) * 2005-04-25 2006-11-02 Cytochroma Inc. LOW-CALCEMIC 16,23-DIENE 25-OXIME ANALOGS OF 1α ,25-DIHYDROXY VITAMIN D3
JP2009508813A (en) * 2005-08-18 2009-03-05 ビオクセル エッセ ピ ア Synthesis of 1α-fluoro-25-hydroxy-16-23E-diene-26,27-bishomo-20-epi-cholecalciferol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2812741C2 (en) * 1977-03-24 1987-03-12 Wisconsin Alumni Research Foundation, Madison, Wis. Vitamin D↓3↓ derivatives, processes and intermediates for their preparation and medicinal products containing them
GB2021115B (en) * 1978-05-19 1982-10-06 Wisconsin Alumni Res Found Vitamin d derivatives
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DE69005897D1 (en) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferol derivatives.

Also Published As

Publication number Publication date
FI890283A0 (en) 1989-01-19
FI890283A (en) 1989-07-21
ES2033467T3 (en) 1993-03-16
PT89486A (en) 1989-10-04
PT89486B (en) 1993-12-31
NO175429B (en) 1994-07-04
ATE74350T1 (en) 1992-04-15
IL88989A0 (en) 1989-08-15
DK169945B1 (en) 1995-04-10
DK19789A (en) 1989-07-21
HU201007B (en) 1990-09-28
JPH0764806B2 (en) 1995-07-12
GR3004786T3 (en) 1993-04-28
FI90764B (en) 1993-12-15
YU47298B (en) 1995-01-31
FI90764C (en) 1994-03-25
BG60530B2 (en) 1995-07-28
DK19789D0 (en) 1989-01-17
IE60921B1 (en) 1994-09-07
IE890157L (en) 1989-07-20
MC1998A1 (en) 1990-01-26
AU2864489A (en) 1989-07-20
NO175429C (en) 1994-10-12
NO890239L (en) 1989-07-21
PH25605A (en) 1991-08-08
ZA8923B (en) 1989-09-27
EP0325279B1 (en) 1992-04-01
AU622139B2 (en) 1992-04-02
CA1337529C (en) 1995-11-07
EP0325279A1 (en) 1989-07-26
HUT49317A (en) 1989-09-28
JPH029861A (en) 1990-01-12
KR960009119B1 (en) 1996-07-13
KR890011838A (en) 1989-08-22
NZ227641A (en) 1991-06-25
YU11789A (en) 1991-04-30
DE58901056D1 (en) 1992-05-07
NO890239D0 (en) 1989-01-19
AR247551A1 (en) 1995-01-31

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Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees