MC1998A1 - Composes pour le traitement des maladies hyperproliferatibes et procede de preparation - Google Patents

Composes pour le traitement des maladies hyperproliferatibes et procede de preparation

Info

Publication number
MC1998A1
MC1998A1 MC902029A MC2029A MC1998A1 MC 1998 A1 MC1998 A1 MC 1998A1 MC 902029 A MC902029 A MC 902029A MC 2029 A MC2029 A MC 2029A MC 1998 A1 MC1998 A1 MC 1998A1
Authority
MC
Monaco
Prior art keywords
hyperproliferatible
diseases
compounds
preparation
treatment
Prior art date
Application number
MC902029A
Other languages
English (en)
Inventor
Giuseppe Baggiolini Enrico
Michael Hennessy Bernard
Shiuey Shian-Jan
Arthur Truitt Gary
Radoje Uskokovic Milan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1998A1 publication Critical patent/MC1998A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
MC902029A 1988-01-20 1989-01-19 Composes pour le traitement des maladies hyperproliferatibes et procede de preparation MC1998A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20

Publications (1)

Publication Number Publication Date
MC1998A1 true MC1998A1 (fr) 1990-01-26

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
MC902029A MC1998A1 (fr) 1988-01-20 1989-01-19 Composes pour le traitement des maladies hyperproliferatibes et procede de preparation

Country Status (23)

Country Link
EP (1) EP0325279B1 (fr)
JP (1) JPH0764806B2 (fr)
KR (1) KR960009119B1 (fr)
AR (1) AR247551A1 (fr)
AT (1) ATE74350T1 (fr)
AU (1) AU622139B2 (fr)
BG (1) BG60530B2 (fr)
CA (1) CA1337529C (fr)
DE (1) DE58901056D1 (fr)
DK (1) DK169945B1 (fr)
ES (1) ES2033467T3 (fr)
FI (1) FI90764C (fr)
GR (1) GR3004786T3 (fr)
HU (1) HU201007B (fr)
IE (1) IE60921B1 (fr)
IL (1) IL88989A (fr)
MC (1) MC1998A1 (fr)
NO (1) NO175429C (fr)
NZ (1) NZ227641A (fr)
PH (1) PH25605A (fr)
PT (1) PT89486B (fr)
YU (1) YU47298B (fr)
ZA (1) ZA8923B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (fr) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dérivés du déhydrocholécalciférol
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
EP0580968B1 (fr) * 1992-05-20 1996-08-28 F. Hoffmann-La Roche Ag Derivés fluorinés de la vitamine D3
CA2096105A1 (fr) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Analogues fluores de vitamine d3
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
TW267161B (fr) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
EP0884308B1 (fr) * 1997-05-02 2003-04-16 Duphar International Research B.V Procédé de préparation de composés de 16-déhydro vitamine D
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
WO2005074389A2 (fr) * 2004-02-03 2005-08-18 Chugai Pharmaceutical Co Ltd Procede de synthese de composes de vitamine d et intermediaires pour la synthese des composes
EP1883626B1 (fr) * 2005-04-25 2017-10-11 OPKO Ireland Global Holdings, Ltd. Analogues d'oxime 16,23-diene 25 a calcemie basse de 1alpha,25-dihydroxy-vitamine d3
CN101287705A (zh) * 2005-08-18 2008-10-15 拜奥艾克塞尔股份公司 1α-氟-25-羟基-16-23E-二烯-26,27-双高-20-表-胆骨化醇的合成

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2384755A1 (fr) * 1977-03-24 1978-10-20 Wisconsin Alumni Res Found Derives de la vitamine d3 ayant une activite antivitamine d
FR2426044A2 (fr) * 1978-05-19 1979-12-14 Wisconsin Research Foundation Derives de la vitamine d3 ayant une activite anti-vitamine d
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (fr) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dérivés du déhydrocholécalciférol

Also Published As

Publication number Publication date
AU2864489A (en) 1989-07-20
DE58901056D1 (de) 1992-05-07
ZA8923B (en) 1989-09-27
PH25605A (en) 1991-08-08
EP0325279B1 (fr) 1992-04-01
AU622139B2 (en) 1992-04-02
JPH029861A (ja) 1990-01-12
YU11789A (en) 1991-04-30
NO890239D0 (no) 1989-01-19
HU201007B (en) 1990-09-28
GR3004786T3 (fr) 1993-04-28
EP0325279A1 (fr) 1989-07-26
IE890157L (en) 1989-07-20
NO890239L (no) 1989-07-21
NZ227641A (en) 1991-06-25
ES2033467T3 (es) 1993-03-16
PT89486A (pt) 1989-10-04
FI890283A (fi) 1989-07-21
ATE74350T1 (de) 1992-04-15
BG60530B2 (bg) 1995-07-28
FI90764B (fi) 1993-12-15
YU47298B (sh) 1995-01-31
CA1337529C (fr) 1995-11-07
IL88989A (en) 1993-08-18
FI890283A0 (fi) 1989-01-19
PT89486B (pt) 1993-12-31
NO175429C (no) 1994-10-12
DK169945B1 (da) 1995-04-10
AR247551A1 (es) 1995-01-31
KR960009119B1 (en) 1996-07-13
IE60921B1 (en) 1994-09-07
JPH0764806B2 (ja) 1995-07-12
NO175429B (no) 1994-07-04
DK19789A (da) 1989-07-21
HUT49317A (en) 1989-09-28
FI90764C (fi) 1994-03-25
DK19789D0 (da) 1989-01-17
KR890011838A (ko) 1989-08-22
IL88989A0 (en) 1989-08-15

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Legal Events

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